How much does weight loss affect hypertension?

Weight loss of 4 kg by diet reduces systolic and diastolic blood pressure (BP) by 4.5 and 3.2 mm Hg, respectively (SOR: A, systematic review with consistent findings). Weight loss of 1 to 1.2 kg by exercise may produce small reductions in systolic or diastolic BP (SOR: B, mixed quality of studies). Available evidence is inadequate to examine the combined effects of diet and exercise

Management of Alcohol Withdrawal Syndrome

AWS may be managed with outpatient therapy if the patient has mild to moderate symptoms. (Strength of Recommendation [SOR]: B, based on one randomized, prospective trial). The Clinical Institute Withdrawal Assessment Scale for Alcohol, Revised (CIWA-Ar) may be used to assess symptom severity. (SOR: C, based on consistent reliability and validity from case series studies). The decision to prescribe medication is based on the severity of symptoms. High-quality randomized controlled trials and meta-analyses suggest that long-acting benzodiazepines are generally preferred for managing AWS in the inpatient setting. (SOR: A). However, there is also evidence that benzodiazepines are safe in the outpatient setting. (SOR: B, based on one randomized prospective trial)