Poetic Inquiry of and on Play

Dear Carl, Pamela, Natalie, Sandra, and Kimberly,Would you like to come out and play? John, Lynn, Celeste, and I are knocking at your door.We wonder if you might be interested in joining us in a poetic inquiry? The call from CJE asks for papers that address play, playfulness, and childhood.Poetically yours,John, Lynn, Celeste, and SeanP.S. Can’t, too busy, don’t have time? Ready or not, here we come

Inhibition of Notch Signaling in Combination with Paclitaxel Reduces Platinum-Resistant Ovarian Tumor Growth

Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United States because of chemoresistant recurrent disease. Our objective was to investigate the efficacy of inhibiting the Notch pathway with a γ-secretase inhibitor (GSI) in an OvCa patient-derived xenograft model as a single agent therapy and in combination with standard chemotherapy. Methods: Immunocompromised mice bearing xenografts derived from clinically platinum-sensitive human ovarian serous carcinomas were treated with vehicle, GSI (MRK-003) alone, paclitaxel and carboplatin (P/C) alone, or the combination of GSI and P/C. Mice bearing platinum-resistant xenografts were given GSI with or without paclitaxel. Gene transcript levels of the Notch pathway target Hes1 were analyzed using RT-PCR. Notch1 and Notch3 protein levels were evaluated. The Wilcoxon rank-sum test was used to assess significance between the different treatment groups. Results: Expression of Notch1 and 3 was variable. GSI alone decreased tumor growth in two of three platinum-sensitive ovarian tumors (p < 0.05), as well as in one of three platinum-sensitive tumors (p = 0.04). The combination of GSI and paclitaxel was significantly more effective than GSI alone and paclitaxel alone in all platinum-resistant ovarian tumors (all p < 0.05). The addition of GSI did not alter the effect of P/C in platinum-sensitive tumors. Interestingly, although the response of each tumor to chronic GSI exposure did not correlate with its endogenous level of Notch expression, GSI did negatively affect Notch signaling in an acute setting. Conclusion: Inhibiting the Notch signaling cascade with a GSI reduces primary human xenograft growth in vivo. GSI synergized with conventional cytotoxic chemotherapy only in the platinum-resistant OvCa models with single agent paclitaxel. These findings suggest inhibition of the Notch pathway in concert with taxane therapy may hold promise for treatment of platinum-resistant OvCa

The Student Movement Volume 105 Issue 9: Zooming Away: COVID Alert Sends AU Remote

NEWS AUSA Hosts AU\u27s Got Talent, Caralynn Chan AU Says an Early Goodbye to Face-to-Face Semester, Joelle Kim Tenth Annual Honors Church Service Reflects on Christian Stewardship, Elianna Srikureja PULSE Election Results, Interviewed by Masy Domecillo Turkey is Overrated: A Korean Variation on Thanksgiving Dinner, Jessica Rim HUMANS Home for the Holidays: How AU Students Celebrate Christmans, Interviewed by Celeste Richardson Reflecting on Fall Semester with Vice President Frances Faehner, Alyssa Henriquez ARTS & ENTERTAINMENT Tribute to Alex Trebek, Hannah Cruse AUdio Christmas EP is TBD, Interviewed by Megan Napod IEDAS Election Aftermath, Lyle Goulbourne On Healing, Adoniah Simonhttps://digitalcommons.andrews.edu/sm-105/1009/thumbnail.jp

The development of a specific pathogen free (SPF) barrier colony of marmosets (Callithrix jacchus) for aging research

A specific pathogen free (SPF) barrier colony of breeding marmosets (Callithrix jacchus) was established at the Barshop Institute for Longevity and Aging Studies. Rodent and other animal models maintained as SPF barrier colonies have demonstrated improved health and lengthened lifespans enhancing the quality and repeatability of aging research. The marmosets were screened for two viruses and several bacterial pathogens prior to establishing the new SPF colony. Twelve founding animals successfully established a breeding colony with increased reproductive success, improved health parameters, and increased median lifespan when compared to a conventionally housed, open colony. The improved health and longevity of marmosets from the SPF barrier colony suggests that such management can be used to produce a unique resource for future studies of aging processes in a nonhuman primate model

Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells

The response to DNA damage in vertebrate cells involves successive recruitment of DNA signalling and repair factors. We used light microscopy to monitor the genetic dependencies of such localization to a single, induced DNA double strand break (DSB) in vertebrate cells. We used an inducible version of the rare-cutting I-SceI endonuclease to cut a chromosomally integrated I-SceI site beside a Tet operator array that was visualized by binding a Tet repressor-GFP fusion. Formation of γ-H2AX foci at a single DSB was independent of ATM or Ku70. ATM-deficient cells showed normal kinetics of 53Bp1 recruitment to DSBs, but Rad51 localization was retarded. 53Bp1 and Rad51 foci formation at a single DSB was greatly reduced in H2AX-null DT40 cells. We also observed decreased inter-sister chromatid distances after DSB induction, suggesting that cohesin loading at DSBs causes elevated sister chromatid cohesion. Loss of ATM reduced DSB-induced cohesion, consistent with cohesin being an ATM target in the DSB response. These data show that the same genetic pathways control how cells respond to single DSBs and to multiple lesions induced by whole-cell DNA damage

The Student Movement Volume 105 Issue 13: AU Students Speak out Against Anti-AAPI Violence

NEWS James White Library Offers Useful Resources to Students, Amanda Cho The Office of Diversity and Inclusion and the Center for Faith Engagement Host Asian American and Pacific Islander Forum, Jenae Rogers The Office of Research and Creative Scholarship Hosts the Undergraduate Research and Honors Scholar Symposium, Caralynn Chan PULSE My Experience with Robinhood, Matthew Jarrard Nature Spots on Campus, Gloria Oh Pilipino Culture Night, Interviews by Masy Domecillo HUMANS Interview with T Bruggemann, Terika Williams Interviewing Andrews University\u27s AAPI Students on Allyship, Interviewed by Abigail Lee Senior Spotlight: Hailey Kim, Interviewed by Celeste Richardson ARTS & ENTERTAINMENT Creative Spotlight: Marcel Mattox, Interviewed by Joshua Deonarine AAPI Documentaries You Need to Watch, Megan Napod Asian Women, Courtesy of Hollywood, Hannah Cruse IDEAS Flying Sparks: The Implications of the Rise in AAPI Hate, Alannah Tjhatra The Three P\u27s of Perspective, Kyara Samuels THE LAST WORD Respecting Apoliticism, Daniel Selfhttps://digitalcommons.andrews.edu/sm-105/1017/thumbnail.jp

The Student Movement Volume 105 Issue 3: Students Take Appling Break

NEWS Reimagining Chapel through Pulse Groups, Jenae Rogers Pacific Union College Students Evacuated After Glass Fire, Staff Unidos Through Ethnicity, Caralynn Chan PULSE Fresh Air, Fresh Produce, Jessica Rim Pumpkin Spice and Everything Nice, Wambui Karanja Yo Tengo Hambre!: A Sample of Hispanic Cuisine, Interviewed by Alec Bofetiado HUMANS Diversity in the English Classroom, Interviewed by Alyssa Henriquez Kyara Samuels on Panamanian Culture, Interviewed by Ben Lee My Multicultural Experience: Eight Students Discuss The Impact of Hispanic Culture on Their Lives, Interviewed by Celeste Richardson ARTS & ENTERTAINMENT Hispanic & Latinx Show and Movie Recommendations!, Megan Napod TikTok, Time\u27s Running Out, Joshua Deonarine Zoey\u27s Extraordinary Playlist, Hannah Cruse IDEAS Conversations With Me, Evin N. Musgrove Faith in Our Current Moment, Adoniah Simon Remembering RBG Part 1: Legacy of the Supreme Court Justice, American Icon and Feminist Champion, Lyle Goulbourne THE LAST WORD Gaming and \u27The Guys\u27, Daniel Selfhttps://digitalcommons.andrews.edu/sm-105/1003/thumbnail.jp

The Student Movement Volume 105 Issue 1: Back with a Bang

NEWS Suicide Awareness Month in the Chaos of 2020, Kavya Mohanram AUSA Lighthouse Vespers: The Gospel in Motion, Caralynn Chan IDEAS A Summer Recap, Alannah Tjhatra How to Survive a Pandemic, Solana Campbell Writing Cards to Senior Citizens, Sung Been Han PULSE Change Day at Michiana Fil-Am: Dual Perspectives from a Student and an Organizer, Masy Domecillo Honors Agape Feast, Jessica Rim HUMANS Chef Linda Brinegar, Interviewed by Alyssa Henriquez Summer During a Global Pandemic, Interviewed by Ben Lee Teaching During COVID-19, Interviewed by Celeste Richardson The Wellness Center Reopening, Interviewed by Terika Williams ARTS & ENTERTAINMENT A Tribute to Chadwick Boseman, Megan Napod Corn and Watermelon for Everyone!, Megan Napod Local Hotspots: (but not the coronavirus kind), Hannah Cruse Radiant Recitals, Isabella Koh THE LAST WORD Where is Home?, Daniel Selfhttps://digitalcommons.andrews.edu/sm-105/1001/thumbnail.jp

The Student Movement Volume 105 Issue 7: Please Pass the Plexiglass: Friends Unite for Shielded Bite

NEWS Receiving the COVID-19 Vaccine, Interviewed by TJ Hunter Andrews University Choral Performs “Celebrating the Light” Concert, Jenae Rogers AUSA Hosts Sabbath Experience at PMC, Caralynn Chan Dr. Kizzmekia Shanta Corbett Gives Lecture on the Safety and Effectiveness of COVID-19 mRNA Vaccines, Terika Williams Loving in the Grey: This Semester’s First In-Person Chapel, Kristin Ferrer PULSE Holilday Recap, Gloria Oh New Year’s Aspirations, Wambui Karanja The Wellness Column: No Longer Sitting Ducks, Jessica Rim Winter Break Endeavors, by HeeYun Oh HUMANS AU Christmas Album Interview, Interview by Abigail Lee My Experience in COVID Isolation, Interview by Terika Williams Spring Semester 2021 Club Events, Interview by Celeste Richardson ARTS & ENTERTAINMENT Creative Spotlight: Brent LaPorre, Interviewed by Megan Napod Current February Favorites, Megan Napod Long Live the King, Joshua Deonarine IDEAS Insurrection, Impeachment, and Inauguration: Three Wednesdays in January, Solana Campbell What We Learned from 2020 and Are Keeping in 2021, Sion Kimhttps://digitalcommons.andrews.edu/sm-105/1000/thumbnail.jp

The Student Movement Volume 105 Issue 6: Waiting for the Election Results to Fall

NEWS ASIS Holds Game Night and Celebrates 75th Independence Day, Amanda Cho Students Witness Trump Parade, Taylor Uphus University Singers, Canta Bella and Pioneer Men\u27s Chorus Perform for The Road Home Concert, Jenae Rogers PULSE De-stressing through Journaling and Painting, Wambui Karanja Dorm Recipes: How to Never Leave Your Room, Jessica Rim Reading Recommendations, Masy Domecillo HUMANS Club Spotlight: Southern Asian Student Association (SASA), Interviewed by Fitz-Earl McKenzie II Senior Spotlight: Delight Pazvakawambwa, Interviewed by Celeste Richardson Thoughts on Voting in the 2020 Election, Interviewed by Pearl Parker ARTS & ENTERTAINMENT ASIS Game Night: Let\u27s Learn Indonesian Games!, Joshua Deonarine Creative Spotlight: Nathanael Cincala, Interviewed by Megan Napod Good Books for Cold Nights, Hannah Cruse IDEAS COVID-19 Update and the Case for Stricter Mandates, Lyle Goulbourne Productivity Tips to Help You Get Smart Fast, Alannah Tjihatra The Confining Routine, Solana Campbellhttps://digitalcommons.andrews.edu/sm-105/1007/thumbnail.jp