Winds as the origin of radio emission in z=2.5z=2.5 radio-quiet extremely red quasars

Most active galactic nuclei (AGNs) are radio-quiet, and the origin of their radio emission is not well-understood. One hypothesis is that this radio emission is a by-product of quasar-driven winds. In this paper, we present the radio properties of 108 extremely red quasars (ERQs) at $z=2-4$. ERQs are among the most luminous quasars ($L_{bol} \sim 10^{47-48}$ erg/s) in the Universe, with signatures of extreme ($\gg 1000$ km/s) outflows in their [OIII]$\lambda$5007 \AA\ emission, making them the best subjects to seek the connection between radio and outflow activity. All ERQs but one are unresolved in the radio on $\sim 10$ kpc scales, and the median radio luminosity of ERQs is $\nu L_\nu [{\rm 6\,GHz}] = 10^{41.0}$ erg/s, in the radio-quiet regime, but one to two orders of magnitude higher than that of other quasar samples. The radio spectra are steep, with a mean spectral index $\langle \alpha \rangle = -1.0$. In addition, ERQs neatly follow the extrapolation of the low-redshift correlation between radio luminosity and the velocity dispersion of [OIII]-emitting ionized gas. Uncollimated winds, with a power of one per cent of the bolometric luminosity, can account for all these observations. Such winds would interact with and shock the gas around the quasar and in the host galaxy, resulting in acceleration of relativistic particles and the consequent synchrotron emission observed in the radio. Our observations support the picture in which ERQs are signposts of extremely powerful episodes of quasar feedback, and quasar-driven winds as a contributor of the radio emission in the intermediate regime of radio luminosity $\nu L_\nu = 10^{39}-10^{42}$ erg/s.Comment: accepted by MNRA

Labours of Love: A Conversation on Art, Gender, and Social Reproduction

Taking the form of a discussion among an art historian, a curator and an artist, the article explores the assumption that it is love, rather than material gain, that motivates art and cultural workers. Addressing the internalisation of the ideology that one loves one's labour, the interlocutors consider the gendered and class conditions of work in the cultural and academic sectors. Reading ‘theory’ against ‘practice’, they reflect on their own work experiences and upbringings, their curatorial research, and their readings of feminist and Marxist theories of artistic and feminised labour. The discussion considers how the precarious conditions of cultural labour today divide and isolate workers, immersing them in antagonism and competition, and how reflections within feminist art history and theory have possibly downplayed the ongoing (rather than historical) importance of class as well as reproductive labour. Highlighting the dangers of over-identifying with work, the three contributors consider the potential of dis-identifying from work roles and from institutional conventions as one strategy that can potentially challenge the exploitation of the self as well as others. The article concludes with a consideration of how ‘labours of love’ might be collectively revalued and prioritised

The Sloan Digital Sky Survey Reverberation Mapping Project: Velocity Shifts of Quasar Emission Lines

Quasar emission lines are often shifted from the systemic velocity due to various dynamical and radiative processes in the line-emitting region. The level of these velocity shifts depends both on the line species and on quasar properties. We study velocity shifts for the line peaks of various narrow and broad quasar emission lines relative to systemic using a sample of 849 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. The coadded (from 32 epochs) spectra of individual quasars have sufficient signal-to-noise ratio (SNR) to measure stellar absorption lines to provide reliable systemic velocity estimates, as well as weak narrow emission lines. The sample also covers a large dynamic range in quasar luminosity (~2 dex), allowing us to explore potential luminosity dependence of the velocity shifts. We derive average line peak velocity shifts as a function of quasar luminosity for different lines, and quantify their intrinsic scatter. We further quantify how well the peak velocity can be measured for various lines as a function of continuum SNR, and demonstrate there is no systematic bias in the line peak measurements when the spectral quality is degraded to as low as SNR~3 per SDSS pixel. Based on the observed line shifts, we provide empirical guidelines on redshift estimation from [OII]3728, [OIII]5008, [NeV]3426, MgII, CIII], HeII1640, broad Hbeta, CIV, and SiIV, which are calibrated to provide unbiased systemic redshifts in the mean, but with increasing intrinsic uncertainties of 46, 56, 119, 205, 233, 242, 400, 415, and 477 km/s, in addition to the measurement uncertainties. These more realistic redshift uncertainties are generally much larger than the formal uncertainties reported by the redshift pipelines for spectroscopic quasar surveys, and demonstrate the infeasibility of measuring quasar redshifts to better than ~200 km/s with only broad lines.Comment: matched to the published version; minor changes and conclusions unchange

Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers

Anxiety is associated with threat-related biases in information processing such as heightened attentional vigilance to potential threat. Such biases are an important focus of psychological treatments for anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) are effective in the treatment of a range of anxiety disorders. The aim of this study was to assess the effect of an SSRI on the processing of threat in healthy volunteers. A selective noradrenergic reuptake inhibitor (SNRI), which is not generally used in the treatment of anxiety, was used as a contrast to assess the specificity of SSRI effects on threat processing. Forty-two healthy volunteers were randomly assigned to 7 d double-blind intervention with the SSRI citalopram (20 mg/d), the SNRI reboxetine (8 mg/d), or placebo. On the final day, attentional and interpretative bias to threat was assessed using the attentional probe and the homograph primed lexical decision tasks. Citalopram reduced attentional vigilance towards fearful faces but did not affect the interpretation of ambiguous homographs as threatening. Reboxetine had no significant effect on either of these measures. Citalopram reduces attentional orienting to threatening stimuli, which is potentially relevant to its clinical use in the treatment of anxiety disorders. This finding supports a growing literature suggesting that an important mechanism through which pharmacological agents may exert their effects on mood is by reversing the cognitive biases that characterize the disorders that they treat. Future studies are needed to clarify the neural mechanisms through which these effects on threat processing are mediated

Patient flow within UK emergency departments: a systematic review of the use of computer simulation modelling methods

Background: Overcrowding in the emergency department (ED) is common in the UK as in other countries worldwide. Computer simulation is one approach used for understanding the causes of ED overcrowding and assessing the likely impact of changes to the delivery of emergency care. However, little is known about the usefulness of computer simulation for analysis of ED patient flow. We undertook a systematic review to investigate the different computer simulation methods and their contribution for analysis of patient flow within EDs in the UK. Methods: We searched eight bibliographic databases (MEDLINE; EMBASE; COCHRANE; WEB OF SCIENCE; CINAHL; INSPEC; MATHSCINET; and ACM DIGITAL LIBRARY) from date of inception until 31 March 2016. Studies were included if they used a computer simulation method to capture patient progression within the ED of an established UK NHS hospital. Studies were summarised in terms of simulation method, key assumptions, input and output data, conclusions drawn, and implementation of results. Results: Twenty one studies met the inclusion criteria. Of these, 19 used discrete event simulation and 2 used system dynamics models. The purpose of many of these studies (n=16; 76%) centred on service redesign. Seven studies (33%) provided no details about the ED being investigated. Most studies (n=18; 86%) used specific hospital models of ED patient flow. Overall, the reporting of underlying modelling assumptions was poor. Nineteen studies (90%) considered patient waiting or throughput times as the key outcome measure. Twelve studies (57%) reported some involvement of stakeholders in the simulation study. However, only 3 studies (14%) reported on the implementation of changes supported by the simulation. Conclusions: We found that computer simulation can provide a means to pre-test changes to ED care delivery before implementation in a safe and efficient manner. However, there are some methodological, data, stakeholder, implementation, and reporting issues, which must be addressed by future studies

Biases in Virial Black Hole Masses: An SDSS Perspective

We compile black hole (BH) masses for $\sim 60,000$ quasars in the redshift range $0.1 \lesssim z \lesssim 4.5$ included in the Fifth Data Release of the Sloan Digital Sky Survey (SDSS), using virial BH mass estimators based on the \hbeta, \MgII, and \CIV emission lines. We find that: (1) within our sample, the widths of the three lines follow log-normal distributions, with means and dispersions that do not depend strongly on luminosity or redshift;(2) the \MgII- and \hbeta-estimated BH masses are consistent with one another; and (3) the \CIV BH mass estimator may be more severely affected by a disk wind component than the \MgII and \hbeta estimators, giving a positive bias in mass correlated with the \CIV-\MgII blueshift. Most SDSS quasars have virial BH masses in the range $10^8-10^9 M_\odot$. There is a clear upper mass limit of $\sim 10^{10} M_\odot$ for active BHs at $z \gtrsim 2$, decreasing at lower redshifts. Making the reasonable assumptions that the underlying BH mass distribution decreases with mass and that the Eddington ratio distribution at fixed BH mass has non-zero width, we show that the measured virial BH mass distribution and Eddington ratio distribution are subject to Malmquist bias. A radio quasar subsample (with $1.5\lesssim z\lesssim 2.3$) has mean virial BH mass larger by $\sim 0.12$ dex than the whole sample. A broad absorption line (BAL) quasar subsample (with $1.7\lesssim z\lesssim 2.2$) has identical virial mass distribution as the nonBAL sample, with no mean offset. (Abridged)Comment: Updated virial mass measurements; improved presentation of the MC simulation; added new discussion sections; conclusions unchanged. The full table1 is available at http://www.astro.princeton.edu/~yshen/BH_mass/datafile1.txt.tar.g

Variations in policies for accessing elective musculoskeletal procedures in the English National Health Service:A documentary analysis

OBJECTIVE: The overall aim of this study was to investigate how commissioning policies for accessing clinical procedures compare in the context of the English National Health Service. Our primary objective was to compare policy wording and categorise any variations identified. Our secondary objective was to explore how any points of variation relate to national guidance. METHODS: This study entailed documentary analysis of commissioning policies that stipulated criteria for accessing eight elective musculoskeletal procedures. For each procedure, we retrieved policies held by regions with higher and lower rates of clinical activity relative to the national average. Policies were subjected to content and thematic analysis, using constant comparison techniques. Matrices and descriptive reports were used to compare themes across policies for each procedure and derive categories of variation that arose across two or more procedures. National guidance relating to each procedure were identified and scrutinised, to explore whether these provided context for explaining the policy variations. RESULTS: Thirty-five policy documents held by 14 geographic regions were included in the analysis. Policies either focused on a single procedure/treatment or covered several procedures/treatments in an all-encompassing document. All policies stipulated criteria that needed to be fulfilled prior to accessing treatment, but there were inconsistences in the evidence cited. Policies varied in recurring ways, with respect to specification of non-surgical treatments and management, requirements around time spent using non-surgical approaches, diagnostic requirements, requirements around symptom severity and disease progression, and use of language, in the form of terms and phrases (‘threshold modifiers’) which could open up or restrict access to care. National guidance was identified for seven of the procedures, but this guidance did not specify criteria for accessing the procedures in question, making direct comparisons with regional policies difficult. CONCLUSIONS: This, to our knowledge, is the first study to identify recurring ways in which policies for accessing treatment can vary within a single-payer system with universal coverage. The findings raise questions around whether formulation of commissioning policies should receive more central support to promote greater consistency – especially where evidence is uncertain, variable or lacking

Markers of cardiac dysfunction in cognitive impairment and dementia

Markers of cardiac dysfunction such as amino terminal pro-brain natriuretic peptide (NTpro-BNP) and high sensitivity cardiac troponin T (hs-cTnT) may be associated with dementia. However, limited data exist on their association with either pre-dementia stages, that is, cognitive impairment no dementia (CIND), or the burden of cerebrovascular diseases (CeVD). We therefore, examined the association of these biomarkers of cardiac dysfunction with CeVD in both CIND and dementia. A case–control study, with cases recruited from memory clinics and controls from memory clinics and community. All subjects underwent collection of blood samples, neuropsychological assessment, and neuroimaging. Subjects were classified as CIND and dementia based on clinical criteria whilst significant CeVD was defined as the presence of cortical infarcts and/or more than 2 lacunes and/or confluent white matter lesions in two regions of brain on Age-Related White Matter Changes Scale. We included a total of 35 controls (mean age: 65.9 years), 78 CIND (mean age: 70.2 years) and 80 cases with dementia (mean age: 75.6 years). Plasma concentrations of hs-cTnT were associated significantly with CeVD in both CIND (odds ratios [OR]: 9.05; 95% confidence interval [CI]: 1.64–49.79) and dementia (OR: 16.89; 95%CI: 2.02–142.67). In addition, NTpro-BNP was associated with dementia with CeVD (OR: 7.74; 95%CI: 1.23–48.58). These associations were independent of other vascular risk factors. In this study, we showed that plasma NTproBNP and hs-cTnT are associated with dementia and CIND, only when accompanied by presence of CeVD