Health Report

This Plan for Health is an unusual undertaking in two respects. It is part of the Go To 2040 regional master plan along with other human services components that have, historically, been outside the purview of planners, who are usually more concerned with issues such as land use, transportation, and solid waste disposal. And the planning horizon covers three decades, providing a rare opportunity for health planners to engage in truly long range planning. Health is more than medical care: a variety of factors determine the health of individuals and a community. These "underlying determinants" include demographic composition, income and poverty, employment, social status, cultural beliefs and practices, level of educational attainment, environmental conditions, genetics, individual behaviors, and public health measures, in addition to the quality and utilization of health care services.Most planning efforts, which attempt to affect community health, deal only with public health and medical services delivery, even though the other factors are known to have a greater influence on community and individual health. This plan approaches the challenge differently; it focuses on the underlying determinants of health and moves beyond the narrower focus that health planners and public health officials traditionally take. This report identifies the connections that education, land use, transportation, food and hunger, civic engagement, workforce, and the economy have with health, and it focuses on strategies and interventions that can be pursued in these sectors to improve health throughout this region

Cross-Florida Barge Canal, 1927-1968

The early and later history of the Cross-Florida Barge Canal is said to be divided by the enactment of the River and Harbor Act, signed into law January 21, 1927 by President Calvin Coolidge. This act authorized the secretary of war to make a preliminary examination and survey of the “Waterway from Cumberland Sound, Georgia and Florida, to the Mississippi River,” and it had had the full support of President Harding, Coolidge’s predecessor, who declared himself in favor of the broadest development of the country’s inland waterways. Henry Holland Buckman, who has been called the “father confessor” of the present canal project, described this legislation as “the movement which finally resulted in beginning construction of the canal.

Richard C. Sewell Correspondence

Entry is a typed biographical sketch

Omega-3 DHA and Sleep in UK Children: Results From the DOLAB Study

Results from the DHA-Oxford-Learning-and-Behaviour study (DOLAB) on the benefits of DHA supplementation for childrens' sleep. See also the article: Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study – a randomized controlled trial. (http://onlinelibrary.wiley.com/enhanced/doi/10.1111/jsr.12135/

Blood Omega-3 Concentrations are Associated With Reading, Working Memory and Behaviour in Healthy Children Aged 7-9 Years

Epidemiological results from the DHA-Oxford-Learning-and-Behaviour study (DOLAB). Presented at the International Society for the Study of Fatty Acids and Lipids (ISSFAL) conference 2012 in Vancouver

Evaluation of Tensile Strength and Repeatability of 3D Printed Carbon Fiber Materials and Processes

As additive manufacturing (AM) with composite materials becomes more widely used in industry to create high-strength components, it is vital to have quantified material properties that provide designers and engineers accurate data to decide which materials are suitable for their applications. This study replicates the build processes and tensile tests undertaken by AM material manufacturers to compare tensile strengths achieved with those stated on the manufacturers' data sheets. These are important data to research and analyze as either it will corroborate properties given by the manufacturers and provide confidence in the values provided or it will show that the manufacturer's values cannot always be achieved and that designers and engineers must be more critical about the values manufacturers are providing when using the materials in their own applications. Tensile tests were performed on additively manufactured specimens that had been built using the same parameters that were used during the manufacturers' testing procedures. Digital image correlation was used to accurately measure strain in the test samples, enabling material properties to be determined. Microscopy analysis enabled the visual inspection of the print quality, the identification of defects, and the determination of volume fraction with the samples. The results show inconsistencies between the tensile strength results achieved during this study and the tensile strengths stated by the manufacturers. The results show that two materials exceeded the expected values and one material did not reach the expected value. Analysis of the 3D printed specimens shows that poor fiber-matrix wetting, large voids, and weak interfacial bonding were accountable for the lower-than-expected tensile strength results. While good print quality, low void percentage, proper fiber-matrix wetting, and good control measures were accountable for results that exceeded expectation. These results show that designers and engineers cannot solely rely on material data sheets to establish the mechanical properties of their 3D printed components

Laboratory and Clinical Studies of Cardiac Transplantation

Cardiac transplantation was carried out on four patients at the Medical College of Virginia between May and October of 1968, in an effort to salvage them from the terminal stages of otherwise uncorrectable heart disease. Despite a strikingly good early recovery from operation in each case, three of the patients died of acute homograft rejection in one to three weeks; our second case is living and well, ten months after operation, and is at this writing the world\u27s third longest survivor. The world experience to June of 1969 includes about 130 cardiac transplants. Of the first 100 patients operated on over six months ago, 20 are surviving, and the majority of these have returned to a productive existence, demonstrating the feasibility of complete rehabilitation of at least some terminal patients after cardiac transplantation. The high mortality rate--significantly higher than was anticipated--has resulted from acute and chronic homograft rejection and from the equally difficult problem of infection. Certain lessons have been learned from our own experience and from the world experience with this procedure, and these will be reviewed in an attempt to establish the current status and future potential of cardiac transplantation

Enhancing the Functionality of a Microscale Bioreactor System as an Industrial Process Development Tool for Mammalian Perfusion Culture

Without a scale-down model for perfusion, high resource demand makes cell line screening or process development challenging; therefore potentially successful cell lines or perfusion processes are unrealised and their ability untapped. We present here the re-functioning of a high capacity microscale system that is typically employed in fed-batch process development to allow perfusion operation utilising in situ gravity settling and automated sampling. In this low resource setting, which involved routine perturbations in mixing, pH and dissolved oxygen concentrations, the specific productivity and the maximum cell concentration were higher than 3.0x106 mg/cell/day and 7x107 cells/ml, respectively, across replicate microscale perfusion runs conducted at one vessel volume exchange per day. A comparative analysis was conducted at bench scale with vessels operated in perfusion mode utilising a cell retention device. Neither specific productivity nor product quality indicated by product aggregation [6%] was significantly different across scales 19 days post inoculation, thus demonstrating this setup to be a suitable and reliable platform for evaluating the performance of cell lines and the effect of process parameters relevant to perfusion mode of culturing

Is Motorized Treadmill Running Biomechanically Comparable to Overground Running? A Systematic Review and Meta-Analysis of Cross-Over Studies

Background Treadmills are often used in research, clinical practice, and training. Biomechanical investigations comparing treadmill and overground running report inconsistent findings. Objective This study aimed at comparing biomechanical outcomes between motorized treadmill and overground running. Methods Four databases were searched until June 2019. Crossover design studies comparing lower limb biomechanics during non-inclined, non-cushioned, quasi-constant-velocity motorized treadmill running with overground running in healthy humans (18-65 years) and written in English were included. Meta-analyses and meta-regressions were performed where possible. Results 33 studies (n = 494 participants) were included. Most outcomes did not differ between running conditions. However, during treadmill running, sagittal foot-ground angle at footstrike (mean difference (MD) − 9.8° [95% confidence interval: − 13.1 to − 6.6]; low GRADE evidence), knee flexion range of motion from footstrike to peak during stance (MD 6.3° [4.5 to 8.2]; low), vertical displacement center of mass/pelvis (MD − 1.5 cm [− 2.7 to − 0.8]; low), and peak propulsive force (MD − 0.04 body weights [− 0.06 to − 0.02]; very low) were lower, while contact time (MD 5.0 ms [0.5 to 9.5]; low), knee flexion at footstrike (MD − 2.3° [− 3.6 to − 1.1]; low), and ankle sagittal plane internal joint moment (MD − 0.4 Nm/kg [− 0.7 to − 0.2]; low) were longer/higher, when pooled across overground surfaces. Conflicting findings were reported for amplitude of muscle activity. Conclusions Spatiotemporal, kinematic, kinetic, muscle activity, and muscle-tendon outcome measures are largely comparable between motorized treadmill and overground running. Considerations should, however, particularly be given to sagittal plane kinematic differences at footstrike when extrapolating treadmill running biomechanics to overground running