Hubble Frontier Fields: a high-precision strong-lensing analysis of the massive galaxy cluster Abell 2744 using∼180 multiple images

We present a high-precision mass model of galaxy cluster Abell 2744, based on a strong gravitational-lensing analysis of the Hubble Space Telescope Frontier Fields (HFF) imaging data, which now include both Advanced Camera for Surveys and Wide Field Camera 3 observations to the final depth. Taking advantage of the unprecedented depth of the visible and near-infrared data, we identify 34 new multiply imaged galaxies, bringing the total to 61, comprising 181 individual lensed images. In the process, we correct previous erroneous identifications and positions of multiple systems in the northern part of the cluster core. With the lenstool software and the new sets of multiple images, we model the cluster using two cluster-scale dark matter haloes plus galaxy-scale haloes for the cluster members. Our best-fitting model predicts image positions with an rms error of 0.79arcsec, which constitutes an improvement by almost a factor of 2 over previous parametric models of this cluster. We measure the total projected mass inside a 200kpc aperture as (2.162±0.005) ×1014 M⊙, thus reaching 1 per cent level precision for the second time, following the recent HFF measurement of MACSJ0416.1−2403. Importantly, the higher quality of the mass model translates into an overall improvement by a factor of 4 of the derived magnification factor. Together with our previous HFF gravitational lensing analysis, this work demonstrates that the HFF data enables high-precision mass measurements for massive galaxy clusters and the derivation of robust magnification maps to probe the early Univers

Hubble Frontier Fields: a high-precision strong-lensing analysis of galaxy cluster MACSJ0416.1-2403 using∼200 multiple images

We present a high-precision mass model of the galaxy cluster MACSJ0416.1-2403, based on a strong-gravitational-lensing analysis of the recently acquired Hubble Space Telescope Frontier Fields (HFF) imaging data. Taking advantage of the unprecedented depth provided by HST/Advanced Camera for Survey observations in three passbands, we identify 51 new multiply imaged galaxies, quadrupling the previous census and bringing the grand total to 68, comprising 194 individual lensed images. Having selected a subset of the 57 most securely identified multiply imaged galaxies, we use the lenstool software package to constrain a lens model comprised of two cluster-scale dark-matter haloes and 98 galaxy-scale haloes. Our best-fitting model predicts image positions with an rms error of 0.68arcsec, which constitutes an improvement of almost a factor of 2 over previous, pre-HFF models of this cluster. We find the total projected mass inside a 200kpc aperture to be (1.60±0.01)×1014 M⊙, a measurement that offers a three-fold improvement in precision, reaching the per cent level for the first time in any cluster. Finally, we quantify the increase in precision of the derived gravitational magnification of high-redshift galaxies and find an improvement by a factor of∼2.5 in the statistical uncertainty. Our findings impressively confirm that HFF imaging has indeed opened the domain of high-precision mass measurements for massive clusters of galaxie

Harnessing the nursing and midwifery workforce to boost Australia\u27s clinical research impact

For the Medical Research Future Fund (MRFF) to achieve its full impact, it is necessary for health practitioners to be trained and reliably funded to deliver research and translation alongside their clinical work. We offer insight into current systems, concerns and suggestions as this applies to clinical research in nursing and midwifery. Nurses and midwives globally have a long record of delivering high quality clinical research that improves care and outcomes. An analysis of four landmark nursing-led studies in the United States illustrates the value-adding potential of such research: for every grant dollar, the return on investment ranged from $202 to$1206. In Australia, investment in nursing- and midwifery-led research also pays dividends for health care costs and population and health system outcomes, as evidenced from the many research contributions of Australian nurses and midwives over the past decade (Box)

Probing quantum and thermal noise in an interacting many-body system

The probabilistic character of the measurement process is one of the most puzzling and fascinating aspects of quantum mechanics. In many-body systems quantum mechanical noise reveals non-local correlations of the underlying many-body states. Here, we provide a complete experimental analysis of the shot-to-shot variations of interference fringe contrast for pairs of independently created one-dimensional Bose condensates. Analyzing different system sizes we observe the crossover from thermal to quantum noise, reflected in a characteristic change in the distribution functions from Poissonian to Gumbel-type, in excellent agreement with theoretical predictions based on the Luttinger liquid formalism. We present the first experimental observation of quasi long-range order in one-dimensional atomic condensates, which is a hallmark of quantum fluctuations in one-dimensional systems. Furthermore, our experiments constitute the first analysis of the full distribution of quantum noise in an interacting many-body system

Measuring spirometry in a lung cancer screening cohort highlights possible underdiagnosis and misdiagnosis of Chronic Obstructive Pulmonary Disease

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is underdiagnosed, and measurement of spirometry alongside low-dose computed tomography (LDCT) screening for lung cancer is one strategy to increase earlier diagnosis of this disease. // Methods: Ever-smokers at high risk of lung cancer were invited to the Yorkshire Lung Screening Trial for a Lung Health Check (LHC) comprising LDCT screening, pre-bronchodilator spirometry and smoking cessation service. In this cross-sectional study we present data on participant demographics, respiratory symptoms, lung function, emphysema on imaging and both self-reported and primary care diagnoses of COPD. Multivariable logistic regression analysis identified factors associated with possible underdiagnosis and misdiagnosis of COPD in this population, with airflow obstruction (AO) defined as FEV1/FVC ratio <0.70. // Results: Of 3,920 LHC attendees undergoing spirometry, 17% had undiagnosed AO with respiratory symptoms, representing potentially undiagnosed COPD. Compared to those with a primary care COPD code, this population had milder symptoms, better lung function, and were more likely to be current smokers (p≤0.001 for all comparisons). Of 836 attendees with a primary care COPD code who underwent spirometry, 19% did not have AO, potentially representing misdiagnosed COPD, although symptom burden was high. // Discussion: Spirometry offered alongside LDCT screening can potentially identify cases of undiagnosed and misdiagnosed COPD. Future research should assess the downstream impact of these findings to determine if any meaningful changes to treatment and outcomes occurs, and also to assess the impact on co-delivering spirometry on other parameters of LDCT screening performance such as participation and adherence. Additionally, work is needed to better understand the aetiology of respiratory symptoms in those with misdiagnosed COPD, to ensure this highly symptomatic group receive evidence-based interventions

Hubble Frontier Fields : the geometry and dynamics of the massive galaxy cluster merger MACSJ0416.1−2403

We use a joint optical/X-ray analysis to constrain the geometry and history of the ongoing merging event in the massive galaxy cluster MACSJ0416.1-2403 (z=0.397). Our investigation of cluster substructure rests primarily on a combined strong- and weak-lensing mass reconstruction based on the deep, high-resolution images obtained for the Hubble Frontier Fields initiative. To reveal the system's dynamics, we complement this lensing analysis with a study of the intra-cluster gas using shallow Chandra data, and a three-dimensional model of the distribution and motions of cluster galaxies derived from over 100 spectroscopic redshifts. The multi-scale grid model obtained from our combined lensing analysis extends the high-precision strong-lensing mass reconstruction recently performed to cluster-centric distances of almost 1 Mpc. Our analysis detects the two well known mass concentrations in the cluster core. A pronounced offset between collisional and collisionless matter is only observed for the SW cluster component, while excellent alignment is found for the NE cluster. Both the lensing analysis and the distribution of cluster light strongly suggest the presence of a third massive structure, almost 2 arcmin SW of the cluster centre. Since no X-ray emission is detected in this region, we conclude that this structure is non-virialised and speculate that it might be part of a large-scale filament almost aligned with our line of sight. Combining all evidence from the distribution of dark and luminous matter, we propose two alternative scenarios for the trajectories of the components of MACSJ0416.1-2403. Upcoming deep X-ray observations that allow the detection of shock fronts, cold cores, and sloshing gas (all key diagnostics for studies of cluster collisions) will allow us to test, and distinguish between these two scenarios

Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects

Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. However, it was not known whether secretory IgA (SIgA) responses to the selected epitopes from HLA-DRB1*04 positive subjects were different compared to controls, or across other caries-related factors such as total IgA (TIgA). Thirty-two total subjects were matched according to HLA type, gender, ethnicity and age. HLA genotyping, oral bacterial, immunoglobulin and antibody analyses were performed. A large observed difference emerged with regard to the natural immune reservoir of TIgA in HLA-DRB1*04 positive subjects, specifically, a 27.6% reduction compared to controls. In contrast to all other epitopes studied, HLA-DRB1*04 positive subjects also exhibited reduced reactivity to I/II epitope 834–853. HLA-DRB1*04 positive subjects exhibited lower specific SIgA activity/TIgA to 834–853 and also a lower specific reactivity to 834–853/whole cell S. mutans UA159. Furthermore, HLA-DRB1*04 positive subjects exhibited lower responses to I/II in its entirety. The large observed difference in TIgA and the 834–853 reactivity pattern across multiple measures suggest potentially important connections pertaining to the link between HLA-DRB1*04 and caries

Framework for evaluating the health impact of the scale-up of malaria control interventions on all-cause child mortality in Sub-Saharan Africa

Concerted efforts from national and international partners have scaled up malaria control interventions, including insecticide-treated nets, indoor residual spraying, diagnostics, prompt and effective treatment of malaria cases, and intermittent preventive treatment during pregnancy in sub-Saharan Africa (SSA). This scale-up warrants an assessment of its health impact to guide future efforts and investments; however, measuring malaria-specific mortality and the overall impact of malaria control interventions remains challenging. In 2007, Roll Back Malaria's Monitoring and Evaluation Reference Group proposed a theoretical framework for evaluating the impact of full-coverage malaria control interventions on morbidity and mortality in high-burden SSA countries. Recently, several evaluations have contributed new ideas and lessons to strengthen this plausibility design. This paper harnesses that new evaluation experience to expand the framework, with additional features, such as stratification, to examine subgroups most likely to experience improvement if control programs are working; the use of a national platform framework; and analysis of complete birth histories from national household surveys. The refined framework has shown that, despite persisting data challenges, combining multiple sources of data, considering potential contributions from both fundamental and proximate contextual factors, and conducting subnational analyses allows identification of the plausible contributions of malaria control interventions on malaria morbidity and mortality

Suppression of AP1 Transcription Factor Function in Keratinocyte Suppresses Differentiation

Our previous study shows that inhibiting activator protein one (AP1) transcription factor function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell proliferation and delays differentiation. To understand the mechanism of action, we compare TAM67 impact in mouse epidermis and in cultured normal human keratinocytes. We show that TAM67 localizes in the nucleus where it forms TAM67 homodimers that competitively interact with AP1 transcription factor DNA binding sites to reduce endogenous jun and fos factor binding. Involucrin is a marker of keratinocyte differentiation that is expressed in the suprabasal epidermis and this expression requires AP1 factor interaction at the AP1-5 site in the promoter. TAM67 interacts competitively at this site to reduce involucrin expression. TAM67 also reduces endogenous c-jun, junB and junD mRNA and protein level. Studies with c-jun promoter suggest that this is due to reduced transcription of the c-jun gene. We propose that TAM67 suppresses keratinocyte differentiation by interfering with endogenous AP1 factor binding to regulator elements in differentiation-associated target genes, and by reducing endogenous c-jun factor expression

The Extraordinary Amount of Substructure in the Hubble Frontier Fields Cluster Abell 2744

We present a joint optical/X-ray analysis of the massive galaxy cluster Abell 2744 (z=0.308). Our strong- and weak-lensing analysis within the central region of the cluster, i.e., at R < 1 Mpc from the brightest cluster galaxy, reveals eight substructures, including the main core. All of these dark-matter halos are detected with a significance of at least 5σ and feature masses ranging from 0.5 to 1.4× 1014M⊙ within R < 150 kpc. Merten et al. (2011) and Medezinski et al. (2016) substructures are also detected by us. We measure a slightly higher mass for the main core component than reported previously and attribute the discrepancy to the inclusion of our tightly constrained strong-lensing mass model built on Hubble Frontier Fields data. X-ray data obtained by XMM-Newton reveal four remnant cores, one of them a new detection, and three shocks. Unlike Merten et al. (2011), we find all cores to have both dark and luminous counterparts. A comparison with clusters of similar mass in the MXXL simulations yields no objects with as many massive substructures as observed in Abell 2744, confirming that Abell 2744 is an extreme system. We stress that these properties still do not constitute a challenge to ΛCDM, as caveats apply to both the simulation and the observations: for instance, the projected mass measurements from gravitational lensing and the limited resolution of the sub-haloes finders. We discuss implications of Abell 2744 for the plausibility of different dark-matter candidates and, finally, measure a new upper limit on the self-interaction cross-section of dark matter of σDM < 1.28 cm2g−1(68% CL), in good agreement with previous results from Harvey et al. (2015)