72 research outputs found
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Current perspectives on dental adhesion:(2) Concepts for operatively managing carious lesions extending into dentine using bioactive and adhesive direct restorative materials
Should new operating procedures arising from COVID-19 make us re-think our management of deep caries?
Influence of filling technique and curing mode on the bond strengths of composite cores to pulpal floor dentin
Effect of waiting interval on chemical activation mode of dual-cure one-step self-etching adhesives on bonding to root canal dentin
Synthesis and Preliminary Evaluation of a Polyolefin-based Core for Carrier-based Root Canal Obturation
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