A Language-Independent Garbage Collector Toolkit

We describe a memory management toolkit for language implementors. It offers efficient and flexible generation scavenging garbage collection. In addition to providing a core of languageindependent algorithms and data structures, the toolkit includes auxiliary components that ease implementation of garbage collection for programming languages. We have detailed designs for Smalltalk and Modula-3 and are confident the toolkit can be used with a wide variety of languages. The toolkit approach is itself novel, and our design includes a number of additional innovations in flexibility, efficiency, accuracy, and cooperation between the compiler and the collector

Initial estimate of NOAA-9 SBUV/2 total ozone drift: Based on comparison with re-calibrated TOMS measurements and pair justification of SBUV/2

Newly recalibrated version 6 Total Ozone Mapping Spectrometer (TOMS) data are used as a reference measurement in a comparison of monthly means of total ozone in 10 degree latitude zones from SBUV/2 and the nadir measurements from TOMS. These comparisons indicate a roughly linear long-term drift in SBUV/2 total ozone relative to TOMS of about 2.5 Dobson units per year at the equator over the first three years of SBUV/2. The pari justification technique is also applied to the SBUV/2 measurements in a manner similar to that used for SBUV and TOMS. The higher solar zenith angles associated with the afternoon orbit of NOAA-9 and the large changes in solar zenith angle associated with its changing equator crossing time degrade the accuracy of the pair justification method relative to its application to SBUV and TOMS, but the results are consistent with the SBUV/2-TOMS comparisons, and show a roughly linear drift in SBUV/2 of 2.5 to 4.5 Dobson units per year in equatorial ozone

Cantor's Illusion

This analysis shows Cantor's diagonal definition in his 1891 paper was not compatible with his horizontal enumeration of the infinite set M. The diagonal sequence was a counterfeit which he used to produce an apparent exclusion of a single sequence to prove the cardinality of M is greater than the cardinality of the set of integers N

Integrin Expression by Human Epidermal Keratinocytes Can Be Modulated by Interferon-γ, Transforming Growth Factor-β, Tumor Necrosis Factor-α, and Culture on a Dermal Equivalent

Receptors of the integrin family are largely confined to the basal layer of keratinocytes, both in human epidermis and in stratified cultures of human keratinocytes. However, suprabasal integrin expression is observed during epidermal wound healing and in psoriatic lesions. We have investigated potential stimuli of suprabasal expression. Addition of transforming growth factor-β (TGF-β), interferon-γ (IFN-γ or tumor necrosis factor-α (TNF-α) to keratinocytes cultured with a 3T3 feeder layer did not induce suprabasal expression. The cytokines caused small changes in the levels of α2β1 or α3β1 on the surface of basal keratinocytes but had no significant effect on the proportion of cells adhering to fibronectin, type IV collagen, and laminin, and did not cause changes in the mobility of integrin subunits on polyacrylamide gels. Injection of TNF-α or IFN-γ intradermally into healthy human volunteers induced an inflammatory response but did not induce suprabasal integrin expression. However, we did observe transient suprabasal Integrin expression when keratinocytes were grown on a dermal equivalent consisting of fibroblasts in a collagen gel. One week after raising the cultures to the air-liquid interface, β1 integrins were found in all the viable cell layers, with suprabasal cells co-expressing integrins and involucrin; 1 week later integrins were confined to the basal layer. Addition of TGF-β, IFN-γ, or TNF-α to the dermal equivalents neither induced nor inhibited suprabasal integrin expression. We conclude that suprabasal integrin expression is not induced by the inflammatory cytokines tested, and instead may reflect the proliferation/differentiation status of the epidermis

Relationship between abuse and neglect in childhood and diabetes in adulthood: Differential effects by sex, national longitudinal study of adolescent health

INTRODUCTION: Few studies have investigated links between child abuse and neglect and diabetes mellitus in nationally representative samples, and none have explored the role of obesity in the relationship. We sought to determine whether child abuse and neglect were associated with diabetes and if so, whether obesity mediated this relationship in a population-representative sample of young adults. METHODS: We used data from 14,493 participants aged 24 to 34 years from Wave IV of the National Longitudinal Study of Adolescent Health to study associations between self-reported child abuse (sexual, physical, or emotional abuse) and neglect as children and diabetes or prediabetes in young adulthood. We conducted sex-stratified logistic regression analyses to evaluate associations in models before and after the addition of body mass index (BMI) as a covariate. RESULTS: Although the prevalence of diabetes was similar for men and women (7.0% vs 6.7%), men were more likely than women to have prediabetes (36.3% vs 24.6%; omnibus P < .001). Among men, recurrent sexual abuse (≥3 lifetime incidents) was significantly associated with diabetes (OR, 3.66; 95% CI, 1.31–10.24), but not with prediabetes. There was no evidence of mediation by BMI. No forms of child abuse or neglect were associated with diabetes or prediabetes among women. CONCLUSIONS: Recurrent sexual abuse is robustly associated with diabetes in young adult men, independently of other forms of child abuse or neglect and BMI. Future research should explore other potential mechanisms for this association to identify avenues for prevention of diabetes among men who have experienced sexual abuse

The efficacy of interventions for behaviourally inhibited preschool-aged children: A meta-analysis

The current systematic review and meta-analyses examined the efficacy of psychological interventions targeting behavioural inhibition and anxiety in preschool-aged children, evaluated within randomised controlled trials. Web of Science, MEDLINE, PsycINFO and CINAHL were systematically searched from inception to March 2021. Ten studies (N = 1475 children, aged 3 – 7 years) were included in the current review. Separate analyses were conducted for behavioural inhibition, anxiety symptoms, and anxiety diagnosis as reported by parents, teachers, and observer-ratings. Pooled outcomes ranged from post-intervention to 12-month follow-up due to the limited number of studies. Meta-analyses revealed that intervention did not reduce behavioural inhibition as assessed by independent observers (SMD = -.13, 95% CI = -.63 to.38), but did reduce behavioural inhibition as reported by parents (SMC = -.64, 95% CI = -1.00 to -.27) and teachers (SMD = -.69, 95% CI = -1.02 to -.36). Additionally, intervention appeared to reduce the risk of anxiety disorders (RR =.75, 95% CI =.62 to.90), and parent-report anxiety symptoms (SMC = -.47, 95% CI = -.83 to -.12) in preschool-aged children. Intervention may be efficacious in reducing anxiety in preschool-aged behaviourally inhibited children. It is less clear whether intervention leads to change in BI

Improvement on the Magnetic Shielding for the XRISM/Resolve Adiabatic Demagnetization Refrigerator

We report modeling, fabrication, cryogenic tensile testing, and magnetic field measurements of a shield around an adiabatic demagnetization stage (ADR) built for the XRISM/Resolve instrument. During testing of a near-identical stage built for Astro-H, a previous spaceflight mission, it was determined that the magnet at full current generated a field external to the shield that violated the maximum dipole-moment requirement of the spacecraft. In addition, there was an interference with the detector assembly nearby when the magnet was greater than 85% of it's typical maximum current. Starting with the Astro-H shield design, we performed a parametric study that increased the thickness of the shield in critical regions. This calculation proceeded until the magnetic field satisfied the estimated maximum field allowed at the detector array based upon the Astro-H measurements. We also performed a detailed measurement of the field generated by the ADR stage at full current as a function of relative angle between the magnet axis and a series of flux-gate magnetometers. Details and results from the calculation and subsequent measurement will be presented

Do Dimensions of Ethnic Identity Mediate the Association Between Perceived Ethnic Group Discrimination and Depressive Symptoms?

Ethnic group discrimination represents a notable risk factor that may contribute to mental health problems among ethnic minority college students. However, cultural resources (e.g., ethnic identity) may promote psychological adjustment in the context of group-based discriminatory experiences. In the current study, we examined the associations between perceptions of ethnic group discrimination and depressive symptoms, and explored dimensions of ethnic identity (i.e., exploration, resolution, and affirmation) as mediators of this process among 2,315 ethnic minority college students (age 18 to 30 years; 37% Black, 63% Latino). Results indicated that perceived ethnic group discrimination was associated positively with depressive symptoms among students from both ethnic groups. The relationship between perceived ethnic group discrimination and depressive symptoms was mediated by ethnic identity affirmation for Latino students, but not for Black students. Ethnic identity resolution was negatively and indirectly associated with depressive symptoms through ethnic identity affirmation for both Black and Latino students. Implications for promoting ethnic minority college students’ mental health and directions for future research are discussed