The academic acclimatisation difficulties of international students of the built environment

Teaching models common to Australasia can be antithetical to those of its Asian neighbours. Australasian andragogy is a bottom-up student-centred mode of knowledge transmission promoting extroverted learning styles, whilst in Asia andragogy is commonly a top-down teacher centred model promoting introspective learning. Yet these teaching styles are in opposition to the cultural-systems attributed to Asia and the West. Such socio-cultural differences are recognised in this research as contributing to the difficulties international Built Environment undergraduates experience when asked to learn in multi-disciplinary collaborative teams. This paper presents the initial stages of a study currently running as a reflexive research program aimed at resolving these learning difficulties. The primary aim of this program is to inform a new culturally inclusive andragogy for design teaching. The outcome of the research questions are addressed through a triangulated analysis including: the formative appraisal of student satisfaction through questionnaires; the summative evaluation of student achievement through the analysis of grades and the assessment of knowledge and skills gained through the measure of student design projects; and illuminative evaluation through focus group discussions and the observation of tutorials.<br /

Robust federated learning with noisy communication

Federated learning is a communication-efficient training process that alternate between local training at the edge devices and averaging of the updated local model at the center server. Nevertheless, it is impractical to achieve perfect acquisition of the local models in wireless communication due to the noise, which also brings serious effect on federated learning. To tackle this challenge in this paper, we propose a robust design for federated learning to decline the effect of noise. Considering the noise in two aforementioned steps, we first formulate the training problem as a parallel optimization for each node under the expectation-based model and worst-case model. Due to the non-convexity of the problem, regularizer approximation method is proposed to make it tractable. Regarding the worst-case model, we utilize the sampling-based successive convex approximation algorithm to develop a feasible training scheme to tackle the unavailable maxima or minima noise condition and the non-convex issue of the objective function. Furthermore, the convergence rates of both new designs are analyzed from a theoretical point of view. Finally, the improvement of prediction accuracy and the reduction of loss function value are demonstrated via simulation for the proposed designs

Methane hydrate recycling offshore of Mauritania probably after the last glacial maximum

To what extent methane liberated from marine hydrate will enter the ocean during a warmer world is unknown. Although methane release due to hydrate dissociation has been modelled, it is unclear whether or not methane will reach the seafloor during a warmer world and therefore contribute to oceanic and atmospheric budgets. Here we show, using a new three-dimensional (3-D) seismic dataset, that some hydrate deposits surround the gas chimneys passing through the HSZ. Bottom water warming since the last glacial maximum (LGM) is interpreted to cause hydrate dissociation but critically some of the released methane was not vented to the ocean. The released gas caused seal failure and free gas entered the hydrate stability zone (HSZ) through vertical gas chimneys to where new hydrate accumulations formed. This process is a new evidence for methane recycling and could account in part for the lack of methane in ice core records that cover warming events during the late Quaternary. This research provides new insight into how methane could be recycled rather than vented during a warmer world

Gas venting that bypasses the feather edge of marine hydrate, offshore Mauritania

Methane can be released from the vast marine hydrate reservoirs that surround continents into oceans and perhaps the atmosphere. But how these pathways work within the global carbon cycle now and during a warmer world is only partially understood. Here we use 3-D seismic data to identify what we interpret to be a gas venting system that bypasses the hydrate stability zone (HSZ) offshore of Mauritania. This venting is manifested by the presence of the acoustic wipe-out (AWO) across a densely faulted succession above a salt diapir and a set of morphological features including a substantial, ∼260 m wide and ∼32 m deep, pockmark at the seabed. The base of the HSZ is marked by a bottom simulating reflector (BSR) which deflects upwards above the diapir, rather than mimicking the seabed. We use a numerical modelling to show that this deflection is caused by the underlying salt diapir. It creates a trapping geometry for gas sealed by hydrate-clogged sediment. After entering the HSZ, some methane accumulated as hydrate in the levees of a buried canyon. Venting in this locality probably reduces the flux of gas to the landward limit of feather edge of hydrate, reducing the volume of gas that would be susceptible for release during a warmer world

Rational-operator-based depth-from-defocus approach to scene reconstruction

This paper presents a rational-operator-based approach to depth from defocus (DfD) for the reconstruction of three-dimensional scenes from two-dimensional images, which enables fast DfD computation that is independent of scene textures. Two variants of the approach, one using the Gaussian rational operators (ROs) that are based on the Gaussian point spread function (PSF) and the second based on the generalized Gaussian PSF, are considered. A novel DfD correction method is also presented to further improve the performance of the approach. Experimental results are considered for real scenes and show that both approaches outperform existing RO-based methods

Motor axonal sprouting and neuromuscular junction loss in an animal model of Charcot-Marie-Tooth disease

Muscle weakness in Charcot-Marie-Tooth Type 1A disease (CMT1A) caused by mutations in peripheral myelin protein 22 (PMP22) has been attributed to an axonopathy that results in denervation and muscle atrophy. The underlying pathophysiological mechanisms involved are not understood. We investigated motor performance, neuromuscular junctions (NMJs), physiological parameters, and muscle morphometry of PMP22 transgenic mice. Neuromuscular junctions were progressively lost in hindlimb muscles of PMP22 transgenic mice, but their motor performance did not completely deteriorate during the observation period. There was considerable variability, including in laterality, in deficits among the animals. Cross-sectional areas and mean fiber size measurements indicated variable myofiber atrophy in hindlimb muscles. There was substantial concomitant axonal sprouting, and loss of neuromuscular junctions was inversely correlated with the accumulated length of axonal branches. Synaptic transmission studied in isolated nerve/muscle preparations indicated variable partial muscle denervation. Acetylcholine sensitivity was higher in the mutant muscles, and maximum tetanic force evoked by direct or indirect stimulation, specific force, and wet weights were markedly reduced in some mutant muscles. In summary, there is partial muscle denervation, and axons may retain some regenerative capacity but fail to reinnervate muscles in PMP22 transgenic mice

Toward a History of Chinese Burial Grounds in Manila during the Spanish Colonial Period

The study of the Chinese burial grounds in Manila provides a window to the world of the Chinese community and the Spanish colonial regime. In the first two and a half centuries of Spanish rule, the Chinese were buried in church or temple grounds, demonstrating the prerogative of religious authorities over the lives of these colonial subjects. In the nineteenth century, the rise of the Chinese population and new approaches to public sanitation paved the way for the establishment of an extramural Chinese public cemetery. The regulations, and the issues that came with administering this cemetery reflect how Chinese elite interests intersected with attempts by a declining colonial power to assert control produced a cemetery like no other in Southeast Asia.L’étude des sites funéraires de Manille ouvre de nouveaux horizons sur la communauté chinoise et le régime colonial espagnol. Dans les deux premiers siècles et demi que dura cette domination, les Chinois ont été ensevelis à l’intérieur ou autour des églises ou encore sur les terrains des temples, démontrant la prérogative des autorités religieuses sur la vie de ces sujets coloniaux. Au cours du xixe siècle, l’augmentation de la population chinoise et les nouvelles conceptions de l’hygiène publique ont ouvert la voie à la création d’un cimetière public chinois extra-muros. Les règlements et les problèmes auxquels ont été confrontés les administrateurs de ce site funéraire révèlent que les intérêts de l’élite chinoise ont recoupé les ultimes tentatives de contrôle de la puissance coloniale, donnant ainsi naissance à un cimetière unique en Asie du Sud-Est

The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma

<p>Abstract</p> <p>Background</p> <p>Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-domain transcription factors. The PEA3 subfamily of ETS-domain transcription factors have been implicated in tumour metastasis in several different cancers.</p> <p>Results</p> <p>Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in oesophageal adenocarcinomas and determined their role in oesophageal adenocarcinoma cell function. PEA3 plays an important role in controlling both the proliferation and invasive properties of OE33 oesophageal adenocarcinoma cells. A key target gene is <it>MMP-1</it>. The ERK MAP kinase pathway activates PEA3 subfamily members and also plays a role in these PEA3 controlled events, establishing the ERK-PEA3-MMP-1 axis as important in OE33 cells. PEA3 subfamily members are upregulated in human adenocarcinomas and expression correlates with <it>MMP-1 </it>expression and late stage metastatic disease. Enhanced ERK signaling is also more prevalent in late stage oesophageal adenocarcinomas.</p> <p>Conclusions</p> <p>This study shows that the ERK-PEA3-MMP-1 axis is upregulated in oesophageal adenocarcinoma cells and is a potentially important driver of the metastatic progression of oesophageal adenocarcinomas.</p