93 research outputs found
Panel: Ethical Dilemmas: Finding Common Ground on Controversial Issues
This panel discussion applied ethics to the theme of the 8th Annual Public Interest Environmental Conference. Panelists examined ways ethics may help reconcile industry (such as business and development) with environmentalism
Recommended from our members
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway
Mutations affecting the ribosome lead to several diseases known as ribosomopathies, with phenotypes that include growth defects, cytopenia, and bone marrow failure. Diamond-Blackfan anemia (DBA), for example, is a pure red cell aplasia linked to the mutation of ribosomal protein (RP) genes. Here we show the knock-down of the DBA-linked RPS19 gene induces the cellular self-digestion process of autophagy, a pathway critical for proper hematopoiesis. We also observe an increase of autophagy in cells derived from DBA patients, in CD34+ erythrocyte progenitor cells with RPS19 knock down, in the red blood cells of zebrafish embryos with RP-deficiency, and in cells from patients with Shwachman-Diamond syndrome (SDS). The loss of RPs in all these models results in a marked increase in S6 kinase phosphorylation that we find is triggered by an increase in reactive oxygen species (ROS). We show that this increase in S6 kinase phosphorylation inhibits the insulin pathway and AKT phosphorylation activity through a mechanism reminiscent of insulin resistance. While stimulating RP-deficient cells with insulin reduces autophagy, antioxidant treatment reduces S6 kinase phosphorylation, autophagy, and stabilization of the p53 tumor suppressor. Our data suggest that RP loss promotes the aberrant activation of both S6 kinase and p53 by increasing intracellular ROS levels. The deregulation of these signaling pathways is likely playing a major role in the pathophysiology of ribosomopathies
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise
Background: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process.Results: Inbred mice heterozygous for a null mutation in DNA methyltransferase 3a (Dnmt3a) or tripartite motif protein 28 (Trim28) show greater coefficients of variance in body weight than their wild-type littermates. Trim28 mutants additionally develop metabolic syndrome and abnormal behavior with incomplete penetrance. Genome-wide gene expression analyses identified 284 significantly dysregulated genes in Trim28 heterozygote mutants compared to wild-type mice, with Mas1, which encodes a G-protein coupled receptor implicated in lipid metabolism, showing the greatest average change in expression (7.8-fold higher in mutants). This gene also showed highly variable expression between mutant individuals.Conclusions: These studies provide a molecular explanation of developmental noise in whole organisms and suggest that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation. These findings have broad implications for understanding the mechanisms underlying sporadic and complex disease in humans
Multicenter evaluation of the clinical utility of laparoscopy-assisted ERCP in patients with Roux-en-Y gastric bypass
Background and Aims
The obesity epidemic has led to increased use of Roux-en-Y gastric bypass (RYGB). These patients have an increased incidence of pancreaticobiliary diseases yet standard ERCP is not possible due to surgically altered gastroduodenal anatomy. Laparoscopic-ERCP (LA-ERCP) has been proposed as an option but supporting data are derived from single center small case-series. Therefore, we conducted a large multicenter study to evaluate the feasibility, safety, and outcomes of LA-ERCP.
Methods
This is retrospective cohort study of adult patients with RYGB who underwent LA-ERCP in 34 centers. Data on demographics, indications, procedure success, and adverse events were collected. Procedure success was defined when all of the following were achieved: reaching the papilla, cannulating the desired duct and providing endoscopic therapy as clinically indicated.
Results
A total of 579 patients (median age 51, 84% women) were included. Indication for LA-ERCP was biliary in 89%, pancreatic in 8%, and both in 3%. Procedure success was achieved in 98%. Median total procedure time was 152 minutes (IQR 109-210) with median ERCP time 40 minutes (IQR 28-56). Median hospital stay was 2 days (IQR 1-3). Adverse events were 18% (laparoscopy-related 10%, ERCP-related 7%, both 1%) with the clear majority (92%) classified as mild/moderate whereas 8% were severe and 1 death occurred.
Conclusion
Our large multicenter study indicates that LA-ERCP in patients with RYGB is feasible with a high procedure success rate comparable with that of standard ERCP in patients with normal anatomy. ERCP-related adverse events rate is comparable with conventional ERCP, but the overall adverse event rate was higher due to the added laparoscopy-related events
Resolving the inner parsec of the blazar J1924â2914 with the Event Horizon Telescope
Rest of authors: Ikeda, Shiro; Impellizzeri, C. M. Violette; Inoue, Makoto; James, David J.; Jannuzi, Buell T.; Jeter, Britton; Jiang, Wu; Jimenez-Rosales, Alejandra; Johnson, Michael D.; Joshi, Abhishek, V; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kawashima, Tomohisa; Keating, Garrett K.; Kettenis, Mark; Kim, Dong-Jin; Kim, Jae-Young; Kim, Jongsoo; Kim, Junhan; Kino, Motoki; Koay, Jun Yi; Kocherlakota, Prashant; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Carsten; Kramer, Michael; Kuo, Cheng-Yu; La Bella, Noemi; Lauer, Tod R.; Lee, Daeyoung; Lee, Sang-Sung; Leung, Po Kin; Levis, Aviad; Li, Zhiyuan; Lindahl, Greg; Lindqvist, Michael; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Lonsdale, Colin; Mao, Jirong; Marchili, Nicola; Markoff, Sera; Marrone, Daniel P.; Marscher, Alan P.; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Michalik, Daniel; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Mueller, Cornelia; Mus, Alejandro; Musoke, Gibwa; Myserlis, Ioannis; Nadolski, Andrew; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Neilsen, Joey; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Nowak, Michael A.; Oh, Junghwan; Okino, Hiroki; Olivares, Hector; Ortiz-Leon, Gisela N.; Oyama, Tomoaki; Ozel, Feryal; Palumbo, Daniel C. M.; Paraschos, Georgios Filippos; Park, Jongho; Parsons, Harriet; Patel, Nimesh; Pen, Ue-Li; Pietu, Vincent; Plambeck, Richard; PopStefanija, Aleksandar; Porth, Oliver; Potzl, Felix M.; Prather, Ben; Preciado-Lopez, Jorge A.; Psaltis, Dimitrios; Pu, Hung-Yi; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Romero-Canizales, Cristina; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruiz, Ignacio; Ruszczyk, Chet; Rygl, Kazi L. J.; Sanchez, Salvador; Sanchez-Arguelles, David; Sanchez-Portal, Miguel; Sasada, Mahito; Satapathy, Kaushik; Savolainen, Tuomas; Schloerb, F. Peter; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; SooHoo, Jason; Souccar, Kamal; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tilanus, Remo P. J.; Titus, Michael; Torne, Pablo; Trent, Tyler; Trippe, Sascha; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Vos, Jesse; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wiik, Kaj; Witzel, Gunther; Wondrak, Michael; Wong, George N.; Wu, Qingwen; Yamaguchi, Paul; Yoon, Doosoo; Young, Andre; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhang, Shuo; Zhao, Shan-Shan.The blazar J1924â2914 is a primary Event Horizon Telescope (EHT) calibrator for the Galactic centerâs black hole
Sagittarius A*. Here we present the first total and linearly polarized intensity images of this source obtained with
the unprecedented 20 ÎŒas resolution of the EHT. J1924â2914 is a very compact flat-spectrum radio source with
strong optical variability and polarization. In April 2017 the source was observed quasi-simultaneously with the
EHT (April 5â11), the Global Millimeter VLBI Array (April 3), and the Very Long Baseline Array (April 28),
giving a novel view of the source at four observing frequencies, 230, 86, 8.7, and 2.3 GHz. These observations
probe jet properties from the subparsec to 100 pc scales. We combine the multifrequency images of J1924â2914 to
study the source morphology. We find that the jet exhibits a characteristic bending, with a gradual clockwise
rotation of the jet projected position angle of about 90° between 2.3 and 230 GHz. Linearly polarized intensity
images of J1924â2914 with the extremely fine resolution of the EHT provide evidence for ordered toroidal
magnetic fields in the blazar compact core.We thank the anonymous reviewer for their thoughtful and
helpful comments. The Event Horizon Telescope Collaboration
thanks the following organizations and programs: the Academy
of Finland (projects 274477, 284495, 312496, 315721); the
Agencia Nacional de InvestigaciĂłn y Desarrollo (ANID), Chile
via NCN19_058 (TITANs) and Fondecyt 3190878, the
Alexander von Humboldt Stiftung; an Alfred P. Sloan Research
Fellowship; Allegro, the European ALMA Regional Centre
node in the Netherlands, the NL astronomy research network
NOVA and the astronomy institutes of the University of
Amsterdam, Leiden University and Radboud University; the
black hole Initiative at Harvard University, through a grant
(60477) from the John Templeton Foundation; the China Scholarship Council; Consejo Nacional de Ciencia y TecnologĂa
(CONACYT, Mexico, projects U0004-246083, U0004-
259839, F0003-272050, M0037-279006, F0003-281692,
104497, 275201, 263356); the Delaney Family via the Delaney
Family John A. Wheeler Chair at Perimeter Institute; DirecciĂłn
General de Asuntos del Personal Académico-Universidad
Nacional AutĂłnoma de MĂ©xico (DGAPA-UNAM, projects
IN112417 and IN112820); the European Research Council
Synergy Grant âBlackHoleCam: Imaging the Event Horizon of
Black Holesâ (grant 610058); the Generalitat Valenciana
postdoctoral grant APOSTD/2018/177 and GenT Program
(project CIDEGENT/2018/021); MICINN Research Project
PID2019-108995GB-C22; the Gordon and Betty Moore
Foundation (grant GBMF-3561); the Istituto Nazionale di
Fisica Nucleare (INFN) sezione di Napoli, iniziative specifiche
TEONGRAV; the International Max Planck Research School
for Astronomy and Astrophysics at the Universities of Bonn
and Cologne; Joint Princeton/Flatiron and Joint Columbia/
Flatiron Postdoctoral Fellowships, research at the Flatiron
Institute is supported by the Simons Foundation; the Japanese
Government (Monbukagakusho: MEXT) Scholarship; the
Japan Society for the Promotion of Science (JSPS) Grant-in-
Aid for JSPS Research Fellowship (JP17J08829); the Key
Research Program of Frontier Sciences, Chinese Academy of
Sciences (CAS, grants QYZDJ-SSW-SLH057, QYZDJSSWSYS008,
ZDBS-LY-SLH011); the Leverhulme Trust Early
Career Research Fellowship; the Max-Planck-Gesellschaft (MPG); the Max Planck Partner Group of the MPG and the
CAS; the MEXT/JSPS KAKENHI (grants 18KK0090,
JP18K13594, JP18K03656, JP18H03721, 18K03709,
18H01245, 25120007); the Malaysian Fundamental Research
Grant Scheme (FRGS) FRGS/1/2019/STG02/UM/02/6; the
MIT International Science and Technology Initiatives (MISTI)
Funds; the Ministry of Science and Technology (MOST) of
Taiwan (105-2112-M-001-025-MY3, 106-2112-M-001-011,
106-2119- M-001-027, 107-2119-M-001-017, 107-2119-M-
001-020, 107-2119-M-110-005, 108-2112-M-001-048, and
109-2124-M-001-005); the National Aeronautics and Space
Administration (NASA, Fermi Guest Investigator grant
80NSSC20K1567, NASA Astrophysics Theory Program grant
80NSSC20K0527, NASA NuSTAR award 80NSSC20K0645);
the National Institute of Natural Sciences (NINS) of Japan; the
National Key Research and Development Program of China
(grant 2016YFA0400704, 2016YFA0400702); the National
Science Foundation (NSF, grants AST-0096454, AST-
0352953, AST-0521233, AST-0705062, AST-0905844, AST-
0922984, AST-1126433, AST-1140030, DGE-1144085, AST-
1207704, AST-1207730, AST-1207752, MRI-1228509, OPP-
1248097, AST-1310896, AST-1555365,AST-1615796, AST-
1715061, AST-1716327, AST-1903847,AST-2034306); the
Natural Science Foundation of China (grants 11573051,
11633006, 11650110427, 10625314, 11721303, 11725312,
11933007, 11991052, 11991053); a fellowship of China
Postdoctoral Science Foundation (2020M671266); the Natural Sciences and Engineering Research Council of Canada
(NSERC, including a Discovery Grant and the NSERC
Alexander Graham Bell Canada Graduate Scholarships-Doctoral
Program); the National Youth Thousand Talents Program
of China; the National Research Foundation of Korea (the
Global PhD Fellowship Grant: grants NRF-
2015H1A2A1033752, 2015- R1D1A1A01056807, the Korea
Research Fellowship Program: NRF-2015H1D3A1066561, Basic Research Support Grant 2019R1F1A1059721); the
Netherlands Organization for Scientific Research (NWO) VICI
award (grant 639.043.513) and Spinoza Prize SPI 78-409; the
New Scientific Frontiers with Precision Radio Interferometry
Fellowship awarded by the South African Radio Astronomy
Observatory (SARAO), which is a facility of the National
Research Foundation (NRF), an agency of the Department of
Science and Technology (DST) of South Africa; the Onsala
Space Observatory (OSO) national infrastructure, for the
provisioning of its facilities/observational support (OSO
receives funding through the Swedish Research Council under
grant 2017-00648) the Perimeter Institute for Theoretical
Physics (research at Perimeter Institute is supported by the
Government of Canada through the Department of Innovation,
Science and Economic Development and by the Province of
Ontario through the Ministry of Research, Innovation and
Science); the Spanish Ministerio de EconomĂa y Competitividad
(grants PGC2018-098915-B-C21, AYA2016-80889-P,
PID2019-108995GB-C21); the State Agency for Research of
the Spanish MCIU through the âCenter of Excellence Severo
Ochoaâ award for the Instituto de AstrofĂsica de AndalucĂa
(SEV-2017-0709); the Toray Science Foundation; the ConsejerĂa
de EconomĂa, Conocimiento, Empresas y Universidad of the
Junta de AndalucĂa (grant P18-FR-1769), the Consejo Superior
de Investigaciones CientĂficas (grant 2019AEP112); the US
Department of Energy (USDOE) through the Los Alamos
National Laboratory (operated by Triad National Security, LLC,
for the National Nuclear Security Administration of the USDOE
(Contract 89233218CNA000001); the European UnionÊŒs Horizon
2020 research and innovation program under grant
agreement No 730562 RadioNet; ALMA North America
Development Fund; the Academia Sinica; Chandra DD7-
18089X and TM6-17006X; the GenT Program (Generalitat
Valenciana) Project CIDEGENT/2018/021. This work used the
Extreme Science and Engineering Discovery Environment
(XSEDE), supported by NSF grant ACI-1548562, and CyVerse,
supported by NSF grants DBI-0735191, DBI-1265383, and
DBI-1743442. XSEDE Stampede2 resource at TACC was
allocated through TG-AST170024 and TG-AST080026N.
XSEDE JetStream resource at PTI and TACC was allocated
through AST170028. The simulations were performed in part on
the SuperMUC cluster at the LRZ in Garching, on the LOEWE
cluster in CSC in Frankfurt, and on the HazelHen cluster at the
HLRS in Stuttgart. This research was enabled in part by support
provided by Compute Ontario (http://computeontario.ca),
Calcul Quebec (http://www.calculquebec.ca) and Compute
Canada (http://www.computecanada.ca). We thank the staff at
the participating observatories, correlation centers, and institutions
for their enthusiastic support. This paper makes use of the
following ALMA data: ADS/JAO.ALMA#2016.1.01154.V
and ADS/JAO.ALMA2016.1.00413.V. ALMA is a partnership
of the European Southern Observatory (ESO; Europe, representing
its member states), NSF, and National Institutes of Natural
Sciences of Japan, together with National Research Council
(Canada), Ministry of Science and Technology (MOST;
Taiwan), Academia Sinica Institute of Astronomy and Astrophysics
(ASIAA; Taiwan), and Korea Astronomy and Space
Science Institute (KASI; Republic of Korea), in cooperationwith
the Republic of Chile. The Joint ALMA Observatory is operated
by ESO, Associated Universities, Inc. (AUI)/NRAO, and the
National Astronomical Observatory of Japan (NAOJ). The
NRAO is a facility of the NSF operated under cooperative
agreement by AUI. APEX is a collaboration between the Max-
Planck-Institut fĂŒr Radioastronomie (Germany), ESO, and the
Onsala Space Observatory (Sweden). The SMA is a joint project
between the SAO and ASIAA and is funded by the Smithsonian
Institution and the Academia Sinica. The JCMT is operated by
the East Asian Observatory on behalf of the NAOJ, ASIAA, and
KASI, as well as the Ministry of Finance of China, Chinese
Academy of Sciences, and the National Key R&D Program (No.
2017YFA0402700) of China. Additional funding support for the
JCMT is provided by the Science and Technologies Facility
Council (UK) and participating universities in the UK and
Canada. The LMT is a project operated by the Instituto Nacional
de AstrĂłfisica, Ăptica, y ElectrĂłnica (Mexico) and the University
of Massachusetts at Amherst (USA). The IRAM 30 m telescope
on Pico Veleta, Spain is operated by IRAM and supported by
CNRS (Centre National de la Recherche Scientifique, France),
MPG (Max-Planck- Gesellschaft, Germany) and IGN (Instituto
GeogrĂĄfico Nacional, Spain). The SMT is operated by the
Arizona Radio Observatory, a part of the Steward Observatory
of the University of Arizona, with financial support of operations
from the State of Arizona and financial support for instrumentation
development from the NSF. Support for SPT participation in
the EHT is provided by the National Science Foundation
through award OPP-1852617 to the University of Chicago.
Partial support is also provided by the Kavli Institute of
Cosmological Physics at the University of Chicago. The SPT
hydrogen maser was provided on loan from the GLT, courtesy
of ASIAA. The EHTC has received generous donations of
FPGA chips from Xilinx Inc., under the Xilinx University
Program. The EHTC has benefited from technology shared under open-source license by the Collaboration for Astronomy
Signal Processing and Electronics Research (CASPER). The
EHT project is grateful to T4Science and Microsemi for their
assistance with Hydrogen Masers. This research has made use of
NASAÊŒs Astrophysics Data System. We gratefully acknowledge
the support provided by the extended staff of the ALMA, both
from the inception of the ALMA Phasing Project through the
observational campaigns of 2017 and 2018. We would like to
thank A. Deller and W. Brisken for EHT-specific support with
the use of DiFX. We acknowledge the significance that
Maunakea, where the SMA and JCMT EHT stations are located,
has for the indigenous Hawaiian people.
We also thank Alexandra Elbakyan for her contributions to
the open science initiative. This research has made use of data
obtained with the Global Millimeter VLBI Array (GMVA),
coordinated by the VLBI group at the Max-Planck-Institut fĂŒr
Radioastronomie (MPIfR). The GMVA consists of telescopes
operated by MPIfR, IRAM, Onsala, Metsahovi, Yebes, the
Korean VLBI Network, the Green Bank Observatory, and the
Very Long Baseline Array (VLBA). The VLBA and the GBT
are facilities of the National Science Foundation under
cooperative agreement by Associated Universities, Inc. The
data were correlated at the DiFX correlator of the MPIfR in
Bonn, Germany. We thank the National Science Foundation
(awards OISE-1743747, AST-1816420, AST-1716536, AST-
1440254, AST-1935980) and the Gordon and Betty Moore
Foundation (GBMF-5278) for financial support of this work.
Support for this work was also provided by the NASA Hubble
Fellowship grant HST-HF2-51431.001-A awarded by the
Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc.,
for NASA, under contract NAS5-26555.http://iopscience.iop.org/0004-637Xam2023Physic
Behavioral responses of terrestrial mammals to COVID-19 lockdowns
DATA AND MATERIALS AVAILABILITY : The full dataset used in the final analyses (33) and associated code (34) are available at Dryad. A subset of the spatial coordinate datasets is available at Zenodo (35). Certain datasets of spatial coordinates will be available only through requests made to the authors due to conservation and Indigenous sovereignty concerns (see table S1 for more information on data use restrictions and contact information for data requests). These sensitive data will be made available upon request to qualified researchers for research purposes, provided that the data use will not threaten the study populations, such as by distribution or publication of the coordinates or detailed maps. Some datasets, such as those overseen by government agencies, have additional legal restrictions on data sharing, and researchers may need to formally apply for data access. Collaborations with data holders are generally encouraged, and in cases where data are held by Indigenous groups or institutions from regions that are under-represented in the global science community, collaboration may be required to ensure inclusion.COVID-19 lockdowns in early 2020 reduced human mobility, providing an opportunity to disentangle its effects on animals from those of landscape modifications. Using GPS data, we compared movements and road avoidance of 2300 terrestrial mammals (43 species) during the lockdowns to the same period in 2019. Individual responses were variable with no change in average movements or road avoidance behavior, likely due to variable lockdown conditions. However, under strict lockdowns 10-day 95th percentile displacements increased by 73%, suggesting increased landscape permeability. Animalsâ 1-hour 95th percentile displacements declined by 12% and animals were 36% closer to roads in areas of high human footprint, indicating reduced avoidance during lockdowns. Overall, lockdowns rapidly altered some spatial behaviors, highlighting variable but substantial impacts of human mobility on wildlife worldwide.The Radboud Excellence Initiative, the German Federal Ministry of Education and Research, the National Science Foundation, Serbian Ministry of Education, Science and Technological Development, Dutch Research Council NWO program âAdvanced Instrumentation for Wildlife Protectionâ, Fondation SegrĂ©, RZSS, IPE, Greensboro Science Center, Houston Zoo, Jacksonville Zoo and Gardens, Nashville Zoo, Naples Zoo, Reid Park Zoo, Miller Park, WWF, ZCOG, Zoo Miami, Zoo Miami Foundation, Beauval Nature, Greenville Zoo, Riverbanks zoo and garden, SAC Zoo, La Passarelle Conservation, Parc Animalier dâAuvergne, Disney Conservation Fund, Fresno Chaffee zoo, Play for nature, North Florida Wildlife Center, Abilene Zoo, a Liber Ero Fellowship, the Fish and Wildlife Compensation Program, Habitat Conservation Trust Foundation, Teck Coal, and the Grand Teton Association. The collection of Norwegian moose data was funded by the Norwegian Environment Agency, the German Ministry of Education and Research via the SPACES II project ORYCS, the Wyoming Game and Fish Department, Wyoming Game and Fish Commission, Bureau of Land Management, Muley Fanatic Foundation (including Southwest, Kemmerer, Upper Green, and Blue Ridge Chapters), Boone and Crockett Club, Wyoming Wildlife and Natural Resources Trust, Knobloch Family Foundation, Wyoming Animal Damage Management Board, Wyoming Governorâs Big Game License Coalition, Bowhunters of Wyoming, Wyoming Outfitters and Guides Association, Pope and Young Club, US Forest Service, US Fish and Wildlife Service, the Rocky Mountain Elk Foundation, Wyoming Wild Sheep Foundation, Wild Sheep Foundation, Wyoming Wildlife/Livestock Disease Research Partnership, the US National Science Foundation [IOS-1656642 and IOS-1656527, the Spanish Ministry of Economy, Industry and Competitiveness, and by a GRUPIN research grant from the Regional Government of Asturias, Sigrid Rausing Trust, Batubay Ăzkan, Barbara Watkins, NSERC Discovery Grant, the Federal Aid in Wildlife Restoration act under Pittman-Robertson project, the State University of New York, College of Environmental Science and Forestry, the Ministry of Education, Youth and Sport of the Czech Republic, the Ministry of Agriculture of the Czech Republic, Rufford Foundation, an American Society of Mammalogists African Graduate Student Research Fund, the German Science Foundation, the Israeli Science Foundation, the BSF-NSF, the Ministry of Agriculture, Forestry and Food and Slovenian Research Agency (CRP V1-1626), the Aage V. Jensen Naturfond (project: Kronvildt - viden, vĂŠrdier og vĂŠrktĂžjer), the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germanyâs Excellence Strategy, National Centre for Research and Development in Poland, the Slovenian Research Agency, the David Shepherd Wildlife Foundation, Disney Conservation Fund, Whitley Fund for Nature, Acton Family Giving, Zoo Basel, Columbus, Bioparc de DouĂ©-la-Fontaine, Zoo Dresden, Zoo Idaho, KolmĂ„rden Zoo, Korkeasaari Zoo, La Passarelle, Zoo New England, Tierpark Berlin, Tulsa Zoo, the Ministry of Environment and Tourism, Government of Mongolia, the Mongolian Academy of Sciences, the Federal Aid in Wildlife Restoration act and the Illinois Department of Natural Resources, the National Science Foundation, Parks Canada, Natural Sciences and Engineering Research Council, Alberta Environment and Parks, Rocky Mountain Elk Foundation, Safari Club International and Alberta Conservation Association, the Consejo Nacional de Ciencias y TecnologĂa (CONACYT) of Paraguay, the Norwegian Environment Agency and the Swedish Environmental Protection Agency, EU funded Interreg SI-HR 410 Carnivora Dinarica project, Paklenica and Plitvice Lakes National Parks, UK Wolf Conservation Trust, EURONATUR and Bernd Thies Foundation, the Messerli Foundation in Switzerland and WWF Germany, the European Unionâs Horizon 2020 research and innovation program under the Marie SkĆodowska-Curie Actions, NASA Ecological Forecasting Program, the Ecotone Telemetry company, the French National Research Agency, LANDTHIRST, grant REPOS awarded by the i-Site MUSE thanks to the âInvestissements dâavenirâ program, the ANR Mov-It project, the USDA Hatch Act Formula Funding, the Fondation Segre and North American and European Zoos listed at http://www.giantanteater.org/, the Utah Division of Wildlife Resources, the Yellowstone Forever and the National Park Service, Missouri Department of Conservation, Federal Aid in Wildlife Restoration Grant, and State University of New York, various donors to the Botswana Predator Conservation Program, data from collared caribou in the Northwest Territories were made available through funds from the Department of Environment and Natural Resources, Government of the Northwest Territories. The European Research Council Horizon2020, the British Ecological Society, the Paul Jones Family Trust, and the Lord Kelvin Adam Smith fund, the Tanzania Wildlife Research Institute and Tanzania National Parks. The Eastern Shoshone and Northern Arapahoe Fish and Game Department and the Wyoming State Veterinary Laboratory, the Alaska Department of Fish and Game, Kodiak Brown Bear Trust, Rocky Mountain Elk Foundation, Koniag Native Corporation, Old Harbor Native Corporation, Afognak Native Corporation, Ouzinkie Native Corporation, Natives of Kodiak Native Corporation and the State University of New York, College of Environmental Science and Forestry, and the Slovenia Hunters Association and Slovenia Forest Service. F.C. was partly supported by the Resident Visiting Researcher Fellowship, IMĂ©RA/Aix-Marseille UniversitĂ©, Marseille. This work was partially funded by the Center of Advanced Systems Understanding (CASUS), which is financed by Germanyâs Federal Ministry of Education and Research (BMBF) and by the Saxon Ministry for Science, Culture and Tourism (SMWK) with tax funds on the basis of the budget approved by the Saxon State Parliament. This article is a contribution of the COVID-19 Bio-Logging Initiative, which is funded in part by the Gordon and Betty Moore Foundation (GBMF9881) and the National Geographic Society.https://www.science.org/journal/sciencehj2023Mammal Research InstituteZoology and Entomolog
Selective Dynamical Imaging of Interferometric Data
Recent developments in very long baseline interferometry (VLBI) have made it possible for the Event Horizon Telescope (EHT) to resolve the innermost accretion flows of the largest supermassive black holes on the sky. The sparse nature of the EHT's (u, v)-coverage presents a challenge when attempting to resolve highly time-variable sources. We demonstrate that the changing (u, v)-coverage of the EHT can contain regions of time over the course of a single observation that facilitate dynamical imaging. These optimal time regions typically have projected baseline distributions that are approximately angularly isotropic and radially homogeneous. We derive a metric of coverage quality based on baseline isotropy and density that is capable of ranking array configurations by their ability to produce accurate dynamical reconstructions. We compare this metric to existing metrics in the literature and investigate their utility by performing dynamical reconstructions on synthetic data from simulated EHT observations of sources with simple orbital variability. We then use these results to make recommendations for imaging the 2017 EHT Sgr A* data set
A Universal Power-law Prescription for Variability from Synthetic Images of Black Hole Accretion Flows
We present a framework for characterizing the spatiotemporal power spectrum of the variability expected from the horizon-scale emission structure around supermassive black holes, and we apply this framework to a library of general relativistic magnetohydrodynamic (GRMHD) simulations and associated general relativistic ray-traced images relevant for Event Horizon Telescope (EHT) observations of Sgr A*. We find that the variability power spectrum is generically a red-noise process in both the temporal and spatial dimensions, with the peak in power occurring on the longest timescales and largest spatial scales. When both the time-averaged source structure and the spatially integrated light-curve variability are removed, the residual power spectrum exhibits a universal broken power-law behavior. On small spatial frequencies, the residual power spectrum rises as the square of the spatial frequency and is proportional to the variance in the centroid of emission. Beyond some peak in variability power, the residual power spectrum falls as that of the time-averaged source structure, which is similar across simulations; this behavior can be naturally explained if the variability arises from a multiplicative random field that has a steeper high-frequency power-law index than that of the time-averaged source structure. We briefly explore the ability of power spectral variability studies to constrain physical parameters relevant for the GRMHD simulations, which can be scaled to provide predictions for black holes in a range of systems in the optically thin regime. We present specific expectations for the behavior of the M87* and Sgr A* accretion flows as observed by the EHT
- âŠ