MILES extended: Stellar population synthesis models from the optical to the infrared

We present the first single-burst stellar population models which covers the optical and the infrared wavelength range between 3500 and 50000 Angstrom and which are exclusively based on empirical stellar spectra. To obtain these joint models, we combined the extended MILES models in the optical with our new infrared models that are based on the IRTF (Infrared Telescope Facility) library. The latter are available only for a limited range in terms of both age and metallicity. Our combined single-burst stellar population models were calculated for ages larger than 1 Gyr, for metallicities between [Fe/H] = -0.40 and 0.26, for initial mass functions of various types and slopes, and on the basis of two different sets of isochrones. They are available to the scientific community on the MILES web page. We checked the internal consistency of our models and compared their colour predictions to those of other models that are available in the literature. Optical and near infrared colours that are measured from our models are found to reproduce the colours well that were observed for various samples of early-type galaxies. Our models will enable a detailed analysis of the stellar populations of observed galaxies.Comment: 9 pages, 10 figures, published in A&

A comparison of the socio-cultural influences on body size perceptions and values among European Australian and Indigenous Fijian adolescent girls

Western women are experiencing increases in the prevalence of overweight and obesity despite valuing slimness as ideal and equating thinness with attractiveness and beauty. Pacific populations are also experiencing high prevalence rates of overweight and obesity. A lage body size, however, has many positive connotations among pacific populations that stem from rich cultural practices such as feasts and deliberate fattening of women. There appears to be many sociocultural factors however, such as images of the slim ideal portrayed in Western media, influencing body image concerns that are shared between the two groups. A qualitative study involving semi-structured interviews was conducted to examine and compare the sociocultural influences on body size perceptionsand values. Participants include 16 European Australian and 16 Indigenous Fijian adolescent girls aged between 15 and 17 years. Inductive thematic analysis and analytical induction were qualitativemethods employed to facilitate interpretation of the findings. Preliminary findings suggest that Fijian adolescent girls experience greater conflict than European Australian girls about the desired body size endorsed in their community. Results also suggest that Indigenous Fijian girls place less importance than Australian girls on manipulating their body to achieve a specific ideal. Specific results of this study are reviewed and recommendations for future research are discussed

Transfer of gene corrected T cells corrects humoral and cytotoxic defects in X-linked lymphoproliferative disease (XLP1)

BACKGROUND: XLP1 arises from mutations in the SH2D1A gene encoding SAP, an adaptor protein expressed in T, NK and NKT cells. Defects lead to abnormalities of T and NK cell cytotoxicity and T cell dependent humoral function. Clinical manifestations include haemophagocytic lymphohistiocytosis (HLH), lymphoma and dysgammaglobulinaemia. Curative treatment is limited to haematopoietic stem cell transplant with outcome reliant on a good donor match. OBJECTIVES: As most symptoms arise from defective T cell function, we investigated whether transfer of SAP gene corrected T cells could reconstitute known effector cell defects. METHODS: CD3+ lymphocytes from sap-deficient mice were transduced with a gammaretroviral vector encoding human SAP cDNA before transfer into sub-lethally irradiated sap-deficient recipients. Following immunisation with the T-dependent antigen NP-CGG, recovery of humoral function was evaluated through germinal centre formation and antigen specific responses. To efficiently transduce patient CD3+ cells, we generated an equivalent lentiviral SAP vector. Functional recovery was demonstrated using in vitro cytotoxicity and TFH cell function assays, alongside tumour clearance in an in vivo LCL lymphoma xenograft model. RESULTS: In sap-deficient mice, 20-40% engraftment of gene modified T cells led to significant recovery of germinal centre formation and NP-specific antibody responses. Gene corrected patient T cells demonstrated improved cytotoxicity and TFH cell function in vitro. Adoptive transfer of gene corrected patient CTLs reduced tumour burden to a level comparable with healthy donor CTLs in an in vivo lymphoma model. CONCLUSIONS: These data demonstrate that autologous T cell gene therapy corrects SAP dependent defects and may offer an alternative therapeutic option for XLP1 patients

Sustainable water use for rice agro-ecosystems in northern Italy

I n the Mediterranean basin, rice is cultivated over an area of 1,300,000 hectares. The most important rice-producing countries are Italy and Spain in Europe (72% of the EU production; 345,000 ha), and Egypt and Turkey among the extra-EU countries (almost totality of the production; 789,000 ha). Traditionally, rice is grown under continuous flooding; thus, it requires much more irrigation than non-ponded crops. The MEDWATERICE project (PRIMA-Section 2-2018; https://www.medwaterice.org/) aims at exploring sustainability of innovative rice irrigation management solutions, in order to reduce rice water consumption and environmental impacts, and to extend rice cultivation outside of traditional paddy areas to meet the escalating demand. Within the MEDWATERICE project, irrigation management options to address the main site-specific problems are being tested for each rice areas involved in the project (IT, ES, PT, EG, TR). Case studies are being conducted in pilot farms, with the involvement of Stake-Holder Panels (SHPs) in each country. Data collected at the farm level will be extrapolated to the irrigation district level, to support water management decisions and policies. Moreover, indicators for quantitative assessment of environmental, economic and social sustainability of the irrigation options will be defined. This work illustrates the first year of results for the Italian Case Study (Lomellina area, Pavia) at the pilot farm scale. This area is characterized by a growing water scarcity in drought years in many districts. Within the farm managed by the National Rice Research Center (CRR), in the agricultural season 2019 the experimentation was conducted in six plots of about 20 m x 80 m each, with two replicates for each of the following water regimes: i) water-seeded rice with continuous flooding (WFL), ii) dry-seeded rice with continuous flooding from the 3-4 leaf stage (DFL), and iii) water seeded-rice with alternate wetting and drying from fertilization at the tillering stage (AWD). One out of the two replicates of each treatment was instrumented with: water inflow and outflow meters, set of piezometers, set of tensiometers and water tubes for the irrigation management in the AWD plots. A soil survey was conducted before the agricultural season (EMI sensor and physico-chemical analysis of soil samples). Periodic measurements of crop biometric parameters (LAI, crop height, crop rooting depth) were performed. Moreover, nutrients (TN, NO3, PO4, K) and two widely used pesticides (Sirtaki \u2013 a.i. Clomazone; Tripion E \u2013 a.i. MCPA) were measured in irrigation water (inflow and outflow), groundwater, and porous cups installed at two soil depths (20 and 70 cm, above and below the plough pan). Finally, rice grain yields and quality (As and Cd in the grain) were determined. First results in terms of cumulative water balance components (rainfall, irrigation inflow and outflow, difference in soil and ponding water storage, evapotranspiration, net percolation), water application efficiency (evapotranspiration over net water input), and water productivity (grain production over net water input), will be presented and discussed. Results of a 1D Richard-equation-based numerical simulation model applied to generalize results obtained under the different irrigation regimes will be moreover illustrated

Body image, body dissatisfaction and weight status in south asian children: a cross-sectional study

Background Childhood obesity is a continuing problem in the UK and South Asian children represent a group that are particularly vulnerable to its health consequences. The relationship between body dissatisfaction and obesity is well documented in older children and adults, but is less clear in young children, particularly South Asians. A better understanding of this relationship in young South Asian children will inform the design and delivery of obesity intervention programmes. The aim of this study is to describe body image size perception and dissatisfaction, and their relationship to weight status in primary school aged UK South Asian children. Methods Objective measures of height and weight were undertaken on 574 predominantly South Asian children aged 5-7 (296 boys and 278 girls). BMI z-scores, and weight status (underweight, healthy weight, overweight or obese) were calculated based on the UK 1990 BMI reference charts. Figure rating scales were used to assess perceived body image size (asking children to identify their perceived body size) and dissatisfaction (difference between perceived current and ideal body size). The relationship between these and weight status were examined using multivariate analyses. Results Perceived body image size was positively associated with weight status (partial regression coefficient for overweight/obese vs. non-overweight/obese was 0.63 (95% CI 0.26-0.99) and for BMI z-score was 0.21 (95% CI 0.10-0.31), adjusted for sex, age and ethnicity). Body dissatisfaction was also associated with weight status, with overweight and obese children more likely to select thinner ideal body size than healthy weight children (adjusted partial regression coefficient for overweight/obese vs. non-overweight/obese was 1.47 (95% CI 0.99-1.96) and for BMI z-score was 0.54 (95% CI 0.40-0.67)). Conclusions Awareness of body image size and increasing body dissatisfaction with higher weight status is established at a young age in this population. This needs to be considered when designing interventions to reduce obesity in young children, in terms of both benefits and harms

ABCD2, ABCD2-I, and OTTAWA scores for stroke risk assessment: a direct retrospective comparison

Transient ischemic attack (TIA) is a neurologic emergency characterized by cerebral ischemia eliciting a temporary focal neurological deficit. Many clinical prediction scores have been proposed to assess the risk of stroke after TIA; however, studies on their clinical validity and comparisons among them are scarce. The objective is to compare the accuracy of ABCD2, ABCD2-I, and OTTAWA scores in the prediction of a stroke at 7, 90 days, and 1 year in patients presenting with TIA. Single-centre, retrospective study including patients with TIA admitted to the Emergency Department of our third-level, University Hospital, between 2018 and 2019. Five hundred three patients were included. Thirty-nine (7.7%) had a stroke within 1 year from the TIA: 9 (1.7%) and 24 (4.7%) within 7 and 90 days, respectively. ABCD2, ABCD2-I, and OTTAWA scores were significantly higher in patients who developed a stroke. AUROCs ranged from 0.66 to 0.75, without statistically significant differences at each time-point. Considering the best cut-off of each score, only ABCD2 > 3 showed a sensitivity of 100% only in the prediction of stroke within 7 days. Among clinical items of each score, duration of symptoms, previous TIA, hemiparesis, speech disturbance, gait disturbance, previous cerebral ischemic lesions, and known carotid artery disease were independent predictors of stroke. Clinical scores have moderate prognostic accuracy for stroke after TIA. Considering the independent predictors for stroke, our study indicates the need to continue research and prompts the development of new tools on predictive scores for TIA

Extreme emission-line galaxies out to z∼\sim1 in zCOSMOS. I. Sample and characterization of global properties

We present a thorough characterization of a large sample of 183 extreme emission-line galaxies (EELGs) at redshift 0.11 < z < 0.93 selected from the 20k zCOSMOS Bright Survey because of their unusually large emission line equivalent widths. We use multiwavelength COSMOS photometry, HST-ACS I-band imaging and optical zCOSMOS spectroscopy to derive the main global properties of EELGs, such as sizes, masses, SFRs, reliable metallicities from both "direct" and "strong-line" methods. The EELGs are compact (R_50 ~ 1.3 kpc), low-mass (log(M*/Msol)~7-10) galaxies forming stars at unusually high specific SFR (log(sSFR/yr) up to ~ -7) compared to main sequence SFGs of the same stellar mass and redshift. At UV wavelengths, the EELGs are luminous and show high surface brightness and include strong Ly$\alpha$ emitters, as revealed by GALEX spectroscopy. We show that zCOSMOS EELGs are high-ionization, low-metallicity systems, with median 12+log(O/H)=8.16, including a handful of extremely metal-deficient galaxies (<10% solar). While ~80% of the EELGs show non-axisymmetric morphologies, including clumpy and tadpole galaxies, we find that ~29% of them show additional low surface-brightness features, which strongly suggest recent or ongoing interactions. As star-forming dwarfs in the local Universe, EELGs are most often found in relative isolation. While only very few EELGs belong to compact groups, almost one third of them are found in spectroscopically confirmed loose pairs or triplets. We conclude that EELGs are galaxies caught in a transient and probably early period of their evolution, where they are efficiently building-up a significant fraction of their present-day stellar mass in an ongoing galaxy-wide starburst. Therefore, the EELGs constitute an ideal benchmark for comparison studies between low- and high-redshift low-mass star-forming galaxies.Comment: Accepted in A&A. Final replacement to match the version in press. It includes a minor change in the title and a new figur

Why do dogs (Canis familiaris) select the empty container in an observational learning task?

Many argue that dogs show unique susceptibility to human communicative signals that make them suitable for being engaged in complex co-operation with humans. It has also been revealed that socially provided information is particularly effective in influencing the behaviour of dogs even when the human’s action demonstration conveys inefficient or mistaken solution of task. It is unclear, however, how the communicative nature of the demonstration context and the presence of the human demonstrator affect the dogs’ object-choice behaviour in observational learning situations. In order to unfold the effects of these factors, 76 adult pet dogs could observe a communicative or a non-communicative demonstration in which the human retrieved a tennis ball from under an opaque container while manipulating another distant and obviously empty (transparent) one. Subjects were then allowed to choose either in the presence of the demonstrator or after she left the room. Results showed a significant main effect of the demonstration context (presence or absence of the human’s communicative signals), and we also found some evidence for the response-modifying effect of the presence of the human demonstrator during the dogs’ choice. That is, dogs predominantly chose the baited container, but if the demonstration context was communicative and the human was present during the dogs’ choice, subjects’ tendency to select the baited container has been reduced. In agreement with the studies showing sensitivity to human’s communicative signals in dogs, these findings point to a special form of social influence in observational learning situations when it comes to learning about causally opaque and less efficient (compared to what comes natural to the dog) action demonstrations

The zCOSMOS 10k-sample: the role of galaxy stellar mass in the colour-density relation up to z=1

[Abridged] With the first 10000 spectra of the flux limited zCOSMOS sample (I<=22.5) we study the evolution of environmental effects on galaxy properties since z=1.0, and disentangle the dependence among galaxy colour, stellar mass and local density (3D local density contrast `delta', computed with the 5th nearest neighbour approach). We confirm that within a luminosity-limited sample (M_B=1) galaxies 'f_red' depends on delta at least up to z=1, with red galaxies residing mainly in high densities. This trend weakens for increasing z, and it is mirrored by the behaviour of the fraction of galaxies with D4000A break >=1.4. We also find that up to z=1 the fraction of galaxies with log(EW[OII]) >=1.15 is higher for lower delta, and also this dependence weakens for increasing z. Given the triple dependence among galaxy colours, stellar mass and delta, the colour-delta relation found in the luminosity-selected sample can be due to the broad range of stellar masses. Thus, we fix the stellar mass and we find that in this case the colour-delta relation is flat up to z=1 for galaxies with log(M/M_sun)>=10.7. This means that for these masses the colour-delta relation found in a luminosity-selected sample is the result of the combined colour-mass and mass-delta relations. In contrast, we find that for 0.1<=z<=0.5 and log(M/M_sun)<=10.7 'f_red' depends on delta even at fixed mass. In these mass and z ranges, environment affects directly also galaxy colours. We suggest a scenario in which the colour depends primarily on stellar mass, but for relatively low mass galaxies the local density modulates this dependence. These galaxies formed more recently, in an epoch when evolved structures were already in place, and their longer SFH allowed environment-driven physical processes to operate during longer periods of time.Comment: 19 pages, 12 figures, submitted to A&A, revised version after referee comment

The zCOSMOS redshift survey : Influence of luminosity, mass and environment on the galaxy merger rate

The contribution of major mergers to galaxy mass assembly along cosmic time is an important ingredient to the galaxy evolution scenario. We aim to measure the evolution of the merger rate for both luminosity/mass selected galaxy samples and investigate its dependence with the local environment. We use a sample of 10644 spectroscopically observed galaxies from the zCOSMOS redshift survey to identify pairs of galaxies destined to merge, using only pairs for which the velocity difference and projected separation of both components with a confirmed spectroscopic redshift indicate a high probability of merging. We have identified 263 spectroscopically confirmed pairs with r_p^{max} = 100 h^{-1} kpc. We find that the density of mergers depends on luminosity/mass, being higher for fainter/less massive galaxies, while the number of mergers a galaxy will experience does not depends significantly on its intrinsic luminosity but rather on its stellar mass. We find that the pair fraction and merger rate increase with local galaxy density, a property observed up to redshift z=1. We find that the dependence of the merger rate on the luminosity or mass of galaxies is already present up to redshifts z=1, and that the evolution of the volumetric merger rate of bright (massive) galaxies is relatively flat with redshift with a mean value of 3*10^{-4} (8*10^{-5} respectively) mergers h^3 Mpc^{-3} Gyr^{-1}. The dependence of the merger rate with environment indicates that dense environments favors major merger events as can be expected from the hierarchical scenario. The environment therefore has a direct impact in shapping-up the mass function and its evolution therefore plays an important role on the mass growth of galaxies along cosmic time.Comment: submitted to A&A, 17 pages, 12 figure