Work-related allergic rhinitis: a contemporary review of the literature

Adverse health effects have been reported in workers exposed to inhaled allergens. Allergic rhinitis is a heterogeneous disorder that significantly affects daily activity, work productivity, sleep, learning, and quality of life in all generations. Occupational-ly-related hazards which contribute to the development of allergic rhinitis represent an important avoidable cause of morbidity. The occupational exposure to chemicals or biological agents is the cause of high incidences of allergic rhinitis and this risk is high when the organization and preparation are inadequate and there is a lacking or insufficient information, education and communication. The prevalence of work-related rhinitis, which encompasses both occupational rhinitis and work-exacerbated rhinitis, is estimated to be 31-61%. Data on occupational rhinitis itself are scarce. Although work-related asthma and allergies are a huge burden for society, investigation of oc-cupational exposures in early work life using an unexposed reference group is rare. Occupational allergic diseases are likely to worsen or become intractable as a result of continuous exposure to high concentrations of causative antigens, and are socioeco-nomically important diseases with which the patients might sometimes lose jobs due to work interruptions. It is important to adequately assess, communicate and manage risks in occupational chemical exposure settings with the aim to protect workers and the necessity to introduce periodic health examinations programs focusing on workers to monitor health and well-being and improve working conditions and the working environment

Editors' Introduction

That swing of the pendulum, with which our time was represented, (Heller 1990), and which either moves forwards denying "what has been" or nostalgically back to the past and therefore eager to recover what has been broken, seems to perpetuate itself in the most sensitive beings. When exhausted by the endless and incessant struggle between what is fleeting and what remains, they take refuge in the  kingdom  of "high culture" (Heller 1999) in order to find a stable home in which to shelter themselves from the uncertainty of these continuous oscillations (Costanzo 2007)..

Medición de títulos de deuda a ser mantenidos hasta su vencimiento y no afectados por coberturas : el caso de títulos que devengan intereses sobre saldos ajustados por CER

La Resolución Técnica (RT) N" 17 de la FACPCE prevé la utilización del Método del Costo Amortizado (o Método de la Tasa Efe ctiva) para la medición periódica primaria de algunos componentes patrimoniales. Entre los que se incluyen las inversiones en títulos de deuda a ser mantenidos hasta su vencimiento y no afectados por coberturas. Básicamente, la medición de activos a través del Método del Costo Amortizado implica sumar a1 importe del activo contabilizado inicialmente -neto de cobranzas- los resultados financieros devengados, calculados "exponencialmente" sobre la base de dicho importe utilizando la tasa interna de retorno determinada al momento de la medición inicial. No obstante, en la aplicación concreta de este método se presentan algunas cuestiones de dudosa resolución. Particularmente, en relación a aquellos títulos de deuda emitidos con tasa de interés variable a determinar para cada servicio de intereses, o bien -como ocurre con gran parte de los títulos que pueden encontrarse en el mercado- emitidos con tasa de interés constante pero que devengan intereses sobre saldos que deben ajustarse también para cada servicio de intereses. En estos casos, al tener que determinar la tasa interna de retorno al momento de la medición inicial, surge la necesidad de "estimar" los flujos de fondos a cobrar, respecto de lo cual ni la normativa vigente -RT No 17- ni la doctrina contable han establecido pautas a seguir. En este marco, en el presente trabajo se analiza el Método del Costo Amortiza como criterio de medición de ciertos títulos de deuda, poniendo especial énfasis en los aspectos que hacen a la concreta y efectiva operativización del mismo en el caso particular de los títulos que devengan intereses sobre saldos ajustados por CER.Fil: Bersia, Paola. Universidad Nacional de Río CuartoFil: Ficco, Cecilia. Universidad Nacional de Río CuartoFil: Ricci, Sergio. Universidad Nacional de Río Cuart

Work-related noise exposure in a cohort of patients with chronic tinnitus: analysis of demographic and audiological characteristics

Work-related noise exposure is one of the major factors contributing to the development of adult-onset hearing loss and tinnitus. The aim of this study was to analyze, in patients with chronic tinnitus and long-term occupational noise exposure, (A) characteristics of hearing loss, tinnitus, comorbidities, demographic characteristics and a history of work-related noise exposure and (B) differences among individuals employed in occupations with high and low risk of developing work-related noise-induced hearing loss (NIHL). One hundred thirty six patients with chronic tinnitus and at least a 10 year-long working history were divided into two groups based on the risk of their profession to induce NIHL. Individuals employed in jobs at high risk for NIHL were mostly males and exhibited a poorer hearing threshold, more evident in the left ear. Tinnitus was mostly bilateral; the next largest presentation was left-sided; patients described their tinnitus as buzzing or high-pitched. Correlation between age, length of tinnitus and worse hearing was found. Patients with a higher degree of hearing impairment were mostly males and were more likely to have a family history of hearing loss and at least one cardiovascular comorbidity. Our study shows some differences in individuals with tinnitus and a history of a profession associated with increased exposure to NIHL compared to those without such a history

A concentration of centimeter-sized grains in the Oph IRS 48 dust trap

Azimuthally asymmetric dust distributions observed with ALMA in transition disks have been interpreted as dust traps. We present VLA Ka band (34 GHz or 0.9 cm) and ALMA Cycle 2 Band 9 (680 GHz or 0.45 mm) observations at 0.2" resolution of the Oph IRS 48 disk, which suggest that larger particles could be more azimuthally concentrated than smaller dust grains, assuming an axisymmetric temperature field or optically thin 680 GHz emission. Fitting an intensity model to both data demonstrates that the azimuthal extent of the millimeter emission is 2.3 $\pm0.9$ times as wide as the centimeter emission, marginally consistent with the particle trapping mechanism under the above assumptions. The 34 GHz continuum image also reveals evidence for ionized gas emission from the star. Both the morphology and the spectral index variations are consistent with an increase of large particles in the center of the trap, but uncertainties remain due to the continuum optical depth at 680 GHz. Particle trapping has been proposed in planet formation models to allow dust particles to grow beyond millimeter sizes in the outer regions of protoplanetary disks. The new observations in the Oph IRS 48 disk provide support for the dust trapping mechanism for centimeter-sized grains, although additional data is required for definitive confirmation.Comment: Language editing and addition reference ALMA dat

R-spondin 1/Dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis

Testicular vasculogenesis is one of the key processes regulating male gonad morphogenesis. The knowledge of the molecular cues underlining this phenomenon is one of today's most challenging issues and could represent a major contribution toward a better understanding of the onset of testicular morphogenetic disorders. R-spondin 1 has been clearly established as a candidate for mammalian ovary determination. Conversely, very little information is available on the expression and role of R-spondin 1 during testicular morphogenesis. This study aims to clarify the distribution pattern of R-spondin 1 and other partners of its machinery during the entire period of testicular morphogenesis and to indicate the role of this system in testicular development. Our whole mount immunofluorescence results clearly demonstrate that R-spondin 1 is always detectable in the testicular coelomic partition, where testicular vasculature is organized, while Dickkopf-1 is never detectable in this area. Moreover, organ culture experiments of embryonic male UGRs demonstrated that Dickkopf-1 acted as an inhibitor of testis vasculature formation. Consistent with this observation, real-time PCR analyses demonstrated that DKK1 is able to slightly but significantly decrease the expression level of the endothelial marker Pecam1. The latter experiments allowed us to observe that DKK1 administration also perturbs the expression level of the Pdgf-b chain, which is consistent with some authors' observations relating this factor with prenatal testicular patterning and angiogenesis. Interestingly, the DKK1 induced inhibition of testicular angiogenesis was rescued by the co-administration of R-spondin 1. In addition, R-spondin 1 alone was sufficient to enhance, in culture, testicular angiogenesis

Quality of life in workers and stress: gender differences in exposure to psychosocial risks and perceived well-being

Background. Quality of working life is the result of many factors inherent in the workplace environment, especially in terms of exposure to psychosocial risks. Objectives. The purpose of this study is to assess the quality of life with special attention to gender differences. Methods. The HSE-IT questionnaire and the WHO-5 Well-Being Index were administered to a group of workers (74 males and 33 females). The authors also used Cronbach’s alpha test to assess the internal consistency of both questionnaires and the Mann–Whitney test to evaluate the significance of gender differences in both questionnaires. Results. The HSE-IT highlighted the existence of work-related stress in all the population with a critical perception regarding the domain “Relationships.” Furthermore, gender analysis highlighted the presence of two additional domains in the female population: “Demand” ( = 0,002) and “Support from Managers” ( = 0,287). The WHO-5 highlighted a well-being level below the standard cut-off point with a significant gender difference ( = 0.009) for males (18, SD = 6) as compared to females (14, SD = 6,4). Cronbach’s alpha values indicated a high level of internal consistency for both of our scales. Conclusions. The risk assessment of quality of working life should take into due account the individual characteristics of workers, with special attention to gender