Clinical Issues in Women with Inherited Bleeding Disorders

Various inherited bleeding disorders deserve careful medical management due to their implications in women’s health. In both hemophilia A and B, almost exclusively, males are affected while carrier females are generally asymptomatic. Nevertheless, carriers may present important bleeding tendencies, which can eventually constitute a serious threat to life, especially after surgery or postpartum. In addition, in rare but significant cases, some genetic mechanisms have been found to cause hemophilia in females. Aside from von Willebrand disease, which is the most widespread and better described hemorrhagic condition in women, platelet disorders and some rare clotting deficiencies cause a wide variety of mucocutaneous bleedings, menorrhagia, or postpartum bleeding, hence constituting an important health risk. A review of the genetic and pathophysiological aspects as well as main clinical complications of all these conditions will allow for preventive practices aimed at improving the quality of life of women with bleeding disorders

DISEÑO DE UN INVERSOR RESONANTE SERIE PUENTE COMPLETO PARA UNA SONOBOYA ACTIVA

Un dispositivo Inversor Resonante Serie Puente Completo fue desarrollado, en forma conjunta por el INIDETAM y el ITC, para optimizar el desempeño de una Sonoboya activa que integra el Sistema de Vigilancia Marítima por Sonar operado y controlado desde una Unidad de Superficie de la Armada de México. El presente trabajo de investigación se enfoca al desarrollo conjunto de un dispositivo de potencia para la Sonoboya Activa, se detalla el análisis, diseño e implementación del inversor resonante y se presentan resultados experimentales de un prototipo de 1kW. El dispositivo está formado por un inversor puente completo que convierte el voltaje CD/CA, y por un tanque resonante que es un circuito LC que provoca la Frecuencia de Resonancia del Inversor ( 14fs"> ) que se conecta en serie con el Transductor.

Variación espacial y temporal de la infestación de la concha por Polydora sp. (Spionidae: Polychaeta) sobre la almeja mano de león (Nodipecten subnodosus) en la laguna Ojo de Liebre, Baja California Sur

En la laguna Ojo de Liebre, Baja California Sur, México, se realizó un estudio sobre la infestación de Nodipecten subnodosus producida por Polydora sp., cuantificándose el daño y las variaciones del crecimiento de la almeja durante 3 años. Se realizaron 10 muestreos entre enero de2013 y octubre de 2015, recolectándose 30 organismos por muestreo en los bancos Zacatoso, Chocolatero, El Dátil y La Concha. Se registraron entre 0 y 13 ampollas por concha, 1.77 ampollas concha-1en promedio. El número de ampollas fue superior en las almejas provenientes de los bancos Chocolatero y Zacatoso, mientras que en los bancos El Dátil y La Concha no solamente disminuyó la infestación, sino que sus intervalos de variación fueron menores. Los bancos con las almejas más pequeñas fueron precisamente los que registraron el mayor número de ampollas, sobre todo el Chocolatero. A pesar de que el número máximo de ampollas se presentó en enero de 2013, mayo de 2014 y marzo de 2015, la tendencia general fue de una reducción en la infestación de poliquetos en las almejas a lo largo del periodo de estudio. ABSTRACT In this study we evaluated the degree of infestation of Polydora sp. in Nodipecten subnodosus (lion’s paw scallop). This research was carriedout in laguna Ojo de Liebre, Baja California Sur, Mexico, quantifying the damage and growth of the clam for three years. A total of 10 samplingswere carried out between January 2013 and October 2015, collecting 30 organisms by sampled at the banks Zacatoso, Chocolatero, El Dátil andLa Concha. There were between 0 and 13 blisters per shell, 1.77 bisters shell-1on average. The number of blisters was higher in the clams of thebanks Chocolatero and Zacatoso, while in the banks El Dátil and La Concha, not only did the infestation decrease, but the variation intervals were

Psychometric characteristics of the Spanish version of instruments to measure neck pain disability

[EN] Background. The NDI, COM and NPQ are evaluation instruments for disability due to NP. There was no Spanish version of NDI or COM for which psychometric characteristics were known. The objectives of this study were to translate and culturally adapt the Spanish version of the Neck Disability Index Questionnaire (NDI), and the Core Outcome Measure (COM), to validate its use in Spanish speaking patients with non-specific neck pain (NP), and to compare their psychometric characteristics with those of the Spanish version of the Northwick Pain Questionnaire (NPQ). Methods. Translation/re-translation of the English versions of the NDI and the COM was done blindly and independently by a multidisciplinary team. The study was done in 9 primary care Centers and 12 specialty services from 9 regions in Spain, with 221 acute, subacute and chronic patients who visited their physician for NP: 54 in the pilot phase and 167 in the validation phase. Neck pain (VAS), referred pain (VAS), disability (NDI, COM and NPQ), catastrophizing (CSQ) and quality of life (SF-12) were measured on their first visit and 14 days later. Patients' self-assessment was used as the external criterion for pain and disability. In the pilot phase, patients' understanding of each item in the NDI and COM was assessed, and on day 1 test-retest reliability was estimated by giving a second NDI and COM in which the name of the questionnaires and the order of the items had been changed. Results. Comprehensibility of NDI and COM were good. Minutes needed to fill out the questionnaires [median, (P25, P75)]: NDI. 4 (2.2, 10.0), COM: 2.1 (1.0, 4.9). Reliability: [ICC, (95%CI)]: NDI: 0.88 (0.80, 0.93). COM: 0.85 (0.75,0.91). Sensitivity to change: Effect size for patients having worsened, not changed and improved between days 1 and 15, according to the external criterion for disability: NDI: -0.24, 0.15, 0.66; NPQ: -0.14, 0.06, 0.67; COM: 0.05, 0.19, 0.92. Validity: Results of NDI, NPQ and COM were consistent with the external criterion for disability, whereas only those from NDI were consistent with the one for pain. Correlations with VAS, CSQ and SF-12 were similar for NDI and NPQ (absolute values between 0.36 and 0.50 on day 1, between 0.38 and 0.70 on day 15), and slightly lower for COM (between 0.36 and 0.48 on day 1, and between 0.33 and 0.61 on day 15). Correlation between NDI and NPQ: r = 0.84 on day 1, r = 0.91 on day 15. Correlation between COM and NPQ: r = 0.63 on day 1, r = 0.71 on day 15. Conclusion. Although most psychometric characteristics of NDI, NPQ and COM are similar, those from the latter one are worse and its use may lead to patients' evolution seeming more positive than it actually is. NDI seems to be the best instrument for measuring NP-related disability, since its results are the most consistent with patient's assessment of their own clinical status and evolution. It takes two more minutes to answer the NDI than to answer the COM, but it can be reliably filled out by the patient without assistanceS

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City.

INTRODUCTION: Several reports have emerged describing the long-term consequences of COVID-19 and its effects on multiple systems. METHODS: As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of the long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected via telephone calls over 90 days post-discharge. Among 4670 patients, we identified 45 symptoms across eight symptom clusters (neurological; mood disorders; systemic; respiratory; musculoskeletal; ear, nose, and throat; dermatological; and gastrointestinal). RESULTS: We observed that the neurological, dermatological, and mood disorder symptom clusters persisted in >30% of patients at 90 days post-discharge. Although most symptoms decreased in frequency between day 30 and 90, alopecia and the dermatological symptom cluster significantly increased (p < 0.00001). Women were more prone than men to develop long-term symptoms, and invasive mechanical ventilation also increased the frequency of symptoms at 30 days post-discharge. CONCLUSION: Overall, we observed that symptoms often persisted regardless of disease severity. We hope these findings will help promote public health strategies that ensure equity in the access to solutions focused on the long-term consequences of COVID-19

Inmovilización de bacterias y microalgas en alginato para remover nitrógeno inorgánico de aguas residuales agroindustriales

IP 1203-12-526-96Incluye anexosinorganico de aguas residuales agroindustriales / Luis E.Gonzalez, Ricardo Vazquez-Juarez, Yoav Bashan. --;En: Simposio Colombiano sobre Biotecnologia Ambiental. (2: may.20-22 1998 : Tunja) -- [s.l : s.n], 1998 -- p;28 cm.;PONENCIA(S) EN CONGRESO: Inmovilizacion de bacterias y microalgas en aliganato para remover nitrogen

Isolation and characterization of microsatellite loci in the whale shark (Rhincodon typus)

In preparation for a study on population structure of the whale shark (Rhincodon typus), nine species-specific polymorphic microsatellite DNA markers were developed. An inicial screening of 50 individuals from Holbox Island, Mexico found all nine loci to be polymorphic, with two to 17 alleles observed per locus. Observed and expected heterozygosity per locus ranged from 0.200 to 0.826 and from 0.213 to 0.857, respectively. Neither statistically significant deviations from Hardy–Weinberg expectations nor statistically significant linkage disequilibrium between loci were observed. These microsatellite loci appear suitable for examining population structure, kinship assessment and other applications

Susceptibility of Litopenaeus schmitti and Cherax quadricarinatus to white spot syndrome virus (WSSV)

 Bioassays were carried out in a closed system to evaluate the susceptibility of Litopenaeus schmitti and Cherax quadricarinatus to white spot syndrome virus (WSSV) using L. vannamei as the positive control reference species. Animals were injected intramuscularly (20 ∞L shrimp–1) with a WSSV preparation obtained from the Aquaculture Pathology Laboratory of the University of Arizona. These infected organisms were reared separately in their respective experimental tank. Susceptibility to WSSV was significantly greater in L. vannamei than in the other two species (P < 0.05). The histological analysis showed characteristic inclusion bodies of WSSV in these three crustacean species, with a different distribution of infection depending on the tissue and species. In situ hybridization also showed these signs of infection in hemocytes and hepatopancreas