Estrategias comerciales para el restaurant Di Limón, en la ciudad de Lambayeque 2017

Para la presente tesis se realizó un análisis previo identificando la carencia de tácticas por lo que se propuso Estrategias comerciales para el restaurant turístico Di Limón, basado en el modelo de Lovelock, el cual abarca 8P´s para el marketing de servicios, haciendo hincapié y adaptación a nuestra realidad solo se tomó 7P’s para el desarrollo de la investigación debido a los datos que se tenía al alcance. El restaurant turístico se encuentra ubicado en la ciudad de Lambayeque, por lo que el objeto de estudio se realizó en la misma localidad y se tomó en cuenta a consumidores de comida criolla. La presente tesis fue de enfoque mixto y de tipo descriptivo con una muestra aleatoria simple donde sus instrumentos de recolección de datos fueron la entrevista y la encuesta. Se realizó entrevista al dueño de la empresa para evaluar aspectos generales respecto a las estrategias que aplica o que considera que aportan con su desarrollo, y por otro lado se realizó 376 encuestas seleccionando personas que pertenezcan a la PEA y estén incluidas en el sector socioeconómico (AB, C) para conocer la percepción del cliente mediante el modelo planteado para la mejora de las estrategias. La recolección se realizó mediante el programa excel el cual nos ayudó con el análisis y traspaso de datos de todas las encuestas, mostrando como resultado las preferencias de los clientes. Como conclusión se determinó que el dueño y los clientes respondían favorablemente al modelo de servicios utilizado en la investigación y este a su vez ayudaría al desarrollo y mejora del servicio del restaurant Di’ Limon

Investigation of Chitosan, Quercetin and Water Interactions using Free Energy Calculations and Molecular Docking

Predicting the preferred orientation of a ligand to a receptor and the free energy (ΔGAB) of these molecules in a solution is very useful for pharmaceutical applications. In this work, ΔGAB between chitosan and quercetin molecules with water were obtained by the thermodynamic integration (TI) method and the chitosan+quercetin complex was investigated by Molecular Docking (MDK). The topology of the molecules was compatible with the CHARMM force-field. Both molecules were solvated with the GROMACS SPC water model. The ΔGAB values of the molecule+water systems with the thermodynamic integration (TI) method was done in a 10 ns simulation. The complex was achieved in a 2.5 nm x 2.5 nm x 2.5 nm box. The ΔGAB values for the molecules+water systems were 14.36 +/- 0.46 and 0.19 +/- 0.53 kJ/mol, respectively. For the complex, nine conformations were obtained for the quercetin around the chitosan. The best conformation showed an affinity energy of -3.8 kcal/mol. The ΔGAB results for the systems confirm the low or no solubility of the molecules in the water under normal conditions, as already demonstrated experimentally. The docking showed that the interaction between chitosan and quercetin molecules involves hydrogen bonds in a specific position. DOI: http://dx.doi.org/10.17807/orbital.v11i2.1344 &nbsp

Morphological priming development in Brazilian Portuguese-speaking children

Many studies have shown that, while reading, the brain works a sort of decomposing process of words, reducing them to its morphemes. Moreover, many studies have shown that morphological awareness, which is the ability to reflect upon the structure of words, may contribute to reading in Brazilian Portuguese. The present study investigated morphological priming in children and evaluated the correlation between morphological priming and morphological awareness scores. One hundred and forty-one children took part in this research: 35 second graders, 33 third graders, 33 fourth graders, and 40 fifth graders. They performed a lexical decision task (LDT) and morphological awareness task. Results indicate that as early as the second grade, children show some degree of morphological priming effects. In addition, children from the fifth grade presented morphological priming effects similar to those of a skilled reader. No correlations between morphological awareness scores and morphological priming effects were found.

Investigação in silico de compostos naturais com potencial inibitório da enzima conversora de angiotensina I em angiotensina II / In silico investigation of natural compounds with inhibitory potential of angiotensin I-converting enzyme I in angiotensin II

A hipertensão arterial é o principal fator de risco para doenças cerebrovasculares e doenças isquêmicas do coração, sendo uma das causas mais importante para a morbidade e a mortalidade cardiovascular. Devido às limitações e severos efeitos colaterais dos fármacos disponíveis no mercado empregados para hipertensão, torna-se necessário o desenvolvimento de novos fármacos, mais eficazes e com menos eventos adversos. Assim, o objetivo deste estudo foi avaliar, por meio de técnicas de modelagem molecular, a solubilidade em água e o coeficiente de partição de nove compostos naturais inibidores da enzima conversora de angiotensina, além de verificar os aspectos moléculas dessas interações. Foi observado que todos os compostos alvos do estudo possuem solubilidade adequada para interagir com barreiras biológicas hidrofóbicas e fluídos hidrofílicos. Foi observado também, que os compostos naturais interagiram de forma atrativa com os aminoácidos do sítio ativo da enzima e com o íon zinco, fator de extrema importância para uma boa inibição da enzima conversora de angiotensina. O presente estudo proporciona uma melhor compreensão da inibição da enzima conversora de angiotensina por compostos naturais, o que pode contribuir para o desenvolvimento de novos anti-hipertensivos. 

Progression to degenerative dementia in mild cognitive impairment patients: a cohort study

Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.Fil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; ArgentinaFil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; ArgentinaFil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; ArgentinaFil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; ArgentinaFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAlzheimer´s Association International ConferenceLos AngelesEstados UnidosAlzheimer´s AssociationAlzheimer´s Associatio

Investigation of Chitosan, Quercetin and Water Interactions using Free Energy Calculations and Molecular Docking

Predicting the preferred orientation of a ligand to a receptor and the free energy (ΔGAB) of these molecules in a solution is very useful for pharmaceutical applications. In this work, ΔGAB between chitosan and quercetin molecules with water were obtained by the thermodynamic integration (TI) method and the chitosan+quercetin complex was investigated by Molecular Docking (MDK). The topology of the molecules was compatible with the CHARMM force-field. Both molecules were solvated with the GROMACS SPC water model. The ΔGAB values of the molecule+water systems with the thermodynamic integration (TI) method was done in a 10 ns simulation. The complex was achieved in a 2.5 nm x 2.5 nm x 2.5 nm box. The ΔGAB values for the molecules+water systems were 14.36 +/- 0.46 and 0.19 +/- 0.53 kJ/mol, respectively. For the complex, nine conformations were obtained for the quercetin around the chitosan. The best conformation showed an affinity energy of -3.8 kcal/mol. The ΔGAB results for the systems confirm the low or no solubility of the molecules in the water under normal conditions, as already demonstrated experimentally. The docking showed that the interaction between chitosan and quercetin molecules involves hydrogen bonds in a specific position. DOI: http://dx.doi.org/10.17807/orbital.v11i2.1344

Defects controlling electrical and optical properties of electrodeposited Bi doped Cu2O

Doping leading to low electrical resistivity in electrodeposited thin films of Cu2O is a straightforward requirement for the construction of efficient electronic and energy devices. Here, Bi (7 at. %) doped Cu2O layers were deposited electrochemically onto Si(100) single-crystal substrates from aqueous solutions containing bismuth nitrate and cupric sulfate. X-ray photoelectron spectroscopy shows that Bi ions in a Cu2O lattice have an oxidation valence of 3þ and glancing angle X-ray diffraction measurements indicated no presence of secondary phases. The reduction in the electrical resistivity from undoped to Bi-doped Cu2O is of 4 and 2 orders of magnitude for electrical measurements at 230 and 300 K, respectively. From variations in the lattice parameter and the refractive index, the electrical resistivity decrease is addressed to an increase in the density of Cu vacancies. Density functional theory (DFT) calculations supported the experimental findings. The DFT results showed that in a 6% Bi doped Cu2O cell, the formation of Cu vacancies is more favorable than in an undoped Cu2O one. Moreover, from DFT data was observed that there is an increase (decrease) of the Cu2O band gap (activation energy) for 6% Bi doping, which is consistent with the experimental results

Electrodeposited Cu2O doped with Cl : electrical and optical properties

For understanding the electrical and optical properties of electrodeposited Cl-doped Cu2O thin films, we have studied layers with increasing thickness and Cl concentrations of 0.8 and 1.2 at. %. The deposits were characterized by measuring the charge transport, the optical reflectance, and the photoluminescence. No significant decrease of electrical resistivity was observed in doped samples compared to undoped ones. A decrease of about five orders of magnitude was measured and ascribed to the presence of pinholes, as confirmed by scanning electron microscopy analyses. From optical measurements, we concluded that the Cl atoms are incorporated into substitutional sites of Cu2O lattices in agreement with photoluminescence results showing a strong reduction in the peak intensity of VO þ2 defects in comparison to undoped layers. Computational calculation using density functional theory has pointed out high formation energy for single Cl related defects, but low formation energy for Cl-defect complexes, such as ClOþVCu, that strongly compensate the carriers generated by the Cl doping

New equipment developed at HCPA for otologic surgery (microcautery) : Part I - technical specifications

Este artigo apresenta a descrição de um microcautério otológico com dispositivos de aspiração e descolamento para utilização em cirurgia otológica. O microcautério foi desenvolvido no Hospital de Clínicas de Porto Alegre, pelos setores de Engenharia Biomédica e Otorrinolaringologia.This article presents the description of an otologic microcautery with aspiration and detachment devices to be used in otologic surgery. The microcautery was developed at Hospital de Clínicas de Porto Alegre, by the Biomedical Engineering and Otorhinolarygology departments