1,684 research outputs found
O método Pilates como opção terapêutica para as queixas de dores musculoesqueléticas em mulheres idosas
Resumo Introdução O processo de envelhecimento está relacionado a alterações fisiológicas que podem comprometer a autonomia, a independência e a qualidade de vida dos idosos. Objetivo Avaliar a prática de exercícios físicos com o método Pilates e sua relação com a melhora da qualidade de vida e redução das queixas de dores musculoesqueléticas em um grupo de mulheres idosas. Método Participaram do estudo 31 mulheres entre 40 e 86 anos que realizaram exercícios de Pilates solo durante oito semanas. Na coleta dos dados, foram utilizados os instrumentos SF-36 e o Questionário Nórdico de Sintomas Osteomusculares. Após oito semanas, foi realizada a reavaliação com os mesmos instrumentos. Resultados O componente físico do SF-36 evoluiu de 58,5% para 90,5%, e o componente mental pontuou 93,5%, apresentando melhora evidente nestes domínios após os exercícios, e as queixas de dores musculoesqueléticas diminuíram em metade da amostra. Conclusão O Pilates foi associado com a redução das queixas de dores musculoesqueléticas e com a melhora da qualidade de vida nos domínios estudados
NPC1 silent variant induces skipping of exon 11 (p.V562V) and unfolded protein response was found in a specific Niemann‐Pick type C patient
Background: Niemann-Pick type C (NPC, MIM #257220) is a neuro-visceral disease, caused predominantly by pathogenic variants in the NPC1 gene. Here we studied patients with clinical diagnosis of NPC but inconclusive results regarding the molecular analysis.
Methods: We used a Next-Generation Sequencing (NGS)-panel followed by cDNA analysis. Latter, we used massively parallel single-cell RNA-seq (MARS-Seq) to address gene profiling changes and finally the effect of different variants on the protein and cellular levels.
Results: We identified novel variants and cDNA analysis allowed us to establish the functional effect of a silent variant, previously reported as a polymorphism. We demonstrated that this variant induces the skipping of exon 11 leading to a premature stop codon and identified it in NPC patients from two unrelated families. MARS-Seq analysis showed that a number of upregulated genes were related to the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress in one specific patient. Also, for all analyzed variants, the NPC1 protein was partially retained in the ER.
Conclusion: We showed that the NPC1 silent polymorphism (p.V562V) is a disease-causing variant in NPC and that the UPR is upregulated in an NPC patient.info:eu-repo/semantics/publishedVersio
Overlap syndrome of systemic lupus erythematosus and systemic sclerosis in a person living with HIV: the paradox of immunodeficiency and autoimmunity coming together / Síndrome de overlap entre lupus eritematoso sistêmico e esclerose sístemica em pessoa vivendo com HIV: o paradoxo da imunodeficiência e autoimunidade
The existence of autoimmune dysfunction in HIV/AIDS patients is intriguing. Many cases are being reported around the world of the combination of HIV with systemic autoimmune diseases. We report a case of an HIV-infected patient that presented alopecia, symmetric polyarthritis, skin thickening and raynaud’s phenomenon. Diagnosis of overlap syndrome of SS and SLE was made and treatment with prednisone, methotrexate and nifedipine started. No HIV flare was documented
Study of Urbanization in Areas of Landsline Risk at the Recreio São Jorge and Novo Recreio Neighborhoods, of the Cabuçu Region, in the Guarulhos Township, State of São Paulo, Brazil
Este artigo, desenvolvido a partir de dissertação de mestrado em Análise Geoambiental da Universidade Guarulhos, apresenta um estudo de urbanização em áreas de risco a escorregamentos dos loteamentos do Recreio São Jorge e Novo Recreio, localizados no município de Guarulhos, São Paulo, Brasil. O estudo adotou a microbacia Taquara do Reino como unidade de planejamento urbano e considerou a carta de zoneamento de risco e suscetibilidade a escorregamentos, assim como a cartografia de restrições legais ao uso do solo. O resultado obtido foi a elaboração de uma alternativa de urbanização como ensaio prático de aplicação dos critérios estudados, considerando a necessidade de melhorar-se as condições ambientais do uso do solo nessa microbacia.This article, developed at the Master´s Program in Geoenvironmental Analysis of the Guarulhos University, presents an urbanization study in areas under landslide risk at the Recreio São Jorge and Novo Recreio neighborhoods, in the city of Guarulhos, State of São Paulo, Brazil. This study adopted the Taquara do Reino watershed as an urban planning unit and considered the zoning map of landslide risk restrictions to land use. This study resulted in the elaboration of an urbanization alternative as a practical test for the studied criteria, considering the need to improve environmental conditions of land use in that watershed
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory
The Auger Engineering Radio Array (AERA) is part of the Pierre Auger
Observatory and is used to detect the radio emission of cosmic-ray air showers.
These observations are compared to the data of the surface detector stations of
the Observatory, which provide well-calibrated information on the cosmic-ray
energies and arrival directions. The response of the radio stations in the 30
to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of
the incoming electric field. For the latter, the energy deposit per area is
determined from the radio pulses at each observer position and is interpolated
using a two-dimensional function that takes into account signal asymmetries due
to interference between the geomagnetic and charge-excess emission components.
The spatial integral over the signal distribution gives a direct measurement of
the energy transferred from the primary cosmic ray into radio emission in the
AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air
shower arriving perpendicularly to the geomagnetic field. This radiation energy
-- corrected for geometrical effects -- is used as a cosmic-ray energy
estimator. Performing an absolute energy calibration against the
surface-detector information, we observe that this radio-energy estimator
scales quadratically with the cosmic-ray energy as expected for coherent
emission. We find an energy resolution of the radio reconstruction of 22% for
the data set and 17% for a high-quality subset containing only events with at
least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO
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