PENGARUH STRUKTUR MODAL, PROFITABILITAS, LEVERAGE DAN GROWTH OPPORTUNITY TERHADAP NILAI PERUSAHAAN

One of the decisions to increase investor’s trust and prosperity is to increase the firm value. The firm value is the investor's perception of the success rate of a company that is often associated with stock prices. By increasing trust in investors, the firm value in a company will increase. The purpose of this study is to determine the effect of capital structure, profitability, leverage, and growth opportunity on the firm value. This study took a sample based on the purposive sampling method in the secondary sectors on the Indonesia Stock Exchange in 2014 - 2018. The number of samples obtained was 41 companies. The analysis technique used in the study is the classic assumption test and panel data regression analysis. The results of this study indicate that capital structure had a significant influence on the firm value, whereas profitability, leverage, and growth opportunity did not significantly influence the firm value

Barriers that Restrict Patient Involvement in Drug Development: An Industrial Perspective

Objective: To explore the barriers restricting the implementation of patient involvement in drug development(PIDD)from an industrial perspective and to get insights on knowledge and awareness of pharmaceutical employees around PIDD and its various facets. Methods: A questionnaire-based survey (n=51) was conducted among the pharmaceutical employees currently working in Research and Development, to seek information regarding barriers pertaining to patient involvement in drug development. The study participants were evaluated for their understanding and awareness around the subject to get insights on the persisting knowledge gaps. The data was analysed descriptively and interpretatively, based on the type of responses obtained. Results: In the study, 74% of the respondents considered lack of dedicated groups as a likely factor hurdling the execution of PIDD. In addition, a total of 62% of the employees corresponded lack of industrial confidence in patient knowledge and skills to hinder the effective industrial implementation of the concept, while 16% of the participants considered proper representation of patient population for PIDD activities unlikely to cause hurdles. Insights on participant’s knowledge and awareness on PIDD and its support organisation, revealed it to beaverage, considering their close associations with drug development activities. Recommendations for improving the current state of patient involvement in drug development were primarily directed towards enhancing knowledge base around the topic, reforming the current industrial practices to better involve patients and strengthening regulations around PIDD. Conclusion: Despite increasing efforts from patient organisations in promoting PIDD within industrial practices by empowering patients through trainings and by coming up with recommendations to recognize patients as equal partners in the venture, there still exists barriers that hinder its practicality. Bridging the gap between the conceptual theories and functionalism is necessary and requires identifying the factors posing challenges and overcoming them by establishing means to improve patient involvement. Assessing the value of methods offered for PIDD execution, expanding the population range and utilising information from regulatory database to gain insights on the state of PIDD, allows for further research

Radiative bb-baryon decays to measure the photon and bb-baryon polarization

The radiative decays of $b$-baryons facilitate the direct measurement of photon helicity in $b\to s\gamma$ transitions thus serving as an important test of physics beyond the Standard Model. In this paper we analyze the complete angular distribution of ground state $b$-baryon ($\Lambda_{b}^{0}$ and $\Xi_{b}^{-}$) radiative decays to multibody final states assuming an initially polarized $b$-baryon sample. Our sensitivity study suggests that the photon polarization asymmetry can be extracted to a good accuracy along with a simultaneous measurement of the initial $b$-baryon polarization. With higher yields of $b$-baryons, achievable in subsequent runs of the Large Hadron Collider (LHC), we find that the photon polarization measurement can play a pivotal role in constraining different new physics scenarios.Comment: Typos corrected, reference adde

Using Ancestry Informative Markers (AIMs) to Detect Fine Structures Within Gorilla Populations

The knowledge of ancestral origin is monumental in conservation of endangered animals since it can aid in preservation of population level genetic integrity and prevent inbreeding among related individuals. Despite maintenance of studbook, the biogeographical affiliation of most captive gorillas is largely unknown, which has constrained management of captive gorillas aiming at maximizing genetic diversity at the population level. In recent years, ancestry informative markers (AIMs) has been successfully employed for the inference of genomic ancestry in a wide range of studies in evolutionary genetics, biomedical research, genetic stock identification, and introgression analysis and forensic analyses. In this study, we sought to derive the AIMs yielding the most cohesive and faithful understanding of biogeographical affiliation of query gorillas. To this end, we compared three commonly used AIMs-determining methods namely, Infocalc, FST, and Smart Principal Component Analysis (SmartPCA) with ADMIXTURE, using gorilla genome data available through Great Ape Genome Project database. Our findings suggest that the SNPs that were detected by at least three of the four AIMs-determining approaches (N = 1,531), is likely most suitable for delineation of gorilla AIMs. It recapitulated the finer structure within western lowland gorilla genomes with high degree of precision. We further have validated the robustness of our results using a randomized negative control containing the same number of SNPs. To the best of our knowledge, this is the first report of an AIMs panel for gorillas that may aid in developing cost-effective resources for large-scale demographic analyses, and greatly help in conservation of this charismatic mega-fauna

Pterocarpus angolensis: Botanical, Chemical and Pharmacological Review of an Endangered Medicinal Plant of India

Herbal products for primary health care are gaining huge interests of the people and the various healthcare professionals. This is mainly because of the local availability and cost-effectiveness of plant remedies over expensive modern treatments. Pterocarpus angolensis, a deciduous plant belonging to the family of Fabaceae is mainly found in the tropical regions of Africa. This tree is rich in medicinal properties which are immensely used by the locals in Africa for the treatment of ringworm infections, ulcers, urinary schistosomiasis, skin injury, etc. The extracts of   P. angolensis are treasured in Africa for their effectiveness against many diseases like gonorrhea, mouth diseases, diarrhea, etc. It is reported to have inhibitory activity against various pathogens like Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium because of the high concentration of bioactive compounds like flavonoids, tannins, and other phenolic compounds in the bark and leaves of the tree. Various research papers demonstrated the polar and nonpolar constituents of this plant showing antimicrobial, anti-plasmodial activities against Streptococcus agalactiae, Candida krusei, etc. In India, very few of these plants have been reported to be alive in the Darjeeling district, West Bengal. But, lack of proper documentation or research paper led to negligence related to the importance of this species and it has already been listed in the IUCN Red List of threatened species. The main objective of this review is to spread awareness about the conservation of the plant possessing such remarkable properties. Secondly, to provide an overview of the phytochemical screening of various important medicinal constituents that this plant possesses and this might lead to change in the field of modern medicine

Effect of charge and spin multiplicity on hyperpolarizabilities of donor-acceptor substituted polyenes

Theoretical studies of the ground state structure and nonlinear optical (NLO) properties of a number of donor-acceptor substituted singlet and triplet (neutral) and doublet (mono-positive and mono-negative) polyenes have been carried out. The variation of NLO property of the investigated molecules has been explained by using previously derived relationships between the different order polarizabilities and ground state dipole moment obtained in the framework of the standard sum-over-state expressions of Orr-Ward-Bishop and the generalized Thomas-Kuhn sum rule. The effect of charge and spin multiplicity on the molecular hyperpolarizabilities have been discussed in terms of relative changes of polarizability and ground state dipole moment. Among the investigated polyenes, the isotropic polarizability and the second-hyperpolarizability are predicted to be larger for the doublet anions in which the NH2 group is pyramidal. The position of nitrogen atom in the p-conjugative path strongly modulates the magnitudes of both the first- and second-hyperpolarizabilities of the investigated polyenes

Gambaran Kejadian Ikutan Pasca Imunisasi Covid-19 pada Mahasiswa Fakultas Kedokteran UKI Penyintas Covid-19 dan Non Penyintas Covid-19

Adverse Events Following Immunization (AEFI) is defined as 'any adverse medical event that occurs after immunization, but which does not necessarily have a cause-and-effect relationship with vaccine use. Research conducted by krammer, et al  said that vaccine recipients with pre-existing immunity (seropositive) experienced systemic side effects with a much higher frequency than antibody-nave vaccines. UKI Medical Faculty student environment class 2018 and 2019. The research design used is descriptive research with a sample of primary data taken using google form as a media for filling out questionnaires with a sampling method with simple random sampling , then the data is collected and will be processed with the Microsoft program excel. The number of respondents in this study amounted to 229 respondents, consisting of 115 students of class 2018 and 114 students of class 2019. The percentage of students who were non-survivors of COVID-19 was 77.73% and survivors of COVID-19 was 27.73%. Types of vaccines 1,2, and 3 received by the two groups included Sinovac, Astrazeneca, Moderna, and Pfizer. Symptoms of AEFI in non-survivors of COVID-19 are dominated by local symptoms in the form of pain at the injection site (vaccine 1; 88.3%, vaccine 2: 92.6%, vaccine 3: 93.8%), followed by other systemic symptoms such as myalgia., fever, and headache (vaccine 1: 11.7%, vaccine 2: 7.4%, vaccine 3: 6.2%). Symptoms of AEFI in COVID-19 survivors are dominated by local symptoms in the form of pain at the injection site (vaccine 1; 69.05%, vaccine 2: 93.55%, in vaccines 3 respondents experienced mixed local and systemic symptoms. Adverse Event Following Immunization (AEFI) which dominated in both groups in the form of local symptoms such as pain at the injection site, followed by systemic symptoms such as fever, myalgia, and headache Keywords: COVID-19, COVID-19 Vaccine, Adverse Events Following Immunization (AEFI)Adverse Events Following Immunization (AEFI) is defined as 'any adverse medical event that occurs after immunization, but which does not necessarily have a cause-and-effect relationship with vaccine use. Research conducted by krammer, et al  said that vaccine recipients with pre-existing immunity (seropositive) experienced systemic side effects with a much higher frequency than antibody-nave vaccines. UKI Medical Faculty student environment class 2018 and 2019. The research design used is descriptive research with a sample of primary data taken using google form as a media for filling out questionnaires with a sampling method with simple random sampling , then the data is collected and will be processed with the Microsoft program excel. The number of respondents in this study amounted to 229 respondents, consisting of 115 students of class 2018 and 114 students of class 2019. The percentage of students who were non-survivors of COVID-19 was 77.73% and survivors of COVID-19 was 27.73%. Types of vaccines 1,2, and 3 received by the two groups included Sinovac, Astrazeneca, Moderna, and Pfizer. Symptoms of AEFI in non-survivors of COVID-19 are dominated by local symptoms in the form of pain at the injection site (vaccine 1; 88.3%, vaccine 2: 92.6%, vaccine 3: 93.8%), followed by other systemic symptoms such as myalgia., fever, and headache (vaccine 1: 11.7%, vaccine 2: 7.4%, vaccine 3: 6.2%). Symptoms of AEFI in COVID-19 survivors are dominated by local symptoms in the form of pain at the injection site (vaccine 1; 69.05%, vaccine 2: 93.55%, in vaccines 3 respondents experienced mixed local and systemic symptoms. Adverse Event Following Immunization (AEFI) which dominated in both groups in the form of local symptoms such as pain at the injection site, followed by systemic symptoms such as fever, myalgia, and headache Keywords: COVID-19, COVID-19 Vaccine, Adverse Events Following Immunization (AEFI

Neonatal screening for congenital hypothyroidism in the Netherlands: Cognitive and motor outcome at 10 years of age

Contains fulltext : 35300.pdf (publisher's version ) (Open Access)CONTEXT: Patients with thyroidal congenital hypothyroidism (CH-T) born in The Netherlands in 1981-1982 showed persistent intellectual and motor deficits during childhood and adulthood, despite initiation of T(4) supplementation at a median age of 28 d after birth. OBJECTIVE: The present study examined whether advancement of treatment initiation to 20 d had resulted in improved cognitive and motor outcome. DESIGN/SETTING/PATIENTS: In 82 Dutch CH-T patients, born in 1992 to 1993 and treated at a median age of 20 d (mean, 22 d; range, 2-73 d), cognitive and motor outcome was assessed (mean age, 10.5 yr; range, 9.6-11.4 yr). Severity of CH-T was classified according to pretreatment free T(4) concentration. MAIN OUTCOME MEASURE: Cognitive and motor outcome of the 1992-1993 cohort in comparison to the 1981 to 1982 cohort was the main outcome measure. RESULTS: Patients with severe CH-T had lower full-scale (93.7), verbal (94.9), and performance (93.9) IQ scores than the normative population (P < 0.05), whereas IQ scores of patients with moderate and mild CH-T were comparable to those of the normative population. In all three severity subgroups, significant motor problems were observed, most pronounced in the severe CH-T group. No correlations were found between starting day of treatment and IQ or motor outcome. CONCLUSIONS: Essentially, findings from the 1992-1993 cohort were similar to those of the 1981-1982 cohort. Apparently, advancing initiation of T(4) supplementation from 28 to 20 d after birth did not result in improved cognitive or motor outcome in CH-T patients

KidneyNetwork:Using kidney-derived gene expression data to predict and prioritize novel genes involved in kidney disease

Abstract: Genetic testing in patients with suspected hereditary kidney disease may not reveal the genetic cause for the disorder as potentially pathogenic variants can reside in genes that are not yet known to be involved in kidney disease. We have developed KidneyNetwork, that utilizes tissue-specific expression to inform candidate gene prioritization specifically for kidney diseases. KidneyNetwork is a novel method constructed by integrating a kidney RNA-sequencing co-expression network of 878 samples with a multi-tissue network of 31,499 samples. It uses expression patterns and established gene-phenotype associations to predict which genes could be related to what (disease) phenotypes in an unbiased manner. We applied KidneyNetwork to rare variants in exome sequencing data from 13 kidney disease patients without a genetic diagnosis to prioritize candidate genes. KidneyNetwork can accurately predict kidney-specific gene functions and (kidney disease) phenotypes for disease-associated genes. The intersection of prioritized genes with genes carrying rare variants in a patient with kidney and liver cysts identified ALG6 as plausible candidate gene. We strengthen this plausibility by identifying ALG6 variants in several cystic kidney and liver disease cases without alternative genetic explanation. We present KidneyNetwork, a publicly available kidney-specific co-expression network with optimized gene-phenotype predictions for kidney disease phenotypes. We designed an easy-to-use online interface that allows clinicians and researchers to use gene expression and co-regulation data and gene-phenotype connections to accelerate advances in hereditary kidney disease diagnosis and research. Translational statement: Genetic testing in patients with suspected hereditary kidney disease may not reveal the genetic cause for the patient’s disorder. Potentially pathogenic variants can reside in genes not yet known to be involved in kidney disease, making it difficult to interpret the relevance of these variants. This reveals a clear need for methods to predict the phenotypic consequences of genetic variation in an unbiased manner. Here we describe KidneyNetwork, a tool that utilizes tissue-specific expression to predict kidney-specific gene functions. Applying KidneyNetwork to a group of undiagnosed cases identified ALG6 as a candidate gene in cystic kidney and liver disease. In summary, KidneyNetwork can aid the interpretation of genetic variants and can therefore be of value in translational nephrogenetics and help improve the diagnostic yield in kidney disease patients.</p