Successful application of AI techniques: A hybrid approach

AI systems provide a lot of promise in the analysis and evaluation of power system data. This article shows some of the benefits of the application of AI, identifying the strengths and weaknesses of the approach, and provides a way forward to apply AI in a meaningful and controlled manner

Successful application of AI techniques: A hybrid approach

AI systems provide a lot of promise in the analysis and evaluation of power system data. This article shows some of the benefits of the application of AI, identifying the strengths and weaknesses of the approach, and provides a way forward to apply AI in a meaningful and controlled manner

A catchment-based study of endocrine disruption in surface waters: multivariate evaluation of the health of a sentinel fish species exposed to sewage treatment works effluent

Summary of the results in the context of EDCAT 5 project aims: 1. By comparing appropriate biomarkers in fish sampled from STW-impacted sites and control sites during the pre-remediation period, to determine whether there was evidence for any effects that might be attributed to the presence of estrogenic (or androgenic, or anti-androgenic/-estrogenic) endocrine disrupting chemicals in the former. This aim was addressed by measuring concentrations of the estrogen-dependent yolk protein precursor vitellogenin, and the androgen-dependent nest glue spiggin in male and female sticklebacks. In addition histological examination of the gonadal structure of fish captured at the impacted and non-impacted sites was employed to seek evidence of overt alterations in reproductive physiology of the fish. For a subset of matched samples from the two rivers, the relative induction of hepatic choriogenin mRNA, a biomarker of estrogen exposure, was measured. Conclusions: Chemistry data provided by EDCAT3&4 showed that estrogenicity of the effluent was low prior to remediation and lower still following installation of the GAC plant. No evidence of overt estrogenic effects was detected in male sticklebacks in the Ray, VTG and ChG levels were similar in males from both rivers. Nor was there any evidence of alterations in spiggin concentrations in the kidneys of males from the Ray compared to the Ock. However, VTG concentrations in female sticklebacks from the Ray were increased following the STW upgrade as were hepatic ChG transcript levels, and kidney spiggin concentrations. No changes in these elements of the reproductive system were observed in females from the Ock across the same time periods. Chemical analysis of the effluent indicated that prior to installation of the GAC plant substantial concentrations of anti-androgenic chemicals were present, together with a wide range of other organics. Concentrations of these were much reduced following the plant upgrade. It is reasonable to suppose that the changes observed in the female reproductive endocrine system following the upgrade were related to the removal of some or all of this complex mixture of chemicals. The absence of effects in males may be related to the balance between exogenous and endogenous signals, or to the specificity of effects exerted by the chemicals present. No intersex fish were detected from either river. A significant bias in favour of females was detected in the stickleback populations in both rivers suggesting a factor associated with life-history of the fish, rather than contaminant burden, was responsible. 2. By comparing appropriate biomarkers in fish sampled from STW-impacted sites and control sites during the pre-remediation period, to determine whether there was evidence for any effects that might be attributed to the presence of “conventionally” toxic chemicals. This was addressed by measurement of the activity of a key Phase I transforming enzyme in the liver of fish, either using direct enzymatic assay (EROD) or by quantifying the levels of expression of the corresponding gene (CYP1A). Conclusions: EROD activity was significantly greater in fish from the Ray than the Ock in two samples collected prior to the installation of the GAC plant (2006, 2007) and this likely reflects the differential contaminant loading in the two rivers. A single sample following the commissioning of the GAC plant (2008) indicated that EROD activity had increased among fish from the Ock while that in fish from the Ray remained unchanged. While a delayed recovery of this biomarker in fish from the Ray may be expected depending on the route of exposure (direct via water or indirect via contaminated food) the reasons for elevated EROD activity in fish from the Ock/Childrey Brook are not immediately evident. Provision of a full data set for Cyp1A expression awaits the repeat of the assay. When this is complete the factors underlying the EROD findings may become clear. 3. To determine whether the adaptive capacity and energetic status of fish varied between the STW-impacted and non-impacted sites. This was addressed by measurement of indicators of stress (whole-body corticosteroid levels), metabolic status (whole-body glucose levels) and anabolic activity (RNA:DNA ratios). Conclusions: The data provide no evidence that the stress response of fish captured in the Ray prior to installation of the GAC plant was modified by exposure to the effluent. However, large variations in whole-body corticosteroid and glucose concentrations in fish from both rivers, with clear trends over time, were closely linked to perturbations in the river flow regime. Whether there was interaction between environmental and chemical factors in determining corticosteroid and glucose status is difficult to discern but it seems likely that variation in these indicators of the stress axis was driven primarily by environmental factors. The RNA:DNA ratios were closely linked with seasonal change in temperature and closely matched observed patterns of weight and length gain in stickleback populations in the two rivers. The longer growth period enjoyed by fish in the Ray was clearly evident. For both rivers, mean anabolic activity was greater during 2008 than 2007 and it seems likely that this is related to adverse effects associated with the periods of extreme flow change observed on both rivers in 2007. 4. To assess whether there were differences in population size and structure between STW-impacted and non-impacted sites. This was addressed by comparison of key somatic measures, in particular frequency distributions for fork length. Conclusions: Because of the extreme patchiness of the distribution of stickleback populations in both rivers accurate abundance estimates were not obtained. However, the catch per unit effort across the life of the project was similar for both rivers. While population size, and age structure (both rivers hosted annual populations), appeared to be similar fish in the Ray were overall larger than those from the Ock, and spawned earlier. The differences in growth and timing of spawning between the rivers were likely to have been associated with the Rodbourne STW effluent. Downstream of the discharge on the Ray water temperatures were consistently 2 – 3oC above those of the Ock. This temperature difference, in combination with the introduction of additional nutrients into the river which is likely to have affected the availaibility of food, probably accounts for the different growth profile among the sticklebacks in the two rivers. However, over and above this difference, there was a significant increase in size of sticklebacks in the Ray between the matched pre- and post-remediation periods in the Ray while no change in size of the fish in the Ock occurred during the same period. Similarly, the RNA:DNA ratio was higher in fish from the Ock during 2007 but greater in fish from the Ray during 2008. Taken together, these observations suggest that there was an improvement in the status of the fish in the Ray following the commissioning of the GAC plant, while the population in the Ock remained relatively stable. It is reasonable to suppose that this may be linked to the reduction of the chemical load entering the Ray at Rodbourne following the installation of the GAC plant. The Ray is “cleaner” now than was the case prior to remediation but remains nutrient rich and several degrees warmer than the Ock, this combination of factors providing fish in the Ray with greater scope for growth relative to populations in the Ock

A Method to Allow Software Detection of Multiple Different Chassis Types That Use a Common PCA

Many computer system designs today implement a common printed circuit board assembly that is used in more than one mechanical chassis. This invention describes a design method that allows software to identify in which chassis the PCA has been installed. The system software is able to determine the chassis type be detecting a set of mounting screw connections that are unique for each particular chassis

Running more than before? The evolution of running load demands in the English Premier League

Purpose The purpose of this study was to assess running load trends (total distance (TD), high-intensity distance (HID; > 5.5ms−1) and sprinting distance (SprD; > 7ms−1)) in the English Premier League (EPL) between the 2014/2015 and 2018/2019 seasons using a semi-automated optical tracking system. Methods A total of 1634 games across 5 seasons (2014/2015–2018/2019) were analysed for team and positional TD, HID and SprD. All matches were tracked using TRACAB® Gen-4 HD motion cameras. Data were analysed to identify significant team and positional differences for each metric. Results Small to moderate increases were seen in team running load for TD (p  =  0.02; effect size (ES): 0.21), HID (p < 0.001; ES: 0.88) and SprD (p < 0.001; ES: 0.67) between 2014/2015 and 2018/2019. Positional analysis showed significant increases in TD for all except for defensive midfielders (DM), attacking midfielders (AM) and wide midfielders (WM) (p < 0.001–0.009; ES: 0.14–0.36); HID for all positions excluding goalkeepers (GK) (p < 0.001–0.007; ES: 0.2–0.54) and SprD for all positions except for GK, central midfielders (CM) and AM, (p < 0.001–0.020; ES: 0.19–0.39). Trivial to small differences were seen in season-to-season comparisons for TD (p < 0.001–0.023; ES: −0.16–0.52), HID (p < 0.001–0.033; ES: 0.10–0.38) and SprD (p < 0.001–0.025; ES: 0.13–0.27) for both team and positional differences. Conclusion Small to moderate increases in team TD, HID and SprD occurred in the EPL between 2014/2015 and 2018/2019, with trivial to small changes in season-to-season variations. Actual changes in running load over time appear to be dependent on playing position. Running load trends should be updated regularly and practitioners should be aware of the variability within their team, and programme accordingly

Coarse-grained model of entropic allostery

Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding. An alternative entropic mechanism of "allostery" suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure. We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect. It also addresses the issue of how the signal information to bind or unbind is transmitted through the protein. The model may be applicable to a wide range of repressors and also to signaling in trans-membrane proteins

Building an initial understanding of UK Recovery College dementia courses: A national survey of Recovery College and memory services staff. Journal: Working with Older People Working with Older People

PurposeRecovery Colleges were developed to support the recovery of people with mental health difficulties through courses co-produced by professionals and people with lived experience. This study aims to examine the use of Recovery Colleges to support people with dementia.Design/methodology/approachA survey was circulated to UK Recovery College and memory service staff, exploring provision, delivery and attendance of dementia courses. Open responses provided insight into participant views about recovery in post-diagnostic support and the practicalities of running dementia courses.FindingsA total of 51 Recovery College staff and 210 memory service staff completed the survey. Twelve Recovery College dementia courses were identified across the UK. Three categories emerged from the qualitative data: post-diagnostic support, recovery in the context of dementia, challenges and areas of innovation

The enigmatic multiple star VV Ori

New photometry, including TESS data, have been combined with recent spectroscopic observations of the Orion Ib pulsating triple-star system VV Ori. This yields a revised set of absolute parameters with increased precision. Two different programs were utilized for the light curve analysis, with results in predictably close agreement. The agreement promotes confidence in the analysis procedures. The spectra were analysed using the {\sc FDBinary} program. The main parameters are as follows: $M_1 = 11.6 \pm 0.14$ and $M_2 = 4.8 \pm 0.06$ (M$_\odot$). We estimate an approximate mass of the wide companion as $M_3 = 2.0 \pm 0.3$ M$_\odot$. Similarly, $R_{1} = 5.11 \pm 0.03$, $R_2 = 2.51 \pm 0.02$, $R_3 = 1.8 \pm 0.1$ (R$_\odot$); $T_{\rm e 1} = 26600 \pm 300$, $T_{\rm e 2} = 16300 \pm 400$ and $T_{\rm e 3} = 10000 \pm 1000$ (K). The close binary's orbital separation is $a= 13.91$ (R$_\odot$); its age is $8 \pm 2$ (Myr) and its photometric distance is $396 \pm 7$ pc. The primary's $\beta$ Cep type oscillations support these properties and confirm our understanding of its evolutionary status. Examination of the well-defined $\lambda$6678 He I profiles reveals the primary to have a significantly low projected rotation: some 80\% of the synchronous value. This can be explained on the basis of the precession of an unaligned spin axis. This proposal can resolve also observed variations of the apparent inclination and address other longer-term irregularities of the system reported in the literature. This topic invites further observations and follow-up theoretical study of the dynamics of this intriguing young multiple star.Comment: 17 pages, 15 figures, 14 tables, accepted by MNRA