Identification of the Different Mechanisms of Activation of a [Ru^II(tpy)(bpy)(OH₂)]²⁺ Catalyst by Modified Ruthenium Sensitizers in Supramolecular Complexes

We report the synthesis and photophysical studies of two different complexes incorporating a chromophore and a catalyst within the same structure. The chromophores used are of the form [(bpy)₂(phen)­Ru^II]²⁺ and [(COOEt)₂bpy)₂(phen)­Ru^II]²⁺. The electron-withdrawing auxophores in the periphery of the bipyridine ligands convey the chromophores with different chemical and photophysical properties. The catalyst incorporated is [Ru^II(tpy)­(bpy)­(OH₂)]²⁺ which has been shown to carry out the catalytic oxidation of water and organic substrates. We present the different mechanisms of light-driven activation observed for the catalyst. Depending on the electronic properties of the chromophores, these can act as antenna systems by activating the catalyst via energy transfer followed by electron transfer to an acceptor or as chromophores, in which case activation of the catalyst is done by direct electron transfer from the photo-oxidized sensitizer. The oxidized form of the catalyst formed by either mechanism is stable on a time scale of milliseconds

Resistance of canola cultivars affect life table parameters of Nysius cymoides (Spinola) (Hemiptera: Lygaeidae)

A life table can be used as an important and appropriate tool to evaluate the susceptibility or resistance level of different host plant cultivars to insect pests. In the current study, we determined the suitability or inferiority of five different canola cultivars (Hayula420, Hayula401, Hayula50, Hayula60, RGS) to Nysius cymoides, under laboratory conditions. Data were analysed based on the age-stage, two-sex life table theory. Nysius cymoides which fed on Hayula420 had the longest nymphal period, while those which fed on Hayula50 had the shortest nymphal period. Developmental times (sum of incubation and nymphal periods) was longest for those which fe d on Hayula420 and the shortest for those which fed on Hayula50. The adult pre-oviposition period (APOP), total pre-oviposition period (TPOP), mean fecundity, and adult longevity of adults reared on different canola cultivars showed significant differences. The highest and lowest net reproductive rates (R0) were obtained for those which fed on Hayula420 (11.40 offspring per individual) and Hayula401 (5.47 offspring per individual), respectively. The highest value (0.0395 d–1) for the intrinsic rate of increase (r) was obtained for those which fed on Hayula 60 cultivar and the lowest value (0.0261 d–1) for those which fed on Hayula401 cultivar. The shortest and longest mean generation times (T) were obtained for those which fed on RGS and H401 cultivars, respectively. The lowest and highest values of life expectancy (exj) were obtained for those which fed on RGS and Hayula420 cultivars, respectively. The results showed that Hayula401 and RGS were not susceptible cultivars to N. cymoides. These cultivars showed higher resistance to N. cymoides, while Hayula60, Hayula420, and Hayula50 were found to be suitable cultivars but with lower resistance to N. cymoides, respectively

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Background: Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses. Objective: We intended to report most common monogenic PADs and to investigate how patients with PAD who were primarily diagnosed as suffering from agammaglobulinemia, hyper-IgM (HIgM) syndrome, and common variable immunodeficiency (CVID) have different clinical and immunological findings. Methods: Stepwise next-generation sequencing and Sanger sequencing were performed for confirmation of the mutations in the patients clinically diagnosed as suffering from agammaglobulinemia, HIgM syndrome, and CVID. Results: Among 550 registered patients, the predominant genetic defects associated with agammaglobulinemia (48 Bruton's tyrosine kinase [BTK] and 6 μ heavy chain deficiencies), HIgM syndrome (21 CD40 ligand and 7 activation-induced cytidine deaminase deficiencies), and CVID (17 lipopolysaccharides-responsive beige-like anchor deficiency and 12 atypical Immunodeficiency, Centromeric instability, and Facial dysmorphism syndromes) were identified. Clinical disease severity was significantly higher in patients with μ heavy chain and CD40 ligand mutations compared with patients with BTK (P = .003) and activation-induced cytidine deaminase (P = .009) mutations. Paralysis following live polio vaccination was considerably higher in patients with μ heavy chain deficiency compared with BTK deficiency (P < .001). We found a genotype-phenotype correlation among patients with BTK mutations regarding clinical manifestation of meningitis and chronic diarrhea. Surprisingly, we noticed that first presentations in most patients with Immunodeficiency, Centromeric instability, and Facial dysmorphism were respiratory complications (P = .008), whereas first presentations in patients with lipopolysaccharides-responsive beige-like anchor deficiency were nonrespiratory complications (P = .008). Conclusions: This study highlights similarities and differences in the clinical and genetic spectrum of the most common PAD-associated gene defects. This comprehensive comparison will facilitate clinical decision making, and improve prognosis and targeted treatment