31 research outputs found
Cosmic Ray Acceleration at the Forward Shock in Tycho's Supernova Remnant: Evidence from Chandra X-ray Observations
We present evidence for cosmic ray acceleration at the forward shock in
Tycho's supernova remnant (SNR) from three X-ray observables: (1) the proximity
of the contact discontinuity to the forward shock, or blast wave, (2) the
morphology of the emission from the rim of Tycho, and (3) the spectral nature
of the rim emission. We determine the locations of the blast wave (BW), contact
discontinuity (CD), and reverse shock (RS) around the rim of Tycho's supernova
remnant using a principal component analysis and other methods applied to new
Chandra data. The azimuthal-angle-averaged radius of the BW is 251". For the CD
and RS we find average radii of 241" and 183", respectively. Taking account of
projection effects, we find ratios of 1:0.93:0.70 (BW:CD:RS). We show these
values to be inconsistent with adiabatic hydrodynamical models of SNR
evolution. The CD:BW ratio can be explained if cosmic ray acceleration of ions
is occurring at the forward shock. The RS:BW ratio, as well as the strong Fe Ka
emission from the Tycho ejecta, imply that the RS is not accelerating cosmic
rays. We also extract radial profiles from ~34% of the rim of Tycho and compare
them to models of surface brightness profiles behind the BW for a purely
thermal plasma with an adiabatic shock. The observed morphology of the rim is
much more strongly peaked than predicted by the model, indicating that such
thermal emission is implausible here. Spectral analysis also implies that the
rim emission is non-thermal in nature, lending further support to the idea that
Tycho's forward shock is accelerating cosmic rays.Comment: 39 pages, 10 figures, accepted by Ap
Reclutamiento y selección de personal
En esta investigación la temática principal es la administración de recursos humanos haciendo énfasis en el subtema de reclutamiento y selección de personal.
En este informe se tiene como objetivo general investigar a cerca del proceso de reclutamiento y selección de personal para fortalecer los conocimientos de la gestión del talento humano.
Acá se podrá verificar la importancia de la administración de recursos en las organizaciones, y sobre todo se demuestran los procesos más cruciales al momento de tener la demanda de uno o varios talentos para determinadas áreas de una empresa o institución. Entre estos procesos se destacan reclutamiento, selección, capacitación y desarrollo y la evaluación del de desempeño. Todos estos son aplicados a cada talento que es integrado a una organización.
Este informe está estructurado bajo cuatro capítulos tales como: capitulo uno: Proceso de reclutamiento del capital humano, capitulo dos: Proceso y técnicas de selección del talento humano, capitulo tres: Capacitación y desarrollo del personal, capitulo cuatro: Evaluación del desempeño del capital humano.
Para llevar a cabo esta investigación y plasmar todo lo que está en este documento, fue necesario poner en práctica una serie de técnicas de investigación documental que permitieron recopilar una inmensa cantidad de información para fundamentar cada uno de los conceptos que se presentan en cada uno de los capítulos de desarrollo de este trabajo, también se necesitó aplicar las normativas APA seis para tener una mejor organización y presentación; igualmente se siguieron los lineamientos establecidos por el departamento de administración de empresas de la universidad UNAN-Managua
RapidPlan Hippocampal Sparing Whole Brain Model Version 2-How far can we reduce the dose?
Whole-brain radiotherapy has been the standard palliative treatment for patients with brain metastases due to its effectiveness, availability, and ease of administration. Recent clinical trials have shown that limiting radiation dose to the hippocampus is associated with decreased cognitive toxicity. In this study, we updated an existing Knowledge Based Planning model to further reduce dose to the hippocampus and improve other dosimetric plan quality characteristics. Forty-two clinical cases were contoured according to guidelines. A new dosimetric scorecard was created as an objective measure for plan quality. The new Hippocampal Sparing Whole Brain Version 2 (HSWBv2) model adopted a complex recursive training process and was validated with five additional cases. HSWBv2 treatment plans were generated on the Varian Halcyo
Hubble Space Telescope WFPC-2 Imaging of Cassiopeia A
The young SNR Cassiopeia A was imaged with WFPC-2 through four filters
selected to capture the complete velocity range of the remnant's main shell in
several important emission lines. Primary lines detected were [O III]
4959,5007, [N II] 6583, [S II] 6716,6731 + [O II] 7319,7330 + [O I] 6300,6364,
and [S III] 9069,9532. About 3/4th of the remnant's main shell was imaged in
all four filters. Considerable detail is observed in the reverse-shocked ejecta
with typical knot scale lengths of 0.2"-0.4" (1 - 2 x 10^16 cm). Both bright
and faint emission features appear highly clumped. Large differences in [S III]
and [O III] line intensities indicating chemical abundance differences are also
seen, particularly in knots located along the bright northern limb and near the
base of the northeast jet. A line of curved overlapping filament in the
remnant's northwestern rim appears to mark the location of the remnant's
reverse shock front in this region. Finger-like ejecta structures elsewhere
suggest cases where the reverse shock front is encountering the remnant's
clumped ejecta. Narrow-band [N II] images of the remnant's circumstellar knots
("QSFs") reveal them to be 0.1"-0.6" thick knots and filaments, often with
diffuse edges facing away from the center of expansion. Three color composite
images of the whole remnant and certain sections along with individual filter
enlargements of selected regions of the bright optical shell are presented and
discussed.Comment: 26 pages, 12 figures Accepted to the Astronomical Journa
In silico trial of simulation-free hippocampal-avoidance whole brain adaptive radiotherapy
BACKGROUND AND PURPOSE: Hippocampal-avoidance whole brain radiotherapy (HA-WBRT) can be a time-consuming process compared to conventional whole brain techniques, thus potentially limiting widespread utilization. Therefore, we evaluated the
MATERIALS AND METHODS: Ten patients previously treated for central nervous system cancers with cone-beam computed tomography (CBCT) imaging were included in this study. The CBCT was the adaptive image-of-the-day to simulate first fraction on-board imaging. Initial contours defined on the MRI were rigidly matched to the CBCT. Online ART was used to create treatment plans at first fraction. Dose-volume metrics of these simulation-free plans were compared to standard-workflow HA-WBRT plans on each patient CT simulation dataset. Timing data for the adaptive planning sessions were recorded.
RESULTS: For all ten patients, simulation-free HA-WBRT plans were successfully created utilizing the online ART workflow and met all constraints. The median hippocampi D
CONCLUSIONS: Simulation-free HA-WBRT, with commercially available systems, was clinically feasible via plan-quality metrics and timing
Reprogramming of root cells during nitrogen-fixing symbiosis involves dynamic polysome association of coding and noncoding RNAs
Translational control is a widespread mechanism that allows the cell to rapidly modulate gene expression in order to provide flexibility and adaptability to eukaryotic organisms. We applied translating ribosome affinity purification combined with RNA sequencing to characterize translational regulation of mRNAs at early stages of the nitrogen-fixing symbiosis established between Medicago truncatula and Sinorhizobium meliloti. Our analysis revealed a poor correlation between transcriptional and translational changes and identified hundreds of regulated protein-coding and long noncoding RNAs (lncRNAs), some of which are regulated in specific cell types. We demonstrated that a short variant of the lncRNA Trans-acting small interference RNA3 (TAS3) increased its association to the translational machinery in response to rhizobia. Functional analysis revealed that this short variant of TAS3 might act as a target mimic that captures microRNA390, contributing to reduce trans acting small interference Auxin Response Factor production and modulating nodule formation and rhizobial infection. The analysis of alternative transcript variants identified a translationally upregulated mRNA encoding subunit 3 of the SUPERKILLER complex (SKI3), which participates in mRNA decay. Knockdown of SKI3 decreased nodule initiation and development, as well as the survival of bacteria within nodules. Our results highlight the importance of translational control and mRNA decay pathways for the successful establishment of the nitrogen-fixing symbiosis.Fil: Traubenik, Laura Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Reynoso, Mauricio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Hobecker, Karen Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Lancia, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Hummel, Maureen. University of California; Estados UnidosFil: Rosen, Benjamin. J. Craig Venter Institute; Estados UnidosFil: Town, Christopher. J. Craig Venter Institute; Estados UnidosFil: Bailey Serres, Julia. University of California; Estados UnidosFil: Blanco, Flavio Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Zanetti, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentin
Dignidad, Poder, Resistencia // Dignity, Power, Resistance
First To Go Abroad is a partnership between the Loyola Marymount University First To Go Program, LMU Study Abroad, and the Council on International Educational Exchange (CIEE), which seeks to increase study abroad opportunities for first-generation college students. In May 2017, fifteen first-gen students and two first-gen faculty mentors traveled together to Santiago, Dominican Republic, where they spent ten days exploring the country and learning about the local cultures, customs, and histories of the people who call the DR home.
Travel is a privilege not all students have the same access to; for some students, this trip was the first time out of the United States. Like the first-generation college experience, the experience of international travel is marked by daily encounters with new spaces, people, and cultural practices that can be at once overwhelming and inspiring. This was a topic of exploration throughout the trip and the subject of the pages contained in this volume.
The narratives published here are the product of a cross-institutional writing workshop, where students from LMU and the Pontificia Universidad Católica Madre y Maestra worked together to draft essays documenting their encounters with change that have pushed boundaries, broken down borders, and generated personal growth. We hope our readers around the world will appreciate these works, which showcase the transformative power of creative and collaborative global encounters
Clinical application of a template-guided automated planning routine
PURPOSE: Determine the dosimetric quality and the planning time reduction when utilizing a template-based automated planning application.
METHODS: A software application integrated through the treatment planning system application programing interface, QuickPlan, was developed to facilitate automated planning using configurable templates for contouring, knowledge-based planning structure matching, field design, and algorithm settings. Validations are performed at various levels of the planning procedure and assist in the evaluation of readiness of the CT image, structure set, and plan layout for automated planning. QuickPlan is evaluated dosimetrically against 22 hippocampal-avoidance whole brain radiotherapy patients. The required times to treatment plan generation are compared for the validations set as well as 10 prospective patients whose plans have been automated by QuickPlan.
RESULTS: The generations of 22 automated treatment plans are compared against a manual replanning using an identical process, resulting in dosimetric differences of minor clinical significance. The target dose to 2% volume and homogeneity index result in significantly decreased values for automated plans, whereas other dose metric evaluations are nonsignificant. The time to generate the treatment plans is reduced for all automated plans with a median difference of 9\u27 50″ ± 4\u27 33″.
CONCLUSIONS: Template-based automated planning allows for reduced treatment planning time with consistent optimization structure creation, treatment field creation, plan optimization, and dose calculation with similar dosimetric quality. This process has potential expansion to numerous disease sites
Dried Blood Spheroids for Dry-State Room Temperature Stabilization of Microliter Blood Samples
It is well-known that 2D dried blood spots on paper offer a facile sample collection, storage, and transportation of blood. However, large volume requirements, possible analyte instability, and difficult sample recovery plague this method, lowering confidence in analyte quantification. For the first time, we demonstrate a new approach using 3D dried blood spheroids for stabilization of small volume blood samples, mitigating these effects without cold storage. Blood spheroids form on hydrophobic paper, preventing interaction between the sample and paper substrate, eliminating all chromatographic effects. Stability of the enzyme alanine transaminase and labile organic compounds such as cocaine and diazepam were also shown to increase in the spheroid by providing a critical radius of insulation. On-surface analysis of the dried blood spheroids using paper spray mass spectrometry resulted in sub-ng/mL limits of detection for all illicit drugs tested, representing 1 order of magnitude improvement compared with analysis from 2D dried blood spots