A Two-Dimensional Mesh Refinement Method for Problems with One-Dimensional Singularities

This paper introduces a method for resolving internal layers that can occur in the solutions of time-dependent differential equations in two space dimensions. Singular features in these solutions that are essentially one-dimensional in nature but are not oriented with the computational mesh are resolved using one-dimensional mesh refinement techniques with a procedure that is similar to an ADI method. A careful interpolation procedure assures that the resolution obtained in each ADI step is not lost in the succeeding ADI step

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.

Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease. However, the location(s) of proteolytic processing and subsequent secretion of APP fragments from highly compartmentalized, euploid neurons that express APP and processing enzymes at normal levels is not well understood. To probe the behavior of endogenous APP, particularly in human neurons, we developed a system using neurons differentiated from human embryonic stem cells, cultured in microfluidic devices, to enable direct biochemical measurements from axons. Using human or mouse neurons in these devices, we measured levels of Aβ, sAPPα, and sAPPβ secreted solely from axons. We found that a majority of the fragments secreted from axons were processed in the soma, and many were dependent on somatic endocytosis for axonal secretion. We also observed that APP and the β-site APP cleaving enzyme were, for the most part, not dependent on endocytosis for axonal entry. These data establish that axonal entry and secretion of APP and its proteolytic processing products traverse different pathways in the somatodendritic compartment before axonal entry

Turbo EP-based Equalization: a Filter-Type Implementation

This manuscript has been submitted to Transactions on Communications on September 7, 2017; revised on January 10, 2018 and March 27, 2018; and accepted on April 25, 2018 We propose a novel filter-type equalizer to improve the solution of the linear minimum-mean squared-error (LMMSE) turbo equalizer, with computational complexity constrained to be quadratic in the filter length. When high-order modulations and/or large memory channels are used the optimal BCJR equalizer is unavailable, due to its computational complexity. In this scenario, the filter-type LMMSE turbo equalization exhibits a good performance compared to other approximations. In this paper, we show that this solution can be significantly improved by using expectation propagation (EP) in the estimation of the a posteriori probabilities. First, it yields a more accurate estimation of the extrinsic distribution to be sent to the channel decoder. Second, compared to other solutions based on EP the computational complexity of the proposed solution is constrained to be quadratic in the length of the finite impulse response (FIR). In addition, we review previous EP-based turbo equalization implementations. Instead of considering default uniform priors we exploit the outputs of the decoder. Some simulation results are included to show that this new EP-based filter remarkably outperforms the turbo approach of previous versions of the EP algorithm and also improves the LMMSE solution, with and without turbo equalization

Enabling Future Sustainability Transitions: An Urban Metabolism Approach to Los Angeles Pincetl et al. Enabling Future Sustainability Transitions

Summary: This synthesis article presents an overview of an urban metabolism (UM) approach using mixed methods and multiple sources of data for Los Angeles, California. We examine electric energy use in buildings and greenhouse gas emissions from electricity, and calculate embedded infrastructure life cycle effects, water use and solid waste streams in an attempt to better understand the urban flows and sinks in the Los Angeles region (city and county). This quantification is being conducted to help policy-makers better target energy conservation and efficiency programs, pinpoint best locations for distributed solar generation, and support the development of policies for greater environmental sustainability. It provides a framework to which many more UM flows can be added to create greater understanding of the study area's resource dependencies. Going forward, together with policy analysis, UM can help untangle the complex intertwined resource dependencies that cities must address as they attempt to increase their environmental sustainability

Expert Decision Making: A Fuzzy-Trace Theory Perspective

This is the author accepted manuscript. The final version is available from Routledge via the ISBN in this recor

Total cross sections for positrons scattered elastically from helium based on new measurements of total ionization cross sections

An improved technique is presented for employing the 2.3m spectrometer to measure total ionization cross sections, Q sub ion, for positrons incident on He. The new ionization cross section agree with the values reported earlier. Estimates are also presented of total elastic scattering cross section, Q sub el, obtained by subtracting from total scattering cross sections, Q sub tot, reported in the literature, the Q sub ion and Q sub Ps (total positronium formation cross sections) and total excitation cross sections, Q sub ex, published by another researcher. The Q sub ion and Q sub el measured with the 3m high resolution time-of-flight spectrometer for 54.9eV positrons are in accord with the results from the 2.3m spectrometer. The ionization cross sections are in fair agreement with theory tending for the most part to be higher, especially at 76.3 and 88.5eV. The elastic cross section agree quite well with theory to the vicinity of 50eV, but at 60eV and above the experimental elastic cross sections climb to and remain at about 0.30 pi a sub o sq while the theoretical values steadily decrease

Incompatibility Systems in Switchgrass

Switchgrass (Panicum virgatum L.), a cross-pollinated perennial, produces very little or no seed when self-pollinated, indicating the presence of self-incompatibility mechanisms. Knowledge of self-incompatibility mechanisms is required to use germplasm effectively in a breeding program. The objective of this study was to characterize features of the incompatibility systems in switchgrass. Seed set and seed characteristics of reciprocal matings of tetraploid, octaploid, and tetraploid x octaploid plants were used as measures of incompatibility. Both bagged mutual pollination and manual emasculation and pollination methods were used to make crosses. The percentages of self-compatibility in the tetraploid and octaploid parent plants were 0.35 and 1.39%, respectively. Prefertilization incompatibility in switchgrass is apparently under gametophytic control, since there were significant differences in percentage of compatible pollen as measured by percentage of total seed set between reciprocal matings within ploidy levels. Results indicated that the prefertilization incompatibility system in switchgrass is similar to the S-Z incompatibility system found in other members of the Poaceae. A postfertilization incompatibility system also exists that inhibits intermatings among octaploid and tetraploid plants. In these interploidy crosses, two very distinctive types of abnormal seed were found. When the female parent was the tetraploid plant, the resulting seed was small and shriveled, while when the female parent was the octaploid, small seed with floury endosperm was obtained. These results are similar to those obtained for endosperm incompatibility due to the endosperm balance number system found in other species

Heterosis in Switchgrass: Spaced Plants

Population and specific hybrids were made between populations and genotypes of switchgrass, Panicum virgatum L., and their progeny were evaluated for heterosis in space-transplanted fi eld trials in eastern Nebraska for a 3-yr period. ‘Kanlow’ (lowland tetraploid) x ‘Summer’ (upland tetraploid) hybrids exhibit midparent heterosis for second- and third-year biomass yields for both population and individual plant hybrids. These data and previously reported molecular marker data indicate that lowland-tetraploid and upland-tetraploid switchgrasses represent different heterotic groups that can potentially be used to produce F1 hybrid cultivars. Hybrids produced from cultivars and experimental strains developed from upland-octaploid germplasm originating from spatially separated western and eastern regions of the original tallgrass or an adjacent forested ecoregion did not exhibit heterosis for any trait evaluated. These results suggest that these upland populations evaluated were from the same or closely related large germplasm pools or heterotic groups. A method for developing F1 switchgrass hybrid cultivars utilizing the gametophytic self-incompatibility mechanism of the species is described