O que é a imaginação?

Trata-se de um fragmento de notas de uma aula ministrada por V. V. Repkin, em 1975, para estudantes do Instituto de Psicologia da Universidade Estatal de Kharkiv, dedicada ao problema da psicologia da imaginação. Os julgamentos do autor, expressos quase cinquenta anos atrás, colocam de manifesto a sua preocupação com a educação da personalidade da criança como objetivo fundamental da teoria da aprendizagem desenvolvimental, em lugar da mera assimilação de conceitos teóricos

Formation of intellectual capital of a professional sports organization

The research is devoted to the formation of the intellectual capital of the sports industry of the Republic of Belarus. The role and importance of the intellectual capital in the professional sports industry of the Republic of Belarus was noted. The structure of the intellectual capital of a professional sports organization and its main elements are considered

Formation of intellectual capital of a professional sports organization

The research is devoted to the formation of the intellectual capital of the sports industry of the Republic of Belarus. The role and importance of the intellectual capital in the professional sports industry of the Republic of Belarus was noted. The structure of the intellectual capital of a professional sports organization and its main elements are considered

DEVELOPMENT OF A E-LEARNING TRAINER WITH FEEDBACK BASED ON MOODLE'S PLUGIN STACK

This thesis describes the current status of online learning systems in the world, why they are needed and what are their drawbacks. Then it's described, why you can create the best systems by using STACK, and a little about such a simulator, which is created by us

THE EFFECT OF BICUCULLINE ON EVOKED POTENTIALS RECORDED IN THE SPINAL CORD OF THE CAT.

THE EFFECT OF BICUCULLINE ON EVOKED POTENTIALS RECORDED IN THE SPINAL CORD OF THE CAT

How Efficient are Firms in Transition Countries? Firm-Level Evidence from Bulgaria and Romania

Stochastic frontier production functions are estimated for Bulgarian (1993–5) and Romanian (1994–5) manufacturing industries using firm-level panel data. The technical efficiency of firms is found to vary significantly both within and across industrial sectors in each country. We find strong evidence of a positive relationship between firm technical efficiency levels and their profitability, which suggests the reforms have succeeded in creating hard budget constraints. The relationship between firm efficiency and size is also found to be positive, suggesting big industrial firms in the former planned economies are not necessarily inefficient.Efficiency; Firm Size; stochastic production frontier

7. Democratic development in Veliky Novgorod

Two roads to promote the development of a democratic culture in Veliky Novgorod in post-Soviet Russia are described. The development of home owner partnerships in the city means privatisation of apartment houses which previously were state property. This required considerable support from city administration to establish both funding, loan and proper economic and administrative routines. Educational programmes were run to develop the competence needed among those to work in the new partnerships. Responsibility for the houses as well as surrounding territory resulted in considerably improved housing conditions. These included effective sharing of common property, better and cheaper maintenance and services, and a better social situation. Secondly the creation of a folk high school or "Peoples university" in Novgorod, in cooperation with the Swedish city of Örebro, is described. Also here the focus is on democratisation especially in practical life. The subjects studied include new communication technologies, foreign languages, and political education. The promotion of culture is important. The education also has a goal to promote employment, e.g. in public health, services or environmental work

Activation of Notch signaling in endothelium cause upregulation of N-terminal acetylated histone 1

Highlights. Notch signaling is known to be important regulator of endothelium homeostasis and cardiovascular disease. Particularly, Notch seems to be associated with pathological changes in endothelium epigenome although no such Notch effects have been found. We have discovered that activation of Notch signaling alters histone 1 repertoire in the human endothelial cells and this is the first example of epigenomic Notch targets.Aim. The disturbance of blood flow and alteration of physiological shear stress is one of the main reasons for endothelial dysfunction. Mechanosensitive and dosedependent Notch pathway is assumed to be an important player of endothelial dysfunction progression, but the molecular mechanisms of the influence of Notch dysregulation on endothelium are still not understood. In particular, there is no data about possible targets of Notch in the endothelial epigenome.Methods. Here we focused on the analysis of changes in histone code of human umbilical vein endothelial cells (HUVEC) after activation of Notch. For this purpose, we transduced cells by lentiviruses with construction for Notch 1 intracellular domain (N1ICD) overexpression or by empty vector (control). Then we isolated histone enriched fraction and secretome proteins and performed their shotgun proteomics analysis on timsToF Pro instrument. Proteomics data are available via ProteomeXchange with identifier PXD032978.Results. We found the shift in proteomics profile of HUVEC caused by Notch activation and, particularly, the increase in the levels of N-terminal acetylated forms of histone 1: H1-0, H1-3, H1-4, H1-5, H1-10. We also found changes in the cell secretome profile which are associated with the decrease in proangiogenic effect of HUVEC secretome.Conclusion. Our data identified epigenomic Notch targets and we assume that changes in H1 repertoire might be associated with cardiovascular disease progression in vivo.Highlights. Notch signaling is known to be important regulator of endothelium homeostasis and cardiovascular disease. Particularly, Notch seems to be associated with pathological changes in endothelium epigenome although no such Notch effects have been found. We have discovered that activation of Notch signaling alters histone 1 repertoire in the human endothelial cells and this is the first example of epigenomic Notch targets.Aim. The disturbance of blood flow and alteration of physiological shear stress is one of the main reasons for endothelial dysfunction. Mechanosensitive and dosedependent Notch pathway is assumed to be an important player of endothelial dysfunction progression, but the molecular mechanisms of the influence of Notch dysregulation on endothelium are still not understood. In particular, there is no data about possible targets of Notch in the endothelial epigenome.Methods. Here we focused on the analysis of changes in histone code of human umbilical vein endothelial cells (HUVEC) after activation of Notch. For this purpose, we transduced cells by lentiviruses with construction for Notch 1 intracellular domain (N1ICD) overexpression or by empty vector (control). Then we isolated histone enriched fraction and secretome proteins and performed their shotgun proteomics analysis on timsToF Pro instrument. Proteomics data are available via ProteomeXchange with identifier PXD032978.Results. We found the shift in proteomics profile of HUVEC caused by Notch activation and, particularly, the increase in the levels of N-terminal acetylated forms of histone 1: H1-0, H1-3, H1-4, H1-5, H1-10. We also found changes in the cell secretome profile which are associated with the decrease in proangiogenic effect of HUVEC secretome.Conclusion. Our data identified epigenomic Notch targets and we assume that changes in H1 repertoire might be associated with cardiovascular disease progression in vivo