232 research outputs found
Nanocarriers for neuromuscular diseases
Overview of the results obtained so far in the frame of a research on suitable nanocarriers for treating myotonic dystroph
First events from the CNGS neutrino beam detected in the OPERA experiment
The OPERA neutrino detector at the underground Gran Sasso Laboratory (LNGS)
was designed to perform the first detection of neutrino oscillations in
appearance mode, through the study of nu_mu to nu_tau oscillations. The
apparatus consists of a lead/emulsion-film target complemented by electronic
detectors. It is placed in the high-energy, long-baseline CERN to LNGS beam
(CNGS) 730 km away from the neutrino source. In August 2006 a first run with
CNGS neutrinos was successfully conducted. A first sample of neutrino events
was collected, statistically consistent with the integrated beam intensity.
After a brief description of the beam and of the various sub-detectors, we
report on the achievement of this milestone, presenting the first data and some
analysis results.Comment: Submitted to the New Journal of Physic
Observation of a first candidate in the OPERA experiment in the CNGS beam
The OPERA neutrino detector in the underground Gran Sasso Laboratory (LNGS)
has been designed to perform the first detection of neutrino oscillations in
direct appearance mode through the study of the
channel. The hybrid apparatus consists of an emulsion/lead target complemented
by electronic detectors and it is placed in the high energy long-baseline CERN
to LNGS beam (CNGS) 730 km away from the neutrino source. Runs with CNGS
neutrinos were successfully carried out in 2008 and 2009. After a brief
description of the beam, the experimental setup and the procedures used for the
analysis of the neutrino events, we describe the topology and kinematics of a
first candidate charged-current event satisfying the kinematical
selection criteria. The background calculations and their cross-check are
explained in detail and the significance of the event is assessed.Comment: 19 pages, 3 figure
A study of multi-jet events at the CERN I3p collider and a search for double patton scattering UA2 Collaboration Bern-Cambridge-CERN-Dortmund-Heidelberg-Melbourne-Milano-Orsay (LAL)-Pavia- Perugia-Pisa-Saclay (CEN)
A study of events containing at least four high transverse momentum jets and a search for double parton scattering (DPS) have been performed using data collected with the UA2 detector at the CERN lbp Collider (x/s= 630 GeV). The results are in good agreement with leading order QCD calculations. A value of at~Ps < 0.82 nb at 95% confidence level (CL) is obtained for the DPS cross section
The Human Papillomavirus Type 31 Late 3âČ Untranslated Region Contains a Complex Bipartite Negative Regulatory Element
The papillomavirus life cycle is tightly linked to epithelial cell differentiation. Production of virus capsid proteins is restricted to the most terminally differentiated keratinocytes in the upper layers of the epithelium. However, mRNAs encoding the capsid proteins can be detected in less-differentiated cells, suggesting that late gene expression is controlled posttranscriptionally. Short sequence elements (less than 80 nucleotides in length) that inhibit gene expression in undifferentiated epithelial cells have been identified in the late 3âČ untranslated regions (UTRs) of several papillomaviruses, including the high-risk mucosal type human papillomavirus type 16 (HPV-16). Here we show that closely related high-risk mucosal type HPV-31 also contains elements that can act to repress gene expression in undifferentiated epithelial cells. However, the HPV-31 negative regulatory element is surprisingly complex, comprising a major inhibitory element of approximately 130 nucleotides upstream of the late polyadenylation site and a minor element of approximately 110 nucleotides mapping downstream. The first 60 nucleotides of the major element have 68% identity to the negative regulatory element of HPV-16, and these elements bind the same cellular proteins, CstF-64, U2AF(65), and HuR. The minor inhibitory element binds some cellular proteins in common with the major inhibitory element, though it also binds certain proteins that do not bind the upstream element
Nanocarriers for neuromuscular diseases
Overview of the results obtained so far in the frame of a research on suitable nanocarriers for treating myotonic dystroph
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