Redes de Sensores sem Fio Aplicadas à Fisioterapia: Implementação e Validação de um Sistema de Monitoramento de Amplitude de Movimento

A amplitude de movimento é um parâmetro importante utilizado na avaliação e durante o tratamento fisioterapêutico. Sistemas disponíveis e utilizados atualmente possuem atuação limitada. A principal contribuição deste trabalho é a especificação, implementação e validação de um sistema de monitoramento, em tempo real, de ângulos articulares baseado em redes de sensores sem fio: FlexMeter. Os nós sensores utilizam acelerômetros para obter as informações de ângulos articulares, e a rede sem fio dá mobilidade ao paciente e ao fisioterapeuta. A validação do sistema incluiu três etapas: validação das medidas com os sensores, validação de usabilidade, e validação de medidas em articulação de joelho. Os resultados da validação demonstraram como o uso do sistema pode facilitar o trabalho do fisioterapeuta

Performance Evaluation of Cryptographic Algorithms over IoT Platforms and Operating Systems

The deployment of security services over Wireless Sensor Networks (WSN) and IoT devices brings significant processing and energy consumption overheads. These overheads are mainly determined by algorithmic efficiency, quality of implementation, and operating system. Benchmarks of symmetric primitives exist in the literature for WSN platforms but they are mostly focused on single platforms or single operating systems. Moreover, they are not up to date with respect to implementations and/or operating systems versions which had significant progress. Herein, we provide time and energy benchmarks of reference implementations for different platforms and operating systems and analyze their impact. Moreover, we not only give the first benchmark results of symmetric cryptography for the Intel Edison IoT platform but also describe a methodology of how to measure energy consumption on that platform

Natural Products: Insights into Leishmaniasis Inflammatory Response

Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous membranes, and internal organs. Despite the relevance of host inflammatory mediators on parasite burden control, Leishmania and host immune cells interaction may generate an exacerbated proinflammatory response that plays an important role in the development of leishmaniasis clinical manifestations. Plant-derived natural products have been recognized as bioactive agents with several properties, including anti-protozoal and anti-inflammatory activities. The present review focuses on the antileishmanial activity of plant-derived natural products that are able to modulate the inflammatory response in vitro and in vivo. The capability of crude extracts and some isolated substances in promoting an anti-inflammatory response during Leishmania infection may be used as part of an effective strategy to fight the disease

INTOXICAÇÃO POR PTERIDIUM ARACHNOIDEUM NO OESTE DE SANTA CATARINA - ESTUDO RETROSPECTIVO (2013-2017)

Samambaia (Pteridium arachnoideum) é uma das plantas tóxicas mais importantes na criação de bovinos de todo o Brasil. O objetivo desse trabalho foi descrever os diagnósticos de intoxicação por samambaia, em bovinos na região oeste de Santa Catarina, realizados pelo Laboratório de Patologia Veterinária (LPV) do IFC – Campus Concórdia, no período entre 2013 e 2017. No período, foram realizadas 641 necropsias de bovinos, sendo que 22 dessas tiveram o diagnóstico de intoxicação por samambaia, totalizando 3,4% da casuística total de necropsias em bovinos. Foram 13 casos de síndrome hemorrágica aguda, seis casos de carcinomas de células escamosas na base da língua, esôfago ou rúmen, e três casos de hematúria enzoótica bovina. Apesar dos inúmeros trabalhos científicos a respeito da toxicidade do P. arachnoideum, o número de diagnósticos dessa intoxicação é alto na região, e a planta ainda é facilmente encontrada. A melhor forma de diminuir as intoxicações é o adequado manejo das pastagens e a correta adubação do solo, evitando com que a planta esteja disponível ao consumo dos animais, porém essa informação precisa ser difundida aos produtores rurais.  Palavras-chave: diagnóstico, patologia, samambaia, hematúria, carcinoma.

Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes

This study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamateinduced. After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos. The rota-rod test (7 rpm/min) was carried out. Geraniol (37.57%) was the main compound of LEO. DSC and TG/DTG proved the complexation. The orofacial nociceptive behavior was significantly (p < 0.05) reduced. The number of Fos-positive cells was significantly changed in the dorsal raphe nucleus (p < 0.01), locus coeruleus (p < 0.001), trigeminal nucleus (p < 0.05), and trigeminal thalamic tract (p < 0.05). LEO-CD did not cause changes in motor coordination in the rota-rod test. Thus, our results suggested that LEO-CD has an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination

Genomics and epidemiology for gastric adenocarcinomas (GE4GAC): a Brazilian initiative to study gastric cancer

Abstract Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings