Correction to: Northerly wind trends along the Portuguese marine coast since 1950

All figure captions are not accurate. Also, there is a repeated error in most figures because the vertical scales incorrectly show Wind Strenght instead of Wind Strength and in Fig. 4 (mid-panel) 2003 instead of 2004.info:eu-repo/semantics/publishedVersio

First record of Cobia (Rachycentron canadum) (Pisces: Rachycentridae) at the coast of Madeira Island (NE Atlantic Ocean

The Cobia Rachycentron canadum is recorded from Madeira Island for the first time. An individual of this species was encountered and video-documented while SCUBA-diving in about 12 m depth at the south coast of this island.info:eu-repo/semantics/publishedVersio

Acoustic inversion of the cold water filaments off the Southwest coast of Portugal

Cold water filaments have important implications in the biological and chemical exchanges between the coastal and offshore ocean. The Cape São Vicente area in the Southwest coast of Portugal is a well know region where such phenomenon is observed. In October 2004, the multidisciplinary project ATOMS, involving oceanographers and acousticians, was conducted with the objective to complement the sea surface temperature (SST) satellite observation with a full water column characterization. Due to weather and technical conditions during the project sea trial, only CTD measurements in upper layers of the water column were performed. These at sea collected data together with archival data from the NODC database, allowed to establish realistic scenario of the 3D temperature distribution in the area, including deeper water layers. Archival data of temperature profiles suggest the occurrence of other important oceanic phenomena such as the subduction of warm Mediterrenean water, that should also influence the acoustic propagation. With the help of forward acoustic modelling the significance and signature of the individual oceanographic phenomena on the acoustic propagation, regarding different sampling strategies of the area by acoustic means is investigated. These investigations allowed to develop strategies to settle the main problem addressed by this work: invert the cold water filament structure by acoustic means in a complex environment where acoustic propagation is affected also by other important oceanic and bathymetric features. Since, the objective of this work, is to evaluate the ability to perform a 3D characterization of vertical structure of the ocean, a minimal transmit-receive acquisition composed of a suspended source from a ship and a drifting vertical array, is assumed. The spatial structure is obtained by a combination of inversions for ”mean” sound speed/temperature perturbations obtained for source-array cross-sections covering the area of interest. Matched-field and ray tracing based tomography techniques are used in the inversion for the ”mean” perturbations. The planned sampling strategies and necessary acoustic equipment to resolve such oceanic features is discussed having in mind future sea trials.ATOMS - POCTI/MAR/15296/1999; FCT Program POSI - QCA III

Family and systems therapy and training in Portugal

"Author's personal copy"The history of systemic family therapy in Portugal since its appearance until the present is discussed. Some data on systemic family therapists' training is provided in the context of the Portuguese Society of Family Therapy and Academic Institutions. In Portugal, family therapy has been extended to various contexts, including medical and community services. Finally, future directions for family and systems therapy practice and training in Portugal are provided emphasizing the importance of family interventions as an important resource to empower families living with health chronic conditions. The Portuguese Family Therapy Society, every 2 years, organizes a scientific Iberian conference with Portuguese and Spanish speakers. This allows the exchange of clinical experience and research about family and systems theory

Sediment-matrix igneous breccias at the top contacts of felsic units in the IPB : implications for VHMS exploration

The Volcanic Sedimentary Complex of the Iberian Pyrite Belt is dominated by mudstone units and comprises felsic lavas/domes and pyroclastic units that define lava-cryptodome-pumice cone volcanoes. Sediment-matrix igneous breccias may outline the contacts of volcanic units, occur within them, or lie laterally to the volcanic centres. These breccias can form by several processes, each with its genetic implications, having nevertheless very similar final aspect. We have distinguished and characterized several sediment-matrix breccia types. The most abundant types are sediment-infill volcanic breccia and peperite; however other types of sediment-matrix breccia were also identified. The correct identification of these breccias is crucial to reconstruct the volcanic centres and to define the stratigraphy, which in mineralized volcanic provinces is a major issue both for metallogenic and mineral exploration models

Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks

Decades of research have disclosed a plethora of alterations in protein glycosylation that decisively impact in all stages of disease and ultimately contribute to more aggressive cell phenotypes. The biosynthesis of cancer-associated glycans and its reflection in the glycoproteome is driven by microenvironmental cues and these events act synergistically toward disease evolution. Such intricate crosstalk provides the molecular foundations for the activation of relevant oncogenic pathways and leads to functional alterations driving invasion and disease dissemination. However, it also provides an important source of relevant glyco(neo)epitopes holding tremendous potential for clinical intervention. Therefore, we highlight the transversal nature of glycans throughout the currently accepted cancer hallmarks, with emphasis on the crosstalk between glycans and the tumor microenvironment stromal components. Focus is also set on the pressing need to include glycans and glycoconjugates in comprehensive panomics models envisaging molecular-based precision medicine capable of improving patient care. We foresee that this may provide the necessary rationale for more comprehensive studies and molecular-based intervention.The authors wish to acknowledge the Portuguese Foundation for Science and Technology (FCT) for the human resources grants: PhD grant SFRH/BD/111242/2015 (AP), and FCT auxiliary researcher grant CEECIND/03186/2017 (JF). FCT is co-financed by European Social Fund (ESF) under Human Potential Operation Programme (POPH) from National Strategic Reference Framework (NSRF). The authors also acknowledge the Portuguese Oncology Institute of Porto Research Centre (CI-IPOP-29-2014; CI-IPOP-58-2015), the PhD Program in Biomedical Sciences of ICBAS-University of Porto, and the Early stage cancer treatment, driven by context of molecular imaging (ESTIMA) framework (NORTE-01-0145-FEDER-000027). The authors were also supported by the CANCER project (NORTE-01-0145-FEDER-000029) co-funded through the NORTE-45-2015-02

Ensaios de integridade estrutural de placas angulares de fixação de fracturas ósseas do fémur

Neste trabalho descreve-se o projecto de um dispositivo mecânico desenvolvido para a realização de ensaios segundo a norma ASTM F384-00 (2000) de placas de osteossíntese anguladas. O dispositivo foi objecto de uma análise estrutural usando o método dos elementos finitos. Algumas placas foram ensaiadas estaticamente e suas características mecânicas, de acordo com a norma, determinadas

Endothelial dysfunction is associated with cerebrovascular events in pre-dialysis ckd patients: A prospective study

Background: Patients with chronic kidney disease (CKD) have markedly increased rates of end stage renal disease, major adverse cardiovascular/cerebrovascular events (MACCEs), and mortality. Endothelial dysfunction (ED) is an early marker of atherosclerosis that is emerging as an increasingly important non-traditional cardiovascular risk factor in CKD. There is a lack of clinical studies examining the association between ED and both cardiovascular and renal endpoints in patients with CKD. Aims: We examined the association between reactive hyperemia index (RHI), a validated measure of endothelial function measured by peripheral arterial tonometry (PAT), with traditional cardiovascular risk factors in pre-dialysis CKD patients and prospectively evaluated the role of RHI as predictor of renal and cardiovascular outcomes in this population. Methods: One hundred and twenty pre-dialysis patients with CKD stages 1 to 5 (CKD group) and 18 healthy kidney donor candidates (control group) were recruited and had a successful RHI measurement by PAT. General demographic and clinical information including traditional cardiovascular risk factors were registered from all participants. Thereafter, patients were prospectively followed-up for a median time of 47 (IQR 19–66) months to determine associations of RHI with renal outcomes, MACCEs, hospitalizations or mortality. Results: In the CKD patient population, the mean age was 57.7 ± 15.5 years, the mean eGFR was 54.9 ± 36.7 mL/min/1.73 m2 (CKD-EPI) and 57 were males (47.5%). At baseline, in univariate analysis, RHI in the CKD group correlated positively with eGFR (r = 0.332, p < 0.0001) and correlated negatively with age (r = -0.469, p < 0.0001), Charlson index (r = -0.399, p < 0.0001), systolic blood pressure (r = -0.256, p = 0.005), and proteinuria (r = 0.211, p = 0.027). Reactive hyperemia index in the control group did not significantly differ from RHI observed in patients with CKD stages 1 to 5 (2.09 ± 0.40 vs. 2.01 ± 0.06, p = 0.493). In adjusted analysis, only age (ß = -0.014, p = 0.003) remained independently associated with RHI at baseline. During follow-up, 8 patients suffered a MACCEs, 33 patients experienced renal function deterioration, 17 patients were hospitalized for medical reasons and 6 patients died. RHI at baseline was not significantly associated with CKD progression (1.94 vs. 2.02, p = 0.584), hospitalizations (1.90 vs. 2.04, p = 0.334), and all-cause mortality (1.65 vs. 2.01, p = 0.208) or MACCEs (1.77 vs. 2.01, p = 0.356), but was significantly associated with cerebrovascular events (1.27 vs. 2.02, p = 0.004) and with a composite cardiovascular outcome (MACCEs, hospital admissions and death; 1.73 vs. 2.07, p = 0.035). Conclusion: Our results suggest that RHI may be a predictor for the development of cerebrovascular events in pre-dialysis CKD patients who may benefit from more aggressive preventive measures.This research was funded by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274), a grant from Portuguese Society of Nephrology