99 research outputs found
Antibacterial activity of six indigenous Indian plants: Acacia nilotica (Fabaceae), Albizia saman (Fabaceae), Azadirachta indica (Meliaceae), Carica papaya (Caricaceae), Cymbopogon citratus (Poaceae) and Mangifera indica (Anacardiaceae)
Plants have been used as major source of active compounds with medicinal importance since human civilization. These naturally occurring pharmacologically active agents have least or no toxicity to the host. The antibacterial activity of extracts (water, acetone and methanol) from six indigenous Indian plants: Acacia nilotica (Fabaceae), Albizia saman (Fabaceae), Azadirachta indica (Meliaceae), Carica papaya (Caricaceae), Cymbopogon citratus (Poaceae) and Mangifera indica (Anacardiaceae) were determined against the pathogenic bacteria (Staphylococcus aureus: ATCC 25923; Escherichia coli: ATCC 25922 and Klebsiella pneumonia: ATCC 700603). The antimicrobial study was carried out by the gel diffusion method and the results show that as compared to aqueous extract, methanolic and acetone extracts were more effective. Of all the studied plants, the methanolic extract of A. saman leaves inhibited the growth of all the three test organisms.Key words: Antibacterial activity, pathogenic bacteria, indigenous plants.
Sonoluminescence and collapse dynamics of multielectron bubbles in helium
Multielectron bubbles (MEBs) differ from gas-filled bubbles in that it is the
Coulomb repulsion of a nanometer thin layer of electrons that forces the bubble
open rather than the pressure of an enclosed gas. We analyze the implosion of
MEBs subjected to a pressure step, and find that despite the difference in the
underlying processes the collapse dynamics is similar to that of gas-filled
bubbles. When the MEB collapses, the electrons inside it undergo strong
accelerations, leading to the emission of radiation. This type of
sonoluminescence does not involve heating and ionisation of any gas inside the
bubble. We investigate the conditions necessary to obtain sonoluminescence from
multielectron bubbles and calculate the power spectrum of the emitted
radiation.Comment: 6 figure
Infrared Absorption Investigations Confirm the Extraterrestrial Origin of Carbonado-Diamonds
The first complete infrared FTIR absorption spectra for carbonado-diamond
confirm the interstellar origin for the most enigmatic diamonds known as
carbonado. All previous attempts failed to measure the absorption of
carbonado-diamond in the most important IR-range of 1000-1300 cm-1 (10.00-7.69
micro-m.) because of silica inclusions. In our investigation, KBr pellets were
made from crushed silica-free carbonado-diamond and thin sections were also
prepared. The 100 to 1000 times brighter synchrotron infrared radiation permits
a greater spatial resolution. Inclusions and pore spaces were avoided and/or
sources of chemical contamination were removed. The FTIR spectra of
carbonado-diamond mostly depict the presence of single nitrogen impurities, and
hydrogen. The lack of identifiable nitrogen aggregates in the infrared spectra,
the presence of features related to hydrocarbon stretch bonds, and the
resemblance of the spectra to CVD and presolar diamonds indicate that
carbonado-diamonds formed in a hydrogen-rich interstellar environment. This is
consistent with carbonado-diamond being sintered and porous, with extremely
reduced metals, metal alloys, carbides and nitrides, light carbon isotopes,
surfaces with glassy melt-like patinas, deformation lamellae, and a complete
absence of primary, terrestrial mineral inclusions. The 2.6-3.8 billion year
old fragmented body was of asteroidal proportions
HighP–TNano-Mechanics of Polycrystalline Nickel
We have conducted highP–Tsynchrotron X-ray and time-of-flight neutron diffraction experiments as well as indentation measurements to study equation of state, constitutive properties, and hardness of nanocrystalline and bulk nickel. Our lattice volume–pressure data present a clear evidence of elastic softening in nanocrystalline Ni as compared with the bulk nickel. We show that the enhanced overall compressibility of nanocrystalline Ni is a consequence of the higher compressibility of the surface shell of Ni nanocrystals, which supports the results of molecular dynamics simulation and a generalized model of a nanocrystal with expanded surface layer. The analytical methods we developed based on the peak-profile of diffraction data allow us to identify “micro/local” yield due to high stress concentration at the grain-to-grain contacts and “macro/bulk” yield due to deviatoric stress over the entire sample. The graphic approach of our strain/stress analyses can also reveal the corresponding yield strength, grain crushing/growth, work hardening/softening, and thermal relaxation under highP–Tconditions, as well as the intrinsic residual/surface strains in the polycrystalline bulks. From micro-indentation measurements, we found that a low-temperature annealing (T < 0.4 Tm) hardens nanocrystalline Ni, leading to an inverse Hall–Petch relationship. We explain this abnormal Hall–Petch effect in terms of impurity segregation to the grain boundaries of the nanocrystalline Ni
Evaluation of sesamum gum as an excipient in matrix tablets
In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated
Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites
The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions.
The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness
of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence
were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density
and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that
the wood in the starch composites did not prevent water loss from the samples.Peer reviewe
Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature
Final report on simplification and streamlining of customs and central excise law and procedures (May 1993). Vol. I
Scale-up effects on dissolution and bioavailability of propranolol hydrochloride and metoprolol tartrate tablet formulations
This study evaluated the effects of batch size on the in vitro dissolution and the in vivo bioavailability of immediate release formulations of propranolol hydrochloride and metoprolol tartrate. The formulations were manufactured as small and large batches (6 kg and 60 kg for propranolol; 14 kg and 66 kg for metoprolol), and dissolution was performed using USP Apparatus I at 100 rpm and pH 1.2. Two panels of 14 subjects each were randomly assigned to receive the small and large batches of either propranolol or metoprolol in an open randomized single-dose study. Blood samples were collected over a 24-hour (propranolol) or 18-hour (metoprolol) period and analyzed by validated methods. As determined by thef2 metric (similarity factor), the dissolution of the small and large batches of propranolol and metoprolol was similar. The mean Cmax and AUCinf for the small batch of propranolol were 79.0 μ g/L and 536 μ g/L/hr and for the large batch they were 83.5 μ g/L and 575 μ g/L/hr. Cmax and AUCinf for the small batch of metoprolol were found to be 95.5 μ g/L and 507 μ g/L/hr and for the large batch, 95.1 μ g/L and 495 μ g/L/hr. The 90% confidence intervals for the small and large batches were within the 80% to 120% range for InCmax, and InAUCinf for both the propranolol and metoprolol formulations. These results suggest that the scale-up process does not significantly affect the bioavailability of highly soluble, highly permeable drugs and in vitro dissolution tests may be useful in predicting in vivo behavior
Scale-up effects on dissolution and bioavailability of propranolol hydrochloride and metoprolol tartrate tablet formulations
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