Методичні рекомендації та вимоги до виконання дипломних робіт студентами освітньо-кваліфікаційного рівня “магістр” спеціальності 8.05030101 “Розробка родовищ та видобування корисних копалин”, спеціалізації “Відкрита розробка родовищ”

Подано методичні рекомендації і вимоги до виконання дипломних робіт освітньо-кваліфікаційного рівня “магістр” студентами спеціальності 8.05030101 “Розробка родовищ та видобування корисних копалин”, спеціалізації “Відкрита розробка родовищ”. Наведено рекомендований склад дипломних робіт, вимоги до їх тематики, змісту та виконання. Сформульовано основні положення орга- нізації виконання дипломної роботи та її захисту. Визначено критерії оцінки дипломної роботи. Викладення матеріалу рекомендацій проілюстровано при- кладами

Отымённые глагольные дериваты как обозначения родства и свойства́ в немецком языке

В статье рассматриваются лексические единицы в классе немецкого глагола, образованные от обозначений родства и свойства́ преимущественно по конфиксальной модели ver + основа + t. Их главными особенностями следует признать нейтральную окрашенность, использование в качестве предикативов и в дословном значении зачастую вопреки созвучию с единицами других словарных множеств

Herramientas normativas sobre la compleja realidad ambiental : sus generalidades

p.1-5El presente trabajo tiene como objetivo de sistematizar el proceso de las herramientas jurídicas básicas sobre el medio ambiente ya que, es de fundamental importancia el conocimiento normativo que va a regular las relaciones sociales para que, desde una perspectiva holística se puedan lograr resoluciones integrales. El derecho ambiental es la respuesta normativa a la creciente degradación que sugre el medio en que vivimos. Se integra con una serie de normas de diverso nivel de importancia (leyes, decretos, ordenazas, resoluciones, etc.) y diverso origen (demanadas del estado nacional, de los estados provinciales o de los municipios), que en algunos casos se superponen y en otros se contradicen. Con una visión interdisciplinaria y en la necesidad de tomar cnocimiento del derecho ambiental y poder identificar, cuál sería la normativa aplicable a una determinada organización/actividad, en una primera instancia y a modo de guía se han elaborado una serie de preguantas esenciales que pueden resultar de gran utilidad para que, la gestión ambiental de los profesionales en su hacer se ajuste a derecho

Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

Plaque rupture occurs if stress within coronary lesions exceeds the protection exerted by the fibrous cap overlying the necrotic lipid core. However, very little is known about the biomechanical stress exerting this disrupting force. Employing optical coherence tomography (OCT), we generated plaque models and performed finite-element analysis to simulate stress distributions within the vessel wall in 10 ruptured and 10 non-ruptured lesions. In ruptured lesions, maximal stress within fibrous cap (peak cap stress [PCS]: 174 ± 67 vs. 52 ± 42 kPa, p<0.001) and vessel wall (maximal plaque stress [MPS]: 399 ± 233 vs. 90 ± 95 kPa, p=0.001) were significantly higher compared to non-ruptured plaques. Ruptures arose in the immediate proximity of maximal stress concentrations (angular distances: 21.8 ± 30.3° for PCS vs. 20.7 ± 23.7° for MPS); stress concentrations excellently predicted plaque rupture (area under the curve: 0.940 for PCS, 0.950 for MPS). This prediction of plaque rupture was superior to established vulnerability features such as fibrous cap thickness or macrophage infiltration. In conclusion, OCT-based finite-element analysis effectively assesses plaque biomechanics, which in turn predicts plaque rupture in patients. This highlights the importance of morpho-mechanic analysis assessing the disrupting effects of plaque stress

Scalable and flexible inference framework for stochastic dynamic single-cell models

Understanding the inherited nature of how biological processes dynamically change over time and exhibit intra- and inter-individual variability, due to the different responses to environmental stimuli and when interacting with other processes, has been a major focus of systems biology. The rise of single-cell fluorescent microscopy has enabled the study of those phenomena. The analysis of single-cell data with mechanistic models offers an invaluable tool to describe dynamic cellular processes and to rationalise cell-to-cell variability within the population. However, extracting mechanistic information from single-cell data has proven difficult. This requires statistical methods to infer unknown model parameters from dynamic, multi-individual data accounting for heterogeneity caused by both intrinsic (e.g. variations in chemical reactions) and extrinsic (e.g. variability in protein concentrations) noise. Although several inference methods exist, the availability of efficient, general and accessible methods that facilitate modelling of single-cell data, remains lacking. Here we present a scalable and flexible framework for Bayesian inference in state-space mixed-effects single-cell models with stochastic dynamic. Our approach infers model parameters when intrinsic noise is modelled by either exact or approximate stochastic simulators, and when extrinsic noise is modelled by either time-varying, or time-constant parameters that vary between cells. We demonstrate the relevance of our approach by studying how cell-to-cell variation in carbon source utilisation affects heterogeneity in the budding yeast Saccharomyces cerevisiae SNF1 nutrient sensing pathway. We identify hexokinase activity as a source of extrinsic noise and deduce that sugar availability dictates cell-to-cell variability

Decline of emergency admissions for cardiovascular and cerebrovascular events after the outbreak of COVID-19

Background The spread of the novel coronavirus SARS-CoV-2 and the guidance from authorities for social distancing and media reporting lead to significant uncertainty in Germany. Concerns have been expressed regarding the underdiagnosing of harmful diseases. We explored the rates of emergency presentations for acute coronary syndrome (ACS) and acute cerebrovascular events (ACVE) before and after spread of SARS-CoV-2. Methods We analyzed all-cause visits at a tertiary university emergency department and admissions for ACS and ACVE before (calendar weeks 1–9, 2020) and after (calendar weeks 10–16, 2020) the first coronavirus disease (COVID-19) case in the region of the Saarland, Germany. The data were compared with the same period of the previous year. Results In 2020 an average of 346 patients per week presented at the emergency department whereas in 2019 an average of 400 patients presented up to calendar week 16 (p = 0.018; whole year 2019 = 395 patients per week). After the first COVID-19 diagnosis in the region, emergency department visit volume decreased by 30% compared with the same period in 2019 (p = 0.0012). Admissions due to ACS decreased by 41% (p = 0.0023 for all; Δ − 71% (p = 0.007) for unstable angina, Δ − 25% (p = 0.42) for myocardial infarction with ST-elevation and Δ − 17% (p = 0.28) without ST-elevation) compared with the same period in 2019 and decreased from 142 patients in calendar weeks 1–9 to 62 patients in calendar weeks 10–16. ACVE decreased numerically by 20% [p = 0.25 for all; transient ischemic attack: Δ − 32% (p = 0.18), ischemic stroke: Δ − 23% (p = 0.48), intracerebral haemorrhage: Δ + 57% (p = 0.4)]. There was no significant change in ACVE per week (p = 0.7) comparing calendar weeks 1–9 (213 patients) and weeks 10–16 (147 patients). Testing of 3756 samples was performed to detect 58 SARS-CoV-2 positive patients (prevalence 1,54%, thereof one patient with myocardial and two with cerebral ischemia) up to calendar week 16 in 2020. Conclusions The COVID-19 pandemic was associated with a significant decrease in all-cause admission and admissions due to cardiovascular events in the emergency department. Regarding acute cerebrovascular events there was a numerical decrease but no significant difference

МИТНЕ ЗАКОНОДАВСТВО УКРАЇНИ ЯК ОСНОВА КАРДИНАЛЬНИХ ЗМІН В СИСТЕМІ УПРАВЛІННЯ ЗЕД

Стаття присвячена аналізу та узагальненню сучасних змін в митному законодавстві України, встановленню невирішених проблем та перспективам розвитку системи управління зовнішньоекономічною діяльністю в Україні на рівні держави на основі еволюції митно-тарифної політики та вдосконалення законодавства.The article is devoted to the analysis and generalization of the temporary changes in the customs legislation of Ukraine, and determination of the unsolved problems in this sphere. Much attention is paid to the prospects of the development of Ukrainian foreign economic activity regulation system on the basis of customs-tariff politics evolution and legislation improvement