MR Spectroscopic Imaging of Peripheral Zone in Prostate Cancer Using a 3T MRI Scanner: Endorectal versus External Phased Array Coils.

Magnetic resonance spectroscopic imaging (MRSI) detects alterations in major prostate metabolites, such as citrate (Cit), creatine (Cr), and choline (Ch). We evaluated the sensitivity and accuracy of three-dimensional MRSI of prostate using an endorectal compared to an external phased array "receive" coil on a 3T MRI scanner. Eighteen patients with prostate cancer (PCa) who underwent endorectal MR imaging and proton (1H) MRSI were included in this study. Immediately after the endorectal MRSI scan, the PCa patients were scanned with the external phased array coil. The endorectal coil-detected metabolite ratio [(Ch+Cr)/Cit] was significantly higher in cancer locations (1.667 ± 0.663) compared to non-cancer locations (0.978 ± 0.420) (P < 0.001). Similarly, for the external phased array, the ratio was significantly higher in cancer locations (1.070 ± 0.525) compared to non-cancer locations (0.521 ± 0.310) (P < 0.001). The sensitivity and accuracy of cancer detection were 81% and 78% using the endorectal 'receive' coil, and 69% and 75%, respectively using the external phased array 'receive' coil

Systematic study of the influence of coherent phonon wave packets on the lasing properties of a quantum dot ensemble

Kohärente Phononen können die Licht-Materie-Wechselwirkung in Halbleiter Nanostrukturen stark ändern. Bei einem Ensemble von Quantenpunkten (QP) als aktivem Lasermedium sind Phononen im Stande, die Laserintensität deutlich zu verstärken oder abzuschwächen. Die Physik des gekoppelten Phonon-Exziton-Licht-Systems wird von verschiedenen Mechanismen dominiert, die im Experiment nicht eindeutig unterschieden werden können, da die komplizierte Probenstruktur zu einem komplexen Verspannungspuls führt, der auf das QP-Ensemble trifft. Hier zeigen wir durch eine umfassende theoretische Studie, wie die Laseremission durch Phononpulse verschiedener Form und QP-Ensembles verschiedener spektraler Verteilung beeinflusst wird. Dies erlaubt einen Einblick in die grundlegenden Wechselspiele des gekoppelten Gesamtsystems. Dadurch können wir zwischen zwei Mechanismen unterschieden: der adiabatischen Verschiebung des Ensembles und dem Schüttel-Effekt. Dies ebnet den Weg zu einer gezielten Kontrolle der Laser Emission durch kohärente Phononen.Coherent phonons can greatly vary light–matter interaction in semiconductor nanostructures placed inside an optical resonator on a picosecond time scale. For an ensemble of quantum dots (QDs) as active laser medium, phonons are able to induce a large enhancement or attenuation of the emission intensity, as has been recently demonstrated. The physics of this coupled phonon–exciton–light system consists of various effects, which in the experiment typically cannot be clearly separated, in particular, due to the complicated sample structure a rather complex strain pulse impinges on the QD ensemble. Here we present a comprehensive theoretical study how the laser emission is affected by phonon pulses of various shapes as well as by ensembles with different spectral distributions of the QDs. This gives insight into the fundamental interaction dynamics of the coupled phonon–exciton–light system, while it allows us to clearly discriminate between two prominent effects: the adiabatic shifting of the ensemble and the shaking effect. This paves the way to a tailored laser emission controlled by phonons.</p

Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer

The purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of prostate cancer (PCa) patients with three classes of pathological Gleason scores (GS). Patients whose GS met these criteria (GS 3 + 3, GS 3 + 4, and GS 4 + 3) were included in this study. The DWI was performed using b values of 0, 50, and 400 s/mm2 in 44 patients using an endorectal coil on a 1.5T MRI scanner. The apparent diffusion coefficient (ADC) values were calculated from the DWI data of patients with three different Gleason scores. In patients with a high-grade Gleason score (4 + 3), the ADC values were lower in the peripheral gland tissue, pathologically determined as tumor compared to low grade (3 + 3 and 3 + 4). The mean and standard deviation of the ADC values for patients with GS 3 + 3, GS 3 + 4, and GS 4 + 3 were 1.135 ± 0.119, 0.976 ± 0.103 and 0.831 ± 0.087 mm2/sec. The ADC values were statistically significant (P < 0.05) between the three different scores with a trend of decreasing ADC values with increasing Gleason scores by one-way ANOVA method. This study shows that the DWI-derived ADC values may help differentiate aggressive from low-grade PCa

SAT-Based Synthesis Methods for Safety Specs

Automatic synthesis of hardware components from declarative specifications is an ambitious endeavor in computer aided design. Existing synthesis algorithms are often implemented with Binary Decision Diagrams (BDDs), inheriting their scalability limitations. Instead of BDDs, we propose several new methods to synthesize finite-state systems from safety specifications using decision procedures for the satisfiability of quantified and unquantified Boolean formulas (SAT-, QBF- and EPR-solvers). The presented approaches are based on computational learning, templates, or reduction to first-order logic. We also present an efficient parallelization, and optimizations to utilize reachability information and incremental solving. Finally, we compare all methods in an extensive case study. Our new methods outperform BDDs and other existing work on some classes of benchmarks, and our parallelization achieves a super-linear speedup. This is an extended version of [5], featuring an additional appendix.Comment: Extended version of a paper at VMCAI'1

Fragmentation of exotic oxygen isotopes

Abrasion-ablation models and the empirical EPAX parametrization of projectile fragmentation are described. Their cross section predictions are compared to recent data of the fragmentation of secondary beams of neutron-rich, unstable 19,20,21O isotopes at beam energies near 600 MeV/nucleon as well as data for stable 17,18O beams

Upgrade of the Glasgow photon tagging spectrometer for Mainz MAMI-C

The Glasgow photon tagging spectrometer at Mainz has been upgraded so that it can be used with the 1500 MeV electron beam now available from the Mainz microtron MAMI-C. The changes made and the resulting properties of the spectrometer are discussed.Comment: 20 pages, 12 figure

Evidence and Ideology in Macroeconomics: The Case of Investment Cycles

The paper reports the principal findings of a long term research project on the description and explanation of business cycles. The research strongly confirmed the older view that business cycles have large systematic components that take the form of investment cycles. These quasi-periodic movements can be represented as low order, stochastic, dynamic processes with complex eigenvalues. Specifically, there is a fixed investment cycle of about 8 years and an inventory cycle of about 4 years. Maximum entropy spectral analysis was employed for the description of the cycles and continuous time econometrics for the explanatory models. The central explanatory mechanism is the second order accelerator, which incorporates adjustment costs both in relation to the capital stock and the rate of investment. By means of parametric resonance it was possible to show, both theoretically and empirically how cycles aggregate from the micro to the macro level. The same mathematical tool was also used to explain the international convergence of cycles. I argue that the theory of investment cycles was abandoned for ideological, not for evidential reasons. Methodological issues are also discussed