Optimal Resting-Growth Strategies of Microbial Populations in Fluctuating Environments

Bacteria spend most of their lifetime in non-growing states which allow them to survive extended periods of stress and starvation. When environments improve, they must quickly resume growth to maximize their share of limited nutrients. Cells with higher stress resistance often survive longer stress durations at the cost of needing more time to resume growth, a strong disadvantage in competitive environments. Here we analyze the basis of optimal strategies that microorganisms can use to cope with this tradeoff. We explicitly show that the prototypical inverse relation between stress resistance and growth rate can explain much of the different types of behavior observed in stressed microbial populations. Using analytical mathematical methods, we determine the environmental parameters that decide whether cells should remain vegetative upon stress exposure, downregulate their metabolism to an intermediate optimum level, or become dormant. We find that cell-cell variability, or intercellular noise, is consistently beneficial in the presence of extreme environmental fluctuations, and that it provides an efficient population-level mechanism for adaption in a deteriorating environment. Our results reveal key novel aspects of responsive phenotype switching and its role as an adaptive strategy in changing environments

Principles of Minimally Invasive Surgery Applied to Oncology Patients

none6noneMattioli, Girolamo; Pio, Luca; Avanzini, Stefano; Granata, Claudio; Blanc, Thomas; Sarnacki, SabineMattioli, Girolamo; Pio, Luca; Avanzini, Stefano; Granata, Claudio; Blanc, Thomas; Sarnacki, Sabin

Constitutive and geometric nonlinear models for the seismic analysis of RC structures with energy dissipators

Nowadays, the use of energy dissipating devices to improve the seismic response of RC structures constitutes a mature branch of the innovative procedures in earthquake engineering. However, even though the benefits derived from this technique are well known and widely accepted, the numerical methods for the simulation of the nonlinear seismic response of RC structures with passive control devices is a field in which new developments are continuously preformed both in computational mechanics and earthquake engineering. In this work, a state of the art of the advanced models for the numerical simulation of the nonlinear dynamic response of RC structures with passive energy dissipating devices subjected to seismic loading is made. The most commonly used passive energy dissipating devices are described, together with their dissipative mechanisms as well as with the numerical procedures used in modeling RC structures provided with such devices. The most important approaches for the formulation of beam models for RC structures are reviewed, with emphasis on the theory and numerics of formulations that consider both geometric and constitutive sources on nonlinearity. In the same manner, a more complete treatment is given to the constitutive nonlinearity in the context of fiber-like approaches including the corresponding cross sectional analysis. Special attention is paid to the use of damage indices able of estimating the remaining load carrying capacity of structures after a seismic action. Finally, nonlinear constitutive and geometric formulations for RC beam elements are examined, together with energy dissipating devices formulated as simpler beams with adequate constitutive laws. Numerical examples allow to illustrate the capacities of the presented formulations.Postprint (published version