Using Push Technology for Maintaining Proficiency and Promoting a Growth Mindset in a STEM Course

Just like physical skills, cognitive skills grow rusty over time unless they are regularly used and practiced. This means that school breaks can have quite negative consequences on student learning. The Keeping in School Shape (KiSS) program is an engaging, innovative and cost-effective intervention that uses push technology to help students maintain proficiency over breaks from school, while also promoting a growth mindset. Theoretically, the KiSS program draws on the well-documented benefits of retrieval practice – the notion that recalling previously material is a very effective way of maintaining cognitive performance. The KiSS program embodies retrieval practice by sending students a multiple-choice mathematics question daily via text messaging or email. A positive mindset regarding the benefits of effort is promoted through feedback messages that encourage program resource use, such as choosing to view a hint and retry a problem instead of giving up. This paper reports on a few aspects of the implementation of the KiSS program at a large university during the summer break for students enrolled in an engineering introductory calculus course sequence

Development of the nanobody display technology to target lentiviral vectors to antigen-presenting cells

Lentiviral vectors (LVs) provide unique opportunities for the development of immunotherapeutic strategies, as they transduce a variety of cells in situ, including antigen-presenting cells (APCs). Engineering LVs to specifically transduce APCs is required to promote their translation towards the clinic. We report on the Nanobody (Nb) display technology to target LVs to dendritic cells (DCs) and macrophages. This innovative approach exploits the budding mechanism of LVs to incorporate an APC-specific Nb and a binding-defective, fusion-competent form of VSV. G in the viral envelope. In addition to production of high titer LVs, we demonstrated selective, Nb-dependent transduction of mouse DCs and macrophages both in vitro and in situ. Moreover, this strategy was translated to a human model in which selective transduction of in vitro generated or lymph node (LN)-derived DCs and macrophages, was demonstrated. In conclusion, the Nb display technology is an attractive approach to generate LVs targeted to specific cell types

Synthesis and Diels-Alder Reactions of 1,2-Dimethylene- and 1,2,9,10-Tetramethylene-[2.2]paracyclophane: New Routes to Bridge-Anellated[2.2]Paracyclophanedienes

The title compounds 8 and 1 have been synthesized in three steps each from 1,2-dibromo[2.2]paracyclophan-1-ene (2) and 1,2,9,10-tetrabromo[2.2]paracyclophane-1,9-diene (4), respectively. Copper-mediated coupling of vinyl bromides 2 and 4 with methyl- and phenylmagnesium bromide gives substituted [2.2]paracyclophanes 3-CH3, 3-Ph, 5-CH3, and 5-Ph in good yields. The high reactivity of the [2.2]paracyclophane-1,2-dimethylene moieties in 8 and 1 in Diels-Alder reactions has been verified in cycloadditions with p-benzoquinone to give 10 and 13 and with naphthalene 1,4-endoxide to yield 12

Healthcare network operation in Iquique after the 2014, Pisagua earthquake

On April 1st, 2014, the 8.2 Mw Pisagua earthquake affected the population in the north of Chile and generated disruption of services in the region. The largest effects of the earthquake were observed in the city of Iquique, capital of the Tarapaca Region, where more than 80% of the population of the region lives. This research describes the response of the public healthcare network of Iquique after the earthquake, and aims to identify the principal factors contributing to the network resilience during the early response and recovery phase after the earthquake. Despite the large magnitude of the earthquake, the observed structural damage was minor in the five healthcare centers considered (i.e., the regional hospital and 4 Primary Healthcare Attention Centers, PHACs). However, disruption of services in the healthcare network was large and due mainly to the collapse of non-structural components. Overall, the proper response of the healthcare network of Iquique was heavily supported by the PHACs, which largely provided first-aid, containment, and low-complexity attention to the population, allowing the hospital to focus on more complex procedures. The findings of this study suggest that the resilience of the healthcare network system, besides the robustness of the network’s facilities and their critical units, is also highly dependent on the interrelations and interactions between them in early post-earthquake recovery phases

High-tech element availability for sustainable energy systems in the 21st century : The Iberian Pyrite Belt as a potential supplier

This work provides estimations on the future raw material demand for the thin-film photovoltaic (PV) elements indium, selenium, tellurium, germanium and gallium. Data calculation has been carried out on the basis of current energy and PV market outlooks. For indium, our calculation yields a maximum cumulative demand of 12 kilotons for the period from 2008 to 2030. The minimum demand for the same period is of 8 kilotons. Additionally, static depletion times for the elements in question have been determined. For indium, the static depletion time of 22 years shows that its supply is highly endangered, particularly if indium consumption for LCD and solar panel production stays on a high level or even increases. The situation for selenium, with a static depletion time of 53 years, is not much better. Therefore, in addition to recycling, the fundamental way to enhance material supply is through intensified exploration for mineral deposits. Such exploration could focus in promising areas, where high-technology elements are already known to exist in sulphide ore deposits, e.g. the Iberian Pyrite Belt (IPB), a metallogenic province known for its massive sulphide ore resources

Clear cell sarcoma of the parotid region

UNIFESP-EPMUNIFESP-EPM Departamento de PatologiaUNIFESP-EPM Departamento de Otorrinolaringologia e Cirurgia de Cabeça e PescoçoUNIFESP, EPM, Depto. de PatologiaUNIFESP, EPM Depto. de Otorrinolaringologia e Cirurgia de Cabeça e PescoçoSciEL

Impact on Chilean hospitals following the 2015 Illapel earthquake

In a post-disaster environment, hospitals play a critical role in healthcare services continuities to the population while effectively coping with eventual losses of functionality. These losses come from physical damage to the facility, loss of utility lifelines, failure in supply chains, and reduction of personnel. However, data describing the detailed performance of hospitals during past earthquakes are scarce. Consequently, following the 2015 Mw 8.3 Illapel earthquake in central Chile, an exhaustive field campaign was carried out in the Coquimbo region to collect substantial perishable data to describe physical damage to hospitals and functionality losses. This study presents first the baseline information obtained in nine surveyed government hospitals, including size, location and type of infrastructure. Then, the seismic impact was analyzed and classified to show the main physical structural and non-structural damage, lifeline interruptions, losses in hospital units, and variations in flow of patients and staff. Transfers, discharges and evacuations of patients that occurred after the event were also reported. We found that the earthquake did not affect strongly the healthcare service despite the fact that most of the structural and non-structural damage was localized in the largest regional hospital. The archival nature of the data collected may deepen our understanding of the post-earthquake healthcare system performance, which is very useful in improving disaster preparation and overall resilience

Diagrams :As large-scale generative systems

[EN] This article aims, on the one hand, to determine the defining characteristics of those approaches to design that are mainly based on the use of graphic diagrams with generative capabilities. On the other hand, it also attempts to clarify the methodological aspects of the insertion of graphic diagramming techniques within the broader field of architectural design processes. Using this conceptual framework, this article also analyzes three contemporary projects in which, supported by the use of digital technologies, graphic diagramming techniques play a critical role in the definition of spatial experiences at the urban scale[ES] Este artículo persigue, por una parte, determinar las características que definen aquellos modos de proyectar apoyados en el empleo de diagramas gráficos con cualidades generativas. Por otra parte, pretende clarificar los aspectos metodológicos relacionados con la inserción de técnicas diagramáticas dentro del ámbito más amplio de los procesos del proyectar arquitectónico. Bajo este marco conceptual, el artículo analiza tres proyectos contemporáneos en los que las técnicas gráficas diagramáticas, apoyadas en el uso de las tecnologías digitales, adquieren un papel protagonista en la definición de ámbitos espaciales de escala urbanaParedes Maldonado, M. (2015). Diagramas: instrumentos generativos de gran escala. EGA. Revista de Expresión Gráfica Arquitectónica. 20(25):168-179. doi:10.4995/ega.2015.1287.SWORD1681792025Cache, B., 1995. Earth Moves. The furnishing of territories. Cambridge: MIT Press.Deleuze, G., Guattari, F., 2004. Mil Mesetas. Capitalismo y Esquizofrenia. Valencia: Pre-textos.Eisenman, P., 1993. Folding in time. The singularity of Rebstockpark. Architectural Design, Vol. 63, No 3/4, pp.38-41.Kwinter, S., 2002. Architectures of time. Toward a theory of the Event in Modenist Culture. Cambridge: MIT Press.De Landa, M., 2010. Deleuze, history and science. New York: Atropos Press.Reiser, J., Umemoto, N., 2006, Atlas of Novel Tectonics. New York: Princeton Architectural Press