Bidirectional irradiance transposition based on the Perez model

The Perez irradiance model offers a practical representation of solar irradiance by considering the sky hemisphere as a three-part geometrical framework, namely, the circumsolar disc, the horizon band and the isotropic background. Furthermore, the simplified Perez diffuse irradiance model, commonly known as the Perez transposition model, is one of the most widely adopted models in tilted irradiance modeling. Although the set of model coefficients reported by Perez et al. (1990) is considered to be at an asymptotic level of optimization, later analyses have shown that coefficients which are adjusted to local conditions may perform better than the original set.<p></p> The model coefficients can be adjusted locally based on multiple datasets of diffuse and global irradiance on tilted and horizontal planes. In this paper, we present a different approach to adjust the coefficients, by using only measurements of global irradiance on tilted and horizontal planes from a tropical climate site, Singapore. A complete set of mathematical solutions to the inverse problem, i.e., irradiance transposition from tilt to horizontal, is also proposed. The data can then be used to generate irradiance maps from in-plane irradiance measurements at photovoltaics (PV) systems. Such maps provide relevant information for PV grid integration.<p></p&gt

The rapid evolution of the central star of the Stingray Nebula - latest news from the HST

SAO 244567 is an unusually fast evolving star. Within twenty years only, it had turned from a B-type supergiant into the central star of the Stingray Nebula. Space- and ground-based observations obtained over the last decades have revealed that its spectrum changes noticeably over just a few years, showing stellar evolution in real time. The low mass of SAO 244567 is, however, in strong contradiction with canonical post-asymptotic giant branch evolution. Thus, its fast evolution has been a mystery for decades. We present preliminary results of the non-LTE spectral analyis of the recently obtained HST/COS observations, which finally allow us to shed light on the evolutionary history of this extraordinary object.Facultad de Ciencias Astronómicas y GeofísicasInstituto de Astrofísica de La Plat

On-demand generation of background--free single photons from a solid-state source

True on--demand high--repetition--rate single--photon sources are highly sought after for quantum information processing applications. However, any coherently driven two-level quantum system suffers from a finite re-excitation probability under pulsed excitation, causing undesirable multi--photon emission. Here, we present a solid--state source of on--demand single photons yielding a raw second--order coherence of $g^{(2)}(0)=(7.5\pm1.6)\times10^{-5}$ without any background subtraction nor data processing. To this date, this is the lowest value of $g^{(2)}(0)$ reported for any single--photon source even compared to the previously best background subtracted values. We achieve this result on GaAs/AlGaAs quantum dots embedded in a low--Q planar cavity by employing (i) a two--photon excitation process and (ii) a filtering and detection setup featuring two superconducting single--photon detectors with ultralow dark-count rates of $(0.0056\pm0.0007) s^{-1}$ and $(0.017\pm0.001) s^{-1}$, respectively. Re--excitation processes are dramatically suppressed by (i), while (ii) removes false coincidences resulting in a negligibly low noise floor

EchoBASE: an integrated post-genomic database for Escherichia coli

EchoBASE (http://www.ecoli-york.org) is a relational database designed to contain and manipulate information from post-genomic experiments using the model bacterium Escherichia coli K-12. Its aim is to collate information from a wide range of sources to provide clues to the functions of the approximately 1500 gene products that have no confirmed cellular function. The database is built on an enhanced annotation of the updated genome sequence of strain MG1655 and the association of experimental data with the E.coli genes and their products. Experiments that can be held within EchoBASE include proteomics studies, microarray data, protein–protein interaction data, structural data and bioinformatics studies. EchoBASE also contains annotated information on ‘orphan’ enzyme activities from this microbe to aid characterization of the proteins that catalyse these elusive biochemical reactions

Resonance fluorescence of GaAs quantum dots with near-unity photon indistinguishability

Photonic quantum technologies call for scalable quantum light sources that can be integrated, while providing the end user with single and entangled photons on-demand. One promising candidate are strain free GaAs/AlGaAs quantum dots obtained by droplet etching. Such quantum dots exhibit ultra low multi-photon probability and an unprecedented degree of photon pair entanglement. However, different to commonly studied InGaAs/GaAs quantum dots obtained by the Stranski-Krastanow mode, photons with a near-unity indistinguishability from these quantum emitters have proven to be elusive so far. Here, we show on-demand generation of near-unity indistinguishable photons from these quantum emitters by exploring pulsed resonance fluorescence. Given the short intrinsic lifetime of excitons confined in the GaAs quantum dots, we show single photon indistinguishability with a raw visibility of $V_{raw}=(94.2\pm5.2)\,\%$, without the need for Purcell enhancement. Our results represent a milestone in the advance of GaAs quantum dots by demonstrating the final missing property standing in the way of using these emitters as a key component in quantum communication applications, e.g. as an entangled source for quantum repeater architectures

Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study

<p>Abstract</p> <p>Background</p> <p>Neuroinflammation and demyelination have been suggested as mechanisms causing HIV-1 associated neurocognitive disorder (HAND). This cross-sectional cohort study explores the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in multiple sclerosis, in the pathogenesis of HAND.</p> <p>Methods</p> <p>IgG antibodies against MOG were measured by ELISA in sera and cerebrospinal fluid (CSF) of 65 HIV-positive patients with HAND (n = 14), cerebral opportunistic infections (HIVOI, n = 25), primary HIV infection (HIVM, n = 5) and asymptomatic patients (HIVasy, n = 21). As control group HIV-negative patients with bacterial or viral CNS infections (OIND, n = 18) and other neurological diseases (OND, n = 22) were included. In a subset of HAND patients MOG antibodies were determined before and during antiviral therapy.</p> <p>Results</p> <p>In serum, significantly higher MOG antibody titers were observed in HAND compared to OND patients. In CSF, significantly higher antibody titers were observed in HAND and HIVOI patients compared to HIVasy and OND patients and in OIND compared to OND patients. CSF anti-MOG antibodies showed a high sensitivity and specificity (85.7% and 76.2%) for discriminating patients with active HAND from asymptomatic HIV patients. MOG immunopositive HAND patients performed significantly worse on the HIV dementia scale and showed higher viral load in CSF. In longitudinally studied HAND patients, sustained antibody response was noted despite successful clearance of viral RNA.</p> <p>Conclusions</p> <p>Persistence of MOG antibodies despite viral clearance in a high percentage of HAND patients suggests ongoing neuroinflammation, possibly preventing recovery from HAND.</p

Antimyelin antibodies in clinically isolated syndromes correlate with inflammation in MRI and CSF

Objective: We investigated the correlation of anti-myelin oligodendrocyte glycoprotein- (anti-MOG) and anti-myelin basic protein antibodies (anti-MBP) in serum of CIS patients with inflammatory signs in MRI and in CSF and, as previously suggested, the incidence of more frequent and rapid progression to clinically definite MS (CDMS). Methods: 133 CIS patients were analysed for anti-MOG and anti-MBP (Western blot). Routine CSF and cranial MRI (quantitatively and qualitatively) measures were analyzed. 55 patients had a follow-up of at least 12 months or until conversion to CDMS. Results: Patients with anti-MOG and anti-MBP had an increased intrathecal IgG production and CSF white blood cell count (p = 0.048 and p = 0.036). When anti-MBP alone, or both antibodies were present the cranial MRI showed significantly more T2 lesions (p = 0.007 and p = 0.01, respectively). There was a trend for more lesion dissemination in anti-MBP positive patients (p = 0.076). Conversely, anti-MOG- and/or anti-MBP failed to predict conversion to CDMS in our follow-up group (n = 55). Only in female patients with at least one MRI lesion (n = 34) did the presence of anti-MOG correlate with more frequent (p = 0.028) and more rapid (p = 0.0209) transition to CDMS. Conclusions: Presence of anti-MOG or anti-MBP or both was not significantly associated with conversion to CDMS in our CIS cohort. However, patients with anti-MOG and anti-MBP had higher lesion load and more disseminated lesions in cranial MRI as well as higher values for CSF leucocytes and intrathecal IgG production. Our data support a correlation of anti-MOG and anti-MBP to inflammatory signs in MRI and CSF. The prognostic value of these antibodies for CDMS, however, seems to be less pronounced than previously reporte

The photospheres of the hottest fastest stars in the Galaxy

We perform nonlocal thermodynamic equilibrium (NLTE) model atmosphere analyses of the three hottest hypervelocity stars (space velocities between ≈1500–2800 km s−1) known to date, which were recently discovered spectroscopically and identified as runaways from Type Ia supernovae. The hottest of the three (J0546+0836, effective temperature Teff = 95 000 ± 15 000 K, surface gravity lo