7,058 research outputs found

    On Formal Consistency between Value and Coordination Models

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    In information systems (IS) engineering dierent techniques for modeling inter-organizational collaborations are applied. In particular, value models estimate the profitability for involved stakeholders, whereas coordination models are used to agree upon the inter-organizational processes before implementing them. During the execution of inter-organizational collaboration, in addition, event logs are collected by the individual organizations representing another view of the IS. The combination of the two models and the event log represent the IS and they should therefore be consistent, i.e., not contradict each other. Since these models are provided by dierent user groups during design time and the event log is collected during run-time consistency is not straight forward. Inconsistency occurs when models contain a conflicting description of the same information, i.e., there exists a conflicting overlap between the models. In this paper we introduce an abstraction of value models, coordination models and event logs which allows ensuring and maintaining alignment between models and event log. We demonstrate its use by outlining a proof of an inconsistency resolution result based on this abstraction. Thus, the introduction of abstractions allows to explore formal inter-model relations based on consistency

    Phenomenology of the minimal supersymmetric U(1)B−L×U(1)RU(1)_{B-L}\times U(1)_R extension of the standard model

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    We discuss the minimal supersymmetric U(1)B−L×U(1)RU(1)_{B-L}\times U(1)_R extension of the standard model. Gauge couplings unify as in the MSSM, even if the scale of U(1)B−L×U(1)RU(1)_{B-L}\times U(1)_R breaking is as low as order TeV and the model can be embedded into an SO(10) grand unified theory. The phenomenology of the model differs in some important aspects from the MSSM, leading potentially to rich phenomenology at the LHC. It predicts more light Higgs states and the mostly left CP-even Higgs has a mass reaching easily 125 GeV, with no constraints on the SUSY spectrum. Right sneutrinos can be the lightest supersymmetric particle, changing all dark matter constraints on SUSY parameter space. The model has seven neutralinos and squark/gluino decay chains involve more complicated cascades than in the MSSM. We also discuss briefly low-energy and accelerator constraints on the model, where the most important limits come from recent Zâ€ČZ' searches at the LHC and upper limits on lepton flavour violation.Comment: 46 pages, 11 figure

    X-Ray Scattering at FeCo(001) Surfaces and the Crossover between Ordinary and Normal Transitions

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    In a recent experiment by Krimmel et al. [PRL 78, 3880 (1997)], the critical behavior of FeCo near a (001) surface was studied by x-ray scattering. Here the experimental data are reanalyzed, taking into account recent theoretical results on order-parameter profiles in the crossover regime between ordinary and normal transitions. Excellent agreement between theoretical expectations and the experimental results is found.Comment: 9 pages, Latex, 1 PostScript figure, to be published in Phys.Rev.

    Tumorangiogenese und Immunsuppression: Strategische Angriffspunkte fĂŒr neue TherapieansĂ€tze beim Plattenepithelkarzinom der Mundhöhle (HNSCC)

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    Zusammenfassung: Hintergrund: Die Tumorangiogenese und tumorassoziierte Immunsuppression sind Grundvoraussetzung fĂŒr eine erfolgreiche Tumorevolution. Unsere bisherigen Analysen zeigen, dass Mundhöhlenkarzinomzellen ĂŒber eine Produktion von TGF-ÎČ1 ("transforming growth factor-beta1") und MCP-1 ("monocyte chemoattractant protein-1") die Makrophageninfiltration in den Tumor stimulieren. Die angelockten Makrophagen produzieren den angiogenetischen sowie immunsupprimierenden Wachstumsfaktor VEGF ("vascular endothelial growth factor") und induzieren zudem die Produktion dieses Faktors ĂŒber Interleukin (IL)-1α in den Tumorzellen. Neuere In-vitro-Studien zeigen, dass RetinsĂ€ure (VitaminA) die TGF-ÎČ1- und MCP-1-Produktion der Tumorzellen hemmt. Deshalb wurde in der vorliegenden Studie der Einfluss von RetinsĂ€ure auf die Makrophageninfiltration und VEGF-Produktion im Mausmodell analysiert. Material und Methoden: MĂ€usen der AJ-Linie (10MĂ€use pro Gruppe) wurden PolyethylenschwĂ€mme (5×2mm3) mit humanen HNSCC-Zellen (450.000-150.0000/10ÎŒl RPMI) subkutan eingepflanzt. MĂ€use mit Tumoren von mindestens 0,7-1 cm3 Durchmesser wurden tĂ€glich mit RetinsĂ€ure (160”g/kg) i.p. behandelt. Nach 21Tagen wurden die SchwĂ€mme entnommen und immunhistologisch nach VEGF-A, MCP-1, CD68 und CD31 untersucht. Die Bestimmung der Serumwerte von VEGF-A und MCP-1 erfolgte mit dem ELISA. Die Organe wurden entnommen und nach Makro- und- Mikrometastasen untersucht. Ergebnisse: Bei allen mit RetinsĂ€ure behandelten Tieren kam es zur vollstĂ€ndigen Tumorregression. Die MĂ€use wiesen keinen Metastasenbefall auf (p=0,00) und die Makrophageninfiltration in den Tumor konnte blockiert werden (p=0,007). Alle behandelten Tiere regulierten die MCP-1- (0pg/ml) und VEGF-A-Serumwerte (12pg/ml) herunter (p=0,001). Schlussfolgerung: Die Ergebnisse zeigen, dass die Blockierung der Makrophageninfiltration in den Tumor mit VitaminA ein möglicher Therapieansatz ist, um die Induktion der zwei wichtigsten Überlebensstrategien des Tumors, Immunsuppression und Angiogenese, zu hemme

    MĂĄquinas para agricultores familiares: ideias, inovaçÔes e criaçÔes apresentadas na 3ÂȘ Mostra de MĂĄquinas e inventos.

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    bitstream/item/130184/1/EMBRAPA-CLIMA-TEMPERADO-LIVRO-MAQUINAS-PARA-AGRICULTORES-FAMILIARES.pdfPelotas, Embrapa Clima Temperado

    Doença de Kikuchi e Fujimoto

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    A doença de Kikuchi e Fujimoto, também conhecida como Linfadenite Histiocítica Necrosante, é uma entidade clínico-patológica rara cuja etiologia permanece desconhecida; tem sido sugerida a possibilidade de uma etiologia auto-imune, mas também tem sido descrita a associação com algumas infecçÔes víricas. Os autores apresentam o caso clínico de uma adolescente de 14 anos internada por febre persistente, volumosa tumefacção cervical e alteração do estado geral. Dos exames complementares efectuados a citologia aspirativa e a biopsia ganglionar levaram ao diagnóstico da doença de Kikuchi e Fujimoto. Após a instituição da corticoterapia, verificou-se uma notória melhoria do quadro clínico

    Activity and interactions of methane seep microorganisms assessed by parallel transcription and FISH-NanoSIMS analyses

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    To characterize the activity and interactions of methanotrophic archaea (ANME) and Deltaproteobacteria at a methane-seeping mud volcano, we used two complimentary measures of microbial activity: a community-level analysis of the transcription of four genes (16S rRNA, methyl coenzyme M reductase A (mcrA), adenosine-5â€Č-phosphosulfate reductase α-subunit (aprA), dinitrogenase reductase (nifH)), and a single-cell-level analysis of anabolic activity using fluorescence in situ hybridization coupled to nanoscale secondary ion mass spectrometry (FISH-NanoSIMS). Transcript analysis revealed that members of the deltaproteobacterial groups Desulfosarcina/Desulfococcus (DSS) and Desulfobulbaceae (DSB) exhibit increased rRNA expression in incubations with methane, suggestive of ANME-coupled activity. Direct analysis of anabolic activity in DSS cells in consortia with ANME by FISH-NanoSIMS confirmed their dependence on methanotrophy, with no ^(15)NH^+_4 assimilation detected without methane. In contrast, DSS and DSB cells found physically independent of ANME (i.e., single cells) were anabolically active in incubations both with and without methane. These single cells therefore comprise an active ‘free-living’ population, and are not dependent on methane or ANME activity. We investigated the possibility of N_2 fixation by seep Deltaproteobacteria and detected nifH transcripts closely related to those of cultured diazotrophic Deltaproteobacteria. However, nifH expression was methane-dependent. ^(15)N_2 incorporation was not observed in single DSS cells, but was detected in single DSB cells. Interestingly, ^(15)N_2 incorporation in single DSB cells was methane-dependent, raising the possibility that DSB cells acquired reduced ^(15)N products from diazotrophic ANME while spatially coupled, and then subsequently dissociated. With this combined data set we address several outstanding questions in methane seep microbial ecosystems and highlight the benefit of measuring microbial activity in the context of spatial associations
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