Maligne odontogene Tumoren

Zusammenfassung: Maligne odontogene Tumoren sind extrem selten. Analog zu den benignen Varianten wird deshalb zwischen malignen epithelialen odontogenen Tumoren, den odontogenen Karzinomen und den noch selteneren malignen mesenchymalen Tumoren, den odontogenen Sarkomen unterschieden. Odontogene Karzinosarkome werden bisher von der WHO nicht als eigenständige Entität anerkannt. Zu den odontogenen Karzinomen gehört das ameloblastische Karzinom, das primäre intraossäre Karzinom, das hellzellige odontogene Karzinom, das geisterzellhaltige odontogene Karzinom und als Sonderfall das metastasierende Ameloblastom. Die odontogenen Sarkome umfassen das ameloblastische Fibrosarkom und das ameloblastische Fibrodentino- und Fibroodontosarkom. Das metastasierende Ameloblastom kann nur an seinen Metastasen diagnostiziert werden. Alle anderen malignen Tumoren weisen eindeutige zelluläre Atypien, ein invasives Wachstum und vermehrt Mitosen auf. Während die odontogenen Sarkome ein niedriges Metastasierungspotenzial zeigen, besitzen odontogene Karzinome, besonders das ameloblastische Karzinom (AmCa) und das odontogene Schattenzellkarzinom (OGCC) sowie das primäre intraossäre Karzinom (PIOC), eine mäßige bis schlechte Prognose mit Überlebensraten nach 5 (AmCa; OGCC) bzw. 3Jahren (PIOC) von etwa 70% bzw. 37%. Die Behandlung der Karzinome muss deshalb radikal und gegebenenfalls multimodal erfolge

Benigne odontogene ektomesenchymale Tumoren

Zusammenfassung: Die Gruppe der odontogenen ektomesenchymalen Tumoren wird von 3Läsionen gebildet, dem odontogenen Fibrom (epithelarm und epithelreich), dem odontogenen Myxom und dem Zementoblastom. Während odontogene Fibrome und Zementoblastome sehr selten sind, ist das odontogene Myxom nach dem keratozystischen odontogenen Tumor, den Odontomen und dem Ameloblastom der vierthäufigste odontogene Tumor. Die Diagnose des Zementoblastoms ergibt sich aus seiner engen Assoziation mit einer Zahnwurzel. Die Abgrenzung odontogener Fibrome und Myxome kann jedoch schwierig werden, da sie histologisch große Ähnlichkeiten mit normalen Zahnstrukturen (Zahnpapille, Zahnfollikel) besitzen, wobei die letzteren häufig als odontogene Tumoren, besonders Myxome, fehlinterpretiert werden, wenn das Röntgenbild (umschriebene Osteolyse mit einem retinierten Zahn) nicht beachtet wird und andere Hinweise (oberflächliche Reste des Schmelzepithels, Dentinfragmente) nicht gesucht werden. Während odontogene Fibrome kaum rezidivieren und lokal exzidiert werden können, zeigen das Zementoblastom und insbesondere das odontogene Myxom eine ausgeprägte Rezidivneigung, sodass besonders bei Myxomen im Oberkiefer primäre Resektionen erforderlich werden, um ein Übergreifen auf Orbita oder Schädelbasis zu verhinder

Bridging languages through images with deep partial canonical correlation analysis

We present a deep neural network that leverages images to improve bilingual text embeddings. Relying on bilingual image tags and descriptions, our approach conditions text embedding induction on the shared visual information for both languages, producing highly correlated bilingual embeddings. In particular, we propose a novel model based on Partial Canonical Correlation Analysis (PCCA). While the original PCCA finds linear projections of two views in order to maximize their canonical correlation conditioned on a shared third variable, we introduce a non-linear Deep PCCA (DPCCA) model, and develop a new stochastic iterative algorithm for its optimization. We evaluate PCCA and DPCCA on multilingual word similarity and cross-lingual image description retrieval. Our models outperform a large variety of previous methods, despite not having access to any visual signal during test time inference. Our code and data are available at: https://github.com/rotmanguy/DPCCA

Погляд на архіви

The resolution at which foraminiferal stable isotopes are applied in paleo-environmental studies is ever increasing, resulting in continuous sampling of sediment cores. The resolution of such continuously sampled records depends on the rate of sedimentation of foraminiferal shells in its relation to the intensity of bioturbation. Bioturbation essentially mixes sediment layers of different age, altering the primary climate signal, thereby impacting the accuracy of both the timing and magnitude of reconstructed climate changes. A new approach to assess and correct the impact of bioturbation is investigated here, based on the δ18O of individual specimens of planktonic foraminifera Globorotalia inflata from a series of boxcore samples in the Eastern North Atlantic. Average δ18O values decrease southward from 1.62 to 1.07‰ with the exception of site T86-11 (1.35‰). The δ18O distribution of each station can be fitted with a uni- to polymodal distribution. A nonunimodal distribution strongly suggests admixing of bioturbated individuals. Quantification of these distributions allows deconvolving the original and bioturbated signals and subsequently provides a correction for bioturbation. © 2013. American Geophysical Union. All Rights Reserved

Dust and dark Gamma-Ray Bursts: mutual implications

In a cosmological context dust has been always poorly understood. That is true also for the statistic of GRBs so that we started a program to understand its role both in relation to GRBs and in function of z. This paper presents a composite model in this direction. The model considers a rather generic distribution of dust in a spiral galaxy and considers the effect of changing some of the parameters characterizing the dust grains, size in particular. We first simulated 500 GRBs distributed as the host galaxy mass distribution, using as model the Milky Way. If we consider dust with the same properties as that we observe in the Milky Way, we find that due to absorption we miss about 10% of the afterglows assuming we observe the event within about 1 hour or even within 100s. In our second set of simulations we placed GRBs randomly inside giants molecular clouds, considering different kinds of dust inside and outside the host cloud and the effect of dust sublimation caused by the GRB inside the clouds. In this case absorption is mainly due to the host cloud and the physical properties of dust play a strong role. Computations from this model agree with the hypothesis of host galaxies with extinction curve similar to that of the Small Magellanic Cloud, whereas the host cloud could be also characterized by dust with larger grains. To confirm our findings we need a set of homogeneous infrared observations. The use of coming dedicated infrared telescopes, like REM, will provide a wealth of cases of new afterglow observations.Comment: 16 pages, 8 figures, accepted by A&

Improvement of lung preservation - From experiment to clinical practice

Background. Reperfusion injury represents a severe early complication following lung transplantation. Among the pathogenetic factors, the high potassium content of Euro-Collins(R) solution is discussed. Material and Methods: In a pig model of orthotopic left-sided lung transplantation we investigated the effect of Euro-Collins solution (EC: n=6) versus low potassium dextran (LPD: Perfadex(R): n = 6). Sham-operated (n = 6) animals served as control. Transplant function, cellular energy metabolism and endothelial morphology served as parameters. In a clinical investigation, 124 patients were evaluated following single (EC: n = 31; LPD n = 37) or double (EC: n = 17; LPD n = 39) lung transplantation, whose organs where preserved with EC (n = 48) or LPD (n = 76). Duration of ischemia, duration of ventilation and stay on ICU were registered. Primary transplant function was evaluated according to AaDO(2) values. Cause of early death (30 days) was declared. Results: Experimental results: After flush with EC and 18 h ischemia, a reduction of tissue ATP content (p < 0.01 vs inital value and LPD) was noted. Endothelial damage after ischemia was severe (p < 0.05 vs control), paO(2) was significantly decreased. Clinical results: In the LPD group, duration of ischemia was longer for the grafts transplanted first (SLTx and DLTx: p = 0.0009) as well as second (2. organ DLTx: p = 0.045). Primary transplant function was improved (day 0: SLTx: p = 0.0015; DLTx: p = 0.0095, both vs EC). Duration of ventilation and stay on ICU were shorter (n.s.). Reperfusion injury-associated death was reduced from 8% (EC) to 0 (LPD). Conclusion: In experimental lung preservation, LPD lead to an improved graft function. These results were confirmed in clinical lung transplantation. Clinical lung preservation, therefore, should be carried out by use of LPD. Copyright (C) 2002 S. Karger AG, Basel

Do we really need fully unsupervised cross-lingual embeddings?

Recent efforts in cross-lingual word embedding (CLWE) learning have predominantly focused on fully unsupervised approaches that project monolingual embeddings into a shared cross-lingual space without any cross-lingual signal. The lack of any supervision makes such approaches conceptually attractive. Yet, their only core difference from (weakly) supervised projection-based CLWE methods is in the way they obtain a seed dictionary used to initialize an iterative self-learning procedure. The fully unsupervised methods have arguably become more robust, and their primary use case is CLWE induction for pairs of resource-poor and distant languages. In this paper, we question the ability of even the most robust unsupervised CLWE approaches to induce meaningful CLWEs in these more challenging settings. A series of bilingual lexicon induction (BLI) experiments with 15 diverse languages (210 language pairs) show that fully unsupervised CLWE methods still fail for a large number of language pairs (e.g., they yield zero BLI performance for 87/210 pairs). Even when they succeed, they never surpass the performance of weakly supervised methods (seeded with 500-1,000 translation pairs) using the same self-learning procedure in any BLI setup, and the gaps are often substantial. These findings call for revisiting the main motivations behind fully unsupervised CLWE methods

Early diagenetic overprint in Caribbean sediment cores and its effect on the geochemical composition of planktonic foraminifera

Early diagenetic features are noticed in the vicinity of carbonate platforms. Planktonic foraminifera of two tropical Atlantic deep-sea sediment cores show the strict relation between micro-scale euhydral crystallites of inorganic precipitates, higher oxygen isotope values and Mg/Ca ratios, and lower Sr/Ca ratios than expected for their pelagic environment in the time interval of ~100 000–550 000 calendar years before present. Laser ablation Mg/Ca (Sr/Ca) of crystallite-bearing foraminiferal chamber walls revealed 4–6 times elevated (2–3 times depleted) ratios, when ablating the diagenetic overgrowth. Crystalline overgrowth in proportion of 10–20% are estimated to cause the observed geochemical alteration. The extent of foraminiferal Mg/Ca alteration, moreover, seems to be controlled by the composition of the bulk sediment, especially the content of high-magnesium calcite. Anomalous ratios of >6 mmol/mol only occur, when high-magnesium calcite has dissolved within the sediment. The older parts (back to ~800 kyrs) of the records are characterized by similar trends of Mg/Ca and Sr/Ca. We discuss possible scenarios to accommodate the obtained geochemical information

Evidence for a Molecular Cloud Origin for Gamma-Ray Bursts: Implications for the Nature of Star Formation in the Universe

It appears that the majority of rapidly-, well-localized gamma-ray bursts with undetected, or dark, optical afterglows, or `dark bursts' for short, occur in clouds of size R > 10L_{49}^{1/2} pc and mass M > 3x10^5L_{49} M_{sun}, where L is the isotropic-equivalent peak luminosity of the optical flash. We show that clouds of this size and mass cannot be modeled as a gas that is bound by pressure equilibrium with a warm or hot phase of the interstellar medium (i.e., a diffuse cloud): Such a cloud would be unstable to gravitational collapse, resulting in the collapse and fragmentation of the cloud until a burst of star formation re-establishes pressure equilibrium within the fragments, and the fragments are bound by self-gravity (i.e., a molecular cloud). Consequently, dark bursts probably occur in molecular clouds, in which case dark bursts are probably a byproduct of this burst of star formation if the molecular cloud formed recently, and/or the result of lingering or latter generation star formation if the molecular cloud formed some time ago. We then show that if bursts occur in Galactic-like molecular clouds, the column densities of which might be universal, the number of dark bursts can be comparable to the number of bursts with detected optical afterglows: This is what is observed, which suggests that the bursts with detected optical afterglows might also occur in molecular clouds. We confirm this by modeling and constraining the distribution of column densities, measured from absorption of the X-ray afterglow, of the bursts with detected optical afterglows: We find that this distribution is consistent with the expectation for bursts that occur in molecular clouds, and is not consistent with the expectation for bursts that occur in diffuse clouds. More...Comment: Accepted to The Astrophysical Journal, 22 pages, 6 figures, LaTe