82 research outputs found
Validating the Automated Assessment of Participation and of Collaboration in Chat Conversations
International audienceAs Computer Supported Collaborative Learning (CSCL) gains a broader usage as a viable alternative to classic educational scenarios, the need for automated tools capable of supporting tutors in the time consuming process of analyzing conversations becomes more stringent. Moreover, in order to fully explore the benefits of such scenarios, a clear demarcation must be made between participation or active involvement, and collaboration that presumes the intertwining of ideas or points of view with other participants. Therefore, starting from a cohesion-based model of the discourse, we propose two computational models for assessing collaboration and participation. The first model is based on the cohesion graph and can be perceived as a longitudinal analysis of the ongoing conversation, thus accounting for participation from a social knowledge-building perspective. In the second approach, collaboration is regarded from a dialogical perspective as the intertwining or overlap of voices pertaining to different speakers, therefore enabling a transversal analysis of subsequent discussion slices
Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing
Recent experiments have shown that spreading epithelial sheets
exhibit a long-range coordination of motility forces that leads to
a buildup of tension in the tissue, which may enhance cell division
and the speed of wound healing. Furthermore, the edges of these
epithelial sheets commonly show finger-like protrusions whereas the
bulk often displays spontaneous swirls of motile cells. To explain
these experimental observations, we propose a simple flocking-type
mechanism, in which cells tend to align their motility forceswith their
velocity. Implementing this idea in amechanical tissue simulation, the
proposed model gives rise to efficient spreading and can explain the
experimentally observed long-range alignment of motility forces in
highly disordered patterns, as well as the buildup of tensile stress
throughout the tissue. Our model also qualitatively reproduces the
dependence of swirl size and swirl velocity on cell density reported in
experiments and exhibits an undulation instability at the edge of the
spreading tissue commonly observed in vivo. Finally, we study the
dependence of colony spreading speed on important physical and
biological parameters and derive simple scaling relations that show
that coordination of motility forces leads to an improvement of the
wound healing process for realistic tissue parameters
Colloquium: Mechanical formalisms for tissue dynamics
The understanding of morphogenesis in living organisms has been renewed by
tremendous progressin experimental techniques that provide access to
cell-scale, quantitative information both on theshapes of cells within tissues
and on the genes being expressed. This information suggests that
ourunderstanding of the respective contributions of gene expression and
mechanics, and of their crucialentanglement, will soon leap forward.
Biomechanics increasingly benefits from models, which assistthe design and
interpretation of experiments, point out the main ingredients and assumptions,
andultimately lead to predictions. The newly accessible local information thus
calls for a reflectionon how to select suitable classes of mechanical models.
We review both mechanical ingredientssuggested by the current knowledge of
tissue behaviour, and modelling methods that can helpgenerate a rheological
diagram or a constitutive equation. We distinguish cell scale ("intra-cell")and
tissue scale ("inter-cell") contributions. We recall the mathematical framework
developpedfor continuum materials and explain how to transform a constitutive
equation into a set of partialdifferential equations amenable to numerical
resolution. We show that when plastic behaviour isrelevant, the dissipation
function formalism appears appropriate to generate constitutive equations;its
variational nature facilitates numerical implementation, and we discuss
adaptations needed in thecase of large deformations. The present article
gathers theoretical methods that can readily enhancethe significance of the
data to be extracted from recent or future high throughput
biomechanicalexperiments.Comment: 33 pages, 20 figures. This version (26 Sept. 2015) contains a few
corrections to the published version, all in Appendix D.2 devoted to large
deformation
Tracking Membrane Protein Association in Model Membranes
Membrane proteins are essential in the exchange processes of cells. In spite of great breakthrough in soluble proteins studies, membrane proteins structures, functions and interactions are still a challenge because of the difficulties related to their hydrophobic properties. Most of the experiments are performed with detergent-solubilized membrane proteins. However widely used micellar systems are far from the biological two-dimensions membrane. The development of new biomimetic membrane systems is fundamental to tackle this issue
A mixed model QTL analysis for sugarcane multiple-harvest-location trial data
Sugarcane-breeding programs take at least 12Â years to develop new commercial cultivars. Molecular markers offer a possibility to study the genetic architecture of quantitative traits in sugarcane, and they may be used in marker-assisted selection to speed up artificial selection. Although the performance of sugarcane progenies in breeding programs are commonly evaluated across a range of locations and harvest years, many of the QTL detection methods ignore two- and three-way interactions between QTL, harvest, and location. In this work, a strategy for QTL detection in multi-harvest-location trial data, based on interval mapping and mixed models, is proposed and applied to map QTL effects on a segregating progeny from a biparental cross of pre-commercial Brazilian cultivars, evaluated at two locations and three consecutive harvest years for cane yield (tonnes per hectare), sugar yield (tonnes per hectare), fiber percent, and sucrose content. In the mixed model, we have included appropriate (co)variance structures for modeling heterogeneity and correlation of genetic effects and non-genetic residual effects. Forty-six QTLs were found: 13 QTLs for cane yield, 14 for sugar yield, 11 for fiber percent, and 8 for sucrose content. In addition, QTL by harvest, QTL by location, and QTL by harvest by location interaction effects were significant for all evaluated traits (30 QTLs showed some interaction, and 16 none). Our results contribute to a better understanding of the genetic architecture of complex traits related to biomass production and sucrose content in sugarcane
Collective invasion in ductal and lobular breast cancer associates with distant metastasis
A novel linkage map of sugarcane with evidence for clustering of retrotransposon-based markers
Actes des 7es Rencontres des Jeunes Chercheurs en Environnements Informatiques pour lâApprentissage Humain
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