Assessment of the performance of a turbulence closure model: along the tidally-influenced Kaipara River to the estuary, NZ

The success of many coastal management projects hinges on the ability to predict the dispersal and settling of sediment particles. Hydrodynamic models have enabled the efficient simulation of sediment transport scenarios at large spatial scales and long time scales. However, these models have limited predictive capacity owing to an incomplete understanding of the processes involved. Turbulence has been shown to have a substantial influence on sediment transport by influencing flocculation (i.e. aggregation of particles), hence driving the behaviour of particles (e.g. deposition, erosion, mixing). Turbulence tends to promote aggregation at low shear stresses and cause floc breakups at high shear stresses. However, despite the key role of turbulence in coastal modelling, there is not a unique approach but several methods to describe turbulence, each based on a different combination of assumptions. We present modelling results exploring the performance of one closure scheme implemented in a hydrodynamic and sediment transport model, Delft3D. The assessment of the performance of the model is based on comparisons with measured data collected in the heavily sediment-laden Kaipara river, New Zealand. Data was collected in October 2013 using Lagrangian “flocdrifter” platforms released at multiple locations to capture both hydrodynamic and sediment data. In general the model was found to be able to reproduce the right order of magnitude of dissipation rates. However, turbulence characteristics in some sections of the river, usually in the vicinity of abrupt bends, are relatively poorly reproduced. Future work will aim to use the present model to improve the conceptual understanding of fundamental physical processes, in particular the effect of turbulence on flocculation, and floc formation and breakup in estuarine and riverine systems

An argument for the use of Aristotelian method in bioethics

The main claim of this paper is that the method outlined and used in Aristotle's Ethics is an appropriate and credible one to use in bioethics. Here “appropriate” means that the method is capable of establishing claims and developing concepts in bioethics and “credible” that the method has some plausibility, it is not open to obvious and immediate objection. It begins by suggesting why this claim matters and then gives a brief outline of Aristotle's method. The main argument is made in three stages. First, it is argued that Aristotelian method is credible because it compares favourably with alternatives. In this section it is shown that Aristotelian method is not vulnerable to criticisms that are made both of methods that give a primary place to moral theory (such as utilitarianism) and those that eschew moral theory (such as casuistry and social science approaches). As such, it compares favourably with these other approaches that are vulnerable to at least some of these criticisms. Second, the appropriateness of Aristotelian method is indicated through outlining how it would deal with a particular case. Finally, it is argued that the success of Aristotle's philosophy is suggestive of both the credibility and appropriateness of his method.</p

High-Quality draft genome sequence of the Lotus spp. microsymbiont Mesorhizobium loti strain CJ3Sym

Mesorhizobium loti strain CJ3Sym was isolated in 1998 following transfer of the integrative and conjugative element ICEMlSymR7A, also known as the R7A symbiosis island, in a laboratory mating from the donor M. loti strain R7A to a nonsymbiotic recipient Mesorhizobium strain CJ3. Strain CJ3 was originally isolated from a field site in the Rocklands range in New Zealand in 1994. CJ3Sym is an aerobic, Gram-negative, non-spore-forming rod. This report reveals the genome of M. loti strain CJ3Sym currently comprises 70 scaffolds totaling 7,563,725 bp. The high-quality draft genome is arranged in 70 scaffolds of 71 contigs, contains 7,331 protein-coding genes and 70 RNA-only encoding genes, and is part of the GEBA-RNB project proposal

Experimental study of double beta decay modes using a CdZnTe detector array

An array of sixteen 1 cm^3 CdZnTe semiconductor detectors was operated at the Gran Sasso Underground Laboratory (LNGS) to further investigate the feasibility of double-beta decay searches with such devices. As one of the double-beta decay experiments with the highest granularity the 4 x 4 array accumulated an overall exposure of 18 kg days. The setup and performance of the array is described. Half-life limits for various double-beta decay modes of Cd, Zn and Te isotopes are obtained. No signal has been found, but several limits beyond 10^20 years have been performed. They are an order of magnitude better than those obtained with this technology before and comparable to most other experimental approaches for the isotopes under investigation. An improved limit for the beta^+/EC decay of Te 120 is given.Comment: 6 pages, 5 figure

The impact of surgical complications on health-related quality of life in women undergoing gynecologic and gynecologic oncology procedures: a prospective longitudinal cohort study

There are currently no assessments of the impact of surgical complications on health-related quality of life in gynecology and gynecologic oncology. This is despite complications being a central focus of surgical outcome measurement, and an increasing awareness of the need for patient-reported data when measuring surgical quality

Examining exercise dependence symptomatology from a self-determination perspective

Background: Based on the theoretical propositions of Self-Determination Theory (SDT; Deci & Ryan, 1985) this study examined whether individuals classified as “nondependent-symptomatic” and “nondependent-asymptomatic” for exercise dependence differed in terms of the level of exercise-related psychological need satisfaction and self-determined versus controlling motivation they reported. Further, we examined if the type of motivational regulations predicting exercise behaviour differed among these groups. Methods: Participants (N = 339), recruited from fitness, community, and retail settings, completed measures of exercise-specific psychological need satisfaction, motivational regulations, exercise behaviour and exercise dependence. Results: Individuals who were nondependent-symptomatic for exercise dependence reported higher levels of competence need satisfaction and all forms of motivational regulation, compared to nondependent-asymptomatic individuals. Introjected regulation approached significance as a positive predictor of strenuous exercise behaviour for symptomatic individuals. Identified regulation was a positive predictor of strenuous exercise for asymptomatic individuals. Conclusions: The findings reinforce the applicability of SDT to understanding engagement in exercise

Scaling-up food policies in the Pacific Islands: protocol for policy engagement and mixed methods evaluation of intervention implementation

Background: There is a crisis of non-communicable diseases (NCDs) in the Pacific Islands, and poor diets are a major contributor. The COVID-19 pandemic and resulting economic crisis will likely further exacerbate the burden on food systems. Pacific Island leaders have adopted a range of food policies and regulations to improve diets. This includes taxes and regulations on compositional standards for salt and sugar in foods or school food policies. Despite increasing evidence for the effectiveness of such policies globally, there is a lack of local context-specific evidence about how to implement them effectively in the Pacific. Methods: Our 5-year collaborative project will test the feasibility and effectiveness of policy interventions to reduce salt and sugar consumption in Fiji and Samoa, and examine factors that support sustained implementation. We will engage government agencies and civil society in Fiji and Samoa, to support the design, implementation and monitoring of evidence-informed interventions. Specific objectives are to: (1) conduct policy landscape analysis to understand potential opportunities and challenges to strengthen policies for prevention of diet-related NCDs in Fiji and Samoa; (2) conduct repeat cross sectional surveys to measure dietary intake, food sources and diet-related biomarkers; (3) use Systems Thinking in Community Knowledge Exchange (STICKE) to strengthen implementation of policies to reduce salt and sugar consumption; (4) evaluate the impact, process and cost effectiveness of implementing these policies. Quantitative and qualitative data on outcomes and process will be analysed to assess impact and support scale-up of future interventions. Discussion: The project will provide new evidence to support policy making, as well as developing a low-cost, high-tech, sustainable, scalable system for monitoring food consumption, the food supply and health-related outcomes

Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

RATIONALE: Eosinophils are associated with airway inflammation in respiratory disease. Eosinophil production and survival is controlled partly by interleukin-5: anti-interleukin-5 agents reduce asthma and response correlates with baseline eosinophil counts. However, whether raised eosinophils are causally related to chronic obstructive pulmonary disease (COPD) and other respiratory phenotypes is not well understood. OBJECTIVES: We investigated causality between eosinophils and: lung function, acute exacerbations of COPD, asthma-COPD overlap (ACO), moderate-to-severe asthma and respiratory infections. METHODS: We performed Mendelian randomisation (MR) using 151 variants from genome-wide association studies of blood eosinophils in UK Biobank/INTERVAL, and respiratory traits in UK Biobank/SpiroMeta, using methods relying on different assumptions for validity. We performed multivariable analyses using eight cell types where there was possible evidence of causation by eosinophils. MEASUREMENTS AND MAIN RESULTS: Causal estimates derived from individual variants were highly heterogeneous, which may arise from pleiotropy. The average effect of raising eosinophils was to increase risk of ACO (weighted median OR per SD eosinophils, 1.44 (95%CI 1.19 to 1.74)), and moderate-severe asthma (weighted median OR 1.50 (95%CI 1.23 to 1.83)), and to reduce forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) and FEV(1) (weighted median estimator, SD FEV(1)/FVC: -0.054 (95% CI -0.078 to -0.029), effect only prominent in individuals with asthma). CONCLUSIONS: Broad consistency across MR methods may suggest causation by eosinophils (although of uncertain magnitude), yet heterogeneity necessitates caution: other important mechanisms may be responsible for the impairment of respiratory health by these eosinophil-raising variants. These results could suggest that anti-IL5 agents (designed to lower eosinophils) may be valuable in treating other respiratory conditions, including people with overlapping features of asthma and COPD