Third Report on the Publication and Conservation of the Tomb of Ramesses III in the Valley of the Kings (KV 11)

Since antiquity, the tomb of Ramesses III (KV 11) has been among the most frequently visited royal tombs in the Valley of the Kings. It was also one of the first to be described and documented in detail by European travellers in the eighteenth to nineteenth centuries. As large parts of the wall decoration of the tomb, especially in its rear, are now destroyed, the drawings, notes and squeezes of those early researchers who saw the site in its former splendour offer an invaluable resource for the reconstruction of the tomb’s unique decoration programme. The collection, revision, and publication of all relevant archive material concerning KV 11 is an important goal of The Ramesses III (KV 11) Publication and Conservation Project. The following article reports on first and preliminary results from the authors’ research in the archives of the British Library and the Victoria and Albert Museum in London, as well as the Bodleian Libraries and the Griffith Institute in Oxford, carried out in September 2019 and made possible through the Centenary Award 2019 of the Egypt Exploration Society

ColloCaid: a tool to help academic English writers find the words they need

This short paper summarizes the development of ColloCaid (www.collocaid.uk), a text editor that supports writers with academic English collocations. After a brief introduction, the paper summarizes how the lexicographic database underlying ColloCaid was compiled, how text editor integration was achieved, and results from initial user studies. The paper concludes by outlining future development

Thermally excited tunneling from a metastable electronic state in a single-Cooper-pair transistor

International audienceMetastable electron traps and two-level systems are common in solid-state devices and lead to background charge movement and charge noise in single-electron and singleCooper-pair transistors. We present measurements of the real-time capture and escape of individual electrons in metastable trapped states at very low temperatures, leading to charge offsets close to 1e. The charge movement exhibits thermal excitation to a hysteretic tunneling transition. The temperature dependence and hysteresis can be explained by the coupling of a two-level system to a quasiparticle trap

Thermal excitation of large charge offsets in a single-Cooper-pair transistor

International audienceCharge offsets and two-level fluctuators are common in single-electron transistors (SET) with a typical magnitude |∆Q| < 0.1e. We now present measurements in a 2e-periodic single-Cooper-pair transistor (SCPT) which exhibited hysteretic charge offsets close to 1e. The real-time capture and escape of individual electrons in metastable trapped states was measured at very low temperatures. This enabled the dynamics of the transitions to be investigated in detail, demonstrating thermal excitation to a hysteretic tunneling transition. We also show that, allowing for the hysteresis, the metastable states are in thermal equilibrium with each other. The observed temperature dependence and hysteresis can be explained by the coupling of a two-level fluctuator to a quasiparticle trap

Counting Individual Electrons on Liquid Helium

We show that small numbers of electrons, including a single electron, can be held in a novel electrostatic trap above the surface of superfluid helium. A potential well is created using microfabricated electrodes in a 5 micron diameter pool of helium. Electrons are injected into the trap from an electron reservoir on a helium microchannel. They are individually detected using a superconducting single-electron transistor (SET) as an electrometer. A Coulomb staircase is observed as electrons leave the trap one-by-one until the trap is empty. A design for a scalable quantum information processor using arrays of electron traps is presentedComment: 15 pages, 5 figure

Remote Detection of Surge-Related Glacier Terminus Change across High Mountain Asia

High Mountain Asia (HMA) hosts the largest glacier concentration outside of polar regions. It is also distinct glaciologically as it forms one of two major surge clusters globally, and many glaciers there contradict the globally observed glacier recession trend. Surging glaciers are critical to our understanding of HMA glacier dynamics, threshold behaviour and flow instability, and hence have been the subject of extensive research, yet many dynamical uncertainties remain. Using the cloud-based geospatial data platform, Google Earth Engine (GEE) and GEE-developed tool, GEEDiT, to identify and quantify trends in the distribution and phenomenological characteristics of surging glaciers synoptically across HMA, we identified 137 glaciers as surging between 1987–2019. Of these, 55 were newly identified, 15 glaciers underwent repeat surges, and 18 were identified with enhanced glaciological hazard potential, most notably from Glacier Lake Outburst Floods (GLOFs). Terminus position time series analysis from 1987–2019 facilitated the development of a six-part phenomenological classification of glacier behaviour, as well as quantification of surge variables including active phase duration, terminus advance distance and rate, and surge periodicity. This research demonstrates the application of remote sensing techniques and the GEE platform to develop our understanding of surging glacier distribution and terminus phenomenology across large areas, as well as their ability to highlight potential geohazard locations, which can subsequently be used to focus monitoring efforts

Rare Copy Number Variants in \u3cem\u3eNRXN1\u3c/em\u3e and \u3cem\u3eCNTN6\u3c/em\u3e Increase Risk for Tourette Syndrome

Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovered to date. We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (\u3c 1% frequency) copy-number variants (CNVs) using SNP microarray data. We observed an enrichment of global CNV burden that was prominent for large (\u3e 1 Mb), singleton events (OR = 2.28, 95% CI [1.39–3.79], p = 1.2 × 10−3) and known, pathogenic CNVs (OR = 3.03 [1.85–5.07], p = 1.5 × 10−5). We also identified two individual, genome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR = 20.3, 95% CI [2.6–156.2]; CNTN6 duplications, OR = 10.1, 95% CI [2.3–45.4]). Approximately 1% of TS cases carry one of these CNVs, indicating that rare structural variation contributes significantly to the genetic architecture of TS

National smokefree law in New Zealand improves air quality inside bars, pubs and restaurants

<p>Abstract</p> <p>Background:</p> <p>We aimed to: (i) assess compliance with a new smokefree law in a range of hospitality settings; and (ii) to assess the impact of the new law by measuring air quality and making comparisons with air quality in outdoor smoking areas and with international data from hospitality settings.</p> <p>Methods:</p> <p>We included 34 pubs, restaurants and bars, 10 transportation settings, nine other indoor settings, six outdoor smoking areas of bars and restaurants, and six other outdoor settings. These were selected using a mix of random, convenience and purposeful sampling. The number of lit cigarettes among occupants at defined time points in each venue was observed and a portable real-time aerosol monitor was used to measure fine particulate levels (PM_2.5).</p> <p>Results:</p> <p>No smoking was observed during the data collection periods among over 3785 people present in the indoor venues, nor in any of the transportation settings. The levels of fine particulates were relatively low inside the bars, pubs and restaurants in the urban and rural settings (mean 30-minute level = 16 μg/m³for 34 venues; range of mean levels for each category: 13 μg/m³to 22 μg/m³). The results for other smokefree indoor settings (shops, offices etc) and for smokefree transportation settings (eg, buses, trains, etc) were even lower. However, some "outdoor" smoking areas attached to bars/restaurants had high levels of fine particulates, especially those that were partly enclosed (eg, up to a 30-minute mean value of 182 μg/m³and a peak of maximum value of 284 μg/m³). The latter are far above WHO guideline levels for 24-hour exposure (ie, 25μg/m³).</p> <p>Conclusion:</p> <p>There was very high compliance with the new national smokefree law and this was also reflected by the relatively good indoor air quality in hospitality settings (compared to the "outdoor" smoking areas and the comparable settings in countries that permit indoor smoking). Nevertheless, adopting enhanced regulations (as used in various US and Canadian jurisdictions) may be needed to address hazardous air quality in relatively enclosed "outdoor" smoking areas.</p

Vocalizing the Angels of Mons: Audio Dramas as Propaganda in the Great War of 1914 to 1918 Societies 2014, 4(2), 180-221; doi:10.3390/soc4020180

Sound drama production prior to the onset of the “Radio Age” underwent a pioneering development during the Great War. This was achieved by the making, publication and distribution of short audio dramas acted with sound effects and music in front of early microphones and released in the form of 78 rpm phonograph discs. Entertaining storytelling through dramatic performance was mobilized for the purposes of improving recruitment and disseminating patriotic endorsement recordings. This article focuses on the sound dramatization of the myth of “The Angels of Mons” released by Regal in 1915. The recording is examined as a text for its significance in terms of propaganda, style of audio-drama, and any cultural role it may have played in the media of the First World War. The Regal disc was an example of what was described at the time as “descriptive sketches.” This article explores why a sound phonograph was used to dramatize the myth that angels intervened to assist the British Expeditionary Force to resist the German Army invading France through Belgium in 1914. A number of historians have discussed the First World War as being a theatre for the first modern media war, in which the process of propaganda was modernized. To what extent does “The Angels of Mons” phonograph and the genre of descriptive sketches support this analysis? Does this short sound drama play have any relevance to the cultural phenomena of spiritualism, modernism and patriotic Christianity identified as being important during the Great War period

Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia

OBJECTIVE: Poorly controlled salt-wasting (SW) congenital adrenal hyperplasia (CAH) patients often require high 9α-fluorocortisol doses as they show high levels of 17-hydroxyprogesterone (17OHP), which is a mineralocorticoid (MC)-receptor antagonist. DESIGN: We investigated the renin-angiotensin-aldosterone system in patients with SW-CAH receiving twice daily modified-release hydrocortisone (MR-HC, Efmody) compared with standard glucocorticoid (GC) therapy. METHODS: Data were analyzed from the 6-month, phase 3 study of MR-HC (n = 42) versus standard GC therapy (n = 41). MC replacement therapy remained unchanged throughout the study. Blood pressure, serum potassium, serum sodium, plasma renin activity (PRA), and serum 17OHP and androstenedione concentrations were analyzed at baseline, 4, 12, and 24 weeks. RESULTS: The median serum 17OHP in the morning was significantly lower on MR-HC compared with standard GC at 24 weeks (2.5 nmol L-1 (IQR 8.3) versus 10.5 nmol L-1 (IQR 55.2), P = .001). PRA decreased significantly from baseline to 24 weeks in patients on MR-HC (0.83 ng L-1 s-1 (IQR 1.0) to 0.48 ng L-1 s-1 (IQR 0.61), P = .012) but not in patients on standard GC (0.53 ng L-1 s-1 (IQR 0.66) to 0.52 ng L-1 s-1 (IQR 0.78), P = .613). Serum sodium concentrations increased from baseline to 24 weeks in patients on MR-HC (138.8 ± 1.9 mmol L-1 to 139.3 ± 1.8 mmol L-1, P = .047), but remained unchanged on standard GC (139.8 ± 1.6 mmol L-1 to 139.3 ± 1.9 mmol L-1, P = .135). No significant changes were seen in systolic and diastolic blood pressure and serum potassium levels. CONCLUSION: 6 months of MR-HC therapy decreased PRA and increased sodium levels indicating a greater agonist action of the 9α-fluorocortisol dose, which may be due to the decreased levels of the MC-receptor antagonist 17OHP