150 research outputs found
On the Global Existence of Bohmian Mechanics
We show that the particle motion in Bohmian mechanics, given by the solution
of an ordinary differential equation, exists globally: For a large class of
potentials the singularities of the velocity field and infinity will not be
reached in finite time for typical initial values. A substantial part of the
analysis is based on the probabilistic significance of the quantum flux. We
elucidate the connection between the conditions necessary for global existence
and the self-adjointness of the Schr\"odinger Hamiltonian.Comment: 35 pages, LaTe
On the Particle Definition in the presence of Black Holes
A canonical particle definition via the diagonalisation of the Hamiltonian
for a quantum field theory in specific curved space-times is presented. Within
the provided approach radial ingoing or outgoing Minkowski particles do not
exist. An application of this formalism to the Rindler metric recovers the
well-known Unruh effect. For the situation of a black hole the Hamiltonian
splits up into two independent parts accounting for the interior and the
exterior domain, respectively. It turns out that a reasonable particle
definition may be accomplished for the outside region only. The Hamiltonian of
the field inside the black hole is unbounded from above and below and hence
possesses no ground state. The corresponding equation of motion displays a
linear global instability. Possible consequences of this instability are
discussed and its relations to the sonic analogues of black holes are
addressed. PACS-numbers: 04.70.Dy, 04.62.+v, 10.10.Ef, 03.65.Db.Comment: 44 pages, LaTeX, no figures, accepted for publication in Phys. Rev.
Geological-geotechnical studies for siting the superconducting super collider in Illinois: results of the spring 1985 test drilling program
Geological-geotechnical studies for siting the superconducting super collider in Illinois: results of the fall 1984 test drilling program
Vacuum Fluctuations, Geometric Modular Action and Relativistic Quantum Information Theory
A summary of some lines of ideas leading to model-independent frameworks of
relativistic quantum field theory is given. It is followed by a discussion of
the Reeh-Schlieder theorem and geometric modular action of Tomita-Takesaki
modular objects associated with the quantum field vacuum state and certain
algebras of observables. The distillability concept, which is significant in
specifying useful entanglement in quantum information theory, is discussed
within the setting of general relativistic quantum field theory.Comment: 26 pages. Contribution for the Proceedings of a Conference on Special
Relativity held at Potsdam, 200
Impact of triaxiality on the rotational structure of neutron-rich rhenium isotopes
A number of 3-quasiparticle isomers have been found and characterised in the odd-mass, neutron-rich, 187Re, 189Re and 191Re nuclei, the latter being four neutrons beyond stability. The decay of the isomers populates states in the rotational bands built upon the 9/2-[514] Nilsson orbital. These bands exhibit a degree of signature splitting that increases with neutron number. This splitting taken together with measurements of the M1/E2 mixing ratios and with the changes observed in the energy of the gamma-vibrational band coupled to the 9/2-[514] state, suggests an increase in triaxiality, with γ values of 5°, 18° and 25° deduced in the framework of a particle-rotor model
Green function techniques in the treatment of quantum transport at the molecular scale
The theoretical investigation of charge (and spin) transport at nanometer
length scales requires the use of advanced and powerful techniques able to deal
with the dynamical properties of the relevant physical systems, to explicitly
include out-of-equilibrium situations typical for electrical/heat transport as
well as to take into account interaction effects in a systematic way.
Equilibrium Green function techniques and their extension to non-equilibrium
situations via the Keldysh formalism build one of the pillars of current
state-of-the-art approaches to quantum transport which have been implemented in
both model Hamiltonian formulations and first-principle methodologies. We offer
a tutorial overview of the applications of Green functions to deal with some
fundamental aspects of charge transport at the nanoscale, mainly focusing on
applications to model Hamiltonian formulations.Comment: Tutorial review, LaTeX, 129 pages, 41 figures, 300 references,
submitted to Springer series "Lecture Notes in Physics
Differences in treatment and survival of older patients with operable breast cancer between the United Kingdom and the Netherlands – A comparison of two national prospective longitudinal multi-centre cohort studies
Background
Previous studies have shown that survival outcomes for older patients with breast cancer vary substantially across Europe, with worse survival reported in the United Kingdom. It has been hypothesised that these differences in survival outcomes could be related to treatment variation.
Objectives
We aimed to compare patient and tumour characteristics, treatment selection and survival outcomes between two large prospective cohorts of older patients with operable breast cancer from the United Kingdom (UK) and The Netherlands.
Methods
Women diagnosed with operable breast cancer aged ≥70 years were included. A baseline comprehensive geriatric assessment was performed in both cohorts, with data collected on age, comorbidities, cognition, nutritional and functional status. Baseline tumour characteristics and treatment type were collected. Univariable and multivariable Cox regression models were used to compare overall survival between the cohorts.
Results
3262 patients from the UK Age Gap cohort and 618 patients from the Dutch Climb cohort were included, with median ages of 77.0 (IQR: 72.0–81.0) and 75.0 (IQR: 72.0–81.0) years, respectively. The cohorts were generally comparable, with slight differences in rates of comorbidity and frailty. Median follow-up for overall survival was 4.1 years (IQR 2.9–5.4) in Age Gap and 4.3 years (IQR 2.9–5.5) in Climb. In Age Gap, both the rates of primary endocrine therapy and adjuvant hormonal therapy after surgery were approximately twice those in Climb (16.6% versus 7.3%, p < 0.001 for primary endocrine therapy, and 62.2% versus 38.8%, p < 0.001 for adjuvant hormonal therapy). There was no evidence of a difference in overall survival between the cohorts (adjusted HR 0.94, 95% CI 0.74–1.17, p = 0.568).
Conclusions
In contrast to previous studies, this comparison of two large national prospective longitudinal multi-centre cohort studies demonstrated comparable survival outcomes between older patients with breast cancer treated in the UK and The Netherlands, despite differences in treatment allocation
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies and contradictions among the various systems currently in use. The classification suggested here is intended to allow pathologists and clinicians to manage their patients with NENs consistently, while acknowledging organ-specific differences in classification criteria, tumor biology, and prognostic factors. The classification suggested is based on a consensus conference held at the International Agency for Research on Cancer (IARC) in November 2017 and subsequent discussion with additional experts. The key feature of the new classification is a distinction between differentiated neuroendocrine tumors (NETs), also designated carcinoid tumors in some systems, and poorly differentiated NECs, as they both share common expression of neuroendocrine markers. This dichotomous morphological subdivision into NETs and NECs is supported by genetic evidence at specific anatomic sites as well as clinical, epidemiologic, histologic, and prognostic differences. In many organ systems, NETs are graded as G1, G2, or G3 based on mitotic count and/or Ki-67 labeling index, and/or the presence of necrosis; NECs are considered high grade by definition. We believe this conceptual approach can form the basis for the next generation of NEN classifications and will allow more consistent taxonomy to understand how neoplasms from different organ systems inter-relate clinically and genetically
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