Effect of prolonged space flight on cardiac function and dimensions

Echocardiographic studies were performed preflight 5 days before launch and on recovery day and 1, 2, 4, 11, 31 and 68 days postflight. From these echocardiograms measurements were made. From these primary measurements, left ventricular end-diastolic volume, end-systolic volume, stroke volume, and mass were derived using the accepted assumptions. Findings in the Scientist Pilot and Pilot resemble those seen in trained distance runners. Wall thickness measurements were normal in all three crewmembers preflight. Postflight basal studies were unchanged in the Commander on recovery day through 68 days postflight in both the Scientist Pilot and Pilot, however, the left ventricular end-diastolic volume, stroke volume, and mass were decreased slightly. Left ventricular function curves were constructed for the Commander and Pilot by plotting stroke volume versus end-diastolic volume. In both astronauts, preflight and postflight data fell on the same straight line demonstrating that no deterioration in cardiac function had occurred. These data indicate that the cardiovascular system adapts well to prolonged weightlessness and suggest that alterations in cardiac dimensions and function are unlikely to limit man's future in space

Siting prisons, sighting communities: geographies of objection in a planning process

This paper reviews the planning process for a Scottish prison located near a former mining village. Analysing the letters of objection submitted by residents offers an opportunity to explore local views about prison and community and to relate these to the unique social and spatial history of the area. The planning process itself structured how residents were able to express themselves and defined what counted as a relevant objection. After deconstructing this process, the paper then restores and uses as a framework for analysis three geographies of objection stripped from local responses to the development proposal: the emotional, temporal, and spatial. Emotional expressions of objection added intensity and gave meaning to claims about the historical decline of the region and also conveyed a deep sense of the proposed building site as a lived space. Particular grounds of opposition—over fear of strangers, the fragility of a local orchid, and the pollution from mining—provide an opportunity to explore the complex nature of place meaning and community identity, ultimately leading to a conclusion that the meaning of place is always in flux. The paper argues that Simmel’s classic concept of the stranger, as the outsider who comes to stay, offers a useful analytic in understanding how the quality of proximal remoteness that prisons and other unwanted developments constitute participates in a constantly evolving sense of the local

Decreasing referrals to transient ischemic attack clinics during the COVID-19 outbreak: results from a multi-centre cross-sectional survey

Objective. The COVID-19 pandemic is having major implications for stroke care with a documented significant fall in hospital acute stroke admissions. We investigated whether COVID-19 has resulted in a decreased number of referrals to the Transient Ischemic Attack (TIA) clinics across the North West London region. Setting and Design. All the TIA clinical leads of the North West London region received an invitation by email to participate in an online survey in May 2020. The survey questionnaire aimed to assess the number of patients with suspected TIA consecutively referred to each of the TIA clinics of the North West London region between 1st March to 30th April 2020, the COVID-19 period, and between 1st March to 30th April 2019. Results. We had a response rate of 100%. During the COVID-19 period, the TIA clinics of the North West London region received 440 referrals compared to 616 referrals received between 1st March to 30th April 2019 with a fall in the number of the referrals by 28.6%. In April 2020 compared with April 2019, the number of the referrals declined by 40.1%. Conclusions. This multicentre analysis documented a significant reduction in the number of patients referred with suspected TIA to the specialised rapid access outpatient clinics in the North West London region during the COVID-19 pandemic. Future studies are needed to confirm our findings and to better characterise the incidence of cerebrovascular disease during the COVID-19 pandemic

Geographies of the COVID-19 pandemic

The spread of the novel coronavirus (SARS-CoV-2) has resulted in the most devastating global public health crisis in over a century. At present, over 10 million people from around the world have contracted the Coronavirus Disease 2019 (COVID-19), leading to more than 500,000 deaths globally. The global health crisis unleashed by the COVID-19 pandemic has been compounded by political, economic, and social crises that have exacerbated existing inequalities and disproportionately affected the most vulnerable segments of society. The global pandemic has had profoundly geographical consequences, and as the current crisis continues to unfold, there is a pressing need for geographers and other scholars to critically examine its fallout. This introductory article provides an overview of the current special issue on the geographies of the COVID-19 pandemic, which includes 42 commentaries written by contributors from across the globe. Collectively, the contributions in this special issue highlight the diverse theoretical perspectives, methodological approaches, and thematic foci that geographical scholarship can offer to better understand the uneven geographies of the Coronavirus/COVID-19. </jats:p

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung

Cytomegalovirus vectors are promising delivery vehicles for vaccine strategies that aim to elicit effector CD8+ T cells. To determine how the route of immunization affects CD8+ T cell responses in the lungs of mice vaccinated with a murine cytomegalovirus vector expressing the respiratory syncytial virus matrix (M) protein, we infected CB6F1 mice via the intranasal or intraperitoneal route and evaluated the M-specific CD8+ T cell response at early and late time points. We found that intranasal vaccination generated robust and durable tissue-resident effector and effector memory CD8+ T cell populations that were undetectable after intraperitoneal vaccination. The generation of these antigen-experienced cells by intranasal vaccination resulted in earlier T cell responses, interferon gamma secretion, and viral clearance after respiratory syncytial virus challenge. Collectively, these findings validate a novel approach to vaccination that emphasizes the route of delivery as a key determinant of immune priming at the site of vulnerability

Plate Wave Propagation in Transversely Isotropic Materials

In this work, the modes of plate wave propagation in a fiber reinforced com posite (assumed to be transversely isotropic) were investigated. The waves were modeled as harmonic plane waves propagating in the plane of an infinite plate whose bounding sur faces were assumed to be stress free. A numerical analysis procedure was developed to calculate the dispersion relationships for plate waves propagating in arbitrary directions in the plate. Particle displacements and stress distributions were calculated for several im portant propagation modes. Possible applications to nondestructive testing of composites are discussed.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

The politics of toponymic continuity: the limits of change and the ongoing lives of street names

There is a widespread recognition in the critical toponymies literature that radical or revolutionary political change is accompanied by the renaming of urban streets and buildings. In particular, through a process of ‘toponymic cleansing’ ideologically inappropriate names are removed from the urban arena and replaced by new names that accord with the agenda, aspirations and values of the new political order. This process is frequently assumed to be clean, decisive and definitive; a clean sweep which results in a comprehensive reconfiguring of the toponymic landscape. However, we argue that the process is far more messy and inconclusive than is often recognised. Streets with inappropriate names may be overlooked; the material signage with the old name may persist long after a street has been through the administrative process of renaming; and old (and ideologically inappropriate) names may remain in widespread daily use long after they have been formally changed. In other words, former toponymies are absent presences that haunt the city long after a period of revolutionary political change has been completed. In this chapter we examine such ‘residual’ toponymies and we illustrate our discussion with a range of examples from post-socialist and post-colonial contexts. We argue that attempts to change everyday ‘worlds of meaning’ through renaming streets are much less successful than is often argued, and we call for a recognition of the performative limits of changing urban place names

Single cell transcriptomics reveal polyclonal memory T cell responses in abacavir patch test positive skin

Capsule Summary. Single-cell responses in HLA-B*57:01 abacavir patch test positive skin remote to the acute hypersensitivity reaction demonstrate polyclonal T-cell activation and proliferation characterized by a transcriptional and cellular response consistent with memory responses to altered peptides