Compressive and shear behaviour of masonry panels: experimentation and numerical analysis

The compressive and shear behavior of masonry is here studied both experimental- ly and numerically. An experimental campaign has been carried out on 9 square-shaped one leaf masonry panels, reproducing historical masonry. Tests have been done for evaluating the elastic and shear moduli in both plane directions, with 6 panels rotated by 90 degrees, lead- ing to vertically aligned bed joints, and 3 panels maintained with horizontal bed joints. Com- pressive tests were executed on 6 masonry panels, 3 of them rotated by 90 degrees. Initial shear strength and shear modulus parallel to bed joints are evaluated through shear tests on 9 masonry triplets. Shear tests are performed on 3 rotated panels, applying an horizontal dis- tributed load, without vertical compression. Attention is paid to the service load state: only the initial phase of the tests is studied. Numerical models are proposed for representing actu- al masonry behavior, both discrete [1] and continuous [2,3], standard and micropolar, ob- tained by homogenization procedures [4]. Several numerical analyses are performed for simulating the experimental tests on masonry triplets and panels. The mechanical elastic pa- rameters of both discrete and continuous models are calibrated starting from laboratory data of masonry constituents and then by fitting the results of the initial phases of the experimental tests on masonry specimens

A finite element-discrete element approach for the analysis of the venice trans-lagoon railway bridge

In this paper, the feasibility of the utilization of a combined finite element/discrete element (FE-DE) approach to investigate the behavior of masonry arch bridges is proposed. Attention is paid to the assessment of the load carrying capacity by means of a suitable coupled FE-DE two-dimensional approach. This paper outlines the fields and limits of applicability of the FE-DE method to the study of masonry arch bridges. The main contribution is to evaluate the applicability of FE-DE, in particular its reliability to describe the nonlinear behavior of masonry arch bridges under increasing static loads, to catch kinematic failure mechanisms and collapse load multipliers, as well as to evaluate the role played by the backfill. A discussion on a possible approach to FE-DE modelling of the Venice trans-Lagoon masonry arch bridge is proposed. With such a purpose, a series of parametric analyses has been conducted in order to evaluate the influence of the different parameters involved on the behavior of the bridges. Pushover analyses have been performed to investigate the nonlinear behavior up to the collapse and up to a clear formation of a failure mechanism in the model

Follicular thyroid carcinoma: Differences in clinical relevance between minimally invasive and widely invasive tumors

Evidence on the biological behavior and clinical courses of minimally invasive and widely invasive follicular thyroid carcinoma (MI-FTC, WI-FTC) is still debatable. The current study was conducted to identify differences between MI and WI tumors and those prognostic parameters influencing late outcome such as local recurrence and survival

Sensitivity to damage imperfection for multileaf masonry walls based on vibrational analyses

Damage-imperfection indicators based on variation of dynamic parameters allow to identify the intrinsic discontinuity and the damage of structures. Here, the structural health monitoring through the vibration-based approach has been carried out by two steps on three different multileaf masonry specimens (full infill, damaged infill, and strengthened infill) subjected to uniaxial compressive load. In the first step, the characterization of initial conditions based on the investigation of the intrinsic discontinuity and the manufacturing imperfections has been done. In this phase, the detection, localization, assessment, and prediction of damage have been given by the comparison between the experimental and numerical modal data calculated by the commercial finite element code. Subsequently, in the second step, starting from the identification of undamaged condition, the damage effects on changes of the dynamic parameters have been recorded. As well known, the incoherent response between the leaves is related to frequency values, damping ratios, and modal shapes

Role of crossmatch testing when Luminex-SAB is negative in renal transplantation

The human leukocyte antigen (HLA) system plays an important role in the acceptance of renal graft. Long and better graft survival has been reported in patients with HLA-identical siblings and a nonreactive cytotoxicity assay (CDC). New methods of HLA-typing and anti-HLA antibody detection techniques such as flow cytometry, solid-phase immunoassays, or antigen bead assays have further improved the outcomes of renal transplant recipients. In the present review, the explicit details of these methodologies are discussed in detail

Statistical Assessment of In-Plane Masonry Panels Using Limit Analysis with Sliding Mechanism

Historical masonry structures have a great interest in civil engineering because they constitute a large part of the world's building heritage. In this paper, the effects that different geometrical (panel ratio, block ratio, and bond type) and mechanical (friction ratio) parameters have on the in-plane structural response of brick masonry panels are investigated. A discrete modeling approach, based on a limit analysis and capable of reproducing sliding mechanisms, formulation by one of the authors has been adopted, enhanced, and implemented. Results, in terms of collapse multipliers and collapse mechanisms, are presented and analyzed following a systematic statistical approach. Statistically significant effects have been found for each factor considered. Furthermore, the statistical model adopted included nonlinear terms that allowed the identification of whether the effect of one parameter on the response depends on the level of any other parameters. Thus, it was observed that two-way factor interactions played an important role in the in-plane response of masonry panels. The panel ratio-friction ratio two-way factor interaction was the one with a more significant effect

Laboratory and numerical experimentation for masonry in compression

In this paper, the initial part of a laboratory and numerical experimental campaign dedicated to historical masonry is described. One leaf masonry panels with regular texture are built in order to simulate a historical material characterised by strong resisting elements and weak mortar joints. Laboratory tests are first dedicated to masonry components and then to the behaviour in compression of masonry panels, which is applied both orthogonal and parallel to bed joints, in order to highlight the orthotropic behaviour of the material. First of all, the mechanical parameters of masonry constituents are calibrated and then a heterogeneous finite element model is introduced and calibrated for reproducing the orthotropic behaviour of masonry, together with the initial elastic response and the initial nonlinear behaviour due to the first level of damage

Unusual metachronous isolated inguinal lymph node metastasis from adenocarcinoma of the sigmoid colon

This study aimed to describe an unusual case of metachronous isolated inguinal lymph nodes metastasis from sigmoid carcinoma. A 62-year-old man was referred to our department because of an obstructing sigmoid carcinoma. Colonoscopy showed the obstructing lesion at 30 cm from the anal verge and abdominal CT revealed a sigmoid lesion infiltrating the left lateral abdominal wall. The patient underwent a colonic resection extended to the abdominal wall. Histology showed an adenocarcinoma of the colon infiltrating the abdominal wall with iuxtacolic nodal involvement. Thirty three months after surgery abdominal CT and PET scan revealed a metastatic left inguinal lymph node involvement. The metastatic lymph node was found strictly adherent to the left iliac-femoral artery and encompassing the origin of the left inferior epigastric artery. Histology showed a metachronous nodal metastasis from colonic adenocarcinoma. Despite metastastic involvement of inguinal lymph node from rectal cancer is a rare but well known clinical entity, to the best of our knowledge, this is the first report of inguinal metastasis from a carcinoma of the left colon. Literature review shows only three other similar reported cases: two cases of inguinal metastasis secondary to adenocarcinoma of the cecum and one case of axillary metastasis from left colonic carcinoma. A metastatic pathway through superficial abdominal wall lymphatic vessels could be possible through the route along the left inferior epigastric artery. The solitary inguinal nodal involvement from rectal carcinoma could have a more favorable prognosis. In the case of nodal metastasis to the body surface lymph nodes from colonic carcinoma, following the small number of such cases reported in the literature, no definitive conclusions can be drawn

Structural Evaluation of Typical Historical Masonry Vaults of Cagliari: Sensitivity to Bricks Arrangements

Masonry vaults have a great diffusion in the historical architectural heritage: in this work, their structural behavior is investigated. Attention is focused on lowered sail vaults composed by several brick arrangements, a typical nineteenth-century masonry vault which have great diffusion in Cagliari (Sardinia). The target is evaluating the role played by bricks arrangement in their mechanical behavior. A series of rigorous laser scanner surveys have been performed in order to obtain the effective geometry both at macro-level – the vault shape – and at micro-level – brick patterns. A NURBS (Non-Uniform Rational B Spline) representation of the geometry is adopted and adaptive upper bound limit analyses are performed. NURBS entities, which are common in commercial CAD packages, have the great advantage to describe complex geometries such as curved elements, with very few elements. An upper bound limit analysis formulation is adopted, in which the NURBS elements forming the mesh are idealized as rigid bodies with dissipation allowed only along interfaces. The mesh constituted by few NURBS elements is progressively adjusted through a genetic algorithm in order to minimize the live load multiplier. Limit analysis is performed initially to determine the collapse multiplier of vertical loads, to assess the load bearing capacity of the vault, then attention is focused on differential settlements, that may be a serious hazard for this structural typology

Whole Exome Sequencing Study of Parkinson Disease and Related Endophenotypes in the Italian Population

Parkinson Disease (PD) is a complex neurodegenerative disorder characterized by large genetic heterogeneity and missing heritability. Since the genetic background of PD can partly vary among ethnicities and neurological scales have been scarcely investigated in a PD setting, we performed an exploratory Whole Exome Sequencing (WES) analysis of 123 PD patients from mainland Italy, investigating scales assessing motor (UPDRS), cognitive (MoCA), and other non-motor symptoms (NMS). We performed variant prioritization, followed by targeted association testing of prioritized variants in 446 PD cases and 211 controls. Then we ran Exome-Wide Association Scans (EWAS) within sequenced PD cases (N = 113), testing both motor and non-motor PD endophenotypes, as well as their associations with Polygenic Risk Scores (PRS) influencing brain subcortical volumes. We identified a variant associated with PD, rs201330591 in GTF2H2 (5q13; alternative T allele: OR [CI] = 8.16[1.08; 61.52], FDR = 0.048), which was not replicated in an independent cohort of European ancestry (1,148 PD cases, 503 controls). In the EWAS, polygenic analyses revealed statistically significant multivariable associations of amygdala- [\u3b2(SE) = -0.039(0.013); FDR = 0.039] and caudate-PRS [0.043(0.013); 0.028] with motor symptoms. All subcortical PRSs in a multivariable model notably increased the variance explained in motor (adjusted-R2 = 38.6%), cognitive (32.2%) and other non-motor symptoms (28.9%), compared to baseline models (~20%). Although, the small sample size warrants further replications, these findings suggest shared genetic architecture between PD symptoms and subcortical structures, and provide interesting clues on PD genetic and neuroimaging features