Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

The drug-induced liver injury network (DILIN) is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study

Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations.

RationaleShorter leukocyte telomere length (LTL) is associated with reduced health-related quality of life and increased risk for acute exacerbations (AEs) and mortality in chronic obstructive pulmonary disease (COPD). Increased physical activity and exercise capacity are associated with reduced risk for AEs and death. However, the relationships between LTL and physical activity, exercise capacity, and AEs in COPD are unknown.MethodsData from 3 COPD cohorts were examined: Cohort 1 (n = 112, physical activity intervention trial), Cohorts 2 and 3 (n = 182 and 294, respectively, separate observational studies). Subjects completed a 6-minute walk test (6MWT) and provided blood for LTL assessment using real-time PCR. Physical activity was measured as average daily step count using an accelerometer or pedometer. Number of self-reported AEs was available for 1) the year prior to enrollment (Cohorts 1 and 3) and 2) prospectively after enrollment (all cohorts). Multivariate models examined associations between LTL and average daily step count, 6MWT distance, and AEs.ResultsA significant association between longer LTL and increased 6MWT distance was observed in the three combined cohorts (β = 3x10-5, p = 0.045). No association between LTL and average daily step count was observed. Shorter LTL was associated with an increased number of AEs in the year prior to enrollment (Cohorts 1 and 3 combined, β = -1.93, p = 0.04) and with prospective AEs (Cohort 3, β = -1.3388, p = 0.0003).ConclusionsAmong COPD patients, increased LTL is associated with higher exercise capacity, but not physical activity. Shorter LTL was associated with AEs in a subgroup of cohorts

Associations between vitamin D, adiposity, and respiratory symptoms in chronic spinal cord injury

<p>Persons with chronic spinal cord injury (SCI) have an increased risk of respiratory-related morbidity and mortality and chronic respiratory symptoms are clinical markers of future respiratory disease. Therefore, we sought to assess potentially modifiable factors associated with respiratory symptoms, with a focus on circulating vitamin D and measures of body fat.</p> <p>Cross-sectional study.</p> <p>Veterans Affairs Medical Center.</p> <p>Three hundred forty-three participants (282 men and 61 women) with chronic SCI participating in an epidemiologic study to assess factors influencing respiratory health recruited from VA Boston and the community.</p> <p>Participants provided a blood sample, completed a respiratory health questionnaire, and underwent dual x-ray absorptiometry (DXA) to assess % body fat. Logistic regression was used to assess cross-sectional associations between respiratory symptoms and plasma vitamin D and measures of body fat with adjustment for a number of potential confounders.</p> <p>Chronic cough, chronic phlegm, any wheeze, persistent wheeze.</p> <p>After adjustment for a number of confounders (including smoking), participants with greater %-android, gynoid, trunk, or total body fat had increased odds ratios for any wheeze and suggestive associations with persistent wheeze, but not with chronic cough or phlegm. Vitamin D levels were not associated with any of the respiratory symptoms.</p> <p>Increased body fat, but not vitamin D, was associated with wheeze in chronic SCI independent of a number of covariates.</p

Social representations of events and people in world history across 12 cultures

Social representations of world history were assessed using the open-ended questions, "What are the most important events in world history?" and "Who are the most influential persons in world history in the last 1,000 years?"Data from six Asian and six Western samples showed cross-cultural consensus. Historical representations were (a) focused on the recent past, (b) centered around politics and war, and (c) dominated by the events of the World Wars and (d) the individual Hitler, who was universally perceived as negative. (e) Representations were more Eurocentric than ethnocentric.(f) The importance of economics and science was underrepresented.(g) Most cultures nominated people (more than events) idiosyncratic to their own culture. These data reflect power relations in the world and provide resources and constraints for the conduct of international relations. The degree of cross-cultural consensus suggests that hybridity across Eastern and Western cultures in the representation of knowledge may be underestimated

The Relationship of Jewish Community Contexts and Jewish Identity: A 22-Community Study

This paper explores the manner in which Jewish community contexts relate to Jewish identity. We employ the Decade 2000 Data Set that contains almost 20,000 randomly selected Jewish households from 22 American Jewish communities interviewed from 2000 to 2010. Because of the large sample size, and its incorporation of community infrastructure data, this research also is able to examine various influences on Jewish identity that have not been definitively addressed in previous research, including the manner in which characteristics of Jewish community infrastructure are related to individuals’ Jewish identity. The Decade 2000 Data Set used for the analysis is described and some of the methodological considerations involved in its use are presented. Jewish identity is conceptualized as multidimensional, and a factor analysis results in four Jewish identity factors: a communal religious factor, a private religious factor, a broader ethnic factor, and a local ethnic factor. Multiple regressions for each of the Jewish identity factors are related to Jewish community characteristics; more commonly researched individual-level variables (Jewish background and connections, family status, socioeconomic status, demographic/geographic characteristics); and survey-level variables (such as size of sample and year of study) are also controlled. Surprisingly, except for the local ethnic factor, Jewish community characteristics have little relationship to individual Jewish identity. The contributions to a “sociology of Jewish place” and suggestions for further research are also discussed