4,109 research outputs found

    Sustainability in the theology curriculum

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    This is the author's PDF version of a book chapter available in Sustainability education: Perspectives and practice across higher education. Edited by Paula Jones, David Selby, and Stephen Sterling. London: Earthscan, 2010. This book chapter was reproduced with the kind permission of EasthScan.This book chapter discusses how theology has the potential to contribute to education for sustainable development

    Academic attainment and special educational needs in extremely preterm children at 11 years of age : the EPICure Study

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    Aim: To assess academic attainment and special educational needs (SEN) in extremely preterm (EP) children in middle childhood. Methods: Of 307 EP (=25 weeks) survivors born in the UK and Ireland in 1995, 219 (71%) were re-assessed at 11 years, with a comparison group of 153 classmates born at term, using standardised tests of cognitive ability and academic attainment and teacher reports of school performance and special educational needs (SEN). Multiple imputation was used to correct for selective dropout. Results: EP children had significantly lower scores than classmates for cognitive ability (-20 points; 95%CI: -23,-17), reading (-18 points; -22,-15) and mathematics (-27 points; -31,-23). Twenty-nine (13%) EP children attended special school. In mainstream schools, 105 (57%) EP children had SEN (OR: 10; 6, 18) and 103 (55%) required SEN resource provision (OR: 10; 5, 18). Teachers rated 50% of EP children with attainment below the average range compared with 5% of classmates (OR: 18; CI: 8, 41). EP children who are entered for mainstream education an academic year early due to preterm birth had similar academic attainment but required more SEN support (OR: 2; 1.1,3.8). Conclusions: EP survivors remain at high risk for learning impairments and poor academic attainment in middle childhood. A significant proportion require full-time specialist education and over half of those attending mainstream schools require additional health or educational resources in order to access the national curriculum. The prevalence and impact of SEN is likely to increase as these children approach the transition to secondary school. -------------------------------------------------------------------------------

    Raptor assemblage, abundance, nesting ecology, and habitat characteristics under intensive forest management in the Central Appalachian Mountains

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    Raptor abundance and diversity were examined in three treatments (20-, 40-, and 80-yr harvest rotations) on an industrial forest in the central Appalachian Mountains. I conducted diurnal broadcast surveys, compared nocturnal survey protocols, examined habitat characteristics at two spatial scales (564 m and 1000 m buffers), and described nesting ecology (including prey composition) of 3 species of diurnal raptors. I detected 17 species and found no significant differences in abundance among treatment for all raptors. Forest-dwelling species were detected more often than edge-dwelling species and Red-shouldered Hawk (Buteo lineatus) was the most abundant species. Using a Barred Owl vocalization survey protocol, Barred Owls were detected most often and most owls were detected. Fourteen nesting attempts were located on the study area. Mammals were delivered most often to three species\u27 nests. My study suggests that at current levels of disturbance, forest-dwelling raptors are able to survive and successfully breed on an active, industrial forest

    Growth rates for subclasses of Av(321)

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    Pattern classes which avoid 321 and other patterns are shown to have the same growth rates as similar (but strictly larger) classes obtained by adding articulation points to any or all of the other patterns. The method of proof is to show that the elements of the latter classes can be represented as bounded merges of elements of the original class, and that the bounded merge construction does not change growth rates

    Guadecitabine, in combination with Cyclophosphamide, promotes anti- cancer immunity in BALB/c mice bearing 4T1 mouse mammary carcinoma

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    Background: The extremely high mortality rate of patients diagnosed with triple negative breast cancer makes it one of the deadliest forms of cancer. Due to the heterogenous nature of tumors, complete clearance is not achieved and clonal selection occurs resulting in tumor cells evading the immune system. I aim to design a therapeutic intervention that is able to elicit an effective immune response against the tumor and instill immunological memory to eradicate primary and metastatic lesions. I hypothesize that the combination of Guad and Cyp will synergize and promote anticancer immunity via increased expression of neo-tumor antigens and depletion of MDSCs and T-regs. Methods: Guadecitabine (Guad), is a second-generation DNA methyltransferase inhibitor (DMNTi) that has been reported to increase antigenicity and deplete myeloid-derived suppressor cells (MDSC’s). Cyclophosphamide (Cyp) is a chemotherapy that has been shown to deplete regulatory T-cells (T-regs). Both MDSD’s and T-regs suppress antitumor immunity. BALB/c mice were challenged with 4T1 tumor cells subcutaneously in the mammary fat pad region. 4T1-bearing mice were administered low-dose Guad and Cyp for ten consecutive days. Tumor growth curves, tumor-infiltrating lymphocytes (TILs) were measured and MDSC’s and T- regs levels were assessed by flow cytometry. Results: Results from this experiment showed significant synergy between Guad and Cyp with both drugs reducing the tumor size over monotherapy. Conclusions: Further analysis of the data along with future experiments will elucidate if this synergy is driven by the depletion of MDSC’s and T-regs alone or the increase in tumor antigenicity inducing increased numbers of TILs.https://scholarscompass.vcu.edu/gradposters/1078/thumbnail.jp

    Community Dialogues for Racial Healing: Participant Handouts

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    Miss RECoP launched in 2016 and continues to be active throughout the state of Mississippi. This dialogue process is a product of their work and has been used throughout the state to promote understanding and healing among different racial/ethnic people. Community Dialogues for Racial Healing now brings this vital work to a national scope to promote healing in other areas of the nation.This is a packet of handouts that go along with the Community Dialogues for Racial Healing: Community Liaison Support Manua

    Chapter 03 - Find & Evaluate Information Sources at Western Libraries

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    Learn to identify and evaluate information sources that can support your research.https://cedar.wwu.edu/research_process/1007/thumbnail.jp

    Improving the Impact of Extension Through the Use of Anticipation Guides

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    In this article, we present the anticipation guide as a tool for preparing Extension audiences to learn the main points of Extension materials. Anticipation guides improve learner comprehension by appealing to an individual\u27s natural curiosity and helping the individual focus on key ideas. Anticipation guides can be used with all types of Extension materials and across all Extension programs. We describe how to create anticipation guides for use with Extension materials and explain how to use them effectively and easily. We also provide examples of anticipation guides based on various Extension topics

    The antibody loci of the domestic goat (Capra hircus)

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    The domestic goat (Capra hircus) is an important ruminant species both as a source of antibody-based reagents for research and biomedical applications and as an economically important animal for agriculture, particularly for developing nations that maintain most of the global goat population. Characterization of the loci encoding the goat immune repertoire would be highly beneficial for both vaccine and immune reagent development. However, in goat and other species whose reference genomes were generated using short-read sequencing technologies, the immune loci are poorly assembled as a result of their repetitive nature. Our recent construction of a long-read goat genome assembly (ARS1) has facilitated characterization of all three antibody loci with high confidence and comparative analysis to cattle. We observed broad similarity of goat and cattle antibody-encoding loci but with notable differences that likely influence formation of the functional antibody repertoire. The goat heavy-chain locus is restricted to only four functional and nearly identical IGHV genes, in contrast to the ten observed in cattle. Repertoire analysis indicates that light-chain usage is more balanced in goats, with greater representation of kappa light chains (~ 20-30%) compared to that in cattle (~ 5%). The present study represents the first characterization of the goat antibody loci and will help inform future investigations of their antibody responses to disease and vaccination

    Multispectral fingerprinting for improved in vivo cell dynamics analysis

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    Background: Tracing cell dynamics in the embryo becomes tremendously difficult when cell trajectories cross in space and time and tissue density obscure individual cell borders. Here, we used the chick neural crest (NC) as a model to test multicolor cell labeling and multispectral confocal imaging strategies to overcome these roadblocks. Results: We found that multicolor nuclear cell labeling and multispectral imaging led to improved resolution of in vivo NC cell identification by providing a unique spectral identity for each cell. NC cell spectral identity allowed for more accurate cell tracking and was consistent during short term time-lapse imaging sessions. Computer model simulations predicted significantly better object counting for increasing cell densities in 3-color compared to 1-color nuclear cell labeling. To better resolve cell contacts, we show that a combination of 2-color membrane and 1-color nuclear cell labeling dramatically improved the semi-automated analysis of NC cell interactions, yet preserved the ability to track cell movements. We also found channel versus lambda scanning of multicolor labeled embryos significantly reduced the time and effort of image acquisition and analysis of large 3D volume data sets. Conclusions: Our results reveal that multicolor cell labeling and multispectral imaging provide a cellular fingerprint that may uniquely determine a cell's position within the embryo. Together, these methods offer a spectral toolbox to resolve in vivo cell dynamics in unprecedented detail
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