Salt forms of sulfadiazine with alkali metal and organic cations

The structures of four salt forms of sulfadiazine (SDH) with alkali metal cations are presented. Three contain the deprotonated SD anion. These are the discrete complex [Li(SD)(OH2)2], (I), and the coordination polymers [Na(SD)]n, (II), and [K(SD)(OH2)2]n, (III). The Na complex (II) is a three-dimensional coordination polymer whilst the K complex (III) has two crystallographically independent [K(SD)(OH2)2] units per asymmetric unit, Z′ = 2, and gives a two dimensional coordination polymer whose layers propagate parallel to the crystallographic ab plane. The different bonding modes of the SD anion in these three complexes is discussed. Structure (IV) contains protonated SDH2 cations and the Orange G (OG), C16H10N2O7S2, dianion in a structure with formula [SDH2]2[Na(OG)(OH2)4]2·3H2O. The [Na(OG)(OH2)4]2 dimers have antiparallel naphthol ring structures joined through two Na centres that bond to the hydrazone anions through the O atoms of the ketone and sulfonate substituents. The structures of the salts formed on reaction of SDH with 2-aminopyridine and ethanolamine are also presented as [C5H7N2][SD], (V), and [HOCH2CH2NH3][SD]·H2O, (VI), respectively. Structure (V) features a heterodimeric R2 2(8) hydrogen bond motif between the cation and the anion whilst structure (VI) has a tetrameric core of two cations linked by a central R2 2(10) hydrogen bonded motif which supports two anions linked to this core by R3 3(8) motifs

Medicalization of Female Beauty: A Content Analysis of Cosmetic Procedures

Over the past decade, cosmetic procedures have significantly increased in options available for females to achieve the American cultural standards of beauty. The purpose of this study is to conduct a content analysis of brochures and to observe what cosmetic procedures are made available to female customers from plastic surgery centers, and also to examine the medical and therapeutic framing techniques used to encourage females to undergo cosmetic procedures. Three plastic surgery centers (overall response rate= 60%) located in one metropolitan area served as participants for this study. The researcher observed the locations and collected all brochures made available. Twenty - one diverse brochures were used in this study as well as the researcher locate d the websites to view any missing information of services offered not included in the brochures. A content analysis was conducted of the brochures. All of the cosmetic surgery centers were accredited and advertised each plastic surgeon’s credibility. Various invasive and noninvasive cosmetic procedures were offered by each center including procedures that focus on the face, breasts, body, and skin care. Additionally, all cosmetic surgery centers marketed their elective surgeries to females by using medical terms as well as therapeutic terms. As the rates of cosmetic procedures have significantly increased overtime, cosmetic surgeons appear to benefit from employing medical terms to diagnose beauty among their target population of healthy females. In addition, using therapeutic terms to ensure increase self - esteem among females is another beneficial framing techniqu

Healthy Eating and Physical Activity Programming at Overnight Summer Camps

Overnight summer camps have previously been overlooked as settings for healthy eating and physical activity programming; however, recent summer camp research has begun to examine how summer camp programming can help fight childhood obesity. The purpose of this research was to identify and examine the efforts that Wisconsin overnight summer camps are taking to support campers in meeting national dietary and physical activity guidelines. Data were collected through in-person or phone interviews with 13 directors and owners of American Camp Association (ACA) accredited camps and were analyzed using a conventional content analysis and inductive thematic analysis approach. Results indicated that camp directors are trying to provide, or are already providing, healthy food that follows the national dietary recommendations and that campers who attend these overnight summer camps in Wisconsin are meeting or exceeding the national physical activity recommendations. Camp directors reported that their campers were physically active because of the amount of walking each camper had to complete in order to get from one activity to another (often across the camp property), in addition to their participation in a variety of program activities. Overnight summer camps are an ideal setting for the promotion of healthy eating and physical activity for children

Impaired contextual modulation of memories in PTSD: an fMRI and psychophysiological study of extinction retention and fear renewal

Post-traumatic stress disorder (PTSD) patients display pervasive fear memories, expressed indiscriminately. Proposed mechanisms include enhanced fear learning and impaired extinction or extinction recall. Documented extinction recall deficits and failure to use safety signals could result from general failure to use contextual information, a hippocampus-dependent process. This can be probed by adding a renewal phase to standard conditioning and extinction paradigms. Human subjects with PTSD and combat controls were conditioned (skin conductance response), extinguished, and tested for extinction retention and renewal in a scanner (fMRI). Fear conditioning (light paired with shock) occurred in one context, followed by extinction in another, to create danger and safety contexts. The next day, the extinguished conditioned stimulus (CS+E) was re-presented to assess extinction recall (safety context) and fear renewal (danger context). PTSD patients showed impaired extinction recall, with increased skin conductance and heightened amygdala activity to the extinguished CS+ in the safety context. However, they also showed impaired fear renewal; in the danger context, they had less skin conductance response to CS+E and lower activity in amygdala and ventral-medial prefrontal cortex compared with combat controls. Control subjects displayed appropriate contextual modulation of memory recall, with extinction (safety) memory prevailing in the safety context, and fear memory prevailing in the danger context. PTSD patients could not use safety context to sustain suppression of extinguished fear memory, but they also less effectively used danger context to enhance fear. They did not display globally enhanced fear expression, but rather showed a globally diminished capacity to use contextual information to modulate fear expression

Elder Financial Exploitation: Implications for Future Policy and Research in Elder Mistreatment

Recent advances in the understanding of elder mistreatment have demonstrated that financial exploitation tends to be one of the most common forms of mistreatment affecting older populations. Agencies such as the World Bank and World Health Organization show significant concern regarding financial exploitation and its connection to physical and emotional injury to victims. The World Bank uses the term “financial violence” as a means of generally describing the harm caused to an individual as a result of financial exploitation or abuse. The proportion of financial exploitation in relation to other forms of elder mistreatment is defined in our research. We discuss the potential impact of elder financial exploitation on victims as well as explore the implications for future research and policy development focused on financial aspects of elder mistreatment and call for further study in the concept of financial exploitation as a violent act

Does Involvement in Healthy Eating Among University Students Differ Based on Exercise Status and Reasons for Exercise?

Background. Unhealthy nutritional habits are a major cause of morbidity and mortality in the US. Research indicates that regular physical activity can influence dietary habits of adults. Purpose. The purpose of this study was to examine whether university students’ involvement in healthy eating differed based on current exercise status and reported reasons for exercising. Methods. A sample of 204 university students completed a 22-item survey on healthy eating and physical activity. Results. Less than 10% met all Food Guide recommendations. The leading barriers to healthy eating were time, convenience and healthy food availability. Less than half exercised on four or more days each week. The leading reasons for exercising were to improve appearance, improve health and lose weight. Being physically active did not have a significant effect on healthy eating, nor did specific reason for exercising. Discussion. Most students did not eat healthy and their physical activity levels did not significantly affect their nutritional habits. Increased awareness campaigns are warranted. Conclusions. Strategies other than physical activity promotion are needed to positively impact students’ healthy eating behaviors. Students should continue to be educated about healthy nutrition and ways to reduce perceived barriers to healthy eating

Does parkland influence walking? The relationship between area of parkland and walking trips in Melbourne, Australia

Background : Using two different measures of park area, at three buffer distances, we sought to investigate the ways in which park area and proximity to parks, are related to the frequency of walking (for all purposes) in Australian adults. Little previous research has been conducted in this area, and results of existing research have been mixed. Methods : Residents of 50 urban areas in metropolitan Melbourne, Australia completed a physical activity survey (n = 2305). Respondents reported how often they walked for &gt;=10 minutes in the previous month. Walking frequency was dichotomised to \u27less than weekly\u27 (less than 1/week) and \u27at least weekly\u27 (1/week or more). Using Geographic Information Systems, Euclidean buffers were created around each respondent\u27s home at three distances: 400metres (m), 800 m and 1200 m. Total area of parkland in each person\u27s buffer was calculated for the three buffers. Additionally, total area of \u27larger parks\u27, (park space &gt;= park with Australian Rules Football oval (17,862 m2)), was calculated for each set of buffers. Area of park was categorised into tertiles for area of all parks, and area of larger parks (the lowest tertile was used as the reference category). Multilevel logistic regression, with individuals nested within areas, was used to estimate the effect of area of parkland on walking frequency. Results : No statistically significant associations were found between walking frequency and park area (total and large parks) within 400 m of respondent\u27s homes. For total park area within 800 m, the odds of walking at least weekly were lower for those in the mid (OR 0.65, 95% CI 0.46-0.91) and highest (OR 0.65, 95% CI 0.44-0.95) tertile of park area compared to those living in areas with the least amount of park area. Similar results were observed for total park area in the 1200 m buffers. When only larger parks were investigated, again more frequent walking was less likely when respondents had access to a greater amount of park area. Conclusions : In this study we found that more park area in residential environments reduced the odds of walking more frequently. Other area characteristics such as street connectivity and destinations may underlay these associations by negatively correlating with park area. <br /

Negative School Experiences and Pain Reliever Misuse among a National Adolescent Sample

A recent public health concern is the nonmedical use of prescription drugs among U.S. adolescents. The purpose of this study was to determine the relationship between negative school experiences and lifetime and past year pain reliever misuse among adolescents enrolled in high school nationwide. A secondary analysis was performed using the National Survey on Drug Use and Health 2017 data. Participants included 8,337 adolescents enrolled in 9th -12th grades. A total of 6.0% of high school students reported they had misused pain relievers in their lifetime, and 3.9% reported they had misused pain relievers during the past year. High school students who reported the following negative school experiences were at increased odds of reporting lifetime pain reliever misuse: liked/hated going to school (adjusted OR [aOR] = 2.04, 95% confidence interval [CI] = 1.66-2.50); felt their coursework was somewhat/very boring (aOR = 1.81, 95%CI = 1.48-2.22), seldom/never meaningful (aOR = 2.01, 95%CI = 1.64-2.45), and/or would be somewhat/very unimportant to them later in life (aOR = 1.64, 95%CI = 1.33-2.01); and had teachers who seldom/never let them know they were doing a good job (aOR = 1.71, 95%CI = 1.40-2.09). High school students who had a “D” grade average or lower (aOR = 2.69, 95%CI = 1.89-3.82) and skipped school on at least one day (aOR = 2.18, 95%CI = 1.76-2.70) were more likely to report lifetime use. Similar significant findings were reported between negative school experiences and past year pain reliever misuse. Negative school experiences are risk factors for lifetime and past year pain reliever misuse among U.S. adolescents. Programming that reduces students’ negative school experiences may create a positive environment, and in turn, reduce misuse

Factors contributing to high performance of sows in free farrowing systems

BackgroundPressure to abolish farrowing crates is increasing, and producers are faced with decisions about which alternative system to adopt. For sow welfare, well designed free farrowing systems without close confinement are considered optimal but producers have concerns about increased piglet mortality, particularly crushing by the sow. Reporting accurate performance figures from commercial farms newly operating such systems could inform the transition process. This study investigated performance on three commercial farms operating four different zero-confinement systems, three of which were newly installed. A total of 3212 litters from 2920 sows were followed from farrowing to weaning over a three-year period with key performance indicators (KPIs) recorded. Mixed Models (LMMs, GLMMs) determined the influence of different factors (e.g. farrowing system, sow parity, management aspects) and litter characteristics on performance, including levels and causes of piglet mortality.ResultsPiglet mortality was significantly influenced by farm/system. Live-born mortality ranged from 10.3 to 20.6% with stillbirths ranging from 2.5 to 5.9%. A larger litter size and higher parity resulted in higher levels of mortality regardless of system. In all systems, crushing was the main cause of piglet mortality (59%), but 31% of sows did not crush any piglets, whilst 26% crushed only one piglet and the remaining sows (43%) crushed two or more piglets. System significantly influenced crushing as a percentage of all deaths, with the system with the smallest spatial footprint (m2) compared to the other systems, recording the highest levels of crushing. Time from the start of the study influenced mortality, with significant reductions in crushing mortality (by ~ 4%) over the course of the three-year study. There was a highly significant effect of length of time (days) between moving sows into the farrowing accommodation and sows farrowing on piglet mortality (P &lt; 0.001). The less time between sows moving in and farrowing, the higher the levels of piglet mortality, with ~ 3% increase in total mortality every five days. System effects were highly significant after adjusting for parity, litter size, and days pre-farrowing.ConclusionThese results from commercial farms demonstrate that even sows that have not been specifically selected for free farrowing are able, in many cases, to perform well in these zero-confinement systems, but that a period of adaptation is to be expected for overall farm performance. There are performance differences between the farms/systems which can be attributed to individual farm/system characteristics (e.g. pen design and management, staff expertise, pig genotypes, etc.). Higher parity sows and those producing very large litters provide a greater challenge to piglet mortality in these free farrowing systems (just as they do in crate systems). Management significantly influences performance, and ensuring sows have plenty of time to acclimatise between moving in to farrowing accommodation and giving birth is a critical aspect of improving piglet survival

Physical Pain and Participation in Organized Activities Among U.S. Adolescents

Chronic physical pain is a public health problem among adolescents in the United States. One important consideration for adolescent healthy development is participation in organized activities. Therefore, the study objective was to examine the associations between repeated or chronic physical pain and participation in organized activities overall and by activity type including sports, clubs, and other organized activities (e.g., dance) among U.S. adolescents. This secondary analysis utilized the 2018-2019 National Survey of Children’s Health (NSCH) combined two-year dataset, and included 24,680 adolescents ages 12-17 years. We conducted unadjusted and adjusted logistic regression analyses to examine the relationships between adolescent physical pain and participation in organized activities overall and by type (sports, clubs, other organized activities). Nearly 14% of adolescents had physical pain in the past 12-months. Unadjusted logistic regression model results indicated that adolescents with physical pain were less likely to participate in organized activities (odds ratio [OR] = 0.81, 95% confidence interval [CI] = 0.66, 0.99) compared to adolescents without physical pain. Concerning specific organized activity type, unadjusted (OR = 0.73, 95%CI = 0.61, 0.86) and adjusted (aOR = 0.83, 95%CI = 0.70, 0.99) model results indicated that adolescents with physical pain were less likely to participate in sports compared to adolescents without physical pain. The current study found that adolescents with physical pain had lower odds of overall participation in organized activities, and specifically sports, when compared to adolescents without physical pain. Findings should be considered when developing and implementing pain prevention and treatment programming for adolescents in school and community settings