Three Parent Babies : Techniques Explained, Objections Examined

The UK Parliament has approved regulations, which come into force in October 2015, that permit the use of new treatment techniques to prevent the transmission of serious mitochondrial diseases from women to their children. The introduction of these techniques—which are not currently carried out in any country in the world—will fly in the face of the opposition that has been raised since discussions to permit clinical applications of the techniques first arose. After outlining some background to the techniques, this article briefly examines three of the objections that have been made against them: that the safety and effectiveness of the procedures have yet to be proven; that the procedures would have an adverse socio-ethical impact; and that the procedures are prohibited in international law. None of these objections are as strong as they appear to have been suggested. Indeed, the UK Parliament’s approval of the regulations should be welcomed

Student Recital: Jonathan Carr, Clarinet

Jonathan Carr is a student of Patti Carlson. This recital is given in partial fulfillment of the requirements for the Master of Music, Music Education degree. Jonathan Carr, clarinet Rebecca Raydo, pian

Solution-focused brief therapy from the perspective of clients with long-term physical health conditions

As long-term physical health conditions are becoming increasingly prevalent in our society, interventions are needed to help individuals live as well as possible. The research explores participants' experiences of solution-focused brief therapy (SFBT) with a view to determining helpful aspects of this. Eleven service users were interviewed, and interviews were analysed using inductive thematic analysis. Participants' responsibility for change and the strengths and resources they possessed were highlighted, along with the focus within therapy on goals. A number of specific SFBT techniques that were perceived as helpful during therapy were described such as reframing, competence talk and reflectiveness, as well as other factors that enabled engagement with the psychologist

Gene therapy for obstetric conditions

The first clinical trials of gene therapy in the 1990s offered the promise of a new paradigm for the treatment of genetic diseases. Over the decades that followed the challenges and setbacks which gene therapy faced often overshadowed any successes. Despite this, recent years have seen cause for renewed optimism. In 2012 Glybera™, an adeno-associated viral vector expressing lipoprotein lipase, became the first gene therapy product to receive marketing authorisation in Europe, with a licence to treat familial lipoprotein lipase deficiency. This followed the earlier licensing in China of two gene therapies: Gendicine™ for head and neck squamous cell carcinoma and Oncorine™ for late-stage nasopharyngeal cancer. By this stage over 1800 clinical trials had been, or were being, conducted worldwide, and the therapeutic targets had expanded far beyond purely genetic disorders. So far no trials of gene therapy have been carried out in pregnancy, but an increasing understanding of the molecular mechanisms underlying obstetric diseases means that it is likely to have a role to play in the future. This review will discuss how gene therapy works, its potential application in obstetric conditions and the risks and limitations associated with its use in this setting. It will also address the ethical and regulatory issues that will be faced by any potential clinical trial of gene therapy during pregnancy

Alien Registration- Carr, A Rebecca (South Thomaston, Knox County)

https://digitalmaine.com/alien_docs/13161/thumbnail.jp

A study of mycorhizal associations in two species of Botrychium

The objectives of this study were to examine and describe the mycorhizae associated with Botrychium dissectum and Botrychium virginianum. The objectives also included trying to isolate the fungi associated with them and to analyze the association. Root sections were cleared and stained by placing them in a saturated solution of chloral hydrate and .01% acid funchsin. These sections were either boiled for fifteen minutes or allowed to stand in the solution for at least two days. Hand sections were mounted in glycerine. Examination of these sections showed fungi to be present in the younger roots of B. dissectum and in smaller amounts in all of the roots of B. virginianum. Infection occurred through the epidermis by aseptate, multinucleate hyphae which penetrated to the fourth cell layer of the cortex. Hyphenknauel (hyphal coils) were found in this area. Within the fifth and sixth cortical layers of both species were Pilzverdauungszellen (fungal digesting cells) and sporangioles. Vesicles were observed only in B. virginianum. Following the initial infecting, no hyphal connections to the epidermis were present. The infecting hyphae were irregular varying in diameter from 4 to 12 microns in B. dissectum and from 2.5 microns in B. virginianum. Swellings often occurred in hyphae where they passed through cell walls of the roots. In B. virginianum these swellings were often dark colored. Septations were seen in hyphae on the outside of the roots of B. virginianum. None were observed in the hyphae within the roots. Because of the size differences and habit of growth of fungi within the two ferns, it is proposed that different fungi infect them. Thin sections of roots were surface sterilized and placed upon Czapek's and malt extract media. Fungal isolates from these were compared to fungi seen within the roots. Since no reproductive structures were observed in the hyphae within the roots and all comparisons had to be made with somatic hyphae, identification of the fungi was not possible. Several methods of spore germination were tried. Since these were not successful and since no gametophytes were found, no studies of the reported endophytic fungi could be made.Rebecca A. CarrNot ListedNot ListedMaster of ArtsDepartment Not ListedCunningham Memorial Library, Terre Haute, Indiana State Universityisua-thesis-1965-carrMastersTitle from document title page. Document formatted into pages: contains 30 p.: ill. Includes appendix

“Posts are my own”: effects of social media disclaimers on perceptions of employees and their organizations from tweets and retweets

PURPOSE – This study empirically assesses the perceptions the public has of employees and their organization following a [re]tweet, and the additional potential ameliorating effect of a disclaimer distancing the organization from the individual employee’s social media presence. DESIGN/METHOD/APPROACH – A fully-crossed 2 (disclaimer v. no disclaimer) × 2 (positive v. negative valence post) × 2 (post v. retweet) experiment exposed participants (N = 173) to an employee’s personal tweet. Resultant perceptions of both the poster (i.e., goodwill) and the poster’s organization (i.e., organizational reputation) were analyzed using planned contrast analyses. FINDINGS – Findings reveal audiences form impressions of individuals based on both tweeted and retweeted content. Perceptions of both the poster’s goodwill and the poster’s organization were commensurate with the valence of the poster’s tweets, stronger when posts were original tweets rather than retweets, and there was a significant interaction effect between valence and [re]tweet. Disclaimers did not significantly affect perceptions, suggesting employers may be better-served by asking employees to omit reference to their employer on their personal social media accounts. ORIGINALITY/VALUE – This research contributes to understanding how employee and organizational reputations are affected by employees’ personal social media content. Results suggest even when a disclaimer explicitly seeks to distance the employee from the organization, audiences still see the employee as informal brand ambassadors of their organization

Exceptional retreat of Novaya Zemlya's marine-terminating outlet glaciers between 2000 and 2013

Novaya Zemlya (NVZ) has experienced rapid ice loss and accelerated marine-terminating glacier retreat during the past 2 decades. However, it is unknown whether this retreat is exceptional longer term and/or whether it has persisted since 2010. Investigating this is vital, as dynamic thinning may contribute substantially to ice loss from NVZ, but is not currently included in sea level rise predictions. Here, we use remotely sensed data to assess controls on NVZ glacier retreat between 1973/76 and 2015. Glaciers that terminate into lakes or the ocean receded 3.5 times faster than those that terminate on land. Between 2000 and 2013, retreat rates were significantly higher on marine-terminating outlet glaciers than during the previous 27 years, and we observe widespread slowdown in retreat, and even advance, between 2013 and 2015. There were some common patterns in the timing of glacier retreat, but the magnitude varied between individual glaciers. Rapid retreat between 2000 and 2013 corresponds to a period of significantly warmer air temperatures and reduced sea ice concentrations, and to changes in the North Atlantic Oscillation (NAO) and Atlantic Multidecadal Oscillation (AMO). We need to assess the impact of this accelerated retreat on dynamic ice losses from NVZ to accurately quantify its future sea level rise contribution