Cuadro de mandos para la producción hortícola en el poniente almeriense

RESUMEN: En el presente documento se exponen los pasos seguidos para la construcción de un cuadro de inteligencia de negocio con R y la librería Shiny. El cuadro de mandos contiene información relativa a productos hortícolas e información climática, de la región geográfica del poniente almeriense. Desde la herramienta, se podrán consultar de forma rápida datos que requieren de un cálculo previo. Vamos a describir todos los pasos, desde la extracción de datos de fuentes heterogéneas hasta el desarrollo de la solución sobre la plataforma R. La herramienta se encuentra desplegada en el entorno shinyapps y se puede acceder de forma pública. ABSTRACT: This document contains the steps followed to build a business intelligence chart with R and the Shiny library. The dashboard contains horticultural products and weather information from the western region of Almería. From the tool, data that requires a prior calculation can be quickly consulted. We are going to describe all the steps, starting with data extraction and ending with the development of the solution on the R platform. The tool is deployed in the shinyapps environment and can be publicly accessed

Real-World Clinical Outcomes and Adverse Events in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib: A Single-Center Retrospective Study

Background and Objectives: The treatment of chronic lymphocytic leukemia (CLL) has acquired new targeted therapies. In clinical trials, ibrutinib improved outcomes safely. Real-world data called for a reappraisal of ibrutinib strategies. We report on a single center’s experience with ibrutinib monotherapy, aiming to explore the outcomes, tolerability, and prognosis of CLL patients in routine clinical practice. Materials and Methods: Data were collected from all CLL patients treated with ibrutinib at Fundeni Clinical Institute, Bucharest, Romania, between January 2016 and June 2021. Results: A total of one hundred twenty-three CLL adult patients were treated with ibrutinib. Of the patients, 87% had relapsed/refractory CLL. The median age at ibrutinib initiation was 65 years; 44.7% of patients were staged Rai III/IV. At 32-month median follow-up, the median progression-free survival (PFS) was 50 months, the overall survival (OS) was not reached, and the overall response rate (ORR) was 86.2%. The age or number of previous therapies did not impact outcomes or tolerability. An Eastern Cooperative Oncology Group performance status (ECOG PS) score ≥ 2 and shorter time from initiation of last therapy (TILT) before ibrutinib predicted inferior PFS. Baseline characteristics had no impact on the OS except for TILT in R/R CLL patients. Drug-related adverse events (AEs) of any grade and grade ≥ 3 AEs were reported in 82.1% and 30.9% of the patients, respectively. Infections were the most common AEs (29.3%). Drug discontinuation was permanent in 43.9% of patients, mainly due to disease progression (17.1%) and toxicity (8.9%). Patients with a Cumulative Illness Rating Scale (CIRS) score ≥ 6 had a higher risk for toxicity-related discontinuation. An ECOG PS ≥ 2 predicted an increased rate of permanent discontinuation and grade ≥ 3 AEs. Conclusions: The outcomes of this study align with the results from ibrutinib clinical trials. Our study demonstrated that poor patient fitness, early relapse before ibrutinib, and permanent ibrutinib discontinuation are essential outcome determinants. Patient comorbidity burden and fitness were significant predictors for ibrutinib intolerance