5,657 research outputs found

    V. problem presentation and advice-giving on a home birth helpline

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    The rate of home births in the UK is very low (around 2%) and many women who would like to give birth at home find it impossible to get midwifery cover or are advised of medical contraindications. The Home Birth Helpline offers support and expertise for women in this situation. Based on the analysis of 80 recorded calls, this article uses conversation analysis (CA) to explore how callers present their reason for calling the helpline, and what this shows about the culturally shared medicalized culture of birth. This research is an example of feminist CA in that it contributes both to the study of childbirth as a key women's health issue and to the study of helpline interaction from a conversation analytic perspectiv

    Transduction of Non-Small Cell Lung Cancer Cells by Adenoviral and Retroviral Vectors

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    Gene transfer into a panel of non-small cell lung cancer (NSCLC) cells by adenoviral (Ad) and retroviral (RV) vectors was studied. Indexed to multiplicity of infection (MOI), Ad vectors transduce squamous, adenosquamous, and malignant mesothelioma cells with greater efficiency than large cells or adenocarcinoma cells. Transduction-sensitive cells bind the Ad vector with specificity for the Ad fiber knob, and internalize vector efficiently. Transduction-refractory cells bind and internalize vector by less efficient pathways. Like Ad vectors, there is heterogeneity in RV transduction efficiencies of different NSCLC subtypes. With respect to the most common cell type metastatic to the pleural space (adenocarcinoma), amphotropic retroviral vectors transduce cells of this subtype more efficiently (at a lower MOI) than Ad. RV transduction is not solely dependent on cellular replication, and both permissive and refractory cell lines express the mRNA for the amphotropic RV receptor. These observations suggest that neither Ad nor RV vectors will suffice a priori as the optimal gene transfer vehicle, and successful gene therapy of lung cancer may require tumor-specific or patient-specific vectors

    Habitat associations of juvenile Atlantic cod (Gadus morhua L.) and sympatric demersal fish communities within shallow inshore nursery grounds

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    Resolving the relationship between demersal fish and sublittoral biotic habitats and substrates is a key element in the protection of important nursery grounds for strengthening fish recruitment. In Norway, coastal Atlantic cod (Gadus morhua L.) is a commercially and culturally important demersal fish for Norwegian coastal communities, and in recent decades the stock has declined to such an extent that a plan to rebuild the stock to biologically safe limits has been implemented. Yet, little is known about the specific biotic and abiotic habitat associations of the early-life stages of coastal cod, which is important for the management and protection of the species. The same shallow, sublittoral zones are inhabited by juveniles and adults of other commercial demersal gadoids and wrasses. This study presents novel findings on associations between juvenile coastal cod and other demersal fish species with seafloor substrates and biological habitats, inferred from five years of extensive fyke net surveys. Newly settled 0-group cod were typically associated with eel grass and red algae biotic habitats on sand and shell sand substrates. However, there was an ontogenic habitat shift amongst one year old (1-group) individuals that became more ubiquitous with their biotic habitat or substrate type choices. The juvenile gadoids saithe (Pollachius virens) and pollack (Pollachius pollachius), were most associated with hard bottom dominated sites with saithe being more abundant at exposed sites, compared to pollack. Goldsinny wrasse (Ctenolabrus rupestris) and corkwing wrasse (Symphodus melops) appeared to favor sugar kelp forests and red algae. Overall, the study identifies the specific sublittoral biotic habitats and substrates important to different early life stages of juvenile coastal cod and other commercially important demersal fish, providing critical information needed for identifying candidate coastal habitats for protection.publishedVersio

    An Emerging Class of Bright, Fast-evolving Supernovae with Low-mass Ejecta

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    A recent analysis of supernova (SN) 2002bj revealed that it was an apparently unique type Ib SN. It showed a high peak luminosity, with absolute magnitude M_R -18.5, but an extremely fast-evolving light curve. It had a rise time of <7 days followed by a decline of 0.25 mag per day in B-band, and showed evidence for very low mass of ejecta (<0.15 M_Sun). Here we discuss two additional historical events, SN 1885A and SN 1939B, showing similarly fast light curves and low ejected masses. We discuss the low mass of ejecta inferred from our analysis of the SN 1885A remnant in M31, and present for the first time the spectrum of SN 1939B. The old environments of both SN 1885A (in the bulge of M31) and SN 1939B (in an elliptical galaxy with no traces of star formation activity), strongly support old white dwarf progenitors for these SNe. We find no clear evidence for helium in the spectrum of SN 1939B, as might be expected from a helium-shell detonation on a white dwarf, suggested to be the origin of SN 2002bj. Finally, the discovery of all the observed fast-evolving SNe in nearby galaxies suggests that the rate of these peculiar SNe is at least 1-2 % of all SNe.Comment: Additional analysis included. ApJ, in pres

    Navigating overgrazing and cultural values through narratives and participatory mapping : a socio-cultural analysis of sheep grazing in the Faroe Islands

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    Long-term livestock grazing has shaped landscapes, biodiversity, societies, cultures, and economies in the North Atlantic over time. However, overgrazing has become a major environmental sustainability challenge for this region, covering the Faroe Islands, Greenland, Iceland, Norway, and Scotland. The objective of this study was to elicit narratives and spatial patterns of local people's management preferences for sheep grazing in the Faroe Islands through a socio-cultural lens. We collected data via a Public Participation Geographic Information Systems (PPGIS) survey with an open question about hopes and concerns for sheep management in the Faroe Islands and a mapping exercise for expressing spatial preferences for sheep management. Four distinct narratives emerged from a qualitative analysis of responses to the open question (n = 184): (1) Sustainable sheep management, (2) Nature without sheep, (3) Sheep as part of Faroese culture, and (4) Sheep as nuisance. Visual inspection of narrative-specific maps with locations where either no or fewer sheep were preferred indicated that sheep management is not simply a 'sheep vs. no sheep' issue but embedded in a more nuanced consideration of the place of sheep in the landscape and society. For example, for some residents sheep-farming is not a commercial enterprise but a social activity and local source of food. Our combined methodological approach using qualitative and spatial data can help researchers in other fields identify the interplay between place-specific areas of grazing management concern and socio-cultural values, enabling more targeted land-use management policies or plans.Peer reviewe
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