Realistic Expanding Source Model for Invariant One-Particle Multiplicity Distributions and Two-Particle Correlations in Relativistic Heavy-Ion Collisions

We present a realistic expanding source model with nine parameters that are necessary and sufficient to describe the main physics occuring during hydrodynamical freezeout of the excited hadronic matter produced in relativistic heavy-ion collisions. As a first test of the model, we compare it to data from central Si + Au collisions at p_lab/A = 14.6 GeV/c measured in experiment E-802 at the AGS. An overall chi-square per degree of freedom of 1.055 is achieved for a fit to 1416 data points involving invariant pi^+, pi^-, K^+, and K^- one-particle multiplicity distributions and pi^+ and K^+ two-particle correlations. The 99-percent-confidence region of parameter space is identified, leading to one-dimensional error estimates on the nine fitted parameters and other calculated physical quantities. Three of the most important results are the freezeout temperature, longitudinal proper time, and baryon density along the symmetry axis. For these we find values of 92.9 +/- 4.4 MeV, 8.2 +/- 2.2 fm/c, and 0.0222 + 0.0096 / - 0.0069 fm^-3, respectively.Comment: 37 pages and 12 figures. RevTeX 3.0. Submitted to Physical Review C. Complete preprint, including device-independent (dvi), PostScript, and LaTeX versions of the text, plus PostScript files of all figures, are available at http://t2.lanl.gov/publications/publications.html or at ftp://t2.lanl.gov/publications/res

Urban Dispersion Program: Urban Measurements Applied to Emergency Response

Air motions in and around cities are highly complex, and the increasing threat of harmful releases into urban atmospheres makes advancing the state-of-science of understanding and modeling atmospheric flows and dispersion in and around cities essential. The four-year Urban Dispersion Program (UDP) funded primarily by the U.S. Department of Homeland Security and the Defense Threat Reduction Agency has recently been completed. The program’s primary focus was to conduct tracer and meteorological field studies in Manhattan to improve our understanding of flow and dispersion of airborne contaminants through and around the deep street canyons of New York City, including outdoor-indoor-subway exchange mechanisms. Additionally, urban dispersion models are being validated and first-responder guidance are being refined using data collected during the two UDP field studies. Pacific Northwest National Laboratory led several government laboratories, universities and private companies in conducting the two UDP field studies. The first study was a small-scale study that investigated dispersion in the immediate vicinity of the Madison Square Garden during March 2005 (MSG05), while the second UDP study was an extensive study conducted during August 2005 in Midtown Manhattan (MID05). A brief overview of the UDP field studies will be given followed by a discussion of some limitations of current urban models in simulating dispersion in urban areas. Some first-responder guidance based on findings from recent urban field studies will also be presented

Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P<0.001) and ETS (P=0.02) expression, decreased SPINK1 expression (P<0.001), and basal-like (P<0.001) molecular subtypes. After adjusting for confounders, the AAM group was associated with higher expression of CRYBB2, GSTM3, and inflammation genes (IL33, IFNG, CCL4, CD3, ICOSLG), and lower expression of mismatch repair genes (MSH2, MSH6) (p<0.001 for all). At the pathway level, the AAM group had higher expression of genes sets related to the immune response, apoptosis, hypoxia, and reactive oxygen species. EAM group was associated with higher levels of fatty acid metabolism, DNA repair, and WNT/beta-catenin signaling. Based on cell lines data, AAM were predicted to have higher potential response to DNA damage. In conclusion, biological characteristics of prostate tumor were substantially different in AAM when compared to EAM. Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men

Expression and function of G-protein-coupled receptorsin the male reproductive tract

This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects on male fertility. Furthermore, the activation of mAChRs induces transactivation of the epidermal growth factor receptor (EGFR) and the Sertoli cell proliferation. The relaxin receptors are present in the testis, RXFP1 in elongated spermatids and Sertoli cells from rat, and RXFP2 in Leydig and germ cells from rat and human, suggesting a role for these receptors in the spermatogenic process. The localization of both receptors in the apical portion of epithelial cells and smooth muscle layers of the vas deferens suggests an involvement of these receptors in the contraction and regulation of secretion.Esta revisão enfatiza a expressão e a função dos receptores muscarínicos, adrenoceptores α1 e receptores para relaxina no sistema reprodutor masculino. A expressão dos receptores muscarínicos e adrenoceptores α1 em compartimentos específicos de dúctulos eferentes, epidídimo, ductos deferentes, vesícula seminal e próstata de várias espécies indica o envolvimento destes receptores na modulação da composição do fluido luminal e na contração do músculo liso, incluindo efeitos na fertilidade masculina. Além disso, a ativação dos receptores muscarínicos leva à transativação do receptor para o fator crescimento epidermal e proliferação das células de Sertoli. Os receptores para relaxina estão presentes no testículo, RXFP1 nas espermátides alongadas e células de Sertoli de rato e RXFP2 nas células de Leydig e germinativas de ratos e humano, sugerindo o envolvimento destes receptores no processo espermatogênico. A localização de ambos os receptores na porção apical das células epiteliais e no músculo liso dos ductos deferentes de rato sugere um papel na contração e na regulação da secreção.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FarmacologiaUNIFESP, EPM, Depto. de FarmacologiaSciEL