AN ECONOMIC ANALYSIS OF PASTURE-RAISED BEEF SYSTEMS IN APPALACHIA

Cow-calf operations are important enterprises for family farmers in Appalachia and provide significant opportunity for supplemental income. This analysis constitutes a thorough economic assessment of pasture-raised beef production, an alternative to traditional production that could benefit the region's producers in terms of profitability and mitigated risk. Stochastic budgeting was utilized for profitability and risk comparison between traditional and pasture-raised operations and accounted for seasonal variability in prices, pasture availability and animal performance. Pasture-raised systems, in relation to traditional ones, were shown to consistently yield higher returns over variable costs and were shown less likely to yield losses over total costs in typical production seasons. Economic risk for pasture-raised producers stems largely from production factors but, overall, is seemingly less pronounced than the market risk faced by traditional producers selling live cattle.Farm Management,

Deer Use of Riparian Zones and Adjacent Pine Plantations in Texas

The authors monitored white-tailed deer (Odocoileus virginianus) use of riparian zones (RZ’s) and adjacent pine plantations of 3 age classes (young, 1 to 3 years old; intermediate, 5 to 7 years old; and older, 9 to 13 years old) using radio telemetry for 2 years on a 1,300 ha study area near Alto, TX. Riparian zones comprised 22.0 percent of the area; young, intermediate, and older pine plantations comprised 19.1 percent, 45.7 percent, and 13.2 percent, respectively. Based on data from 4 to 9 deer the first year and 12 to 17 deer the second year, home ranges averaged 103, 71, 95, and 114 ha during spring, summer, fall, and winter, respectively, and were composed primarily of intermediate-age plantations and RZ’s. Deer showed significant preferences for intermediate-age pine plantations during all seasons and for RZ’s during fall and winter. Older plantations produced little forage due to canopy closure, and were generally avoided throughout the year. Young plantations, which provided the most forage but the least cover, received relatively light yearlong use and were a minor component of deer home ranges. For females and young males, this study demonstrates that, where available, RZ’s may comprise an important component of deer home ranges in intensively managed forests

The Production of Propionic Acid from Pentoses by Propionibacterium pentosaceum

Propionibacterium pentosaceum attacks pentoses (xylose, arabinose) with the production of propionic and acetic acids

An analysis of a long-lived MCV observed over the Southern Plains using Potential Vorticity diagnostics.

On the morning of 28 May 1998, a mesoscale convectively-generated vortex (MCV) was observed over the Southern Plains. This MCV was evident in the GOES-8 visual satellite imagery resulting in a spectacular picture. An analysis of this event is offered using many data sources, including products available now via the world-wide-web (WWW), the National Center for Environmental Prediction (NCEP) re-analyses, and Eta model initializations. This MCV developed out of a mesoscale convective system (MCS) that existed during 26 and 27 May over Texas. This MCV was associated with reports of severe weather and heavy precipitation over southern Arkansas. While the MCV is shown to have characteristics similar to other MCV events documented, this event is unique in that it maintained it's character, while propagating further east than other events. A dynamical analysis using potential vorticity diagnostics (PV) shows that the mid-latitude vorticity field strengthened at least partially as a result of diabatic heating. Also, the most severe weather was associated with high values of integrated 500 - 300 hPa PV values over the Southern Plains

LPS from P. gingivalis

Objective. Oral inflammatory pathologies are linked to increased oxidative stress, thereby partly explaining their relevance in the etiology of systemic disorders. The purpose of this work was to determine the degree to which LPS from Porphyromonas gingivalis, the primary pathogen related to oral inflammation, altered gingival mitochondrial function and reactive oxygen species generation. Methods. Human gingival fibroblast (HGF-1) cells were treated with lipopolysaccharide of P. gingivalis. Mitochondrial function was determined via high-resolution respirometry. Results. LPS-treated HGF-1 cells had significantly higher mitochondrial complex IV and higher rates of mitochondrial respiration. However, this failed to translate into greater ATP production, as ATP production was paradoxically diminished with LPS treatment. Nevertheless, production of the reactive H2O2 was elevated with LPS treatment. Conclusions. LPS elicits an increase in gingival cell mitochondria content, with a subsequent increase in reactive oxygen species production (i.e., H2O2), despite a paradoxical reduction in ATP generation. These findings provide an insight into the nature of oxidative stress in oral inflammatory pathologies

Hypoglycemia in Type 1 Diabetic Pregnancy: Role of preconception insulin aspart treatment in a randomized study

Objective: A recent randomized trial compared prandial insulin aspart (IAsp) with human insulin in type 1 diabetic pregnancy. The aim of this exploratory analysis was to investigate the incidence of severe hypoglycemia during pregnancy and compare women enrolled preconception with women enrolled during early pregnancy. Research design and methods: IAsp administered immediately before each meal was compared with human insulin administered 30 min before each meal in 99 subjects (44 to IAsp and 55 to human insulin) randomly assigned preconception and in 223 subjects (113 for IAsp and 110 for human insulin) randomly assigned in early pregnancy (<10 weeks). NPH insulin was the basal insulin. Severe hypoglycemia (requiring third-party assistance) was recorded prospectively preconception (where possible), during pregnancy, and postpartum. Relative risk (RR) of severe hypoglycemia was evaluated with a gamma frailty model. Results: Of the patients, 23% experienced severe hypoglycemia during pregnancy with the peak incidence in early pregnancy. In the first half of pregnancy, the RR of severe hypoglycemia in women randomly assigned in early pregnancy/preconception was 1.70 (95% CI 0.91–3.18, P = 0.097); the RR in the second half of pregnancy was 1.35 (0.38–4.77, P = 0.640). In women randomly assigned preconception, severe hypoglycemia rates occurring before and during the first and second halves of pregnancy and postpartum for IAsp versus human insulin were 0.9 versus 2.4, 0.9 versus 2.4, 0.3 versus 1.2, and 0.2 versus 2.2 episodes per patient per year, respectively (NS). Conclusions: These data suggest that initiation of insulin analog treatment preconception rather than during early pregnancy may result in a lower risk of severe hypoglycemia in women with type 1 diabetes

Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent

Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaffold, and have found that many of the compounds exert potent cytotoxic activity against human cancer cell lines. One of the most potent compounds, BA-TPQ [(11,12),7-(benzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one], was active against a variety of human cancer cell lines, and inhibited the growth of breast and prostate xenograft tumors in mice. However, there was some toxicity noted in the mice following administration of the compound. In order to further the development of BA-TPQ, and in a search for potential sites of accumulation that might underlie the observed toxicity of the compound, we accomplished preclinical pharmacological studies of the compound. We herein report the in vitro and in vivo pharmacological properties of BA-TPQ, including its stability in plasma, plasma protein binding, metabolism by S9 enzymes, and plasma and tissue distribution. We believe these studies will be useful for further investigations, and may be useful for other investigators examining the use of similar compounds for cancer therapy

Does the risk of cerebral palsy increase or decrease with increasing gestational age?

BACKGROUND: It is generally accepted that the risk of cerebral palsy decreases with increasing gestational age of live born infants. However, recent studies have shown that cerebral palsy often has prenatal antecedents including congenital malformations, vascular insults and maternal infection. Cerebral palsy is therefore better viewed as occurring among fetuses, rather than among infants. We explored the epidemiologic implications of this change in perspective. METHODS: We used recently published data from Shiga Prefecture, Japan and from North-East England to examine the pattern of gestational age-specific rates of cerebral palsy under these alternative perspectives. We first calculated gestational age-specific rates of cerebral palsy as per convention, by dividing the number of cases of cerebral palsy identified among live births within any gestational age category by the number of live births in that gestational age category. Under the alternative formulation, we calculated gestational age-specific rates of cerebral palsy by dividing the number of cases of cerebral palsy identified among live births within any gestational age category by the number of fetuses who were at risk of being born at that gestation and being afflicted with cerebral palsy. RESULTS: Under the conventional formulation, cerebral palsy rates decreased with increasing gestational age from 63.9 per 1,000 live births at <28 weeks gestation to 0.9 per 1,000 live births at 37 or more weeks gestation. When fetuses were viewed as potential candidates for cerebral palsy, cerebral palsy rates increased with increasing gestational age from 0.08 per 1,000 fetuses at risk at <28 weeks gestation to 0.9 per 1,000 fetuses at risk at 37 or more weeks gestation. CONCLUSIONS: The fetuses-at-risk approach is the appropriate epidemiologic formulation for calculating the gestational age-specific rate of cerebral palsy from a causal perspective. It shows that the risk of cerebral palsy increases as gestational duration increases. This compelling view of cerebral palsy risk may help refocus research aimed at understanding and preventing cerebral palsy

Direct ionization and electron capture in M

This article discusses direct ionization and electron capture in M-shell x-ray production by fluorine ions