1,065 research outputs found
Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype.
It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome. In particular, individuals with a Cys634-Arg substitution should have a greater risk of developing parathyroid disease. We, therefore, analyzed 94 unrelated families from Germany with inherited medullary thyroid carcinoma (MTC) for mutation of the ret protooncogene. In all but 1 of 59 families with MEN 2A, germline mutations in the extracellular domain of the ret protein were found. Some 81% of the MEN 2A mutations affected codon 634. Phenotype-genotype correlations suggested that the prevalence of pheochromocytoma and hyperparathyroidism is significantly higher in families with codon 634 mutations, but there was no correlation with the nature of the mutation. In all but 1 of 27 familial MTC (FMTC) families, mutations were detected in 1 of 4 cysteines in the extracellular domain of the ret protooncogene. Half of the FMTC mutations affected codon 634. Mutations outside of codon 634 occurred more often in FMTC families than in MEN 2A families. In all but 1 of 8 MEN 2B patients, de novo mutations in codon 918 were found. These data confirm the preferential localization of MEN 2-associated mutations and the correlation between disease phenotype and the position of the ret mutation, but there was no correlation between the occurrence of hyperparathyroidism or pheochromocytoma and the nature of the mutation
Electronic Structure of Transition Metals Fe, Ni and Cu in the GW Approximation
The quasiparticle band structures of 3d transition metals, ferromagnetic Fe,
Ni and paramagnetic Cu, are calculated by the GW approximation. The width of
occupied 3d valence band, which is overestimated in the LSDA, is in good
agreement with experimental observation. However the exchange splitting and
satellite in spectra are not reproduced and it is required to go beyond the GW
approximation. The effects of static screening and dynamical correlation are
discussed in detail in comparison with the results of the static COHSEX
approximation. The dynamical screening effects are important for band width
narrowing.Comment: 4 pages, 3 figure
Dark matter powered stars: Constraints from the extragalactic background light
The existence of predominantly cold non-baryonic dark matter is unambiguously
demonstrated by several observations (e.g., structure formation, big bang
nucleosynthesis, gravitational lensing, and rotational curves of spiral
galaxies). A candidate well motivated by particle physics is a weakly
interacting massive particle (WIMP). Self-annihilating WIMPs would affect the
stellar evolution especially in the early universe. Stars powered by
self-annihilating WIMP dark matter should possess different properties compared
with standard stars. While a direct detection of such dark matter powered stars
seems very challenging, their cumulative emission might leave an imprint in the
diffuse metagalactic radiation fields, in particular in the mid-infrared part
of the electromagnetic spectrum. In this work the possible contributions of
dark matter powered stars (dark stars; DSs) to the extragalactic background
light (EBL) are calculated. It is shown that existing data and limits of the
EBL intensity can already be used to rule out some DS parameter sets.Comment: Accepted for publication in ApJ; 7 pages, 5 figure
Probing the origin of VHE emission from M 87 with MWL observations in 2010
The large majority of extragalactic very high energy (VHE; E>100 GeV) sources
belongs to the class of active galactic nuclei (AGN), in particular the BL Lac
sub-class. AGNs are characterized by an extremely bright and compact emission
region, powered by a super-massive black hole (SMBH) and an accretion disk, and
relativistic outflows (jets) detected all across the electro-magnetic spectrum.
In BL Lac sources the jet axis is oriented close to the line of sight, giving
rise to a relativistic boosting of the emission. In radio galaxies, on the
other hand, the jet makes a larger angle to the line of sight allowing to
resolve the central core and the jet in great details. The giant radio galaxy M
87 with its proximity (1 6Mpc) and its very massive black hole ((3-6) x 10^9
M_solar) provides a unique laboratory to investigate VHE emission in such
objects and thereby probe particle acceleration to relativistic energies near
SMBH and in jets. M 87 has been established as a VHE emitter since 2005. The
VHE emission displays strong variability on time-scales as short as a day. It
has been subject of a large joint VHE and multi-wavelength (MWL) monitoring
campaign in 2008, where a rise in the 43 GHz VLBA radio emission of the
innermost region (core) was found to coincide with a flaring activity at VHE.
This had been interpreted as a strong indication that the VHE emission is
produced in the direct vicinity of the SMBH black hole. In 2010 again a flare
at VHE was detected triggering further MWL observations with the VLBA, Chandra,
and other instruments. At the same time M 87 was also observed with the
Fermi-LAT telescope at GeV energies and the European VLBI Network (EVN). In
this contribution preliminary results from the campaign will be presented.Comment: 5 pages, 2 figures, in the proceedings of the "International Workshop
on Beamed and Unbeamed Gamma-Rays from Galaxies" 11-15 April 2011, Lapland
Hotel Olos, Muonio, Finland, Journal of Physics: Conference Series Volume
355, 201
Discovery of VHE gamma-rays from Centaurus A
We report the discovery of faint very high energy (VHE, E > 100 GeV)
gamma-ray emission from the radio galaxy Centaurus A in deep observations
performed with the H.E.S.S. experiment. A signal with a statistical
significance of 5.0 sigma is detected from the region including the radio core
and the inner kpc jets. The integral flux above an energy threshold of ~250 GeV
is measured to be 0.8% of the flux of the Crab Nebula and the spectrum can be
described by a power law with a photon index of 2.7 +/- 0.5_stat +/- 0.2_sys.
No significant flux variability is detected in the data set. The discovery of
VHE gamma-ray emission from Centaurus A reveals particle acceleration in the
source to >TeV energies and, together with M 87, establishes radio galaxies as
a class of VHE emitters.Comment: 4 pages, 3 figures, submitted as proceeding to the 44th Recontre de
Moriond "Very High Energy Phenomena in the Universe", contains an updated SED
including the recent Fermi dat
Proton G_E/G_M from beam-target asymmetry
The ratio of the proton's electric to magnetic form factor, G_E/G_M, can be
extracted in elastic electron-proton scattering by measuring either cross
sections, beam-target asymmetry or recoil polarization. Separate determinations
of G_E/G_M by cross sections and recoil polarization observables disagree for
Q^2 > 1 (GeV/c)^2. Measurement by a third technique might uncover an unknown
systematic error in either of the previous measurements. The beam-target
asymmetry has been measured for elastic electron-proton scattering at Q^2 =
1.51 (GeV/c)^2 for target spin orientation aligned perpendicular to the beam
momentum direction. This is the largest Q^2 at which G_E/G_M has been
determined by a beam-target asymmetry experiment. The result, \muG_E/G_M =
0.884 +/- 0.027 +/- 0.029, is compared to previous world data.Comment: 8 pages, 6 figures, Updated to be version published in Physical
Review
A comparison of forward and backward pp pair knockout in 3He(e,e'pp)n
Measuring nucleon-nucleon Short Range Correlations (SRC) has been a goal of
the nuclear physics community for many years. They are an important part of the
nuclear wavefunction, accounting for almost all of the high-momentum strength.
They are closely related to the EMC effect. While their overall probability has
been measured, measuring their momentum distributions is more difficult. In
order to determine the best configuration for studying SRC momentum
distributions, we measured the He reaction, looking at events
with high momentum protons ( GeV/c) and a low momentum neutron
( GeV/c). We examined two angular configurations: either both protons
emitted forward or one proton emitted forward and one backward (with respect to
the momentum transfer, ). The measured relative momentum distribution
of the events with one forward and one backward proton was much closer to the
calculated initial-state relative momentum distribution, indicating that
this is the preferred configuration for measuring SRC.Comment: 8 pages, 9 figures, submitted to Phys Rev C. Version 2 incorporates
minor corrections in response to referee comment
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