Adaptive Filtering for Large Space Structures: A Closed-Form Solution

In a previous paper Schaechter proposes using an extended Kalman filter to estimate adaptively the (slowly varying) frequencies and damping ratios of a large space structure. The time varying gains for estimating the frequencies and damping ratios can be determined in closed form so it is not necessary to integrate the matrix Riccati equations. After certain approximations, the time varying adaptive gain can be written as the product of a constant matrix times a matrix derived from the components of the estimated state vector. This is an important savings of computer resources and allows the adaptive filter to be implemented with approximately the same effort as the nonadaptive filter. The success of this new approach for adaptive filtering was demonstrated using synthetic data from a two mode system

Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701–negative recipients

Design of a Scalable Modular Production System for a Two-stage Food Service Franchise System

The geographically distributed production of fresh food poses unique challenges to the production system design because of their stringent industry and logistics requirements. The purpose of this research is to examine the case of a European fresh food manufacturer’s approach to introduce a scalable modular production concept for an international two‐stage gastronomy franchise system in order to identify best practice guidelines and to derive a framework for the design of distributed production systems that perform in a highly dynamic environment. The design framework was developed by creating a theoretical model through literature review and the thorough analysis of an industrial case. Information was collected through multiple site visits, workshops and semi‐structured interviews with the company’s key staff of the project, as well as examination of relevant company documentations. By means of a scenario for the Central European market, the model was reviewed in terms of its development potential and finally approved for implementation. However, research through case survey requires further empirical investigation to fully establish this approach as a valid and reliable design tool

Seasonality in the alpine water logistic system on a regional basis

International audienceIn this study the water logistic system is defined as the interaction of the subsystems water resources, water supply and water demand in terms of water flow. The analysis of a water balance in alpine regions is strongly influenced by both temporal and spatial seasonal fluctuations within these elements, the latter due to the vertical dimension of mountainous areas. Therefore the determination of different seasons plays a key role within the assessment of alpine water logistic systems. In most studies a water balance for a certain region is generated on an annual, monthly or classic 4-seasonal basis. This paper presents a GIS-based multi criteria method to determine an optimal winter and summer period, taking into account different water demand stakeholders, alpine hydrology and the characteristic present day water supply infrastructure of the Alps. Technical snow-making and (winter) tourism were identified as the two major seasonal water demand stakeholders in the study area, which is the Kitzbueheler region in the Austrian Alps. Based upon the geographical datasets mean snow cover start and end date, winter was defined as the period from December to March, and summer as the period from April to November

EC 11481-2303 - A Peculiar Subdwarf OB Star Revisited

EC 11481-2303 is a peculiar, hot, high-gravity pre-white dwarf. Previous optical spectroscopy revealed that it is a sdOB star with an effective temperature (Teff) of 41790 K, a surface gravity log(g)= 5.84, and He/H = 0.014 by number. We present an on-going spectral analysis by means of non-LTE model-atmosphere techniques based on high-resolution, high-S/N optical (VLT-UVES) and ultraviolet (FUSE, IUE) observations. We are able to reproduce the optical and UV observations simultaneously with a chemically homogeneous NLTE model atmosphere with a significantly higher effective temperature and lower He abundance (Teff = 55000 K, log (g) = 5.8, and He / H = 0.0025 by number). While C, N, and O appear less than 0.15 times solar, the iron-group abundance is strongly enhanced by at least a factor of ten.Comment: 8 pages, 11 figure

Superlattice with hot electron injection: an approach to a Bloch oscillator

A semiconductor superlattice with hot electron injection into the miniband is considered. The injection changes the stationary distribution function and results in a qualitative change of the frequency behaviour of the differential conductivity. In the regime with Bloch oscillating electrons and injection into the upper part of the miniband the region of negative differential conductivity is shifted from low frequencies to higher frequencies. We find that the dc differential conductivity can be made positive and thus the domain instability can be suppressed. At the same time the high-frequency differential conductivity is negative above the Bloch frequency. This opens a new way to make a Bloch oscillator operating at THz frequencies.Comment: RevTeX, 8 pages, 2 figures, to be published in Phys. Rev. B, 15 Januar 200

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.

NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity. NAIPs (NLR family, apoptosis inhibitory proteins) are NLRs that appear to function as cytosolic immunoreceptors for specific bacterial proteins, including flagellin and the inner rod and needle proteins of bacterial type III secretion systems (T3SSs). Despite strong biochemical evidence implicating NAIPs in specific detection of bacterial ligands, genetic evidence has been lacking. Here we report the use of CRISPR/Cas9 to generate Naip1(-/-) and Naip2(-/-) mice, as well as Naip1-6(Δ/Δ) mice lacking all functional Naip genes. By challenging Naip1(-/-) or Naip2(-/-) mice with specific bacterial ligands in vivo, we demonstrate that Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin. Previously generated Naip5(-/-) mice retain some residual responsiveness to flagellin in vivo, whereas Naip1-6(Δ/Δ) mice fail to respond to cytosolic flagellin, consistent with previous biochemical data implicating NAIP6 in flagellin detection. Our results provide genetic evidence that specific NAIP proteins function to detect specific bacterial proteins in vivo

Prospective Genetic Screening Decreases the Incidence of Abacavir Hypersensitivity Reactions in the Western Australian HIV Cohort Study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipient

Quasi-point separation of variables for the Henon-Heiles system and a system with quartic potential

We examine the problem of integrability of two-dimensional Hamiltonian systems by means of separation of variables. The systematic approach to construction of the special non-pure coordinate separation of variables for certain natural two-dimensional Hamiltonians is presented. The relations with SUSY quantum mechanics are discussed.Comment: 11 pages, Late