Micro RNA facilitated chemoresistance in gastric cancer: a novel biomarkers and potential therapeutics

Introduction: In spite of the substantial advances in clinical practice, Gastric cancer (GC) remains the third leading cause of cancer death worldwide. The incidence of drug resistance remains a hindrance to effective treatment for GC. Although the molecular mechanisms of chemoresistance have broadly studied, the gene regulation and expression mechanisms of miRNA have not entirely understood. Methods: Online databases of PubMed, Scopus, Google Scholar, and Embase databases were searched to retrieve relevant publications. The following keywords were used: MicroRNA, Noncoding RNA, miRNA, Gastric cancer, drug resistance, and chemoresistance. Results: miRNAs play a pivotal role in the initiation, progression of tumor and metastasis, as well as in the development of pathways mediating resistance to chemotherapy in GC. Unluckily, to date, there is no consistent, reliable biomarker available to predict the response of chemotherapy before the start of the treatment. Discussion: In this review, we would like to provide an overview of the miRNAs and miRNA facilitated chemoresistance machinery in GC to develop a personalized treatment to overcome GC drug resistance

Palaeomagnetic, geochronological and geochemical study of Mesoproterozoic Lakhna Dykes in the Bastar Craton, India: Implications for the Mesoproterozoic supercontinent

Palaeomagnetic analysis of the Lakhna Dykes (Bastar Craton, India) yields a palaeopole at 36.6°N, 132.8°E, dp=12.4°, dm=15.9°, and the U--Pb zircon age obtained from one of the rhyolitic dykes is 1466.4±2.6 Ma (MSWD=0.21, concordia age based on two analyses with identical Pb--U ages), similar to previously published U\Pb ages. Major and trace element analyses of the Lakhna Dykes show shoshonitic and high-K calc-alkaline affinities consistent with a subduction related characteristics suggesting an active continental margin setting. This is in keeping with the Palaeo- to Mesoproterozoic tectonic environments in the eastern Indian margin. The new 1460 Ma Indian palaeopole was used to test possible palaeopositions of India within the Mesoproterozoic supercontinent Columbia. Of the four palaeomagnetically permissible reconstructions, juxtaposing western India against south-west Baltica is geologically the most reliably constrained and best fitting model. Our preferred reconstruction implies a long Palaeo- to Mesoproterozoic accretionary orogen stretching from south-eastern Laurentia through south-western Baltica to south-eastern India. Breakup of India and Baltica probably occurred in the Late Mesoproterozoic, but additional constraints are needed

Study of the Salem-Attur shear zone, east of Salem, Tamil Nadu: a new kinematic interpretation

A study of the mylonites of the Salem-Attur shear zone at Udayapatti and Sarkar Nattar Mangalam reveals that the shear zone developed in the form of a northeasterly vergent subhorizontal thrust which has been refolded into variable attitude due to late stage folding. The subhorizontal mylonitic foliation with NE trending stretching lineation bears testimony to such an explanation. The earlier impression that the shear zone is vertical comes from the folded part of the thrust as the mylonites have assumed a vertical attitude on the limb of the fold

A Study of Mylonites from parts of the Salem-Attur Shear Zone (Tamil Nadu) and its Tectonic Implications

The E-W running Salem-Attur shear zone demarcates the tectonic boundary between Archaean Dharwar Craton in the north and Proterozoic Southern granulite terrane in the south. This study reveals that the shear zone is a low angle thrust. The thrust zone is around 10 m thick and it merges with the main shear zone along the strike. The thrust is developed on charnockite near Odyarpatti, which is retrograded into schists. Further, it is marked by gently dipping mylonitic foliation and subhorizontal lineation. The S-C fabric, mantled porphyroclasts and intragranular faults indicate northeasterly slip along the thrust. Recumbent shear folds SF 1 are developed within the thrust zone. The thrust has been folded by late stage F 2 fold which has brought variation in the orientation of the mylonitic foliation from subhorizontal to vertical attitude; the mylonitic lineations have been rotated to subvertical orientation also. Additionally, the F 2 crenulations and shear cleavages and intersection lineations are superimposed on the mylonitic fabric. Thrusting along the Salem-Attur shear zone is probably the cause for upliftment of the charnockites to the upper crust. Post-upliftment stage has witnessed brittle deformation in the form of development of shear fractures in NNE-SSW and E-W directions. Pseudotachylites are emplaced along these fractures

SHRIMP geochronology for the 1450 Ma Lakhna dyke swarm: Its implication for the presence of Eoarchaean crust in the Bastar Craton and 1450-517 Ma depositional age for Purana basin (Khariar), Eastern Indian Peninsula - Reply

The paper is a reply on the comments by Basu and Bickford on the article Ratre et al., 2010, JAES 39, 565-577, that reports an age range of 1450-517 Ma for the Khariar basin (Purana) in India. Basu and Bickford agree with the lower age of the basin but they argue for ca 1000 Ma as the upper age. Though our inference about the upper age at 517 Ma is based on structural studies, we still maintain that. (C) 2011 Elsevier Ltd. All rights reserved

Association of TP53 gene codon 72 polymorphism with incidence of cervical cancer in Chhattisgarh

580-585TP53 gene encoding polymorphisms is a risk allele in terms of carcinogenesis. Here, we studied the risk assessment and association of TP53 to understand the cancer biology and behaviour in cervical cancer patients and possible anticancer drug development interfering with p53 protein production. TP53 gene encodes a central protein of apoptosis pathway p53 and its allelic variant has been postulated to play a vital role in carcinogenesis in addition to a variety of neurodegenerative disorders. We undertook a case control study, to examine the possible association of TP53 gene codon 72 polymorphism in leukocyte DNA from a total of 200 subjects (100 controls and 100 cases). TP53 codon Arg72Pro (rs1042522) genotype was identified using allele specific PCR and RFLP with statistical analysis using Vassar Stats (online). In Chhattisgarh population, individuals with GC and GG genotypes of TP53 gene codon 72 polymorphism has a significantly higher risk of cervical cancer (OR=6.36, 95%CI=2.8-14.03 and OR=7.42, 95%CI=3.5-15.9) as compared to CC genotype (OR=1) which was taken as reference. The 'G' allele was found to confer a significant risk of cervical cancer (OR= 3.69, 95%CI= 2.40-5.5) compared to 'C' allele. The present case control study demonstrated the prevalence of the Arg/Arg (GG) genotype in women with cervical cancer among Chhattisgarh population

Erythrocyte microRNAs: a tiny magic bullet with great potential for sickle cell disease therapy

Sickle cell disease (SCD) is a severe hereditary blood disorder caused by a mutation of the beta-globin gene, which results in a substantial reduction in life expectancy. Many studies are focused on various novel therapeutic strategies that include re-activation of the γ-globin gene. Among them, expression therapy caused by the fetal hemoglobin (HbF) at a later age is highly successful. The induction of HbF is one of the dominant genetic modulators of the hematological and clinical characteristics of SCD. In fact, HbF compensates for the abnormal beta chain and has an ameliorant effect on clinical complications. Erythropoiesis is a multi-step process that involves the proliferation and differentiation of a small population of hematopoietic stem cells and is affected by several factors, including signaling pathways, transcription factors, and small non-coding RNAs (miRNAs). miRNAs play a regulatory role through complex networks that control several epigenetic mechanisms as well as the post-transcriptional regulation of multiple genes. In this review, we briefly describe the current understanding of interactions between miRNAs, their molecular targets, and their regulatory effects in HbF induction in SCD

Impact of Different Irrigation Techniques on Wheat Crop Micro-climate

Aim of this experiment is to study the impact of irrigation techniques on microclimate of wheat crop in terms of temperature and humidity. Randomized block design is used on the wheat crop (Triticum aestivum L.) variety Karan Narendra (DBW 222) at research farm of ICAR-CSSRI, Karnal during the Rabi 2021-22. In conventional practice treatment, higher temperature fluctuation was observed and was 0.5-1°C cooler as compared to other plots. Drip irrigation treatment showed most stable crop microclimate in terms of canopy temperature and humidity dynamics. A sharp rise in temperature at maturity cause dryness in crop and leads to lower productivity. Except at physiological maturity, canopy was cooler than the ambient air, while relative humidity was higher both during morning and evening hour

Clinical and Epidemiological profile of Anemia in central India

Background: The present, hospital based prevalence study has been conducted to assess the clinical and epidemiological profile of anemia in central India. Methods: In this study 200 patients of anemia from medical out patients department and indoor wards, age between 15-70 years, randomly selected without any bias for sex, occupation, socio-economic status and duration of disease. Results: This study shows that maximum number of patients (40%) were from age group 21-30 years. Between 15-30 years age group, prevalence of anemia was more in females than males. 57% study population have moderate anemia and 41% patients have severe anemia. Weakness & easy fatigability were most common (100%) presenting symptoms and pallor was most common (98% patients) clinical sign. Microcytic and hypochromic type peripheral smear was most common laboratory findings (59% cases). Nutritional anemia was the most common type of anemia (84%). Conclusions: Nutritional deficiency anemia is the most common cause of anemia among population, and iron deficiency is the most common nutritional deficiency in population

Evaluation and Comparison of Oral & Periodontal Health Status in Post-menopausal Females with and Without Xerostomia: an Observational Study

Background & Objective - Menopause is the permanent cessation of menstrual periods, whether occurs naturally or induced by surgery, chemotherapy, or radiation. It is accompanied by hormonal changes, predominantly decrease in estrogen and androgen levels. Females experience varying oral symptoms that may result from endocrine disturbances, multiple vitamin and mineral deficiencies and psychological dynamics during their menopausal years. Main oral symptoms associated during menopause include xerostomia, burning mouth and altered taste perception. Xerostomia leads to change in salivary pH thereby increasing the risk for oral diseases including periodontal diseases. Saliva contributes to maintenance of the oral pH by neutralizing acids from food and beverages, as well as from bacterial activity, thereby reducing the risk of periodontal disease. After menopause, reduced salivary flow rate and low pH may make females prone to oral health problems. Hence, the main goal of this study is toevaluate and compare the periodontal health status in post-menopausal females with and without xerostomia. Methodology-A total of 204 post-menopausal have been observed and their oral & periodontal status data was analyzed & interpreted.Result & Conclusion- Post-menopausal females with xerostomia were observed to have poor oral hygiene and severe periodontitis in comparison to non- xerostomia group.&nbsp