ABSORPTION CORRECTION METHOD FOR THE SIMULTANEOUS ESTIMATION OF N-ACETYL-L-CYSTEINE AND AMBROXOL HYDROCHLORIDE IN BULK AND IN COMBINED TABLET DOSAGE FORM

Objective: The objective of this research was to estimate the concentrations of N-Acetyl-L-cysteine (NAC) and Ambroxol Hydrochloride (AMB) simultaneously, in bulk and combined tablet formulation using a new, simple, precise and accurate absorption correction method using UV Spectrophotometer.Methods: The concentrations of both the drugs (NAC and AMB) were determined using absorption correction method as; at 244 nm only AMB gave substantial absorbance and at 220 nm both NAC and AMB gave absorbance. Distilled water was used as a common solvent for both the drugs and the method was developed. Further statistical evaluations were carried out and the method was validated.Results: In the range of 3-18 µg/ml for AMB at 244 nm and 20-120 µg/ml for NAC at 220 nm, the Beer's law was obeyed. Percentage recovery for AMB was in the range 100.50-101.10% and for NAC it was 99.85-100.20%. The % RSD values reported were less than 2. The developed method was validated and was found to be linear, accurate, precise and also rugged.Conclusion: The results obtained clearly demonstrated that the proposed method of analysis was simple, sensitive, accurate, precise, rapid and also economical and could be applied successfully for the simultaneous estimation of NAC and AMB in bulk and combined tablet formulation.Keywords: N-Acetyl-L-cysteine, Ambroxol Hydrochloride, Absorption correction method, Mucolytic, UV spectrophotomete

Albumin Microspheres as an Ocular Delivery System for Pilocarpine Nitrate

Pilocarpine nitrate loaded egg albumin microspheres were prepared by thermal denaturation process in the size range of 1-12 μm. A series of batches were prepared to study factors, which may affect the size and entrapment efficiency of drug in microspheres and optimized the process. Drug loaded microspheres so obtained were evaluated for their size, entrapment efficiency, release rate and biological response. Electron photomicrographs were taken (8000X) to study the morphological characteristics of microspheres. The entrapment and encapsulation of pilocarpine after process optimization was found to be 82.63% and 62.5% respectively. In vitro dissolution rate studies revealed that the release of drug from the microspheres followed spherical matrix mechanism. Biological response of microspheric suspension was measured by reduction in intraocular pressure in albino rabbit eyes and compared with marketed eye drops. Various pharmacokinetic parameters viz. onset of action, duration of action, Tmax and AUC were studied. A measurable difference was found in the mean miotic response, duration and AUC of pilocarpine nitrate microspheric suspension

Colon targeted drug delivery system: A review on current approaches

The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn’s disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon

COMPARATIVE EVALUATION OF THE DIMENSIONAL ACCURACY OF ONE-STEP VERSUS TWO STEP PUTTY WASH IMPRESSION TECHNIQUES USING TWO DIFFERENT COMMERCIALLY AVAILABLE ADDITION SILICONE ELASTOMERIC IMPRESSION MATERIALS – AN In-vitro STUDY

Introduction: An exact impression of dental and dentoalveolar structures is a significant and fundamental prerequisite for the exact fixture of the prosthesis. The advancement of the prosthesis with respect to fit, accuracy, and long life are dependent upon the impression materials, the strategies utilized, and the duration of time of pouring the impression. Aim: Compare and Evaluate the Dimensional Accuracy of One-Step versus Two-Step Putty Wash Impression Techniques Using Two Different Commercially Available Addition Silicone Elastomeric Impression Materials. Methodology: Impressions were made of a metal die having reference lines on it, by one-step wash impression technique and two-step impression technique. After making the impression, impression was allowed to set for 1 hour and then poured in Zhermack die stone. Die stone was allowed to set. Stone dies were obtained from each group. Metal die and stone dies from each group were assessed under stereo microscope 10x zoom using reference lines. Results: When compared to a one-step putty wash impression approach, a two-step putty wash impression process was more reliable. Comparing Virtual (Ivoclar Vivadent, USA) addition polyvinyl siloxane impression material to Aquasil (Dentsply, Germany), it was discovered that it was more accurate. Based on the findings, it has been determined that Ivoclar Vivadent Virtual addition silicone is more precise than Zhermack Aquasil addition silicone and that two-step putty wash impression method is more accurate than one-step putty wash impression method. Conclusion: Inside impediments of this study the following outcomes were drawn that two-stage clay wash impression method is more precise when contrasted with one stage clay wash impression strategy with a spacer of 1 mm for light body consistency expansion polyvinyl siloxane impression material. And The Ivoclar Vivadent Virtual expansion polyvinyl impression material showed more exactness when contrasted with Zhermack Aquasil expansion polyvinyl impression material utilizing one stage and two-stage clay wash impression strategies

Designing of Software Simulation Test bed for 3G Wireless Communication System

Abstract In this paper software is developed for wireless communication test bed which simulates a 3G Wireless Communication System using Wideband Code Division Multiple Access (CDMA) link. CDMA is a popular technology in cellular systems due to its superior capacity and performance. The designer of CDMA systems has a wide array of signal processing algorithms to choose from and a variety of operating environments to deal with. The test bed is a tool to evaluate these design options and trade-offs in different scenarios. The backbone of this system is a wireless WCDMA multiuser link built using Simulink and Matlab. We investigate the bit error rate at both uplink and downlink for different channel conditions. The software test bed developed can be an invaluable tool for learners and researchers for investigating the design and implementation of 3G Wireless Communication systems