Estrategias de comunicación en Redes sociales en el sector de la moda: análisis del uso de imágenes en Instagram

[ES] Las tecnologías de la información y la comunicación (TIC) y la consecuente digitalización de la Sociedad han producido fuertes cambios en los comportamientos empresariales, transformando muchos de estos sectores. Las plataformas de redes sociales se han convertido en una herramienta de comunicación, publicidad y marketing para las empresas, sustentadas por la interacción que ofrecen con los usuarios, siendo el sector de la moda un ejemplo paradigmático, especialmente en las plataformas gráficas centradas en la imagen, como Instagram. El presente TFM tiene como objetivo identificar las distintas estrategias de comunicación que desarrollan las distintas marcas de una misma empresa a partir de las imágenes publicadas en Instagram. Para ello se utiliza Inditex, una de las empresas textiles con más renombre en España, como caso de estudio. En primer lugar se propone una taxonomía para clasificar imágenes basada en tres dimensiones (propósito de la imagen; morfología de la imagen; prendas y accesorios mostrados en la imagen). En segundo lugar, se descargan todas las imágenes publicadas por todas las marcas de Inditex durante tres meses en Instagram y se clasifican en función de la taxonomía propuesta inicialmente. Los resultados muestran que, según el propósito, más de la mitad de las imágenes son de humanización, fundamentalmente en color y con dimensiones dispares según la marca, y refleja sobre todo colección para mujeres. Se concluye que las imágenes analizadas reflejan, a pesar de las diferentes estrategias de comunicación gráfica, la orientación de la marca, con una clara orientación hacia la moda femenina. Oysho, Stradivarius y Uterqüe solo ofrecen colección para mujeres. Zara y Massimo Dutti son las únicas con colección para niños, mientras que Massimo Dutti y Uterqüe emplean siempre las mismas estrategias en la publicación de sus imágenes. La taxonomía de imágenes se demuestra adecuada, escalable y extrapolable a otras plataformas gráficas.[EN] Information and communication technologies (ICT) and the consequent digitalization of the society have produced strong changes in business behaviors, transforming many of these sectors. Social media platforms have become a communication, advertising and marketing tool for companies, supported by the interaction they offer with users, the fashion sector being a paradigmatic example, especially in image-centric graphic platforms , like Instagram. The purpose of this TFM is to identify the different communication strategies developed by the different brands of the same company from the images published on Instagram. For this, Inditex, one of the most renowned textile companies in Spain, is used as a case study. First, a taxonomy is proposed to classify images based on three dimensions (purpose of the image; morphology of the image; garments and accessories shown in the image). Secondly, all the images published by all Inditex brands are downloaded for three months on Instagram and classified according to the taxonomy initially proposed. The results show that, according to the purpose, more than half of the images are of humanization, fundamentally in color and with different dimensions according to the brand, and reflects mainly collection for women. It is concluded that the analyzed images reflect, despite the different graphic communication strategies, the brand orientation, with a clear orientation towards women's fashion. Oysho, Stradivarius and Uterqüe only offer collection for women. Zara and Massimo Dutti are the only ones with a children's collection, while Massimo Dutti and Uterqüe always use the same strategies in publishing their images. The taxonomy of images proves adequate, scalable and extrapolable to other graphic platforms.Rata, A. (2019). Estrategias de comunicación en Redes sociales en el sector de la moda: análisis del uso de imágenes en Instagram. http://hdl.handle.net/10251/128594TFG

Nerve sheath tumor, benign neurogenic slow-growing solitary neurilemmoma of the left ulnar nerve: A case and review of literature

This paper represent a report of a case with ulnar nerve schwannoma(neurilemmoma), benign neurogenic slow-growing, tumors originating from Schwann cells along the course of a nerve (1) (2) (3). Schwannomas are the most common tumors of the peripheral nerves which occur in the adults (0.8–2%) (5). Usually they progress slowly and so they can remain painless swellings for a few years before other symptoms appear. Most of these lesions could be diagnosed clinically, are mobile in the longitudinal plane along the course of the involved nerve but not in the transverse plane (7). EMG, MRI, and ultrasonography are useful tools in the diagnosis. The definitive treatment of benign peripheral nerve schwannomatosis is complete enucleation of the tumor mass without damaging the intact nerve fascicles followed by confirmatory hystopathological examination (12). We present the case of a 62 years old right hand-dominant female who notice a slow increasing bulge over the inner aspect of her distal volar left forearm superior to the wrist, for a longer period of time not exactly specified; this was tracked and associated by pain, tingling and numbness over inner one and half fingers of her left hand in progress until the presentations. A diagnosis of soft-tissue tumor was presumed clinically. The other investigations were ultrasonography (US), nerve conduction studies (NCSs) such as sensory nerve action potential (SNAP) and compound muscle action potential (CMAP). In this case IRM was suggestive of a benign growth in her left ulnar nerve in the forearm region. Microsurgical techniques were used for ample enucleation of the tumor the distal volar left forearm. Subsequent histopathological examination confirmed the presumed diagnosis of a benign cellular schwannoma. At her last follow-up one month after surgery, the patient was neurological gradually improving sensory and motor function and she is highly satisfied with the results of surgery

Psychometric Assessment of the Need Satisfaction and Frustration Scale with Professional Romanian Athletes

Background: Although athletes’ experiences of autonomy, competence, and relatedness play in key role in their motivation, performance-related outcomes, and wellness, there is no evidence to date on measures of autonomy, competence, and relatedness in the Romanian sport context. Building upon self-determination theory, the objective of this research was to adapt the Need Satisfaction and Frustration Scale and analyze its psychometric properties in the Romanian sport context. Methods: The participants were 642 professional athletes (354 males and 288 females; Mage = 22.81, SD = 5.78) who competed at the international and/or national level. Results: The results from confirmatory factor analyses psychometrically supported a six-factor correlated model, which was invariant across gender, age, and sport. Convergent validity was met by average variance extracted values between 0.60 and 0.74. Discriminant validity was underpinned by values from −0.72 to 0.72 for a heterotrait–monotrait ratio of correlations among the six factors. Reliability was endorsed by Cronbach’s alpha scores between 0.75 and 0.89, and between 0.76 and 0.89 for Raykov’s composite reliability coefficient. Criterion validity was supported by positive relationships of autonomy, competence, and relatedness satisfaction to autonomous motivation, and positive associations of autonomy, competence, and relatedness frustration with controlled motivation and amotivation. Conclusions: The Need Satisfaction and Frustration Scale is shown to be a valid and reliable measure of need satisfaction and frustration in professional Romanian athletes

Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours

Background: BAL101553 (lisavanbulin), the lysine prodrug of BAL27862 (avanbulin), exhibits broad anti-proliferative activity in human cancer models refractory to clinically relevant microtubule-targeting agents. Methods: This two-part, open-label, phase 1/2a study aimed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of 2-h infusion of BAL101553 in adults with advanced or recurrent solid tumours. The MTD was determined using a modified accelerated titration design in phase I. Patients received BAL101553 at the MTD and at lower doses in the phase 2a expansion to characterise safety and efficacy and to determine the recommended phase 2 dose (RP2D). Results: Seventy-three patients received BAL101553 at doses of 15–80 mg/m2 (phase 1, n = 24; phase 2a, n = 49). The MTD was 60 mg/m2; DLTs observed at doses ≥60 mg/m2 were reversible Grade 2–3 gait disturbance with Grade 2 peripheral sensory neuropathy. In phase 2a, asymptomatic myocardial injury was observed at doses ≥45 mg/m2. The RP2D for 2-h intravenous infusion was 30 mg/m2. The overall disease control rate was 26.3% in the efficacy population. Conclusions: The RP2D for 2-h infusion of BAL101553 was well tolerated. Dose-limiting neurological and myocardial side effects were consistent with the agent’s vascular-disrupting properties. Clinical trial registration: EudraCT: 2010-024237-23

Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study

Objective: Regorafenib demonstrated efficacy in patients with metastatic colorectal cancer (mCRC). Lack of predictive biomarkers, potential toxicities and cost-effectiveness concerns highlight the unmet need for better patient selection. Design: Patients with RAS mutant mCRC with biopsiable metastases were enrolled in this phase II trial. Dynamic contrast-enhanced (DCE) MRI was acquired pretreatment and at day 15 post-treatment. Median values of volume transfer constant (Ktrans), enhancing fraction (EF) and their product KEF (summarised median values of Ktrans× EF) were generated. Circulating tumour (ct) DNA was collected monthly until progressive disease and tested for clonal RAS mutations by digital-droplet PCR. Tumour vasculature (CD-31) was scored by immunohistochemistry on 70 sequential tissue biopsies. Results: Twenty-seven patients with paired DCE-MRI scans were analysed. Median KEF decrease was 58.2%. Of the 23 patients with outcome data, >70% drop in KEF (6/23) was associated with higher disease control rate (p=0.048) measured by RECIST V. 1.1 at 2 months, improved progression-free survival (PFS) (HR 0.16 (95% CI 0.04 to 0.72), p=0.02), 4-month PFS (66.7% vs 23.5%) and overall survival (OS) (HR 0.08 (95% CI 0.01 to 0.63), p=0.02). KEF drop correlated with CD-31 reduction in sequential tissue biopsies (p=0.04). RAS mutant clones decay in ctDNA after 8 weeks of treatment was associated with better PFS (HR 0.21 (95% CI 0.06 to 0.71), p=0.01) and OS (HR 0.28 (95% CI 0.07–1.04), p=0.06). Conclusions: Combining DCE-MRI and ctDNA predicts duration of anti-angiogenic response to regorafenib and may improve patient management with potential health/economic implications

Extracranial soft-tissue Tumors: repeatability of apparent diffusion coefficient estimates from diffusion-weighted MR imaging

Purpose To assess the repeatability of apparent diffusion coefficient (ADC) estimates in extracranial soft-tissue diffusion-weighted magnetic resonance imaging across a wide range of imaging protocols and patient populations. Materials and Methods Nine prospective patient studies and one prospective volunteer study, performed between 2006 and 2016 with research ethics committee approval and written informed consent from each subject, were included in this single-institution study. A total of 141 tumors and healthy organs were imaged twice (interval between repeated examinations, 45 minutes to 10 days, depending the on study) to assess the repeatability of median and mean ADC estimates. The Levene test was used to determine whether ADC repeatability differed between studies. The Pearson linear correlation coefficient was used to assess correlation between coefficient of variation (CoV) and the year the study started, study size, and volumes of tumors and healthy organs. The repeatability of ADC estimates from small, medium, and large tumors and healthy organs was assessed irrespective of study, and the Levene test was used to determine whether ADC repeatability differed between these groups. Results CoV aggregated across all studies was 4.1% (range for each study, 1.7%–6.5%). No correlation was observed between CoV and the year the study started or study size. CoV was weakly correlated with volume (r = −0.5, P = .1). Repeatability was significantly different between small, medium, and large tumors (P < .05), with the lowest CoV (2.6%) for large tumors. There was a significant difference in repeatability between studies—a difference that did not persist after the study with the largest tumors was excluded. Conclusion ADC is a robust imaging metric with excellent repeatability in extracranial soft tissues across a wide range of tumor sites, sizes, patient populations, and imaging protocol variations

Applicateur local endocavitaire d’ultrasons thérapeutiques intégré avec antenne réceptrice RF pour la thérapie thermique sous contrôle d’IRM de haute résolution

This thesis presents technical and methodological developments aiming tooffer a viable alternative for the treatment of digestive cancers (rectum and esophagus). Compared to the standard methods of therapy, the high intensity contact ultrasound guided by MRI is a less invasive approach. MRI offers 2 advantages: good spatial resolution, and real-time temperature control. This treatment method requires efficacy and safety. Three prototypes of RF coil integrated with ultrasound transducers were built in order to increase the spatial and temporal resolution ofthe MR images, and the accuracy of the temperature measurement. The integrated coils showed a better sensitivity compared to a standard extracorporeal coil. Anatomical (voxel 0.4x0.4x5 mm3)and thermometry (voxel 0.75x0.75x8 mm3, 2s/image) high resolution MR images were acquired in-vivo. The temperature was measured, within a radius of 20 mm from the balloon, with a standard deviation <1°C. The flow artifacts caused by the water circulating inside the cooling balloon could be shifted out of the region of interest. The temperature evolution was controlled automatically, at different depths, with one control point per beam. The controller showed a good accuracy during in-vivo experiments (standard deviation less than 5%). The phased-arrayultra sound transducer permits the successive activation of multiple beams during the same dynamic of sonication. Simulations were conducted in order to offer an optimal treatment planning for a defined tumor. A new design of ultrasound transducer with 256 elements with revolution symmetry, based on a natural geometrical focalization, was proposed.Cette thèse présente des développements techniques et méthodologiques visant une alternative viable pour le traitement des cancers digestifs (rectum, œsophage). Par rapport aux méthodes standards de thérapie, les ultrasons de contact de haute intensité sous guidage IRM sont une approche moins invasive. L’IRM offre 2 avantages: bonne résolution spatiale et contrôle en temps réel de la température. Cette méthode de traitement demande efficacité et sécurité. Trois prototypes d’antenne RF intégrées à des transducteurs ultrasonores ont été réalisés afin d’améliorer la résolution spatiale et temporelle des images IRM et la précision de la mesure de température. Les antennes intégrées ont montré une meilleure sensibilité par rapport à une antenne extra corporelle standard. Des images IRM haute résolution, anatomiques (voxel0.4x0.4x5 mm3) et de thermométrie (voxel 0.75x0.75x8 mm3, 2s/image) ont été acquises in-vivo.La température a été mesurée, dans un rayon de 20 mm au-delà du ballon, avec un écart type<1°C. Les artéfacts de flux causés par l’eau circulante à l’intérieur du ballon de refroidissement ont pu être projetés hors de la région d’intérêt. L’évolution de la température a été contrôlée automatiquement, à des profondeurs variables, avec un point de contrôle par faisceau. Le contrôleur a montré une grande précision in-vivo (écart type <5%). Le transducteur ultrasonore matriciel permet d’activer successivement plusieurs faisceaux pendant la même dynamique de tir.Des simulations ont été conduites afin de proposer une planification du traitement optimale pour une tumeur désignée. Un nouveau concept de sonde ultrasonore à 256 éléments avec focalisation géométrique naturelle a été proposé

Antitumoral Drug-Loaded Biocompatible Polymeric Nanoparticles Obtained by Non-Aqueous Emulsion Polymerization

Non-aqueous dispersions (NAD) with two types of polymeric nanoparticles (NPs), such as hydrophobic poly(&epsilon;-caprolactone) (PCL) and hydrophilic cross-linked poly(vinylpyrrolidone) (PNVP), were synthesized in the present study starting from monomer-in-silicone oil (PDMS) polymerizable non-aqueous emulsions stabilized with the same tailor-made PDMS-based block copolymer. These NPs were loaded with CCisplatin, an antitumoral model drug, directly from the emulsion polymerization step, and it was observed that the presence of the drug leads only to a slight increase of the NPs size, from 120 to 150 nm. The drug release kinetics was evaluated at 37 &deg;C in phosphate buffer at pH = 7.4 and it appeared that the drug release rate from the hydrophilic cross-linked PNVP-based NPs is higher than that from the hydrophobic PCL-based NPs. Moreover, haemolysis tests revealed the fact that these two types of NPs have a good compatibility with the blood. Furthermore, for both the free and drug-loaded NPs, the in vitro cytotoxicity and apoptosis was studied on two types of cancer cell lines, such as MCF-7 (breast cancer cell line) and A-375 (skin cancer cell line). Both types of NPs had no cytotoxic effect but, at a concentration of 500 &mu;g/mL, presented an apoptotic effect similar to that of the free drug